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MX2016013493A - Metodos, kits y aparato para expandir una población de células. - Google Patents

Metodos, kits y aparato para expandir una población de células.

Info

Publication number
MX2016013493A
MX2016013493A MX2016013493A MX2016013493A MX2016013493A MX 2016013493 A MX2016013493 A MX 2016013493A MX 2016013493 A MX2016013493 A MX 2016013493A MX 2016013493 A MX2016013493 A MX 2016013493A MX 2016013493 A MX2016013493 A MX 2016013493A
Authority
MX
Mexico
Prior art keywords
cells
population
expanding
kits
provides
Prior art date
Application number
MX2016013493A
Other languages
English (en)
Other versions
MX380519B (es
Inventor
Germeroth Lothar
Stemberger Christian
Original Assignee
Juno Therapeutics Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Juno Therapeutics Gmbh filed Critical Juno Therapeutics Gmbh
Publication of MX2016013493A publication Critical patent/MX2016013493A/es
Publication of MX380519B publication Critical patent/MX380519B/es

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5156—Animal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
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    • C07K2319/00—Fusion polypeptide
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/51—B7 molecules, e.g. CD80, CD86, CD28 (ligand), CD152 (ligand)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2537/00—Supports and/or coatings for cell culture characterised by physical or chemical treatment
    • C12N2537/10—Cross-linking

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Abstract

La presente invención se refiere a métodos in vitro para expandir una población de células, tales como linfocitos, que comprende poner en contacto una muestra que comprende una población de células con un reactivo de multimerización. El reactivo de multimerización tiene reversiblemente sobre sí (unido a él) un primer agente que provee una señal de activación primaria a las células y opcionalmente, un segundo agente que provee una señal co-estimulatoria. La invención también provee reactivos multimerización, kits, disposiciones y un aparato para expandir células.
MX2016013493A 2014-04-16 2015-04-16 Métodos, kits y aparato para expandir una población de células. MX380519B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461980506P 2014-04-16 2014-04-16
PCT/EP2015/058339 WO2015158868A2 (en) 2014-04-16 2015-04-16 Methods, kits and apparatus for expanding a population of cells

Publications (2)

Publication Number Publication Date
MX2016013493A true MX2016013493A (es) 2017-05-10
MX380519B MX380519B (es) 2025-03-12

Family

ID=53052805

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016013493A MX380519B (es) 2014-04-16 2015-04-16 Métodos, kits y aparato para expandir una población de células.
MX2020014089A MX2020014089A (es) 2014-04-16 2016-10-13 Metodos, kits y aparato para expandir una poblacion de celulas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2020014089A MX2020014089A (es) 2014-04-16 2016-10-13 Metodos, kits y aparato para expandir una poblacion de celulas.

Country Status (27)

