AU2001234705A1 - Indalone and benzimidazolone inhibitors of factor xa - Google Patents
Indalone and benzimidazolone inhibitors of factor xaInfo
- Publication number
- AU2001234705A1 AU2001234705A1 AU2001234705A AU3470501A AU2001234705A1 AU 2001234705 A1 AU2001234705 A1 AU 2001234705A1 AU 2001234705 A AU2001234705 A AU 2001234705A AU 3470501 A AU3470501 A AU 3470501A AU 2001234705 A1 AU2001234705 A1 AU 2001234705A1
- Authority
- AU
- Australia
- Prior art keywords
- indalone
- benzimidazolone
- inhibitors
- factor
- benzimidazolone inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 108010074860 Factor Xa Proteins 0.000 title 1
- MYONAGGJKCJOBT-UHFFFAOYSA-N benzimidazol-2-one Chemical compound C1=CC=CC2=NC(=O)N=C21 MYONAGGJKCJOBT-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17939200P | 2000-02-01 | 2000-02-01 | |
| US60179392 | 2000-02-01 | ||
| US19173300P | 2000-03-24 | 2000-03-24 | |
| US60191733 | 2000-03-24 | ||
| PCT/US2001/003224 WO2001057019A1 (en) | 2000-02-01 | 2001-02-01 | INDALONE AND BENZIMIDAZOLONE INHIBITORS OF FACTOR Xa |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2001234705A1 true AU2001234705A1 (en) | 2001-08-14 |
Family
ID=26875284
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2001234705A Abandoned AU2001234705A1 (en) | 2000-02-01 | 2001-02-01 | Indalone and benzimidazolone inhibitors of factor xa |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20020019395A1 (en) |
| EP (1) | EP1263754A1 (en) |
| AU (1) | AU2001234705A1 (en) |
| WO (1) | WO2001057019A1 (en) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002070478A1 (en) | 2001-03-06 | 2002-09-12 | Astrazeneca Ab | Indolone derivatives having vascular-damaging activity |
| AU2003302238A1 (en) | 2002-12-03 | 2004-06-23 | Axys Pharmaceuticals, Inc. | 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors |
| TWI289141B (en) | 2003-03-11 | 2007-11-01 | Hoffmann La Roche F. Ag. | Quinolinone derivatives and uses thereof |
| US7521448B2 (en) * | 2003-08-21 | 2009-04-21 | Osi Pharmaceuticals, Inc. | N-substituted benzimidazolyl c-Kit inhibitors |
| US7442709B2 (en) | 2003-08-21 | 2008-10-28 | Osi Pharmaceuticals, Inc. | N3-substituted imidazopyridine c-Kit inhibitors |
| AP2006003553A0 (en) | 2003-08-21 | 2006-04-30 | Osi Pharm Inc | N-substituted pyrazolyl-amidyl-benzimidazolyl C- kit inhibitors. |
| BRPI0518794A2 (en) * | 2004-12-01 | 2008-12-09 | Osi Pharm Inc | compound, composition, method of treating hyperproliferative disorder, and combinatorial library |
| US7728013B2 (en) | 2005-05-10 | 2010-06-01 | Intermune, Inc. | Method of modulating stress-activated protein kinase system |
| CA2615007A1 (en) | 2005-07-13 | 2007-01-18 | F. Hoffmann-La Roche Ag | Benzimidazole derivatives as 5-ht6,5-ht24 |
| JP5209481B2 (en) * | 2005-09-30 | 2013-06-12 | グラクソ グループ リミテッド | Compounds having activity at the M1 receptor and their use in medicine |
| WO2007036715A2 (en) * | 2005-09-30 | 2007-04-05 | Glaxo Group Limited | Compounds which have activity at m1 receptor and their uses in medicine |
| JP5209479B2 (en) * | 2005-09-30 | 2013-06-12 | グラクソ グループ リミテッド | Benzimidazolones having activity at the M1 receptor |
| GB0718415D0 (en) * | 2007-09-20 | 2007-10-31 | Glaxo Group Ltd | Compounds |
| ES2567283T3 (en) | 2008-06-03 | 2016-04-21 | Intermune, Inc. | Compounds and methods to treat inflammatory and fibrotic disorders |
| TWI501967B (en) | 2010-12-16 | 2015-10-01 | Janssen R&D Ireland | Azaindoles as respiratory syncytial virus antiviral agents |
