MX2017003464A - Inhibidores de histona desmetilasa. - Google Patents
Inhibidores de histona desmetilasa.Info
- Publication number
- MX2017003464A MX2017003464A MX2017003464A MX2017003464A MX2017003464A MX 2017003464 A MX2017003464 A MX 2017003464A MX 2017003464 A MX2017003464 A MX 2017003464A MX 2017003464 A MX2017003464 A MX 2017003464A MX 2017003464 A MX2017003464 A MX 2017003464A
- Authority
- MX
- Mexico
- Prior art keywords
- cancer
- compositions
- compounds
- histone demethylase
- useful
- Prior art date
Links
- 102000008157 Histone Demethylases Human genes 0.000 title abstract 2
- 108010074870 Histone Demethylases Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 206010005003 Bladder cancer Diseases 0.000 abstract 1
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 abstract 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 abstract 1
- 206010060862 Prostate cancer Diseases 0.000 abstract 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 abstract 1
- 208000005718 Stomach Neoplasms Diseases 0.000 abstract 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 206010017758 gastric cancer Diseases 0.000 abstract 1
- -1 imidazole-pyridine derivative compounds Chemical class 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 201000005202 lung cancer Diseases 0.000 abstract 1
- 208000020816 lung neoplasm Diseases 0.000 abstract 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 abstract 1
- 201000001441 melanoma Diseases 0.000 abstract 1
- 230000001613 neoplastic effect Effects 0.000 abstract 1
- 201000002528 pancreatic cancer Diseases 0.000 abstract 1
- 208000008443 pancreatic carcinoma Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Chemical class 0.000 abstract 1
- 201000011549 stomach cancer Diseases 0.000 abstract 1
- 201000005112 urinary bladder cancer Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención se relaciona generalmente a composiciones y métodos para tratar cáncer y enfermedades neoplasticas. Se porporcionan en la presente compuestos derivados de imidazol-piridina sustituidos y composiciones farmacéuticas que comprense los compuestos. Los presentes compuestos y composiciones son útiles para la inhibición de enzimas de histonia desmetilasa. Además, los presentes compuestos y composiciones son útiles para el tratamiento de cáncer pancreático, cáncer de próstata, cáncer de seno, cáncer de vejiga, cáncer de pulmón, cáncer gástrico, leucemia y/o melanoma y los similares.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462051268P | 2014-09-16 | 2014-09-16 | |
| PCT/US2015/050289 WO2016044342A1 (en) | 2014-09-16 | 2015-09-15 | Histone demethylase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2017003464A true MX2017003464A (es) | 2017-07-13 |
Family
ID=55533770
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017003464A MX2017003464A (es) | 2014-09-16 | 2015-09-15 | Inhibidores de histona desmetilasa. |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US9676770B2 (es) |
| EP (1) | EP3193881B1 (es) |
| JP (1) | JP6660060B2 (es) |
| KR (1) | KR20170048590A (es) |
| CN (1) | CN107073006A (es) |
| AU (1) | AU2015317904A1 (es) |
| BR (1) | BR112017005128A2 (es) |
| CA (1) | CA2961525A1 (es) |
| CL (1) | CL2017000643A1 (es) |
| CO (1) | CO2017002772A2 (es) |
| EA (1) | EA201790502A1 (es) |
| EC (1) | ECSP17020172A (es) |