Country Link
US (2) US11274278B2 (es)
EP (2) EP3132247B1 (es)
JP (4) JP6696969B2 (es)
KR (2) KR102459384B1 (es)
CN (3) CN106414724A (es)
AU (2) AU2015248786B2 (es)
BR (1) BR112016024072B1 (es)
CA (2) CA3176848A1 (es)
CY (1) CY1124717T1 (es)
DK (1) DK3132247T3 (es)
ES (1) ES2892927T3 (es)
HR (1) HRP20211430T1 (es)
HU (1) HUE056852T2 (es)
IL (3) IL293587B2 (es)
LT (1) LT3132247T (es)
MX (2) MX380519B (es)
MY (1) MY184699A (es)
PH (2) PH12016502017B1 (es)
PL (1) PL3132247T3 (es)
PT (1) PT3132247T (es)
RS (1) RS62471B1 (es)
RU (2) RU2735640C9 (es)
SA (3) SA516380090B1 (es)
SG (2) SG10201808491UA (es)
SI (1) SI3132247T1 (es)
SM (1) SMT202100600T1 (es)
WO (1) WO2015158868A2 (es)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106940268B (zh) 2012-02-23 2021-09-21 朱诺治疗有限公司 细胞和其它复杂生物材料的色谱分离
RU2735640C9 (ru) * 2014-04-16 2021-02-08 Юно Терепьютикс Гмбх Способы, наборы и устройство для размножения популяции клеток
CN113046321A (zh) 2014-04-23 2021-06-29 朱诺治疗学股份有限公司 分离、培养和遗传工程改造用于过继治疗的免疫细胞群的方法
RU2761555C2 (ru) * 2015-10-22 2021-12-09 Джуно Терапьютикс Гмбх Способы, наборы, средства и устройства для трансдукции
MA45488A (fr) 2015-10-22 2018-08-29 Juno Therapeutics Gmbh Procédés, kits et appareil de culture de cellules
MA45489A (fr) 2015-10-22 2018-08-29 Juno Therapeutics Gmbh Procédés de culture de cellules, kits et appareil associés
EP3192810A1 (en) 2016-01-14 2017-07-19 Deutsches Krebsforschungszentrum Psma binding antibody and uses thereof
CN107129988A (zh) * 2016-02-29 2017-09-05 广西医科大学 一种特异性结合cd3的核酸适配体及其筛选方法和应用
AU2017272349B2 (en) * 2016-06-02 2022-12-01 Klotho Therapeutics, Inc. Therapeutic recombinant klotho proteins and compositions and methods involving the same
BR112019001327A2 (pt) 2016-07-29 2019-04-30 Juno Therapeutics Inc anticorpos anti-idiotípicos e métodos relacionados
US10294454B2 (en) 2016-08-24 2019-05-21 General Electric Company Methods and kits for cell activation
WO2018106732A1 (en) * 2016-12-05 2018-06-14 Juno Therapeutics, Inc. Production of engineered cells for adoptive cell therapy
US11624046B2 (en) * 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
US12234441B2 (en) * 2017-03-31 2025-02-25 Terumo Bct, Inc. Cell expansion
JP7393945B2 (ja) * 2017-03-31 2023-12-07 テルモ ビーシーティー、インコーポレーテッド 細胞増殖
JP7339160B2 (ja) * 2017-04-27 2023-09-05 ジュノ セラピューティクス ゲーエムベーハー オリゴマー粒子試薬およびその使用方法
EP3704230B1 (en) 2017-11-01 2024-10-23 Juno Therapeutics, Inc. Process for generating therapeutic compositions of engineered cells
MA51154A (fr) * 2017-12-15 2020-10-21 Aleta Biotherapeutics Inc Variants de cd19
CN107904278B (zh) * 2017-12-25 2021-07-20 北昊干细胞与再生医学研究院有限公司 检测药物对细胞增殖影响的方法
US11149244B2 (en) * 2018-04-04 2021-10-19 Southwest Research Institute Three-dimensional bioreactor for T-cell activation and expansion for immunotherapy
US20210087530A1 (en) * 2018-05-08 2021-03-25 Life Technologies Corporation Compositions and methods for culturing and expanding cells
CN112912103B (zh) * 2018-05-21 2025-08-29 广州邦定生物技术有限公司 多价蛋白质复合物
EP3833742A2 (en) * 2018-08-09 2021-06-16 Juno Therapeutics, Inc. Processes for generating engineered cells and compositions thereof
JP7495409B2 (ja) 2018-09-11 2024-06-04 ドイチェス クレブスフォルシュングスツェントルム シュティフトゥング デス エッフェントリッヒェンレヒツ 改善された抗ｆｌｔ３抗原結合タンパク質
EP3623383A1 (en) 2018-09-11 2020-03-18 Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts Improved bispecific flt3xcd3 antigen binding proteins
CN112955532A (zh) * 2018-09-24 2021-06-11 西南研究院 三维生物反应器
