[go: up one dir, main page]

AR065076A1 - Vacuna contra el papilomavirus - Google Patents

Vacuna contra el papilomavirus

Info

Publication number
AR065076A1
AR065076A1 ARP080100357A ARP080100357A AR065076A1 AR 065076 A1 AR065076 A1 AR 065076A1 AR P080100357 A ARP080100357 A AR P080100357A AR P080100357 A ARP080100357 A AR P080100357A AR 065076 A1 AR065076 A1 AR 065076A1
Authority
AR
Argentina
Prior art keywords
papillomavirus
polypeptide
nucleotide
vector
papilomavirus
Prior art date
Application number
ARP080100357A
Other languages
English (en)
Original Assignee
Transgene Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transgene Sa filed Critical Transgene Sa
Publication of AR065076A1 publication Critical patent/AR065076A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La presente refiere al uso de una molécula de ácido nucleico que codifica al menos un polipéptido E2 del papilomavirus, un vector, una partícula vírica infecciosa o una composicion de los mismo para la preparacion de un fármaco destinado al tratamiento de un paciente con una infeccion permanente por papilomavirus causada por al menos un papiIomavirus. La presente también proporciona un vector que comprende una molécula de ácido nucleico que comprende una primera secuencia nucleotídica que codifica un polipéptido El del papilomavirus y una segunda secuencia nucleotídica que codifica un polipéptido E2 del papilomavirus en el que la porcion de 3' del primer nucleotido (que en el contexto natural es 100% idéntica a la porcion de 5' del segundo nucleotido) se modifica para exhibir un porcentaje de identidad entre dichas porciones del 75% como máximo.
ARP080100357A 2007-01-30 2008-01-29 Vacuna contra el papilomavirus AR065076A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07360004 2007-01-30
EP07360018 2007-05-15

Publications (1)

Publication Number Publication Date
AR065076A1 true AR065076A1 (es) 2009-05-13

Family

ID=39399907

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080100357A AR065076A1 (es) 2007-01-30 2008-01-29 Vacuna contra el papilomavirus

Country Status (20)