| ES (1) | ES2911292T3 (es) |
| IL (1) | IL251103A0 (es) |
| MX (1) | MX2017003464A (es) |
| SG (1) | SG11201702108PA (es) |
| WO (1) | WO2016044342A1 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2903081A1 (en) | 2013-03-14 | 2014-09-25 | Quanticel Pharmaceuticals, Inc. | Histone demethylase inhibitors |
| MX2017003464A (es) * | 2014-09-16 | 2017-07-13 | Celgene Quanticel Res Inc | Inhibidores de histona desmetilasa. |
| US9896436B2 (en) | 2014-09-16 | 2018-02-20 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| US9586949B2 (en) | 2015-02-09 | 2017-03-07 | Incyte Corporation | Aza-heteroaryl compounds as PI3K-gamma inhibitors |
| TWI824309B (zh) | 2015-11-06 | 2023-12-01 | 美商英塞特公司 | 作為PI3K-γ抑制劑之雜環化合物 |
| ES2995198T3 (en) * | 2016-01-05 | 2025-02-07 | Incyte Corp | Pyridine compounds as pi3k-gamma inhibitors |
| JP6970680B2 (ja) * | 2016-03-15 | 2021-11-24 | セルジーン クオンティセル リサーチ，インク． | ヒストンデメチラーゼ阻害剤 |
| US10150754B2 (en) | 2016-04-19 | 2018-12-11 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| WO2017223414A1 (en) | 2016-06-24 | 2017-12-28 | Incyte Corporation | HETEROCYCLIC COMPOUNDS AS PI3K-γ INHIBITORS |
| BR112020007593A2 (pt) | 2017-10-18 | 2020-09-24 | Incyte Corporation | derivados de imidazol condensados substituídos por grupos hidróxi terciários como inibidores de pi3k-gama |
| CR20250050A (es) | 2018-09-05 | 2025-03-19 | Incyte Corp | Formas cristalinas de un inhibidor de fosfoinositida 3–quinasa (pi3k) (divisional 2021-0165) |
| CN111116571B (zh) * | 2019-12-27 | 2022-07-12 | 吉首大学 | 含恶唑及三唑双杂环的化合物及其制备与应用方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU3127900A (en) | 1998-12-23 | 2000-07-31 | Du Pont Pharmaceuticals Company | Thrombin or factor xa inhibitors |
| EA200300508A1 (ru) | 2000-10-26 | 2004-06-24 | Туларик Инк. | Противовоспалительные агенты |
| GB0217780D0 (en) | 2002-07-31 | 2002-09-11 | Glaxo Group Ltd | Compounds |
| US20040127733A1 (en) | 2002-10-31 | 2004-07-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | New beta-agonists, processes for preparing them and their use as pharmaceutical compositions |
| DE102004021779A1 (de) | 2004-04-30 | 2005-11-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Beta-Agonisten, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
| JP2009519998A (ja) | 2005-12-19 | 2009-05-21 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | アミノアルコール誘導体の過活動膀胱の治療の為の使用 |
| EP2205589B1 (en) | 2007-10-03 | 2011-03-23 | Vertex Pharmaceuticals Incorporated | C-met protein kinase inhibitors |
| DE102009019962A1 (de) | 2009-05-05 | 2010-11-11 | Merck Patent Gmbh | 3-([1,2,3]Triazol-4-yl)-pyrrolo[2,3-b]pyridinderivate |
| ES2444543T3 (es) | 2009-11-10 | 2014-02-25 | Pfizer Inc | Inhibidores de la N1-pirazoloespirocetona acetil-CoA carboxilasa |
| EA022964B1 (ru) | 2010-01-13 | 2016-03-31 | Темперо Фармасьютикалз, Инк. | Соединения, ингибирующие ферменты гистондеацетилазы, и фармацевтическая композиция, содержащая данные соединения |
| EP3763367A1 (en) | 2012-12-06 | 2021-01-13 | Celgene Quanticel Research, Inc. | Pyridine-pyrazole derivatives as histone demethylase inhibitors |
| CA2903081A1 (en) | 2013-03-14 | 2014-09-25 | Quanticel Pharmaceuticals, Inc. | Histone demethylase inhibitors |
| US9695167B2 (en) | 2014-07-10 | 2017-07-04 | Incyte Corporation | Substituted triazolo[1,5-a]pyridines and triazolo[1,5-a]pyrazines as LSD1 inhibitors |
