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MX2017000181A - Celulas madre limbales de mamifero cultivadas, metodos para generarlas y sus usos. - Google Patents

Celulas madre limbales de mamifero cultivadas, metodos para generarlas y sus usos.

Info

Publication number
MX2017000181A
MX2017000181A MX2017000181A MX2017000181A MX2017000181A MX 2017000181 A MX2017000181 A MX 2017000181A MX 2017000181 A MX2017000181 A MX 2017000181A MX 2017000181 A MX2017000181 A MX 2017000181A MX 2017000181 A MX2017000181 A MX 2017000181A
Authority
MX
Mexico
Prior art keywords
lsc
population
generating
methods
limbal stem
Prior art date
Application number
MX2017000181A
Other languages
English (en)
Inventor
Zhang Kang
Quyang Hong
Hou Rui
Cai Huimin
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Publication of MX2017000181A publication Critical patent/MX2017000181A/es

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
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Abstract

La invención proporciona una población de células madre o progenitoras limbales (LSC) aisladas o población similar a LSC que comprende un ácido nucleico químicamente sintetizado, recombinante o aislado que codifica PAX6 integrado en un cromosoma, o alternativamente, no integrado que permanece como un material genético extracromosómico, en donde la población de LSC aislada está sustancialmente libre de células no de LSC o en donde la población similar a LSC está sustancialmente libre de células no similares a LSC, o en donde la población de LSC o similar a LSC aislada está sustancialmente libre de células no de LSC y no similares a LSC y usos de las mismas.
MX2017000181A 2014-06-27 2015-06-29 Celulas madre limbales de mamifero cultivadas, metodos para generarlas y sus usos. MX2017000181A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462018396P 2014-06-27 2014-06-27
PCT/US2015/038384 WO2015200920A1 (en) 2014-06-27 2015-06-29 Cultured mammalian limbal stem cells, methods for generating the same, and uses thereof

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MX2017000181A true MX2017000181A (es) 2017-05-01

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MX2017000181A MX2017000181A (es) 2014-06-27 2015-06-29 Celulas madre limbales de mamifero cultivadas, metodos para generarlas y sus usos.

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US (1) US20170233698A1 (es)
EP (1) EP3161127A4 (es)
JP (1) JP2017522016A (es)
KR (1) KR20170020527A (es)
CN (1) CN107075469A (es)
CA (1) CA2953524A1 (es)
IL (1) IL249828A0 (es)
MX (1) MX2017000181A (es)
SG (2) SG10201806498RA (es)
WO (1) WO2015200920A1 (es)

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JP2023522784A (ja) * 2020-04-27 2023-05-31 ノバルティス アーゲー 眼細胞療法のための方法及び組成物
CN113736735B (zh) * 2020-05-27 2024-02-20 深圳华大生命科学研究院 体外诱导类角膜缘干细胞的方法及试剂盒
MY208025A (en) * 2020-12-23 2025-04-08 Univ Kebangsaan Malaysia A corneal-healing device and method for producing the same
CN112626019A (zh) * 2020-12-28 2021-04-09 武汉爱尔眼科医院有限公司 一种眼角膜及角膜缘单细胞悬液的制备方法
CN115068504A (zh) * 2021-03-12 2022-09-20 广州康睿生物医药科技股份有限公司 一种角膜修复材料及其制备方法和用途
WO2023182856A1 (ko) * 2022-03-24 2023-09-28 서울대학교산학협력단 로-키나제 억제제를 포함하는 켈로이드 등 피부 섬유화 질환의 예방 또는 치료용 약학적 조성물 및 그의 용도
CN115094038A (zh) * 2022-07-15 2022-09-23 中国医学科学院北京协和医院 一种角膜基质细胞原代培养的方法
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SG11201610857TA (en) 2017-01-27
JP2017522016A (ja) 2017-08-10
CN107075469A (zh) 2017-08-18
US20170233698A1 (en) 2017-08-17
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KR20170020527A (ko) 2017-02-22
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