MX2016016281A - Polipeptidos receptores formulados y metodos relacionados. - Google Patents
Polipeptidos receptores formulados y metodos relacionados.Info
- Publication number
- MX2016016281A MX2016016281A MX2016016281A MX2016016281A MX2016016281A MX 2016016281 A MX2016016281 A MX 2016016281A MX 2016016281 A MX2016016281 A MX 2016016281A MX 2016016281 A MX2016016281 A MX 2016016281A MX 2016016281 A MX2016016281 A MX 2016016281A
- Authority
- MX
- Mexico
- Prior art keywords
- related methods
- formulated
- receptor polypeptides
- disclosed
- methods
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 2
- 102000018918 Activin Receptors Human genes 0.000 abstract 1
- 108010052946 Activin Receptors Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1796—Receptors; Cell surface antigens; Cell surface determinants for hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Se revela en la presente una composición a base de un receptor de activina lIB y métodos de uso relacionados, por ejemplo, para tratar tumores sólidos. También se revelan métodos de preparación del compuesto y la formulación.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462012104P | 2014-06-13 | 2014-06-13 | |
| US201462047995P | 2014-09-09 | 2014-09-09 | |
| US201462058789P | 2014-10-02 | 2014-10-02 | |
| US201562142812P | 2015-04-03 | 2015-04-03 | |
| PCT/US2015/035818 WO2015192127A2 (en) | 2014-06-13 | 2015-06-15 | Formulated receptor polypeptides and related methods |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2016016281A true MX2016016281A (es) | 2017-03-31 |
Family
ID=54834575
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016016281A MX2016016281A (es) | 2014-06-13 | 2015-06-15 | Polipeptidos receptores formulados y metodos relacionados. |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US20170202909A1 (es) |
| EP (1) | EP3155008B1 (es) |
| JP (1) | JP2017519009A (es) |
| KR (1) | KR20170035891A (es) |
| CN (1) | CN107074931A (es) |
| AP (1) | AP2016009647A0 (es) |
| AU (1) | AU2015274293A1 (es) |
| BR (1) | BR112016029211A2 (es) |
| CA (1) | CA2952231A1 (es) |
| CL (1) | CL2016003191A1 (es) |
| EA (1) | EA201692568A1 (es) |
| IL (1) | IL249373A0 (es) |
| MX (1) | MX2016016281A (es) |
| PE (1) | PE20170471A1 (es) |
| PH (1) | PH12016502479A1 (es) |
| SG (1) | SG11201610432UA (es) |
| TN (1) | TN2016000551A1 (es) |
| TW (1) | TW201625675A (es) |
| WO (1) | WO2015192127A2 (es) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1973559E (pt) | 2005-11-23 | 2013-02-19 | Acceleron Pharma Inc | Antagonistas de activina-actriia e utilizações para promover o crescimento ósseo |
| US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
| US8895016B2 (en) | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
| CN103920139B (zh) | 2007-02-01 | 2018-02-02 | 阿塞勒隆制药公司 | 活化素‑actriia拮抗剂及在治疗或预防乳腺癌中的用途 |
| TW201940502A (zh) | 2007-02-02 | 2019-10-16 | 美商艾瑟勒朗法瑪公司 | 衍生自ActRIIB的變體與其用途 |
| TWI667038B (zh) | 2007-02-09 | 2019-08-01 | 美商艾瑟勒朗法瑪公司 | 包含ActRIIa-Fc融合蛋白的醫藥組合物;ActRIIa-Fc融合蛋白於治療或預防與癌症相關的骨質流失之用途;ActRIIa-Fc融合蛋白於治療或預防多發性骨髓瘤之用途 |
| US7960343B2 (en) | 2007-09-18 | 2011-06-14 | Acceleron Pharma Inc. | Activin-ActRIIa antagonists and uses for decreasing or inhibiting FSH secretion |
| TWI748373B (zh) | 2008-08-14 | 2021-12-01 | 美商艾瑟勒朗法瑪公司 | 使用gdf阱以增加紅血球水平 |