| MX2017003464A (es) | 2014-09-16 | 2017-07-13 | Celgene Quanticel Res Inc | Inhibidores de histona desmetilasa. |
| US9896436B2 (en) * | 2014-09-16 | 2018-02-20 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
-
2015
- 2015-09-15 MX MX2017003464A patent/MX2017003464A/es unknown
- 2015-09-15 BR BR112017005128A patent/BR112017005128A2/pt not_active Application Discontinuation
- 2015-09-15 KR KR1020177009901A patent/KR20170048590A/ko not_active Withdrawn
- 2015-09-15 ES ES15842092T patent/ES2911292T3/es active Active
- 2015-09-15 CA CA2961525A patent/CA2961525A1/en not_active Abandoned
- 2015-09-15 EA EA201790502A patent/EA201790502A1/ru unknown
- 2015-09-15 EP EP15842092.7A patent/EP3193881B1/en not_active Not-in-force
- 2015-09-15 JP JP2017514411A patent/JP6660060B2/ja not_active Expired - Fee Related
- 2015-09-15 US US14/855,269 patent/US9676770B2/en active Active
- 2015-09-15 SG SG11201702108PA patent/SG11201702108PA/en unknown
- 2015-09-15 AU AU2015317904A patent/AU2015317904A1/en not_active Abandoned
- 2015-09-15 CN CN201580060763.8A patent/CN107073006A/zh active Pending
- 2015-09-15 WO PCT/US2015/050289 patent/WO2016044342A1/en not_active Ceased
-
2017
- 2017-03-12 IL IL251103A patent/IL251103A0/en unknown
- 2017-03-16 CL CL2017000643A patent/CL2017000643A1/es unknown
- 2017-03-23 CO CONC2017/0002772A patent/CO2017002772A2/es unknown
- 2017-03-31 EC ECIEPI201720172A patent/ECSP17020172A/es unknown
- 2017-05-05 US US15/588,495 patent/US10071984B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| BR112017005128A2 (pt) | 2018-07-31 |
| WO2016044342A1 (en) | 2016-03-24 |
| US9676770B2 (en) | 2017-06-13 |
| US10071984B2 (en) | 2018-09-11 |
| ES2911292T3 (es) | 2022-05-18 |
| ECSP17020172A (es) | 2017-05-31 |
| SG11201702108PA (en) | 2017-04-27 |
| EP3193881B1 (en) | 2022-02-09 |
| JP2017527590A (ja) | 2017-09-21 |
| CA2961525A1 (en) | 2016-03-24 |
| CN107073006A (zh) | 2017-08-18 |
| EP3193881A1 (en) | 2017-07-26 |
| EP3193881A4 (en) | 2018-02-21 |
| JP6660060B2 (ja) | 2020-03-04 |
| EA201790502A1 (ru) | 2017-10-31 |
| CO2017002772A2 (es) | 2017-06-09 |
| CL2017000643A1 (es) | 2017-12-01 |
| IL251103A0 (en) | 2017-04-30 |
| US20170240529A1 (en) | 2017-08-24 |
| US20160108033A1 (en) | 2016-04-21 |
| AU2015317904A1 (en) | 2017-04-06 |
| KR20170048590A (ko) | 2017-05-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2017003464A (es) | Inhibidores de histona desmetilasa. | |
| TW201613882A (en) | Histone demethylase inhibitors | |
| MX2020010496A (es) | Inhibidores de desmetilasa-1 especifica de lisina. | |
| SA515360657B1 (ar) | مثبطات ديميثيلاز هيستون | |
| MX381597B (es) | Inhibidores demetilasa-1 específica de lisina. | |
| PH12016502179A1 (en) | Inhibitors of lysine specific demethylase-1 | |
| MX376632B (es) | Inhibidores de demetilasa-1 especifica de lisina. | |
| MX376207B (es) | Inhibidores de demetilasa-1 especifica de lisina. | |
| MX2015007205A (es) | Inhibidores de la desmetilasa de histona. | |
| MX391865B (es) | Inhibidores de demetilasa-1 especifica de lisina. | |
| PH12018500899A1 (en) | Compositions and methods for inhibiting arginase activity | |
| MX2017003466A (es) | Inhibidores de histona desmetilasa. | |
| MX2017003463A (es) | Inhibidores de histona desmetilasa. |