AU2019370705B2 (en) 2018-10-31 2026-01-22 Juno Therapeutics Gmbh Methods for selection and stimulation of cells and apparatus for same
KR20200132147A (ko) * 2019-05-15 2020-11-25 의료법인 성광의료재단 자연 살해 세포의 배양용 조성물 및 이를 이용한 방법
US20220241702A1 (en) * 2019-05-24 2022-08-04 Sol Bio Corporation Affinity isolation system and method using switch-like binding reaction
CA3139965A1 (en) * 2019-06-07 2020-12-10 Ivie AIFUWA Automated t cell culture
CN114929360A (zh) 2019-10-30 2022-08-19 朱诺治疗学有限公司 细胞选择和/或刺激装置及使用方法
EP3822288A1 (en) 2019-11-18 2021-05-19 Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts Antibodies targeting, and other modulators of, the cd276 antigen, and uses thereof
US20230192869A1 (en) 2019-12-06 2023-06-22 Juno Therapeutics, Inc. Anti-idiotypic antibodies to gprc5d-targeted binding domains and related compositions and methods
JP2023504740A (ja) 2019-12-06 2023-02-06 ジュノー セラピューティクス インコーポレイテッド Ｂｃｍａ標的結合ドメインに対する抗イディオタイプ抗体ならびに関連する組成物および方法
CA3163761C (en) 2020-01-31 2023-07-11 Herbert Stadler Methods of isolating a biological entity
CN115361955A (zh) 2020-02-12 2022-11-18 朱诺治疗学股份有限公司 针对bcma的嵌合抗原受体t细胞组合物及其方法和用途
EP4103204A1 (en) 2020-02-12 2022-12-21 Juno Therapeutics, Inc. Cd19-directed chimeric antigen receptor t cell compositions and methods and uses thereof
US12241086B2 (en) 2020-04-15 2025-03-04 Amgen Inc. Process for generating genetically engineered autologous T cells
US12378521B2 (en) 2020-04-15 2025-08-05 Amgen Inc. Method for enhancing production of genetically engineered autologous T cells
EP4192868A1 (en) 2020-08-05 2023-06-14 Juno Therapeutics, Inc. Anti-idiotypic antibodies to ror1-targeted binding domains and related compositions and methods
EP4240756A1 (en) 2020-11-04 2023-09-13 Juno Therapeutics, Inc. Cells expressing a chimeric receptor from a modified invariant cd3 immunoglobulin superfamily chain locus and related polynucleotides and methods
WO2022133169A1 (en) 2020-12-18 2022-06-23 Century Therapeutics, Inc. Chimeric antigen receptor systems with adaptable receptor specificity
CN117321417A (zh) 2021-03-22 2023-12-29 朱诺治疗学股份有限公司 确定治疗性细胞组合物的效力的方法
KR20240018454A (ko) 2021-05-06 2024-02-13 주노 테라퓨틱스 게엠베하 T 세포의 자극 및 형질도입 방법
EP4373920A1 (en) 2021-07-19 2024-05-29 Repairon Immuno GmbH Method of producing a population of immune cells from pluripotent stem cells
WO2023213969A1 (en) 2022-05-05 2023-11-09 Juno Therapeutics Gmbh Viral-binding protein and related reagents, articles, and methods of use
EP4615960A1 (en) 2022-11-09 2025-09-17 C3S2 GmbH Methods for manufacturing engineered immune cells
KR20250121074A (ko) 2022-12-09 2025-08-11 주노 쎄러퓨티크스 인코퍼레이티드 홀로그래픽 이미징을 사용하여 세포 표현형을 예측하기 위한 기계 학습 방법
EP4658675A1 (en) 2023-02-03 2025-12-10 C3S2 GmbH Methods for non-viral manufacturing of engineered immune cells
WO2024182516A1 (en) 2023-02-28 2024-09-06 Juno Therapeutics, Inc. Cell therapy for treating systemic autoimmune diseases
CN121311765A (zh) 2023-04-18 2026-01-09 朱诺治疗学股份有限公司 评估治疗性细胞组合物的效力的细胞毒性测定
CN121464348A (zh) 2023-05-23 2026-02-03 朱诺治疗学股份有限公司 T细胞的激活标记物和评估t细胞激活的方法
CN117448255B (zh) * 2023-09-28 2024-12-31 深圳市龙华区人民医院 S2饲养细胞、制备方法及其应用
WO2025109111A1 (en) * 2023-11-22 2025-05-30 Immudex Aps Immune cell activating multimers
KR102824339B1 (ko) * 2024-07-01 2025-06-26 현대자동차주식회사 배터리 제어 장치 및 그 방법
WO2026020055A2 (en) 2024-07-18 2026-01-22 Juno Therapeutics, Inc. Methods for assessing exosomes in a cell composition and related uses

