MX2016013911A - Sales y polimorfos de un compuesto imidazopiridinil-aminopiridina sustituido. - Google Patents
Sales y polimorfos de un compuesto imidazopiridinil-aminopiridina sustituido.Info
- Publication number
- MX2016013911A MX2016013911A MX2016013911A MX2016013911A MX2016013911A MX 2016013911 A MX2016013911 A MX 2016013911A MX 2016013911 A MX2016013911 A MX 2016013911A MX 2016013911 A MX2016013911 A MX 2016013911A MX 2016013911 A MX2016013911 A MX 2016013911A
- Authority
- MX
- Mexico
- Prior art keywords
- compound
- salts
- polymorphs
- free base
- forms
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 11
- 229940126062 Compound A Drugs 0.000 abstract 15
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 abstract 15
- 239000012458 free base Substances 0.000 abstract 7
- 239000007787 solid Substances 0.000 abstract 3
- HNFMVVHMKGFCMB-UHFFFAOYSA-N 3-[3-[4-(1-aminocyclobutyl)phenyl]-5-phenylimidazo[4,5-b]pyridin-2-yl]pyridin-2-amine Chemical compound NC1=NC=CC=C1C1=NC2=CC=C(C=3C=CC=CC=3)N=C2N1C1=CC=C(C2(N)CCC2)C=C1 HNFMVVHMKGFCMB-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente solicitud se refiere a sales del compuesto A, 3-(3-(4-(1-aminociclobutil)fenil)-5-fenil-3H-imidazo[4,5-b] piridin-2-il)piridin-2-amina, formas sólidas de la base libre del compuesto A o de las sales del compuesto A, formas amorfas de la base libre del compuesto A o de sales del compuesto A, formas cristalinas de la base libre del compuesto A o de sales del compuesto A, polimorfos de la base libre del compuesto A o de sales del compuesto A y mesomorfos de la base libre de compuesto A o de sales del compuesto A; la presente solicitud también se refiere a composiciones farmacéuticas que comprenden estas sales, formas de estado sólido, formas amorfas, formas cristalinas, polimorfos o mesomorfos de la base libre del compuesto A o de sales del compuesto A; la presente solicitud proporciona métodos para preparar estas sales, formas sólidas, formas amorfas, formas cristalinas, polimorfos o mesomorfos de la base libre del compuesto A o de las sales del compuesto A.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461982692P | 2014-04-22 | 2014-04-22 | |
| PCT/US2015/027045 WO2015164479A1 (en) | 2014-04-22 | 2015-04-22 | Salts and polymorphs of a substituted imidazopyridinyl-aminopyridine compound |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2016013911A true MX2016013911A (es) | 2017-03-07 |
| MX375758B MX375758B (es) | 2025-03-06 |
Family
ID=54321420
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016013911A MX375758B (es) | 2014-04-22 | 2015-04-22 | Sales y polimorfos de un compuesto imidazopiridinil-aminopiridina sustituido. |
| MX2020009412A MX2020009412A (es) | 2014-04-22 | 2016-10-21 | Sales y polimorfos de un compuesto imidazopiridinil-aminopiridina sustituido. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020009412A MX2020009412A (es) | 2014-04-22 | 2016-10-21 | Sales y polimorfos de un compuesto imidazopiridinil-aminopiridina sustituido. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US9422283B2 (es) |
| EP (2) | EP3653627A1 (es) |
| JP (2) | JP6961348B2 (es) |
| KR (1) | KR20160143842A (es) |
| CN (2) | CN106795153B (es) |
| AU (2) | AU2015249809B2 (es) |
| BR (1) | BR112016024521A2 (es) |
| CA (1) | CA2945778A1 (es) |
| DK (1) | DK3134407T3 (es) |
| ES (1) | ES2745156T3 (es) |
| HU (1) | HUE046150T2 (es) |
| IL (1) | IL248342A (es) |
| MX (2) | MX375758B (es) |
| PL (1) | PL3134407T3 (es) |
| PT (1) | PT3134407T (es) |
| RU (1) | RU2732125C2 (es) |