Country Link
US (1) US8420103B2 (es)
EP (2) EP2118292B1 (es)
JP (1) JP5474567B2 (es)
KR (1) KR101636575B1 (es)
CN (1) CN101617052A (es)
AR (1) AR065076A1 (es)
AT (1) ATE518958T1 (es)
AU (1) AU2008209759B2 (es)
BR (1) BRPI0806350A2 (es)
CA (1) CA2675355C (es)
CL (1) CL2008000249A1 (es)
DK (1) DK2118292T3 (es)
IL (2) IL199939A (es)
MX (1) MX2009008118A (es)
PE (1) PE20081723A1 (es)
PL (1) PL2118292T3 (es)
RU (2) RU2482189C2 (es)
TW (1) TW200840869A (es)
WO (1) WO2008092854A2 (es)
ZA (1) ZA200904932B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008250521B2 (en) * 2007-05-15 2013-04-18 Transgene S.A. Signaling peptides
BRPI0810305A2 (pt) * 2007-05-15 2018-07-10 Transgene Sa "vetor, molécula de ácido nucléico substancialmente isolada, célula hospedeira, composição farmacêutica, uso de uma molécula de ácido nucléico, uso de um vetor, uso de uma célula hospedeira e uso de uma composição"
CN107723299B (zh) * 2011-10-12 2022-02-01 宾夕法尼亚大学理事会 用于人乳头状瘤病毒的疫苗及其使用方法
WO2014009433A1 (en) 2012-07-10 2014-01-16 Transgene Sa Mycobacterium resuscitation promoting factor for use as adjuvant
HK1220905A1 (zh) * 2013-03-12 2017-05-19 The Trustees Of The University Of Pennsylvania 用於人乳头状瘤病毒的改进疫苗及其使用方法
WO2015149051A1 (en) * 2014-03-28 2015-10-01 The Johns Hopkins University Treatment regimen using cancer vaccines and local adjuvants and their use
DK3215187T3 (en) * 2014-11-04 2018-12-10 Janssen Vaccines & Prevention Bv THERAPEUTIC HPV16 VACCINES
WO2016168862A1 (en) * 2015-04-17 2016-10-20 Memorial Sloan-Kettering Cancer Center Use of mva or mvadeltae3l as immunotherapeutic agents against solid tumors
KR20190033483A (ko) * 2016-06-03 2019-03-29 이투빅스 코포레이션 인간 파필로마바이러스 (hpv)-연관 질환의 치료를 위한 조성물 및 방법
EP3518966A1 (en) * 2016-09-29 2019-08-07 GlaxoSmithKline Biologicals S.A. Compositions and methods of treatment of persistent hpv infection
JP7334124B2 (ja) 2017-06-21 2023-08-28 トランジェーヌ 個別化ワクチン
EP3461497A1 (en) 2017-09-27 2019-04-03 GlaxoSmithKline Biologicals S.A. Viral antigens
US11012555B2 (en) 2017-11-20 2021-05-18 International Business Machines Corporation Non-verbal sensitive data authentication
WO2019151760A1 (ko) * 2018-02-02 2019-08-08 주식회사 에스엘백시젠 신규 다가 hpv 백신 조성물
US12391746B2 (en) 2018-02-20 2025-08-19 Emory University HPV proteins, antibodies, and uses in managing abnormal epithelial cell growth
WO2019170820A1 (en) 2018-03-07 2019-09-12 Transgene Parapoxvirus vectors
EP3891123A4 (en) 2018-12-03 2022-12-14 Board of Regents, The University of Texas System OLIGO-BENZAMIDE ANALOGS AND THEIR USE IN THE TREATMENT OF CANCER
CN116200416B (zh) * 2023-02-15 2024-03-12 北京康乐卫士生物技术股份有限公司 一种基于Tac启动子的质粒表达载体构建及其用途
WO2025199501A1 (en) * 2024-03-22 2025-09-25 Gritstone Bio, Inc. Human papillomavirus (hpv) vaccines