Family Cites Families (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4361549A (en) 1979-04-26 1982-11-30 Ortho Pharmaceutical Corporation Complement-fixing monoclonal antibody to human T cells, and methods of preparing same
EP0198015B2 (en) 1984-10-02 1995-07-19 Biogen, Inc. Production of streptavidin-like polypeptides
US4851341A (en) 1986-12-19 1989-07-25 Immunex Corporation Immunoaffinity purification system
US6352694B1 (en) 1994-06-03 2002-03-05 Genetics Institute, Inc. Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
DE4237113B4 (de) 1992-11-03 2006-10-12 "Iba Gmbh" Peptide und deren Fusionsproteine, Expressionsvektor und Verfahren zur Herstellung eines Fusionsproteins
EP0700430B1 (en) 1993-06-04 2005-04-20 The United States of America as Represented by the Secretary of the Navy Methods for selectively stimulating proliferation of t cells
WO1996023879A1 (en) 1995-01-30 1996-08-08 Terrapin Technologies, Inc. Glubodies - multiplicities of proteins capable of binding a variety of small molecules
WO1996024606A1 (en) 1995-02-09 1996-08-15 University Of Washington Modified-affinity streptavidin
CA2222035A1 (en) 1995-04-11 1997-03-27 Trustees Of Boston University Streptavidin mutants
DE19641876B4 (de) 1996-10-10 2011-09-29 Iba Gmbh Streptavidinmuteine
WO1998040396A1 (en) 1997-03-14 1998-09-17 Trustees Of Boston University Multiflavor streptavidin
US5985658A (en) 1997-11-14 1999-11-16 Health Research Incorporated Calmodulin-based cell separation technique
US6664042B1 (en) 1999-01-26 2003-12-16 Cornell Research Foundation, Inc. Determining viral load in double negative T cells
EP2332978B1 (en) * 1999-02-03 2014-04-02 Amgen, Inc Novel polypeptides involved in immune response
HK1046154B (zh) 1999-02-04 2009-12-31 Pluristem Ltd. 维持和扩增造血干细胞和/或祖细胞的方法和仪器
DE19932688B4 (de) 1999-07-13 2009-10-08 Scil Proteins Gmbh Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen
US20030235908A1 (en) 2000-02-24 2003-12-25 Xcyte Therapies, Inc. Activation and expansion of cells
US7572631B2 (en) 2000-02-24 2009-08-11 Invitrogen Corporation Activation and expansion of T cells
EP1227321A1 (en) 2000-12-28 2002-07-31 Institut für Bioanalytik GmbH Reversible MHC multimer staining for functional purification of antigen-specific T cells
DE10113776B4 (de) 2001-03-21 2012-08-09 "Iba Gmbh" Isoliertes streptavidinbindendes, kompetitiv eluierbares Peptid, dieses umfassendes Fusionspeptid, dafür codierende Nukleinsäure, Expressionsvektor, Verfahren zur Herstellung eines rekombinanten Fusionsproteins und Verfahren zum Nachweis und/oder zur Gewinnung des Fusionsproteins
WO2003029462A1 (en) 2001-09-27 2003-04-10 Pieris Proteolab Ag Muteins of human neutrophil gelatinase-associated lipocalin and related proteins
DE50307984D1 (de) 2002-03-01 2007-09-27 Volker A Erdmann Streptavidin-Bindungspeptid
US7754155B2 (en) 2002-03-15 2010-07-13 Ross Amelia A Devices and methods for isolating target cells
WO2003090781A1 (en) 2002-04-23 2003-11-06 Meir Strahilevitz Methods and devices for targeting a site in a mammal and for removing species from a mammal
FR2841905B1 (fr) 2002-07-05 2004-09-03 Centre Nat Rech Scient Fragments fab mutants de l'anticorps anti-cd4 chimere 13b8.2 et leurs applications
ES2375724T3 (es) 2002-09-27 2012-03-05 The General Hospital Corporation Dispositivo microflu�?dico para seperación de células y sus usos.
CA2565581C (en) 2003-05-02 2014-07-08 Insception Bioscience, Inc. Apparatus and methods for amplification of blood stem cell numbers
