[go: up one dir, main page]

MX2016009072A - Fusion de antigenos micobacterianos heterooligomericos. - Google Patents

Fusion de antigenos micobacterianos heterooligomericos.

Info

Publication number
MX2016009072A
MX2016009072A MX2016009072A MX2016009072A MX2016009072A MX 2016009072 A MX2016009072 A MX 2016009072A MX 2016009072 A MX2016009072 A MX 2016009072A MX 2016009072 A MX2016009072 A MX 2016009072A MX 2016009072 A MX2016009072 A MX 2016009072A
Authority
MX
Mexico
Prior art keywords
mycobacterium
mycobacterial antigens
present
antigens
heterooligomeric
Prior art date
Application number
MX2016009072A
Other languages
English (en)
Inventor
Nathalie Silvestre
François Penin
Jean-Baptiste Marchand
Original Assignee
Transgene Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transgene Sa filed Critical Transgene Sa
Publication of MX2016009072A publication Critical patent/MX2016009072A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1289—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Mycobacteriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24141—Use of virus, viral particle or viral elements as a vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere generalmente a combinaciones inmunogénas novedosas que comprenden o que codifican para por lo menos dos antígenos micobacterianos heterooligoméricos y de preferencia un polipéptido de fusión que comprende dichos dos antígenos micobacterianos heterooligoméricos, en donde los antígenos micobacterianos se seleccionan del grupo de antígenos Esx, PE y PPE de una especie de Mycobacterium, en particular un Mycobacterium del complejo de la tuberculosis, tal como Mycobacterium tuberculosis (Mtb); la presente invención se refiere también a vectores, células hospederas y composiciones que comprenden o que codifican para dicha combinación inmunógena, así como a métodos para expresar y producir la misma; la presente invención se refiere también a métodos de uso de dicha combinación inmunógena, polipéptido de fusión, vector, célula hospedera o composición, particularmente para inducir o estimular una respuesta inmune con el objetivo de proveer una respuesta protectora contra una infección por Mycobacterium o cualquier enfermedad causada por o asociada con una infección por Mycobacterium.
MX2016009072A 2014-01-09 2015-01-09 Fusion de antigenos micobacterianos heterooligomericos. MX2016009072A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14305030 2014-01-09
PCT/EP2015/050344 WO2015104380A1 (en) 2014-01-09 2015-01-09 Fusion of heterooligomeric mycobacterial antigens

Publications (1)

Publication Number Publication Date
MX2016009072A true MX2016009072A (es) 2017-05-08

Family

ID=49989636

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016009072A MX2016009072A (es) 2014-01-09 2015-01-09 Fusion de antigenos micobacterianos heterooligomericos.

Country Status (12)

Country Link
US (1) US10765731B2 (es)
EP (1) EP3092000A1 (es)
JP (1) JP6605480B2 (es)
KR (1) KR20160130216A (es)
CN (1) CN106103471B (es)
BR (1) BR112016015936A2 (es)
CA (1) CA2936131A1 (es)
IL (1) IL246659A0 (es)
MX (1) MX2016009072A (es)
RU (1) RU2695462C2 (es)
SG (1) SG11201605595YA (es)
WO (1) WO2015104380A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX366206B (es) * 2012-07-10 2019-07-02 Transgene Sa Vacuna de antígeno micobacteriano.
WO2016131945A1 (en) 2015-02-20 2016-08-25 Transgene Sa Combination product with autophagy modulator
CN105601747B (zh) * 2015-10-21 2019-05-28 中山大学 一种结核杆菌融合蛋白及其在诱导外周血单个核细胞产生细胞因子的应用
CN105218680B (zh) * 2015-10-21 2019-06-25 中山大学 一种用于诱导外周血单个核细胞产生细胞因子的结核分支杆菌融合蛋白
US20190134190A1 (en) 2016-05-04 2019-05-09 Transgene Sa Combination therapy with cpg tlr9 ligand
WO2017205225A2 (en) * 2016-05-21 2017-11-30 Infectious Disease Research Institute Compositions and methods for treating secondary tuberculosis and nontuberculous mycobacterium infections
EP3474889A4 (en) 2016-06-22 2020-04-29 International AIDS Vaccine Initiative, Inc. RECOMBINANT CYTOMEGALOVIRUS VECTORS FOR USE AS TUBERCULOSIS VACCINES
EP3522920A2 (en) 2016-10-10 2019-08-14 Transgene SA Immunotherapeutic product and mdsc modulator combination therapy
EP3697806A4 (en) 2017-10-17 2021-10-27 International AIDS Vaccine Initiative, Inc. TUBERCULOSIS ANTIGEN CASSETTES
KR102004902B1 (ko) * 2017-12-26 2019-07-29 연세대학교 산학협력단 융합 단백질을 포함하는 결핵 예방용 조성물
CN110684116B (zh) * 2019-08-23 2022-04-26 成都可恩生物科技有限公司 一种结核分枝杆菌eec融合蛋白、制备方法及其应用
CN110590957B (zh) * 2019-09-11 2021-06-01 中国人民解放军总医院第八医学中心 一种融合蛋白及其在抗结核分枝杆菌的免疫保护中的应用
RU2724896C1 (ru) * 2019-11-14 2020-06-26 федеральное государственное бюджетное учреждение "Национальный исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации Полиантигенная вакцина для профилактики и вспомогательного лечения туберкулеза
CN111269297B (zh) * 2020-01-23 2021-11-30 郑州伊美诺生物技术有限公司 一种结核分枝杆菌刺激抗原的制备方法
WO2024027910A1 (en) * 2022-08-03 2024-02-08 BioNTech SE Rna for preventing or treating tuberculosis
AU2023317822A1 (en) * 2022-08-03 2025-02-13 BioNTech SE Rna for preventing or treating tuberculosis
CN116162141B (zh) * 2022-11-30 2024-04-12 中国疾病预防控制中心传染病预防控制所 一种结核分枝杆菌抗原epcra013及其应用
CN116063418B (zh) * 2022-12-08 2024-04-12 中国疾病预防控制中心传染病预防控制所 结核分枝杆菌抗原组合物epdpa015及其制备方法与应用
CN116106544A (zh) * 2023-01-10 2023-05-12 南京农业大学 一种牛分枝杆菌抗体检测试剂盒