| SG (1) | SG11201608722QA (es) |
| TW (1) | TWI652266B (es) |
| WO (1) | WO2015164479A1 (es) |
| ZA (1) | ZA201607107B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20210105931A (ko) | 2018-12-20 | 2021-08-27 | 머크 샤프 앤드 돔 코포레이션 | Nrtti 화합물의 신규 결정질 형태 |
| KR102737283B1 (ko) * | 2019-07-17 | 2024-12-03 | 서밋 (옥스포드) 리미티드 | 리디닐라졸 및 이의 결정 형태의 제조방법 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| JP3729343B2 (ja) * | 2000-04-27 | 2005-12-21 | アステラス製薬株式会社 | 縮合ヘテロアリール誘導体 |
| US6403588B1 (en) * | 2000-04-27 | 2002-06-11 | Yamanouchi Pharmaceutical Co., Ltd. | Imidazopyridine derivatives |
| GB0206860D0 (en) * | 2002-03-22 | 2002-05-01 | Glaxo Group Ltd | Compounds |
| CN102127078A (zh) * | 2005-07-14 | 2011-07-20 | 安斯泰来制药株式会社 | Janus激酶3的杂环类抑制剂 |
| DE602007004092D1 (de) * | 2006-03-22 | 2010-02-11 | Vertex Pharma | C-met-proteinkinasehemmer zur behandlung proliferativer erkrankungen |
| US8136543B2 (en) * | 2009-01-27 | 2012-03-20 | Fisher Controls International, Llc | Axial flow control valves having an internal actuator |
| IT1395963B1 (it) * | 2009-06-04 | 2012-11-02 | Rottapharm Spa | Forme cristalline di 6-(1h-imidazol-1-il)-2-fenil chinazolina e dei suoi sali |
| RU2619463C2 (ru) * | 2009-12-30 | 2017-05-16 | Аркьюл, Инк. | Замещенные имидазопиридинил-аминопиридиновые соединения, полезные при лечении рака |
| WO2012177852A1 (en) | 2011-06-24 | 2012-12-27 | Arqule, Inc | Substituted imidazopyridinyl compounds |
| US8609688B2 (en) | 2011-06-24 | 2013-12-17 | Arqule, Inc. | Substituted imidazopyridinyl-aminopyridine compounds |
-
2015
- 2015-04-22 ES ES15783385T patent/ES2745156T3/es active Active
- 2015-04-22 DK DK15783385.6T patent/DK3134407T3/da active
- 2015-04-22 BR BR112016024521A patent/BR112016024521A2/pt not_active Application Discontinuation
- 2015-04-22 WO PCT/US2015/027045 patent/WO2015164479A1/en not_active Ceased
- 2015-04-22 EP EP19184995.9A patent/EP3653627A1/en not_active Withdrawn
- 2015-04-22 PL PL15783385T patent/PL3134407T3/pl unknown
- 2015-04-22 PT PT15783385T patent/PT3134407T/pt unknown
- 2015-04-22 MX MX2016013911A patent/MX375758B/es active IP Right Grant
- 2015-04-22 EP EP15783385.6A patent/EP3134407B1/en active Active
- 2015-04-22 RU RU2016145264A patent/RU2732125C2/ru active
- 2015-04-22 AU AU2015249809A patent/AU2015249809B2/en not_active Ceased
- 2015-04-22 CA CA2945778A patent/CA2945778A1/en active Pending
- 2015-04-22 SG SG11201608722QA patent/SG11201608722QA/en unknown
- 2015-04-22 US US14/693,015 patent/US9422283B2/en active Active
- 2015-04-22 KR KR1020167032091A patent/KR20160143842A/ko not_active Ceased
- 2015-04-22 TW TW104112870A patent/TWI652266B/zh not_active IP Right Cessation
- 2015-04-22 HU HUE15783385A patent/HUE046150T2/hu unknown
- 2015-04-22 CN CN201580033637.3A patent/CN106795153B/zh not_active Expired - Fee Related
- 2015-04-22 CN CN202010103721.0A patent/CN111499627A/zh active Pending
- 2015-04-22 JP JP2016564070A patent/JP6961348B2/ja not_active Expired - Fee Related
-
2016
- 2016-10-13 IL IL248342A patent/IL248342A/en active IP Right Grant
- 2016-10-14 ZA ZA2016/07107A patent/ZA201607107B/en unknown
- 2016-10-21 MX MX2020009412A patent/MX2020009412A/es unknown
-
2019
- 2019-07-19 AU AU2019206118A patent/AU2019206118B2/en not_active Ceased
- 2019-12-24 JP JP2019232895A patent/JP2020073523A/ja active Pending
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Legal Events
| Date | Code | Title | Description |
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| FG | Grant or registration |