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MX2017004200A - Compuestos de heteroarilo como inhibidores de tirosina-cinasa de bruton (btk) y usos de estos. - Google Patents

Compuestos de heteroarilo como inhibidores de tirosina-cinasa de bruton (btk) y usos de estos.

Info

Publication number
MX2017004200A
MX2017004200A MX2017004200A MX2017004200A MX2017004200A MX 2017004200 A MX2017004200 A MX 2017004200A MX 2017004200 A MX2017004200 A MX 2017004200A MX 2017004200 A MX2017004200 A MX 2017004200A MX 2017004200 A MX2017004200 A MX 2017004200A
Authority
MX
Mexico
Prior art keywords
btk inhibitors
heteroaryl compounds
compounds
btk
inhibitors
Prior art date
Application number
MX2017004200A
Other languages
English (en)
Other versions
MX385082B (es
Inventor
Liu-Bujalski Lesley
Jones Reinaldo
L Johnson Theresa
Qiu Hui
Goutopoulos Andreas
Neagu Constantin
Seenisamy Jeyaprakashnarayanan
Potnick Justin
D Caldwell Richard
Gardberg Anna
A Sherer Brian
Gaillard Pascale
Cho WON Annie
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54337891&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2017004200(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of MX2017004200A publication Critical patent/MX2017004200A/es
Publication of MX385082B publication Critical patent/MX385082B/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Hematology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
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  • Communicable Diseases (AREA)
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Abstract

La presenPte invención se refiere a compuestos de imidazopiridina de la fórmula I, y composiciones farmacéuticamente aceptables de éstos, útiles como inhibidores de BTK.
MX2017004200A 2014-10-06 2015-10-06 Compuestos de heteroarilo como inhibidores de tirosina-cinasa de bruton (btk) y usos de estos. MX385082B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462060249P 2014-10-06 2014-10-06
PCT/US2015/054221 WO2016057500A1 (en) 2014-10-06 2015-10-06 Heteroaryl compounds as btk inhibitors and uses thereof

Publications (2)

Publication Number Publication Date
MX2017004200A true MX2017004200A (es) 2017-06-15
MX385082B MX385082B (es) 2025-03-14

Family

ID=54337891

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017004200A MX385082B (es) 2014-10-06 2015-10-06 Compuestos de heteroarilo como inhibidores de tirosina-cinasa de bruton (btk) y usos de estos.

Country Status (20)

Country Link
US (2) US10253023B2 (es)
EP (1) EP3204382B1 (es)
JP (1) JP6856526B2 (es)
KR (1) KR102523111B1 (es)
CN (1) CN107001362A (es)
AR (1) AR102177A1 (es)
AU (1) AU2015328285B2 (es)
BR (1) BR112017006305B1 (es)
CA (1) CA2960401C (es)
CL (1) CL2017000786A1 (es)
ES (1) ES2907622T3 (es)
IL (1) IL251441B (es)
MX (1) MX385082B (es)
NZ (1) NZ729603A (es)
PH (1) PH12017500408B1 (es)
RU (1) RU2742122C2 (es)
SG (1) SG11201701573QA (es)
UA (1) UA125061C2 (es)
WO (1) WO2016057500A1 (es)
ZA (1) ZA201701501B (es)

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TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
MA45116A (fr) 2016-05-26 2021-06-02 Incyte Corp Composés hétérocycliques comme immunomodulateurs
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JP6954994B2 (ja) * 2016-08-16 2021-10-27 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ 可逆性ｂｔｋ阻害剤としてのオキソ−イミダゾピリジン及びその使用
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US10280164B2 (en) 2016-09-09 2019-05-07 Incyte Corporation Pyrazolopyridone compounds and uses thereof
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US20180072741A1 (en) 2016-09-09 2018-03-15 Incyte Corporation Pyrazolopyrimidine compounds and uses thereof
EP3558963B1 (en) 2016-12-22 2022-03-23 Incyte Corporation Bicyclic heteroaromatic compounds as immunomodulators
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US20180228786A1 (en) 2017-02-15 2018-08-16 Incyte Corporation Pyrazolopyridine compounds and uses thereof
CN106939009A (zh) * 2017-03-31 2017-07-11 牡丹江医学院 一种用于治疗脑震荡的药物及其制备方法
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