WO2004104185A1 (en) 2003-05-08 2004-12-02 Xcyte Therapies, Inc. Generation and isolation of antigen-specific t cells
CA2546066A1 (en) 2003-11-20 2005-06-02 Biosensor Applications Sweden Ab (Publ) Mixture of at least two different antibodies specific for predetermined antigens and use of the mixture
SE0400181D0 (sv) 2004-01-29 2004-01-29 Gyros Ab Segmented porous and preloaded microscale devices
DE602005013957D1 (de) 2004-06-03 2009-05-28 Meso Scale Technologies Llc Verfahren zur durchführung von vollbluttests
JP5255841B2 (ja) 2004-10-15 2013-08-07 ジェネンコー・インターナショナル・インク 競合示差スクリーニング
WO2006058226A2 (en) * 2004-11-24 2006-06-01 The Trustees Of Boston University Modified dimeric streptavidins and uses thereof
US20060252087A1 (en) 2005-01-18 2006-11-09 Biocept, Inc. Recovery of rare cells using a microchannel apparatus with patterned posts
US7704708B2 (en) * 2006-02-13 2010-04-27 Uti Limited Partnership Monomeric streptavidin muteins
US7855057B2 (en) 2006-03-23 2010-12-21 Millipore Corporation Protein splice variant/isoform discrimination and quantitative measurements thereof
US20090208471A1 (en) 2006-04-07 2009-08-20 Yun Theodore J Isolation and Use of Human Regulatory T Cells
US20070238169A1 (en) * 2006-04-11 2007-10-11 The Board Of Trustees Of The Leland Stanford Junior University Cell sorter and culture system
US20080085532A1 (en) 2006-09-18 2008-04-10 Jorn Gorlach Method for determining the immune status of a subject
PL2091965T3 (pl) 2006-10-17 2013-10-31 Oncotherapy Science Inc Szczepionki peptydowe przeciwko nowotworom z ekspresją polipeptydów MPHOSPH1 lub DEPDC1
US8043822B2 (en) 2006-11-02 2011-10-25 Kyowa Medex Co., Ltd. Method of immunoassaying a component to be measured
EP2518193A3 (en) 2006-11-15 2013-01-23 Invitrogen Dynal AS Methods for reversibly binding a biotin compound to a support
US20080131415A1 (en) 2006-11-30 2008-06-05 Riddell Stanley R Adoptive transfer of cd8 + t cell clones derived from central memory cells
CN101226118B (zh) 2007-01-19 2010-06-16 中国医学科学院肿瘤研究所 一种兼容免疫荧光分析的细胞化学染色方法及其用途
WO2008118476A2 (en) * 2007-03-26 2008-10-02 Codon Devices, Inc. Cell surface display, screening and production of proteins of interest
EP3620465B1 (en) 2007-07-03 2025-02-19 Dako Denmark A/S Improved methods for generation, labeling and use of mhc multimers
WO2009024591A1 (en) 2007-08-20 2009-02-26 Bio-Medisinsk Innovasjon As Pvii phage display
US8727132B2 (en) 2007-12-07 2014-05-20 Miltenyi Biotec Gmbh Sample processing system and methods
CN107254517A (zh) 2008-01-18 2017-10-17 哈佛大学校长及研究员协会 在体液中检测疾病或病症标志的方法
WO2009097119A2 (en) 2008-01-29 2009-08-06 Fred Hutchinson Cancer Research Center Identification of cd8+ t cells that are cd161hi and/or il18r(alpha)hi and have rapid drug efflux capacity
CN101446576B (zh) 2008-12-29 2011-06-22 江苏省苏微微生物研究有限公司 一种微囊藻毒素-lr单抗免疫亲和柱的制备和使用方法
WO2010080032A2 (en) 2009-01-09 2010-07-15 Stichting Het Nederlands Kanker Instituut Bead-assisted viral transduction
US20110070581A1 (en) 2009-04-27 2011-03-24 Amit Gupta Separation of Leukocytes
US20120214187A1 (en) * 2009-11-02 2012-08-23 Ffina Biolutions, Llc Method for Enhancing the Sensitivity of Antibody Based Assays
US20120321665A1 (en) * 2009-12-14 2012-12-20 Benaroya Research Institute At Virginia Mason Compositions and methods for treating airway inflammatory diseases