| TWI527814B (en) | 2010-12-16 | 2016-04-01 | 健生科學愛爾蘭無限公司 | Azabenzimidazoles as respiratory syncytial virus antiviral agents |
| TWI515187B (en) * | 2010-12-16 | 2016-01-01 | 健生科學愛爾蘭無限公司 | Anthraquinone as an antiviral agent for respiratory fusion virus |
| DK2864323T3 (en) | 2012-06-15 | 2017-08-14 | Janssen Sciences Ireland Uc | 1,3-DIHYDRO-2H-BENZIMIDAZOLE-2 UNDERIVATIVES SUBSTITUTED BY HETEROCYCLES AS ANTIVIRUS AGENTS AGAINST RESPIRATORY SYNCYTIAL VIRUS |
| AR092742A1 (en) | 2012-10-02 | 2015-04-29 | Intermune Inc | ANTIFIBROTIC PYRIDINONES |
| US9765039B2 (en) | 2012-11-21 | 2017-09-19 | Zenith Epigenetics Ltd. | Biaryl derivatives as bromodomain inhibitors |
| WO2014080290A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Cyclic amines as bromodomain inhibitors |
| WO2014096965A2 (en) | 2012-12-21 | 2014-06-26 | Rvx Therapeutics Inc. | Novel heterocyclic compounds as bromodomain inhibitors |
| WO2015004534A2 (en) | 2013-06-21 | 2015-01-15 | Zenith Epigenetics Corp. | Novel substituted bicyclic compounds as bromodomain inhibitors |
| JP6461121B2 (en) | 2013-06-21 | 2019-01-30 | ゼニス・エピジェネティクス・リミテッドＺｅｎｉｔｈ Ｅｐｉｇｅｎｅｔｉｃｓ Ｌｔｄ． | Novel bicyclic bromodomain inhibitors |
| CN105593224B (en) | 2013-07-31 | 2021-05-25 | 恒元生物医药科技(苏州)有限公司 | Novel quinazolinones as bromodomain inhibitors |
| CA2943363A1 (en) | 2014-04-02 | 2015-10-08 | Intermune, Inc. | Anti-fibrotic pyridinones |
| EP3227280B1 (en) | 2014-12-01 | 2019-04-24 | Zenith Epigenetics Ltd. | Substituted pyridines as bromodomain inhibitors |
| US10710992B2 (en) | 2014-12-01 | 2020-07-14 | Zenith Epigenetics Ltd. | Substituted pyridinones as bromodomain inhibitors |
| US10292968B2 (en) | 2014-12-11 | 2019-05-21 | Zenith Epigenetics Ltd. | Substituted heterocycles as bromodomain inhibitors |
| CN107406438B (en) | 2014-12-17 | 2021-05-14 | 恒翼生物医药科技(上海)有限公司 | Inhibitors of bromodomains |
| EP3932914A1 (en) | 2015-03-13 | 2022-01-05 | Valo Health, Inc. | Alpha-cinnamide compounds and compositions as hdac8 inhibitors |
| WO2018168898A1 (en) | 2017-03-15 | 2018-09-20 | 大日本住友製薬株式会社 | Novel benzimidazolone compound and pharmaceutical use thereof |
| GB201721812D0 (en) | 2017-12-22 | 2018-02-07 | Reviral Ltd | Pharmaceutical compounds |
| EP4165034A1 (en) | 2020-06-11 | 2023-04-19 | Janssen Sciences Ireland Unlimited Company | Hemi (l)-tartrate forms of 3-({5-chloro-1-[3-(methylsulfonyl)propyl]-1h-indol-2 yl} methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2h-imidazo[4,5-c]pyridin-2-one and pharmaceutical compositions comprising the same |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA985247B (en) * | 1997-06-19 | 1999-12-17 | Du Pont Merck Pharma | Guanidine mimics as factor Xa inhibitors. |
| AU735144B2 (en) * | 1997-07-23 | 2001-07-05 | Yamanouchi Pharmaceutical Co., Ltd. | Novel hexahydro-1,4-diazepine derivatives or their salts |
| AU2074699A (en) * | 1998-01-26 | 1999-08-09 | Yamanouchi Pharmaceutical Co., Ltd. | Novel benzene-fused heterocyclic derivatives or salts thereof |
-
2001
- 2001-02-01 AU AU2001234705A patent/AU2001234705A1/en not_active Abandoned
- 2001-02-01 WO PCT/US2001/003224 patent/WO2001057019A1/en not_active Ceased
- 2001-02-01 EP EP01906845A patent/EP1263754A1/en not_active Withdrawn
- 2001-02-01 US US09/773,372 patent/US20020019395A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20020019395A1 (en) | 2002-02-14 |
| EP1263754A1 (en) | 2002-12-11 |
| WO2001057019A1 (en) | 2001-08-09 |
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