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MX2017011778A - Compuestos y composiciones de alfa-cinamida como inhibidores de histona desacetilasa 8 (hdac8). - Google Patents

Compuestos y composiciones de alfa-cinamida como inhibidores de histona desacetilasa 8 (hdac8).

Info

Publication number
MX2017011778A
MX2017011778A MX2017011778A MX2017011778A MX2017011778A MX 2017011778 A MX2017011778 A MX 2017011778A MX 2017011778 A MX2017011778 A MX 2017011778A MX 2017011778 A MX2017011778 A MX 2017011778A MX 2017011778 A MX2017011778 A MX 2017011778A
Authority
MX
Mexico
Prior art keywords
alpha
compositions
inhibitors
hdac8 inhibitors
cinnamide compounds
Prior art date
Application number
MX2017011778A
Other languages
English (en)
Inventor
W Martin Matthew
W Bair Kenneth
Zheng Xiaozhang
Yee Ng Pui
Han Bingsong
R Thomason Jennifer
Margaret Zablocki Mary
Liu Cuixian
Rudnitskaya Aleksandra
Barczak Nicholas
R Lancia David Jr
Original Assignee
Forma Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forma Therapeutics Inc filed Critical Forma Therapeutics Inc
Publication of MX2017011778A publication Critical patent/MX2017011778A/es

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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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Abstract

La presente invención se refiere a inhibidores de histona deacetilasas, en particular HDAC8, que son útiles para el tratamiento de cáncer y otras enfermedades y trastornos, así como la síntesis y aplicaciones de los inhibidores.
MX2017011778A 2015-03-13 2016-03-11 Compuestos y composiciones de alfa-cinamida como inhibidores de histona desacetilasa 8 (hdac8). MX2017011778A (es)

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US201562132895P 2015-03-13 2015-03-13
US201562184335P 2015-06-25 2015-06-25
US201562270371P 2015-12-21 2015-12-21
PCT/US2016/022029 WO2016149099A1 (en) 2015-03-13 2016-03-11 Alpha-cinnamide compounds and compositions as hdac8 inhibitors

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EP3932914A1 (en) 2015-03-13 2022-01-05 Valo Health, Inc. Alpha-cinnamide compounds and compositions as hdac8 inhibitors
WO2017030892A1 (en) 2015-08-14 2017-02-23 Reaction Biology Corp. Histone deacetylase inhibitors and methods for use thereof
US10029995B2 (en) 2015-09-03 2018-07-24 Forma Therapeutics, Inc. [6,6] fused bicyclic HDAC8 inhibitors
TWI659949B (zh) * 2016-05-16 2019-05-21 臺北醫學大學 組蛋白去乙醯酶6抑制劑及其用途
US20180127386A1 (en) 2016-10-20 2018-05-10 Forma Therapeutics, Inc. Methods using hdac11 inhibitors
CN107056631A (zh) * 2017-04-14 2017-08-18 六盘水师范学院 一种基于Heck反应的2‑烯基苯胺类化合物制备方法
US11230524B2 (en) * 2017-08-17 2022-01-25 Standard Llc Myocyte enhancer factor 2 (MEF2) modulators
MX2020011087A (es) * 2018-04-20 2021-01-08 Valo Early Discovery Inc Isoindolinas como inhibidores de histonas desacetilasas (hdac).
US11535607B2 (en) 2018-04-20 2022-12-27 Valo Health, Inc. Isoindolines as HDAC inhibitors
KR102055369B1 (ko) * 2018-08-09 2019-12-12 충북대학교 산학협력단 신규한 3/4-((치환된 벤즈아미도페녹시)메틸)-n-히드록시 벤즈아미드/프로펜아미드 화합물 및 이의 용도
CN113015735B (zh) * 2018-12-06 2024-06-21 诺华股份有限公司 用于诱导软骨发生以治疗关节损害的5-羟基-7-氧杂双环[2.2.1]庚烷-2-甲酰胺衍生物
CN113493407B (zh) * 2020-04-03 2025-01-28 中国医学科学院药物研究所 一种吡啶类化合物及其制法和药物用途
CN111728961B (zh) * 2020-08-05 2021-06-15 牡丹江医学院 一种用于治疗老年痴呆的药物组合物及其用途
CN114605304A (zh) * 2020-12-04 2022-06-10 杭州中美华东制药有限公司 一种(±)-2-(4-(1-氧代异吲哚-2-基)苯基)丁酸乙酯的合成方法
CN113192633B (zh) * 2021-05-24 2022-05-31 山西大学 基于注意力机制的胃癌细粒度分类方法
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