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MD4349B1 - Compusul N-(3-metoxifenil)-2-(piridin-2-ilmetilen)-hidrazincarbotioamidă - inhibitor al proliferării celulelor MeW-164 ale melanomului uman - Google Patents

Compusul N-(3-metoxifenil)-2-(piridin-2-ilmetilen)-hidrazincarbotioamidă - inhibitor al proliferării celulelor MeW-164 ale melanomului uman Download PDF

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Publication number
MD4349B1
MD4349B1 MDA20140062A MD20140062A MD4349B1 MD 4349 B1 MD4349 B1 MD 4349B1 MD A20140062 A MDA20140062 A MD A20140062A MD 20140062 A MD20140062 A MD 20140062A MD 4349 B1 MD4349 B1 MD 4349B1
Authority
MD
Moldova
Prior art keywords
human melanoma
compound
hydrazinecarbothioamide
ylmethylene
mew
Prior art date
Application number
MDA20140062A
Other languages
English (en)
Russian (ru)
Other versions
MD4349C1 (ro
Inventor
Aurelian Gulea
Andrzej Lipkowski
Olga Garbuz
Joanna MATALINSKA
Victor Ţapcov
Original Assignee
Universitatea De Stat Din Moldova
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universitatea De Stat Din Moldova filed Critical Universitatea De Stat Din Moldova
Priority to MDA20140062A priority Critical patent/MD4349C1/ro
Publication of MD4349B1 publication Critical patent/MD4349B1/ro
Publication of MD4349C1 publication Critical patent/MD4349C1/ro

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Invenţia se referă la chimie şi medicină, şi anume la un compus organic din clasa tioamidelor care poate găsi aplicare în medicină în calitate de preparat citostatic la profilaxia şi tratamentul melanomului uman.Esenţa invenţiei constă în sinteza compusului N-(3-metoxifenil)-2-(piridin-2-ilmetilen)-hidrazincarbotioamidă cu formula:,care manifestă proprietatea de inhibare a proliferării celulelor MeW-164 ale melanomului uman.
MDA20140062A 2014-06-23 2014-06-23 Compusul N-(3-metoxifenil)-2-(piridin-2-ilmetilen)-hidrazincarbotioamidă - inhibitor al proliferării celulelor MeW-164 ale melanomului uman MD4349C1 (ro)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MDA20140062A MD4349C1 (ro) 2014-06-23 2014-06-23 Compusul N-(3-metoxifenil)-2-(piridin-2-ilmetilen)-hidrazincarbotioamidă - inhibitor al proliferării celulelor MeW-164 ale melanomului uman

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MDA20140062A MD4349C1 (ro) 2014-06-23 2014-06-23 Compusul N-(3-metoxifenil)-2-(piridin-2-ilmetilen)-hidrazincarbotioamidă - inhibitor al proliferării celulelor MeW-164 ale melanomului uman

Publications (2)

Publication Number Publication Date
MD4349B1 true MD4349B1 (ro) 2015-05-31
MD4349C1 MD4349C1 (ro) 2015-12-31

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Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20140062A MD4349C1 (ro) 2014-06-23 2014-06-23 Compusul N-(3-metoxifenil)-2-(piridin-2-ilmetilen)-hidrazincarbotioamidă - inhibitor al proliferării celulelor MeW-164 ale melanomului uman

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MD (1) MD4349C1 (ro)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD4520B1 (ro) * 2016-12-16 2017-10-31 Государственный Университет Молд0 N-(4-butoxifenil)-2-(piridin-2-ilmetiliden)hidrazincarbotioamida în calitate de inhibitor al proliferării celulelor T-47D ale cancerului mamar

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5281715A (en) * 1992-05-13 1994-01-25 Yale University 2-formylpyridine thiosemicarbazone compounds
CN102210698A (zh) * 2004-01-02 2011-10-12 维奥恩药品公司 包含3-氨基吡啶-2-甲醛缩氨基硫脲的癌症治疗
CN101260121A (zh) * 2007-03-07 2008-09-10 卡南吉医药科技（上海）有限公司 杂芳环缩氨基硫脲与过渡金属的络合物及其在制备抗肿瘤药物中的应用
MD3655G2 (ro) * 2007-09-03 2009-02-28 Государственный Университет Молд0 Inhibitor al leucemiei mieloide umane în bază de bis(2-hidroxi-8-fenil-triciclo/7.3.1.0.2,7/tridecan-13-on-tiosemicarbazonato)cupru
MD3771G2 (ro) * 2008-04-30 2009-07-31 Государственный Университет Молд0 Inhibitori ai enzimei 17β-HSD, stimulatoare a multiplicării celulelor cancerului prostatei
WO2010006438A1 (en) * 2008-07-17 2010-01-21 Critical Outcome Technologies Inc. Thiosemicarbazone inhibitor compounds and cancer treatment methods
MD3890G2 (ro) * 2008-09-08 2009-12-31 Государственный Университет Молд0 Inhibitori ai leucemiei mieloide umane în baza compuşilor coordinativi ai cuprului(II) cu salicilidentiosemicarbazide
MD3995C2 (ro) * 2009-05-11 2010-07-31 Государственный Университет Молд0 Utilizare a di(µ-Ofenoxi)-di{[2-(4-aminobenzensulfamido)-5-etil-1,3,4-tiadiazol]-3,5-dibromosalicilidentiosemicarbazonato(-1)-cupru} în calitate de inhibitor al proliferării celulelor T-47D ale cancerului mamar
MD3996C2 (ro) * 2009-05-25 2010-07-31 Государственный Университет Молд0 Percloraţi de 5-R-saliciliden-4-feniltiosemicarbazonato(1-)-aquacupru(II) ce posedă proprietăţi de inhibitori ai activităţii enzimei 17 b-HSD (tipul 1)
MD4190C1 (ro) * 2011-06-16 2013-07-31 Государственный Университет Молд0 Inhibitor al leucemiei mieloide umane în bază de {bis[2-(3,5-dibromo-2-hidroxifenil)-2-oxoetil-piperidin-1-carboditioato(1-)-O,O']cupru}
MD4215C1 (ro) * 2012-07-09 2013-11-30 Государственный Университет Молд0 Inhibitor al leucemiei mieloide umane în bază de N-(4-(5-(piridin-2-il)-4,5-dihidro-1H-pirazol-3-il)fenil)-2-(piridin-2-ilmetilen)-hidrazincarbotioamidă

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD4520B1 (ro) * 2016-12-16 2017-10-31 Государственный Университет Молд0 N-(4-butoxifenil)-2-(piridin-2-ilmetiliden)hidrazincarbotioamida în calitate de inhibitor al proliferării celulelor T-47D ale cancerului mamar

Also Published As

Publication number Publication date
MD4349C1 (ro) 2015-12-31

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FG4A Patent for invention issued
KA4A Patent for invention lapsed due to non-payment of fees (with right of restoration)
MM4A Patent for invention definitely lapsed due to non-payment of fees