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4711955A (en) 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
US4603112A (en) 1981-12-24 1986-07-29 Health Research, Incorporated Modified vaccinia virus
US4769330A (en) 1981-12-24 1988-09-06 Health Research, Incorporated Modified vaccinia virus and methods for making and using the same
CA1223831A (en) 1982-06-23 1987-07-07 Dean Engelhardt Modified nucleotides, methods of preparing and utilizing and compositions containing the same
FR2643817B1 (fr) 1989-03-06 1993-12-17 Transgene Sa Composition pharmaceutique, utile a titre preventif ou curatif contre les tumeurs induites par les papillomavirus
DE3642912A1 (de) 1986-12-16 1988-06-30 Leybold Ag Messeinrichtung fuer paramagnetische messgeraete mit einer messkammer
FR2632863B2 (fr) 1987-10-29 1990-08-31 Transgene Sa Virus du fowlpox recombinant et vaccins derives de ces virus
US5100587A (en) 1989-11-13 1992-03-31 The United States Of America As Represented By The Department Of Energy Solid-state radioluminescent zeolite-containing composition and light sources
US5756102A (en) 1990-11-20 1998-05-26 Virogenetics Corporation Poxvirus-canine distemper virus (CDV) recombinants and compositions and methods employing the recombinants
EP0575491B1 (en) 1991-03-07 2003-08-13 Virogenetics Corporation Genetically engineered vaccine strain
GB9105383D0 (en) * 1991-03-14 1991-05-01 Immunology Ltd An immunotherapeutic for cervical cancer
US5179993A (en) 1991-03-26 1993-01-19 Hughes Aircraft Company Method of fabricating anisometric metal needles and birefringent suspension thereof in dielectric fluid
DE4123760C2 (de) 1991-07-18 2000-01-20 Dade Behring Marburg Gmbh Seroreaktive Bereiche auf den HPV 16 Proteinen E1 und E2
US6013638A (en) 1991-10-02 2000-01-11 The United States Of America As Represented By The Department Of Health And Human Services Adenovirus comprising deletions on the E1A, E1B and E3 regions for transfer of genes to the lung
GB9223084D0 (en) 1992-11-04 1992-12-16 Imp Cancer Res Tech Compounds to target cells
WO1994012629A1 (en) * 1992-12-02 1994-06-09 Baylor College Of Medicine Episomal vectors for gene therapy
FR2705686B1 (fr) 1993-05-28 1995-08-18 Transgene Sa Nouveaux adénovirus défectifs et lignées de complémentation correspondantes.
US6133028A (en) 1993-05-28 2000-10-17 Transgene S.A. Defective adenoviruses and corresponding complementation lines
US5698443A (en) 1995-06-27 1997-12-16 Calydon, Inc. Tissue specific viral vectors
PT757717E (pt) * 1994-05-16 2006-09-29 Merck & Co Inc Vacinas de papilomavirus
US5525711A (en) 1994-05-18 1996-06-11 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Pteridine nucleotide analogs as fluorescent DNA probes
US6638762B1 (en) 1994-11-28 2003-10-28 Genetic Therapy, Inc. Tissue-vectors specific replication and gene expression
US5998205A (en) 1994-11-28 1999-12-07 Genetic Therapy, Inc. Vectors for tissue-specific replication
FR2727689A1 (fr) 1994-12-01 1996-06-07 Transgene Sa Nouveau procede de preparation d'un vecteur viral
US5837520A (en) 1995-03-07 1998-11-17 Canji, Inc. Method of purification of viral vectors
FR2749323B1 (fr) 1996-06-04 1998-07-10 Pasteur Merieux Serums Vacc Pseudo-particules virales utiles en tant que vecteur de delivrance d'acide nucleique
BR9710030A (pt) 1996-07-01 1999-08-10 Rhone Poulenc Rorer Sa Processo de produção de adenovírus recombinantes processo de purificação de adenovírus recombinantes a partir de um meio biológico preparação viral purificada composição farmacêutica e utilização de iodixanol-5,5'-[(2-Hidroxipropil-1,3-Propanottl)-Bis[N,N'-Bis(2,3-Didroxipropil-2,4,6-Triodo-1,3-Benzenocarboxamida]
JP4492826B2 (ja) 1996-11-20 2010-06-30 イントロジェン セラピューティクス，インコーポレイテッド アデノウイルスベクターの産生および精製のための改良された方法
ES2283032T3 (es) 1996-12-13 2007-10-16 Schering Corporation Metodos para purificar virus.
EP0988053A1 (en) 1997-06-11 2000-03-29 Aquila Biopharmaceuticals, Inc. Purified saponins as oral adjuvants
FR2766091A1 (fr) 1997-07-18 1999-01-22 Transgene Sa Composition antitumorale a base de polypeptide immunogene de localisation cellulaire modifiee
WO1999014377A2 (en) 1997-09-16 1999-03-25 Innogenetics N.V. Detection and identification of human papillomavirus by pcr and type-specific reverse hybridization
FR2774699B1 (fr) * 1997-11-17 2003-10-03 Rhone Poulenc Rorer Sa Methode de reduction des evenements de recombinaison homologue
FR2777570A1 (fr) 1998-04-17 1999-10-22 Transgene Sa Mutant ayant une activite phosphoribosyl transferase
JP3864610B2 (ja) 1998-05-21 2007-01-10 旭硝子株式会社 水分散型撥水撥油剤組成物およびその製造方法
US6900049B2 (en) 1998-09-10 2005-05-31 Cell Genesys, Inc. Adenovirus vectors containing cell status-specific response elements and methods of use thereof
US20020037274A1 (en) 1998-10-26 2002-03-28 Angelica Williams Single agent method for killing tumor and tumor associated endothelial cells using adenoviral mutants
US6582693B2 (en) * 1998-11-30 2003-06-24 Lemery, S.A. De C.V. Recombinant MVA virus expressing the E2 gene of Bovine papillomavirus and its use in the therapy of tumors generated by papillomaviruses
FR2787465A1 (fr) 1998-12-21 2000-06-23 Transgene Sa Procede d'inactivation des virus enveloppes dans une preparation virale de virus non enveloppes
PL349074A1 (en) 1998-12-31 2002-07-01 Aventis Pharma Sa Method for separating viral particles
DE60010654T2 (de) 1999-02-04 2005-06-16 Geron Corp., Menlo Park Replikativer virus gesteuert von dem promotor der reversen telomerase transkriptase zur behandlung von krebs
DE60029195T2 (de) 1999-02-22 2007-06-28 Transgene S.A. Verfahren zur Gewinnung von purifizierter Virenzusammensetzung
US6492169B1 (en) 1999-05-18 2002-12-10 Crucell Holland, B.V. Complementing cell lines
ES2233437T3 (es) 1999-08-25 2005-06-16 MERCK & CO., INC. Genes sinteticos del papilomavirus optimizados para expresion en celulas humanas.
DK1230378T3 (da) 1999-11-15 2007-10-08 Onyx Pharma Inc Et onkolytisk adenovirus
CA2341356C (en) 2000-04-14 2011-10-11 Transgene S.A. Poxvirus with targeted infection specificity
US20020029498A1 (en) * 2000-07-03 2002-03-14 Howard Harrison Rapid cool iron and related iron improvements
BR0112637A (pt) 2000-07-21 2003-06-10 Glaxo Group Ltd Sequências do vìrus do papiloma códon-otimizadas
CA2448908C (en) 2001-05-30 2008-03-18 Transgene S.A. Adenovirus protein ix, its domains involved in capsid assembly, transcriptional activity and nuclear reorganization
US20050118139A1 (en) 2001-08-23 2005-06-02 Lingyi Huang Vaccine using papilloma virus e proteins delivered by viral vector
IL164172A0 (en) * 2002-05-16 2005-12-18 Bavarian Nordic As Intergenic regions as insertion sites in the genome of modified vaccinia virus ankara (mva)
GB0222953D0 (en) * 2002-10-03 2002-11-13 Glaxo Group Ltd Novel Compounds
CN1950106A (zh) * 2003-12-24 2007-04-18 莱顿大学医学中心 用作肿瘤特异性疫苗的合成蛋白质
US20070014810A1 (en) 2003-12-31 2007-01-18 Denise Baker Inducing cellular immune responses to human papillomavirus using peptide and nucleic acid compositions