| US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
| CN102482339B (zh) | 2009-06-08 | 2015-06-17 | 阿塞勒隆制药公司 | 用于增加产热脂肪细胞的方法 |
| KR20210034684A (ko) | 2009-06-12 | 2021-03-30 | 악셀레론 파마 인코포레이티드 | 절두된 ActRIIB-FC 융합 단백질 |
| JP6267425B2 (ja) | 2009-11-17 | 2018-01-24 | アクセルロン ファーマ, インコーポレイテッド | 筋ジストロフィー治療のためのユートロフィン誘導に関するactriibタンパク質およびその改変体およびその使用 |
| KR20130132824A (ko) | 2010-11-08 | 2013-12-05 | 악셀레론 파마 인코포레이티드 | Actriia 결합제 및 이의 용도 |
| MX389254B (es) | 2012-11-02 | 2025-03-20 | Celgene Corp | Antagonistas de activina-actrii y usos para tratar trastornos oseos y otros. |
| EA201591423A1 (ru) | 2013-02-01 | 2016-01-29 | Санта Мария Биотерапевтикс, Инк. | Введение антитела к активину-а пациентам |
| AP2017009674A0 (en) | 2014-06-13 | 2017-01-31 | Acceleron Pharma Inc | Methods and compositions for treating ulcers |
| CN107683287B (zh) | 2015-04-22 | 2022-05-06 | 奥健公司 | 用于治疗肌肉萎缩疾病的新型杂合actriib配体陷阱蛋白 |
| KR20180128405A (ko) * | 2016-02-22 | 2018-12-03 | 악셀레론 파마 인코포레이티드 | 면역 활성 증가에 사용하기 위한 ActRII 길항제 |
| JOP20190085A1 (ar) | 2016-10-20 | 2019-04-17 | Biogen Ma Inc | طرق علاج الضمور العضلي ومرض العظام باستخدام بروتينات احتجاز مركب ترابطي actriib هجين حديثة |
| JP7139326B2 (ja) | 2016-11-10 | 2022-09-20 | ケロス セラピューティクス インコーポレイテッド | アクチビンIIa型受容体変異体および同変異体を含む医薬組成物 |
| US11932699B2 (en) | 2017-09-07 | 2024-03-19 | Jcr Pharmaceuticals Co., Ltd. | Aqueous pharmaceutical composition |
| CA3080656A1 (en) | 2017-10-30 | 2019-05-09 | Baxalta GmbH | Environmentally compatible detergents for inactivation of lipid-enveloped viruses |
| KR20200085832A (ko) | 2017-11-09 | 2020-07-15 | 케로스 테라퓨틱스, 인크. | 액티빈 수용체 유형 iia 변이체 및 그의 사용 방법 |
| JP7510875B2 (ja) | 2018-01-12 | 2024-07-04 | ケロス セラピューティクス インコーポレイテッド | アクチビンiib型受容体変異体および同変異体を含む医薬組成物 |
| KR20250133994A (ko) | 2018-05-09 | 2025-09-09 | 케로스 테라퓨틱스, 인크. | 액티빈 수용체 유형 iia 변이체 및 그의 사용 방법 |
| EP3843709A1 (en) * | 2018-08-29 | 2021-07-07 | Translate Bio, Inc. | Improved process of preparing mrna-loaded lipid nanoparticles |
| KR20210102874A (ko) * | 2018-10-12 | 2021-08-20 | 어드밴스드 액셀러레이터 어플리케이션즈 인터내셔널 에스.에이. | 방사성 표지된 gprp 길항제 및 계면활성제를 포함하는 약학적 조성물 |
| TWI878344B (zh) * | 2019-09-17 | 2025-04-01 | 瑞士商諾華公司 | 放射性標記grpr拮抗劑之方法及其套組 |
| CA3168001A1 (en) * | 2020-02-21 | 2021-08-26 | Spitfire Pharma Llc | Glp-1r and gcgr agonists, formulations, and methods of use |
| KR20230004515A (ko) | 2020-03-20 | 2023-01-06 | 케로스 테라퓨틱스, 인크. | 액티빈 수용체 유형 ii 키메라 및 이의 사용 방법 |
| WO2021189010A1 (en) | 2020-03-20 | 2021-09-23 | Keros Therapeutics, Inc. | Methods of using activin receptor type iib variants |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4263428A (en) | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| EP0088046B1 (de) | 1982-02-17 | 1987-12-09 | Ciba-Geigy Ag | Lipide in wässriger Phase |
| HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
| DE3474511D1 (en) | 1983-11-01 | 1988-11-17 | Terumo Corp | Pharmaceutical composition containing urokinase |
| AU648505B2 (en) | 1989-05-19 | 1994-04-28 | Amgen, Inc. | Metalloproteinase inhibitor |
| JP4454859B2 (ja) | 1998-11-13 | 2010-04-21 | イミュネックス・コーポレーション | ヒトtslpdnaおよびポリペプチド |
| JP4038118B2 (ja) | 2002-11-29 | 2008-01-23 | 株式会社コガネイ | 流体圧シリンダ |
| US9283260B2 (en) * | 2006-04-21 | 2016-03-15 | Amgen Inc. | Lyophilized therapeutic peptibody formulations |
