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MX2017005788A - Vacunas terapeuticas contra el vph16. - Google Patents

Vacunas terapeuticas contra el vph16.

Info

Publication number
MX2017005788A
MX2017005788A MX2017005788A MX2017005788A MX2017005788A MX 2017005788 A MX2017005788 A MX 2017005788A MX 2017005788 A MX2017005788 A MX 2017005788A MX 2017005788 A MX2017005788 A MX 2017005788A MX 2017005788 A MX2017005788 A MX 2017005788A
Authority
MX
Mexico
Prior art keywords
hpv
protein
vaccines against
therapeutic vaccines
against hpv16
Prior art date
Application number
MX2017005788A
Other languages
English (en)
Other versions
MX379069B (es
Inventor
Khan Selina
M Bunnik Evelien
H H V Custers Jerôme
Ch Scheper Gerrit
Oosterhuis Koen
Gilles Uil Taco
Original Assignee
Janssen Vaccines & Prevention Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52020908&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2017005788(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Vaccines & Prevention Bv filed Critical Janssen Vaccines & Prevention Bv
Publication of MX2017005788A publication Critical patent/MX2017005788A/es
Publication of MX379069B publication Critical patent/MX379069B/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01—DNA viruses
    • C07K14/025—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N15/86—Viral vectors
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N2710/10011—Adenoviridae
    • C12N2710/10041—Use of virus, viral particle or viral elements as a vector
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    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2710/20011—Papillomaviridae
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/106—Plasmid DNA for vertebrates
    • C12N2800/107—Plasmid DNA for vertebrates for mammalian

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Otolaryngology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)

Abstract

La invención proporciona construcciones de ácidos nucleicos diseñadores y polipéptidos que pueden utilizarse como vacunas terapéuticas contra VPH16. Estos polipéptidos comprenden esencialmente todos los epítopos de células T posibles de oncoproteínas E6 y E7 del VPH 16, pero, no obstante, tienen una actividad transformante fuertemente reducida (en comparación con E6 y E7 wt) hasta no detectable, que comprenden fragmentos de las proteínas E6 y E7 que han sido re-ordenadas, conteniendo al mismo tiempo un número minimizado de neo-epítopos indeseados. La invención proporciona una molécula de ácido nucleico que codifica un polipéptido que comprende una secuencia como la recogida en la SEQ ID NO: 1. En determinadas realizaciones, el polipéptido codificado comprende, además, al menos un epítopo de una proteína E2 del virus del papiloma humano (VPH), por ejemplo una proteína E2 de VPH 16.
MX2017005788A 2014-11-04 2015-11-03 Vacunas terapeuticas contra el vph16. MX379069B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14191660 2014-11-04
PCT/EP2015/075516 WO2016071306A1 (en) 2014-11-04 2015-11-03 Therapeutic hpv16 vaccines

Publications (2)

Publication Number Publication Date
MX2017005788A true MX2017005788A (es) 2017-08-02
MX379069B MX379069B (es) 2025-03-10

Family

ID=52020908

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017005788A MX379069B (es) 2014-11-04 2015-11-03 Vacunas terapeuticas contra el vph16.

Country Status (34)

Country Link
US (4) US9701721B2 (es)
EP (2) EP3215187B1 (es)
JP (2) JP6325751B2 (es)
KR (1) KR20170083562A (es)
CN (1) CN107075521B (es)
AR (1) AR102527A1 (es)
AU (2) AU2015341926B2 (es)
BR (1) BR112017009177A2 (es)
CA (1) CA2965562C (es)
CL (1) CL2017001089A1 (es)
CO (1) CO2017004838A2 (es)
CY (1) CY1121377T1 (es)
DK (1) DK3215187T3 (es)
EA (1) EA035461B1 (es)
ES (1) ES2697903T3 (es)
HR (1) HRP20181895T1 (es)
HU (1) HUE040440T2 (es)
IL (1) IL251895B (es)
LT (1) LT3215187T (es)
MA (2) MA46378A (es)
MD (1) MD3215187T2 (es)
MX (1) MX379069B (es)
MY (1) MY181175A (es)
NZ (1) NZ730802A (es)
PL (1) PL3215187T3 (es)
PT (1) PT3215187T (es)
RS (1) RS58080B1 (es)
SA (1) SA517381457B1 (es)
SG (1) SG11201702997YA (es)
SI (1) SI3215187T1 (es)
SM (1) SMT201800602T1 (es)
TW (2) TWI731654B (es)
WO (1) WO2016071306A1 (es)
ZA (1) ZA201703055B (es)

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