MX2015007205A - Inhibidores de la desmetilasa de histona. - Google Patents
Inhibidores de la desmetilasa de histona.Info
- Publication number
- MX2015007205A MX2015007205A MX2015007205A MX2015007205A MX2015007205A MX 2015007205 A MX2015007205 A MX 2015007205A MX 2015007205 A MX2015007205 A MX 2015007205A MX 2015007205 A MX2015007205 A MX 2015007205A MX 2015007205 A MX2015007205 A MX 2015007205A
- Authority
- MX
- Mexico
- Prior art keywords
- cancer
- histone demethylase
- compounds
- compositions
- demethylase inhibitors
- Prior art date
Links
- 102000008157 Histone Demethylases Human genes 0.000 title abstract 2
- 108010074870 Histone Demethylases Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- XEODJMCAUUKTEC-UHFFFAOYSA-N 3-(1h-pyrazol-5-yl)pyridazine Chemical class N1C=CC(C=2N=NC=CC=2)=N1 XEODJMCAUUKTEC-UHFFFAOYSA-N 0.000 abstract 1
- 206010005003 Bladder cancer Diseases 0.000 abstract 1
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 206010060862 Prostate cancer Diseases 0.000 abstract 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 abstract 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 201000005202 lung cancer Diseases 0.000 abstract 1
- 208000020816 lung neoplasm Diseases 0.000 abstract 1
- 201000001441 melanoma Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Chemical class 0.000 abstract 1
- 150000005292 pyrazolylpyridines Chemical class 0.000 abstract 1
- -1 pyrazolylpyrimidine derivative compounds Chemical class 0.000 abstract 1
- 201000005112 urinary bladder cancer Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
En el presente documento se proporcionan compuestos derivados de pirazolilpiridina, pirazolilpiridazina y pirazolilpirimidina sustituidas y composiciones farmacéuticas que comprenden dichos compuestos. Los compuestos y las composiciones en cuestión son útiles para la inhibición de la desmetilasa de histona. Adicionalmente, los compuestos y las composiciones en cuestión son útiles para el tratamiento del cáncer, tal como el cáncer de próstata, el cáncer de mama, el cáncer de vejiga, el cáncer de pulmón y/o el melanoma, y similares.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261734330P | 2012-12-06 | 2012-12-06 | |
| US201361784414P | 2013-03-14 | 2013-03-14 | |
| PCT/US2013/073424 WO2014089364A1 (en) | 2012-12-06 | 2013-12-05 | Histone demethylase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2015007205A true MX2015007205A (es) | 2016-03-31 |
Family
ID=50884011
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015007205A MX2015007205A (es) | 2012-12-06 | 2013-12-05 | Inhibidores de la desmetilasa de histona. |
Country Status (7)
| Country | Link |
|---|---|
| US (7) | US9604961B2 (es) |
| EP (2) | EP2928471B1 (es) |
| JP (1) | JP6256771B2 (es) |
| CA (1) | CA2894399A1 (es) |
| ES (1) | ES2834959T3 (es) |
| MX (1) | MX2015007205A (es) |
| WO (1) | WO2014089364A1 (es) |
Families Citing this family (76)
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|---|---|---|---|---|
| PT2903968T (pt) | 2012-10-02 | 2017-03-13 | Gilead Sciences Inc | Inibidores de desmetilases de histonas |
| US9604961B2 (en) | 2012-12-06 | 2017-03-28 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| EP2961736B1 (en) | 2013-02-27 | 2018-04-11 | Gilead Sciences, Inc. | Inhibitors of histone demethylases |
