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MX2017004510A - Triazolopirazinonas como inhibidores de pde1. - Google Patents

Triazolopirazinonas como inhibidores de pde1.

Info

Publication number
MX2017004510A
MX2017004510A MX2017004510A MX2017004510A MX2017004510A MX 2017004510 A MX2017004510 A MX 2017004510A MX 2017004510 A MX2017004510 A MX 2017004510A MX 2017004510 A MX2017004510 A MX 2017004510A MX 2017004510 A MX2017004510 A MX 2017004510A
Authority
MX
Mexico
Prior art keywords
triazolopyrazinones
pde1 inhibitors
pde1
inhibitors
medicament
Prior art date
Application number
MX2017004510A
Other languages
English (en)
Inventor
Kehler Jan
Kyhn Rasmussen Lars
Jessing Mikkel
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck As filed Critical H Lundbeck As
Publication of MX2017004510A publication Critical patent/MX2017004510A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención proporciona triazolopirazinonas como inhibidores de PDE1 y su uso como un medicamento, en particular para el tratamiento de trastornos neurodegenerativos y trastornos psiquiátricos.
MX2017004510A 2014-10-10 2015-10-09 Triazolopirazinonas como inhibidores de pde1. MX2017004510A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA201400582 2014-10-10
PCT/EP2015/073417 WO2016055618A1 (en) 2014-10-10 2015-10-09 Triazolopyrazinones as pde1 inhibitors

Publications (1)

Publication Number Publication Date
MX2017004510A true MX2017004510A (es) 2017-06-28

Family

ID=58698606

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017004510A MX2017004510A (es) 2014-10-10 2015-10-09 Triazolopirazinonas como inhibidores de pde1.

Country Status (25)

Country Link
US (1) US10150771B2 (es)
EP (1) EP3204387B1 (es)
JP (1) JP6596489B2 (es)
KR (1) KR20170066417A (es)
CN (1) CN106715438B (es)
AR (1) AR102227A1 (es)
AU (1) AU2015329898A1 (es)
BR (1) BR112017006940A2 (es)
CA (1) CA2961986A1 (es)
CL (1) CL2017000817A1 (es)
CO (1) CO2017002708A2 (es)
DO (1) DOP2017000080A (es)
EA (1) EA201790575A1 (es)
EC (1) ECSP17018120A (es)
ES (1) ES2735733T3 (es)
IL (1) IL251420A0 (es)
MX (1) MX2017004510A (es)
PE (1) PE20180024A1 (es)
PH (1) PH12017500621A1 (es)
RU (1) RU2017111888A (es)
SG (1) SG11201702874YA (es)
SV (1) SV2017005419A (es)
TN (1) TN2017000099A1 (es)
TW (1) TW201629064A (es)
WO (1) WO2016055618A1 (es)

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* Cited by examiner, † Cited by third party
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TW201629064A (zh) 2014-10-10 2016-08-16 Ｈ 朗德貝克公司 作爲ｐｄｅ１抑制劑之三唑並吡酮
TW201643167A (zh) * 2015-04-22 2016-12-16 Ｈ 朗德貝克公司 作爲ｐｄｅ１抑制劑之咪唑並三酮
JO3627B1 (ar) 2015-04-30 2020-08-27 H Lundbeck As إيميدازو بيرازينونات على هيئة مثبطات pde1
TWI729109B (zh) 2016-04-12 2021-06-01 丹麥商Ｈ 朗德貝克公司 作爲PDE1抑制劑的1,5-二氫-4H-吡唑并[3,4-d]嘧啶-4-酮和1,5-二氫-4H-吡唑并[4,3-c]吡啶-4-酮
US10034861B2 (en) * 2016-07-04 2018-07-31 H. Lundbeck A/S 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
JOP20170164A1 (ar) 2016-08-25 2019-01-30 Lilly Co Eli مشتق ترايازولو بيرازينون مفيد كمثبط لـ pde1 بشري
EP3529250B1 (en) 2016-10-18 2023-12-06 H. Lundbeck A/S Imidazopyrazinones, pyrazolopyrimidinones and pyrazolopyridinones as pde1 inhibitors
AU2017350477A1 (en) 2016-10-28 2019-04-18 H. Lundbeck A/S Combination treatments comprising administration of imidazopyrazinones
AU2017350473A1 (en) * 2016-10-28 2019-04-18 H. Lundbeck A/S Combination treatments comprising imidazopyrazinones for the treatment of psychiatric and/or cognitive disorders
JOP20190126A1 (ar) 2016-12-22 2019-05-28 H Lundbeck As بيرازولو [3، 4-b] بيريدينات وإيميدازو [1، 5-b] بيريدازينات على هيئة مثبطات PDE1
MX390582B (es) 2016-12-28 2025-03-20 Dart Neuroscience Llc Star Compuestos de pirazolopirimidinona sustituida como inhibidores de fosfodiesterasas 2 (pde2)
AR112457A1 (es) * 2017-08-02 2019-10-30 Lilly Co Eli Derivados de [1,2,4]triazolo[4,3-a]pirazin-6(5h)-ona
DK3717488T3 (da) 2017-11-27 2021-12-13 Dart Neuroscience Llc Substituerede furanopyrimidinforbindelser som pde1-inhibitorer
AR113926A1 (es) * 2017-12-14 2020-07-01 H Lundbeck As Derivados de 1h-pirazolo[4,3-b]piridinas
PT3723807T (pt) * 2017-12-14 2021-11-26 H Lundbeck As Tratamentos de associação que compreendem a administração de 1h-pirazolo[4,3-b]piridinas
CN117447475A (zh) * 2017-12-20 2024-01-26 H.隆德贝克有限公司 作为PDE1抑制剂的吡唑并[4,3-b]吡啶和咪唑并[1,5-a]嘧啶
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Also Published As

Publication number Publication date
CN106715438B (zh) 2019-04-12
TW201629064A (zh) 2016-08-16
JP6596489B2 (ja) 2019-10-23
WO2016055618A1 (en) 2016-04-14
SG11201702874YA (en) 2017-05-30
DOP2017000080A (es) 2017-05-15
CO2017002708A2 (es) 2017-06-30
US20170298072A1 (en) 2017-10-19
AU2015329898A1 (en) 2017-03-30
JP2017530173A (ja) 2017-10-12
ECSP17018120A (es) 2017-08-31
IL251420A0 (en) 2017-05-29
EP3204387B1 (en) 2019-06-12
CL2017000817A1 (es) 2017-11-03
US10150771B2 (en) 2018-12-11
KR20170066417A (ko) 2017-06-14
BR112017006940A2 (pt) 2018-01-09
ES2735733T3 (es) 2019-12-20
EP3204387A1 (en) 2017-08-16
EA201790575A1 (ru) 2017-07-31
PH12017500621A1 (en) 2017-09-25
PE20180024A1 (es) 2018-01-09
SV2017005419A (es) 2017-06-07
AR102227A1 (es) 2017-02-15
TN2017000099A1 (en) 2018-07-04
CN106715438A (zh) 2017-05-24
CA2961986A1 (en) 2016-04-14
RU2017111888A (ru) 2018-11-12

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