Also Published As

Publication number Publication date
EP2118292B1 (en) 2011-08-03
KR101636575B1 (ko) 2016-07-05
JP2010516287A (ja) 2010-05-20
BRPI0806350A2 (pt) 2011-09-06
ZA200904932B (en) 2010-04-28
CA2675355C (en) 2015-04-28
MX2009008118A (es) 2009-10-13
WO2008092854A2 (en) 2008-08-07
KR20090129399A (ko) 2009-12-16
ATE518958T1 (de) 2011-08-15
IL199939A (en) 2013-02-28
EP2118292A2 (en) 2009-11-18
DK2118292T3 (da) 2011-10-24
JP5474567B2 (ja) 2014-04-16
RU2482189C2 (ru) 2013-05-20
US20100143408A1 (en) 2010-06-10
IL199939A0 (en) 2010-04-15
PE20081723A1 (es) 2008-12-14
CL2008000249A1 (es) 2008-05-30
IL215599A0 (en) 2011-11-30
AU2008209759A1 (en) 2008-08-07
PL2118292T3 (pl) 2011-12-30
AU2008209759B2 (en) 2013-03-21
RU2013102035A (ru) 2014-07-27
CN101617052A (zh) 2009-12-30
RU2009130791A (ru) 2011-03-10
TW200840869A (en) 2008-10-16
EP2390340A3 (en) 2012-02-22
WO2008092854A3 (en) 2008-10-30
IL215599A (en) 2014-11-30
EP2390340A2 (en) 2011-11-30
US8420103B2 (en) 2013-04-16
CA2675355A1 (en) 2008-08-07