| TWI454479B (zh) * | 2007-03-06 | 2014-10-01 | Amgen Inc | 變異之活動素受體多肽及其用途 |
| KR20100120289A (ko) * | 2008-01-15 | 2010-11-15 | 애보트 게엠베하 운트 콤파니 카게 | 분말상 단백질 조성물 및 이의 제조 방법 |
| EA201100832A1 (ru) * | 2008-11-26 | 2011-12-30 | Амген Инк. | Варианты полипептидов рецептора iib активина и их применение |
| RU2600847C2 (ru) * | 2010-05-10 | 2016-10-27 | Интас Биофармасьютикалс Лимитед | Жидкий состав полипептидов, содержащих fc-домен иммуноглобулина |
| JP5782185B2 (ja) | 2012-06-01 | 2015-09-24 | 日本電信電話株式会社 | パケット転送処理方法およびパケット転送処理装置 |
| EA201591423A1 (ru) * | 2013-02-01 | 2016-01-29 | Санта Мария Биотерапевтикс, Инк. | Введение антитела к активину-а пациентам |
| US9300829B2 (en) | 2014-04-04 | 2016-03-29 | Canon Kabushiki Kaisha | Image reading apparatus and correction method thereof |
| WO2016205370A1 (en) * | 2015-06-15 | 2016-12-22 | Santa Maria Biotherapeutics, Inc. | Methods of using activin receptor iib-based proteins |
-
2015
- 2015-06-15 CA CA2952231A patent/CA2952231A1/en active Pending
- 2015-06-15 US US15/316,767 patent/US20170202909A1/en not_active Abandoned
- 2015-06-15 TW TW104119310A patent/TW201625675A/zh unknown
- 2015-06-15 AU AU2015274293A patent/AU2015274293A1/en not_active Abandoned
- 2015-06-15 BR BR112016029211A patent/BR112016029211A2/pt not_active Application Discontinuation
- 2015-06-15 SG SG11201610432UA patent/SG11201610432UA/en unknown
- 2015-06-15 EA EA201692568A patent/EA201692568A1/ru unknown
- 2015-06-15 AP AP2016009647A patent/AP2016009647A0/en unknown
- 2015-06-15 JP JP2016572730A patent/JP2017519009A/ja active Pending
- 2015-06-15 EP EP15805829.7A patent/EP3155008B1/en active Active
- 2015-06-15 CN CN201580043173.4A patent/CN107074931A/zh active Pending
- 2015-06-15 TN TN2016000551A patent/TN2016000551A1/en unknown
- 2015-06-15 WO PCT/US2015/035818 patent/WO2015192127A2/en not_active Ceased
- 2015-06-15 MX MX2016016281A patent/MX2016016281A/es unknown
- 2015-06-15 KR KR1020177001016A patent/KR20170035891A/ko not_active Withdrawn
- 2015-06-15 PE PE2016002711A patent/PE20170471A1/es not_active Application Discontinuation
-
2016
- 2016-12-04 IL IL249373A patent/IL249373A0/en unknown
- 2016-12-12 PH PH12016502479A patent/PH12016502479A1/en unknown
- 2016-12-13 CL CL2016003191A patent/CL2016003191A1/es unknown
-
2023
- 2023-07-20 US US18/224,463 patent/US20240277805A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IL249373A0 (en) | 2017-02-28 |
| KR20170035891A (ko) | 2017-03-31 |
| TN2016000551A1 (en) | 2018-04-04 |
| WO2015192127A2 (en) | 2015-12-17 |
| CN107074931A (zh) | 2017-08-18 |
| EP3155008A2 (en) | 2017-04-19 |
| WO2015192127A3 (en) | 2016-03-17 |
| BR112016029211A2 (pt) | 2018-01-30 |
| US20170202909A1 (en) | 2017-07-20 |
| AU2015274293A1 (en) | 2017-02-02 |
| US20240277805A1 (en) | 2024-08-22 |
| PE20170471A1 (es) | 2017-05-14 |
| AP2016009647A0 (en) | 2016-12-31 |
| SG11201610432UA (en) | 2017-01-27 |
| EP3155008A4 (en) | 2018-05-16 |
| EA201692568A1 (ru) | 2017-05-31 |
| TW201625675A (zh) | 2016-07-16 |
| EP3155008B1 (en) | 2020-08-26 |
| JP2017519009A (ja) | 2017-07-13 |
| CL2016003191A1 (es) | 2017-11-10 |
| CA2952231A1 (en) | 2015-12-17 |
| PH12016502479A1 (en) | 2017-04-10 |
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