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MX2017002896A - Uso del agente de refuerzo del receptor del acido gamma-aminobutirico tipo a (gabaa) en la preparacion de un sedante y medicamento anestesico. - Google Patents

Uso del agente de refuerzo del receptor del acido gamma-aminobutirico tipo a (gabaa) en la preparacion de un sedante y medicamento anestesico.

Info

Publication number
MX2017002896A
MX2017002896A MX2017002896A MX2017002896A MX2017002896A MX 2017002896 A MX2017002896 A MX 2017002896A MX 2017002896 A MX2017002896 A MX 2017002896A MX 2017002896 A MX2017002896 A MX 2017002896A MX 2017002896 A MX2017002896 A MX 2017002896A
Authority
MX
Mexico
Prior art keywords
preparation
sedative
reinforcing agent
medicament
gabaa receptor
Prior art date
Application number
MX2017002896A
Other languages
English (en)
Other versions
MX387490B (es
Inventor
Linlin Qin
Jianyu Liu
Mo Yi
Li Fangqiong
Yu Yan
Li Honghu
Mu Hong
Zhang Yuquan
Yu Qingyang
Cheng Fujun
Yan Pangke
Zhao Ziwei
Original Assignee
Sichuan Haisco Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sichuan Haisco Pharmaceutical Co Ltd filed Critical Sichuan Haisco Pharmaceutical Co Ltd
Publication of MX2017002896A publication Critical patent/MX2017002896A/es
Publication of MX387490B publication Critical patent/MX387490B/es

Links

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/18—Arrangements for indicating condition of container contents, e.g. sterile condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
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    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
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    • A61P25/08—Antiepileptics; Anticonvulsants
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C07C39/17—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings containing other rings in addition to the six-membered aromatic rings, e.g. cyclohexylphenol
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    • C07—ORGANIC CHEMISTRY
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
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    • C07F9/08—Esters of oxyacids of phosphorus
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Abstract

La presente invención está relacionada a una preparación farmacéutica de un compuesto de la fórmula (I) o estereoisómero, sal farmacéuticamente aceptable, o profármaco del mismo, y un método novedoso para la anestesia general o sedación en mamíferos; también se proporcionan kits y productos fabricados del medicamento y la composición farmacéutica y un método para utilizar el medicamento y la composición farmacéutica; R1, R2 y n son como se definen en la descripción. (ver Fórmula).
MX2017002896A 2014-09-04 2015-08-28 Uso del agente de refuerzo del receptor del ácido gamma-aminobutírico tipo a (gabaa) en la preparación de un sedante y medicamento anestésico. MX387490B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201410449723 2014-09-04
CN201410449571 2014-09-04
PCT/CN2015/088341 WO2016034079A1 (zh) 2014-09-04 2015-08-28 一种gabaa受体增强剂用于制备镇静麻醉的药物中的用途

Publications (2)

Publication Number Publication Date
MX2017002896A true MX2017002896A (es) 2017-05-30
MX387490B MX387490B (es) 2025-03-18

Family

ID=55439127

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017002896A MX387490B (es) 2014-09-04 2015-08-28 Uso del agente de refuerzo del receptor del ácido gamma-aminobutírico tipo a (gabaa) en la preparación de un sedante y medicamento anestésico.

Country Status (16)

Country Link
US (1) US10729666B2 (es)
EP (1) EP3189834B1 (es)
JP (1) JP6502480B2 (es)
KR (1) KR102056649B1 (es)
CN (1) CN105579034B (es)
AU (1) AU2015311394B2 (es)
BR (1) BR112017004448B1 (es)
CA (1) CA2959812C (es)
EA (1) EA035649B1 (es)
ES (1) ES2973259T3 (es)
MX (1) MX387490B (es)
MY (1) MY194087A (es)
PT (1) PT3189834T (es)
TW (1) TWI650119B (es)
WO (1) WO2016034079A1 (es)
ZA (1) ZA201701785B (es)

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TW202221720A (zh) 2020-08-03 2022-06-01 大陸商四川海思科製藥有限公司 確定異丙酚及其衍生物群體藥代動力學模型的方法及系統
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CN113081964B (zh) * 2021-04-14 2022-09-02 广州市力鑫药业有限公司 一种盐酸戊乙奎醚纳米药物及其制备方法
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CN114931551B (zh) * 2022-05-11 2023-04-25 四川科瑞德制药股份有限公司 一种25℃储存稳定的米库氯铵注射液及其制备方法和用途
CN116570718B (zh) * 2023-04-26 2025-09-30 四川大学华西医院 一种包含局麻药和磷丙泊酚二钠的药物组合物、其制备方法和用途以及一种联合用药物

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