| JP2017066030A (ja) * | 2014-02-04 | 2017-04-06 | アグロカネショウ株式会社 | 新規なピラゾール誘導体およびこれを有効成分とする農園芸用薬剤 |
| CA2946538A1 (en) | 2014-04-04 | 2015-10-08 | Del Mar Pharmaceuticals | Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer |
| SI3160952T1 (sl) | 2014-06-25 | 2021-07-30 | Celgene Quanticel Research, Inc. | Zaviralci histon demetilaz |
| MX375960B (es) * | 2014-07-31 | 2025-03-06 | Basf Se | Proceso para la preparacion de pirazoles. |
| JP6689821B2 (ja) | 2014-08-12 | 2020-04-28 | シンジェンタ パーティシペーションズ アーゲー | 硫黄含有置換基を有する殺有害生物的に活性な複素環式誘導体 |
| EA201790154A1 (ru) | 2014-08-27 | 2017-08-31 | Джилид Сайэнс, Инк. | Соединения и способы для ингибирования гистоновых деметилаз |
| US9896436B2 (en) | 2014-09-16 | 2018-02-20 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| US9676770B2 (en) | 2014-09-16 | 2017-06-13 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| AU2016260784B2 (en) | 2015-05-11 | 2020-03-12 | Basf Se | Process for preparing 4-amino-pyridazines |
| AU2017216082B2 (en) | 2016-02-02 | 2020-12-03 | Basf Se | Catalytic hydrogenation process for preparing pyrazoles |
| US20190055212A1 (en) * | 2016-02-16 | 2019-02-21 | Stephen Gwaltney | Histone demethylase inhibitors |
| WO2017161033A1 (en) * | 2016-03-15 | 2017-09-21 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| US10150754B2 (en) | 2016-04-19 | 2018-12-11 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| WO2017198785A1 (en) * | 2016-05-18 | 2017-11-23 | Ieo - Istituto Europeo Di Oncologia S.R.L. | Oxime derivatives useful as inhibitors of histone demethylase kdm4c |
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-
2013
- 2013-12-05 US US14/650,241 patent/US9604961B2/en active Active
- 2013-12-05 MX MX2015007205A patent/MX2015007205A/es unknown
- 2013-12-05 EP EP13861234.6A patent/EP2928471B1/en active Active
- 2013-12-05 EP EP20194603.5A patent/EP3763367A1/en not_active Withdrawn
- 2013-12-05 US US14/098,415 patent/US8987461B2/en active Active
- 2013-12-05 WO PCT/US2013/073424 patent/WO2014089364A1/en not_active Ceased
- 2013-12-05 ES ES13861234T patent/ES2834959T3/es active Active
- 2013-12-05 JP JP2015545854A patent/JP6256771B2/ja not_active Expired - Fee Related
- 2013-12-05 CA CA2894399A patent/CA2894399A1/en not_active Abandoned
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- 2017-02-16 US US15/434,472 patent/US10173996B2/en active Active
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| Publication number | Publication date |
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| US20170158664A1 (en) | 2017-06-08 |
| US20160347733A1 (en) | 2016-12-01 |
| US9908865B2 (en) | 2018-03-06 |
| US9107916B2 (en) | 2015-08-18 |
| ES2834959T3 (es) | 2021-06-21 |
| US20160002201A1 (en) | 2016-01-07 |
| US9458129B2 (en) | 2016-10-04 |
| US20140194469A1 (en) | 2014-07-10 |
| US8987461B2 (en) | 2015-03-24 |
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| US20160068507A1 (en) | 2016-03-10 |
| US20170275266A1 (en) | 2017-09-28 |
| US9714230B2 (en) | 2017-07-25 |
| EP2928471A1 (en) | 2015-10-14 |
| JP2016501882A (ja) | 2016-01-21 |
| EP3763367A1 (en) | 2021-01-13 |
| CA2894399A1 (en) | 2014-06-12 |
| US9604961B2 (en) | 2017-03-28 |
| EP2928471A4 (en) | 2016-06-15 |
| US20150164872A1 (en) | 2015-06-18 |
| WO2014089364A1 (en) | 2014-06-12 |
| JP6256771B2 (ja) | 2018-01-10 |
| EP2928471B1 (en) | 2020-10-14 |
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