Similar Documents

Publication Publication Date Title
AR065076A1 (es) Vacuna contra el papilomavirus
HRP20180282T1 (hr) Imunoterapija na bazi indoleamin 2, 3-dioksigenaze
BRPI0922867B8 (pt) glicoproteina de fusão (f) de vírus sincicial respiratório (rsv), ácido nucleico isolado, célula hospedeira, composição de vacina e micela purificada
CO6290791A2 (es) Vacunas y composiciones inmunogénicas que contienen nuevas cepas del circo virus porcino tipo 2b para inmunizar cerdos contra pmws
BRPI0821034A8 (pt) Vírus influenza b recombinante, seu uso, metodo de preparação, composição de vacina o contendo e seu gene m, bem como ácido nucléico isolado, molécula do vírus influenza m e seu uso e método para aumentar a taxa de crescimento de vírus influenza b deficiente de replicação
WO2013039861A3 (en) Engineered nucleic acids and methods of use thereof
EA201190327A1 (ru) Новые конструкции белка вируса папилломы человека (hpv) и их применение в предупреждении заболевания, вызываемого hpv
BR112014015016A8 (pt) Proteína homodimérica de duas cadeias de aminoácidos idênticas, cadeia de aminoácido, molécula de ácido nucléico, composição farmacêutica, célula hospedeira, método de preparação de uma proteína homodimérica, método para preparação de uma vacina, vacina e método de tratamento ou prevenção
CO6440541A2 (es) Virus de diarrea viral bovina con una proteina erns modificada
BR112022016992A2 (pt) Vacina com base em poxvírus recombinante contra ví-rus sars-cov-2
MX340880B (es) Vacunas mejoradas y metodos para uso de las mismas.
CL2012000447A1 (es) Composición o vacuna que comprende un vector viral de un paramixovirus aviar 8 (apmv-8) recombinante; método para producir dicho vector; y uso para preparar medicamento útil para inducir una respuesta inmunológica.
AR101814A1 (es) Partícula de tipo virus flavivirus
BRPI0816134A2 (pt) Herpesvírus, sequência de dna, vetor, célula, vírus, método para produção de partículas infecciosas, partículas infecciosas, vacina, uso de herpesvírus ou da sequência de dna ou do vetor ou das partículas infecciosas, e, método para o tratamento preventivo e/ou terapêutico de uma doença.
AR080313A1 (es) Composiciones de virus de moquillo canino (cdv) recombinante y sus usos
PE20140871A1 (es) COMPOSICIONES Y METODOS DE VACUNA DEL VIRUS TIPO 1b DE DIARREA VIRAL BOVINA
EA201390812A1 (ru) Лиофилизированные вирусные составы
AR094725A1 (es) Parvovirus 5a porcino, métodos de uso y vacuna
PE20090653A1 (es) Formulacion inmunogenica, porque comprende una cepa recombinante atenuada de mycobacterium, preferentemente la cepa recombinante bacilo de calmette y guerin (bcg), que expresa al menos una proteina o fragmento inmunogenico del virus respiratorio sinc
MX2013003245A (es) Vacuna contra virus de diarrea viral de bovinos.
BR112012024224A2 (pt) mutações da faixa de hospedeiro de flavivírus e seu uso.
CR20140101A (es) Inmunoterapia contra el vhc
AR082281A1 (es) Vectores de parapoxvirus
AR071125A1 (es) Peptidos muy puenteados a partir de actinomadura namibiensis
ECSP22064620A (es) COMPOSICIÓN INMUNOGÉNICA VIVA RECOMBINANTE QUE COMPRENDE EL VIRUS DE LA ENFERMEDAD DE NEWCASTLE (NDV) QUE EXPRESA LA SUBUNIDAD S1 Y EL RBD DE LA PROTEINA SPIKE DEL SARS-CoV-2

Legal Events

Date Code Title Description
FA Abandonment or withdrawal