EP2363501A1 (en) 2010-03-02 2011-09-07 Universitätsklinikum Hamburg-Eppendorf Method for isolating target cells
EP2601521B1 (en) 2010-08-06 2018-05-02 Ludwig-Maximilians-Universität München Identification of t cell target antigens
WO2012058627A2 (en) 2010-10-29 2012-05-03 Miqin Zhang Pre-targeted nanoparticle system and method for labeling biological particles
CN106074601A (zh) 2011-03-23 2016-11-09 弗雷德哈钦森癌症研究中心 用于细胞免疫治疗的方法和组合物
ES2682750T5 (en) * 2011-07-18 2025-02-04 Iba Lifesciences Gmbh Method of reversibly staining a target cell
WO2013038272A2 (en) 2011-09-13 2013-03-21 Uti Limited Partnership Streptavidin mutein exhibiting reversible binding for biotin and streptavidin binding peptide tagged proteins
CN106940268B (zh) 2012-02-23 2021-09-21 朱诺治疗有限公司 细胞和其它复杂生物材料的色谱分离
UA114108C2 (uk) * 2012-07-10 2017-04-25 Борд Оф Ріджентс, Дзе Юніверсіті Оф Техас Сістем Моноклональне антитіло для застосування в діагностиці і терапії злоякісних пухлин і аутоімунного захворювання
EA028988B1 (ru) 2012-07-13 2018-01-31 Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания Способ in vitro анализа культуры генетически модифицированных т-клеток для детекции загрязнения
ES2842102T3 (es) 2012-08-20 2021-07-12 Hutchinson Fred Cancer Res Método y composiciones para inmunoterapia celular
JP6475630B2 (ja) 2012-11-16 2019-02-27 イーベーアー ゲーエムベーハー ストレプトアビジン突然変異タンパク質およびそれらを使用する方法
CN103305464B (zh) 2013-06-05 2015-04-15 南昌大学 直接分离cd4+和cd8+淋巴细胞的方法
US9698876B2 (en) 2013-07-23 2017-07-04 Telefonaktiebolaget Lm Ericsson (Publ) Transmission mode allocation in LTE networks
ES2837856T3 (es) 2013-12-20 2021-07-01 Hutchinson Fred Cancer Res Moléculas efectoras quiméricas etiquetadas y receptores de las mismas
SG10202109752XA (en) 2014-04-07 2021-10-28 Novartis Ag Treatment of cancer using anti-cd19 chimeric antigen receptor
RU2735640C9 (ru) * 2014-04-16 2021-02-08 Юно Терепьютикс Гмбх Способы, наборы и устройство для размножения популяции клеток
CN113046321A (zh) 2014-04-23 2021-06-29 朱诺治疗学股份有限公司 分离、培养和遗传工程改造用于过继治疗的免疫细胞群的方法
EP3134512B1 (en) 2014-04-24 2019-01-02 Miltenyi Biotec GmbH Method for automated generation of genetically modified t cells
PL3134095T3 (pl) 2014-04-25 2020-10-19 Bluebird Bio, Inc. Ulepszone sposoby produkcji komórek do adoptywnych terapii komórkowych
EP3137905B1 (en) * 2014-04-30 2021-01-13 IBA GmbH Method of isolating a target cell
IL254817B2 (en) 2015-04-08 2023-12-01 Novartis Ag Cd20 therapies, cd22 therapies, and combination therapies with a cd19 chimeric antigen receptor (car) - expressing cell
WO2016166568A1 (en) 2015-04-16 2016-10-20 Juno Therapeutics Gmbh Methods, kits and apparatus for expanding a population of cells
RU2761555C2 (ru) 2015-10-22 2021-12-09 Джуно Терапьютикс Гмбх Способы, наборы, средства и устройства для трансдукции
MA45488A (fr) 2015-10-22 2018-08-29 Juno Therapeutics Gmbh Procédés, kits et appareil de culture de cellules
MA45489A (fr) 2015-10-22 2018-08-29 Juno Therapeutics Gmbh Procédés de culture de cellules, kits et appareil associés
CN116041538A (zh) 2015-12-03 2023-05-02 朱诺治疗学股份有限公司 修饰的嵌合受体及相关组合物和方法
JP7339160B2 (ja) 2017-04-27 2023-09-05 ジュノ セラピューティクス ゲーエムベーハー オリゴマー粒子試薬およびその使用方法
EP3833742A2 (en) 2018-08-09 2021-06-16 Juno Therapeutics, Inc. Processes for generating engineered cells and compositions thereof
AU2019370705B2 (en) 2018-10-31 2026-01-22 Juno Therapeutics Gmbh Methods for selection and stimulation of cells and apparatus for same

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