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4603112A (en) 1981-12-24 1986-07-29 Health Research, Incorporated Modified vaccinia virus
US7045313B1 (en) 1982-11-30 2006-05-16 The United States Of America As Represented By The Department Of Health And Human Services Recombinant vaccinia virus containing a chimeric gene having foreign DNA flanked by vaccinia regulatory DNA
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
EP0575491B1 (en) 1991-03-07 2003-08-13 Virogenetics Corporation Genetically engineered vaccine strain
US6013638A (en) 1991-10-02 2000-01-11 The United States Of America As Represented By The Department Of Health And Human Services Adenovirus comprising deletions on the E1A, E1B and E3 regions for transfer of genes to the lung
FR2705686B1 (fr) 1993-05-28 1995-08-18 Transgene Sa Nouveaux adénovirus défectifs et lignées de complémentation correspondantes.
US6133028A (en) 1993-05-28 2000-10-17 Transgene S.A. Defective adenoviruses and corresponding complementation lines
ATE278794T1 (de) 1995-06-15 2004-10-15 Crucell Holland Bv Verpackungssysteme für humane, menschliche adenoviren, zur verwendung in die gentherapie
UA68327C2 (en) 1995-07-04 2004-08-16 Gsf Forschungszentrum Fur Unwe A recombinant mva virus, an isolated eukaryotic cell, infected with recombinant mva virus, a method for production in vitro of polypeptides with use of said cell, a method for production in vitro of virus parts (variants), vaccine containing the recombinant mva virus, a method for immunization of animals
FR2751343B1 (fr) 1996-07-16 1998-12-18 Transgene Sa Procede de conservation de virus recombinants infectieux, suspension aqueuse virale et utilisation comme medicament
EP0988053A1 (en) 1997-06-11 2000-03-29 Aquila Biopharmaceuticals, Inc. Purified saponins as oral adjuvants
FR2766091A1 (fr) 1997-07-18 1999-01-22 Transgene Sa Composition antitumorale a base de polypeptide immunogene de localisation cellulaire modifiee
MXPA00006168A (es) * 1997-12-23 2005-02-24 Genesis Res & Dev Corp Ltd Composiciones derivadas de mycrobacterium vaccae y metodos para su uso.
US6328978B1 (en) 1997-12-23 2001-12-11 Genesis Research & Development Corp. Ltd. Methods for the treatment of immunologically-mediated skin disorders
DE60029195T2 (de) 1999-02-22 2007-06-28 Transgene S.A. Verfahren zur Gewinnung von purifizierter Virenzusammensetzung
ATE485382T1 (de) 1999-05-17 2010-11-15 Crucell Holland Bv Rekombinantes adenovirus des ad26-serotyps
AU2002231639B2 (en) 2000-11-23 2007-01-04 Bavarian Nordic A/S Modified vaccinia ankara virus variant
US7393539B2 (en) 2001-06-22 2008-07-01 Health Protection Agency Mycobacterial antigens expressed under low oxygen tension
AU2002314358C1 (en) 2001-07-04 2009-03-26 The Secretary Of State For Health Mycobacterial antigens expressed during latency
UA82466C2 (uk) 2001-07-18 2008-04-25 Бавариан Нордика А/С Спосіб посилення ампліфікації хордопоксвірусу
GB0125535D0 (en) 2001-10-24 2001-12-12 Microbiological Res Authority Mycobacterial genes down-regulated during latency
DE60205388T2 (de) 2001-12-10 2006-03-30 Bavarian Nordic A/S Poxvirus-enthaltende zusammensetzungen und verfahren zu ihrer herstellung
FR2836924B1 (fr) 2002-03-08 2005-01-14 Vivalis Lignees de cellules aviaires utiles pour la production de substances d'interet
AU2003242504A1 (en) 2002-07-13 2004-02-02 Statens Serum Institut Therapeutic tuberculosis vaccines
AU2003262790A1 (en) 2003-03-17 2004-10-11 Merck & Co., Inc. Adenovirus serotype 24 vectors, nucleic acids and virus produced thereby
EP1611237A1 (en) 2003-03-28 2006-01-04 Merck & Co., Inc. Adenovirus serotype 34 vectors, nucleic acids and virus produced thereby
WO2005061534A2 (en) * 2003-12-23 2005-07-07 Statens Serum Institut Improved tuberculosis vaccines
ATE449105T1 (de) 2004-01-23 2009-12-15 Angeletti P Ist Richerche Bio Impfstoffträger für schimpansen-adenovirus
CA2837748C (en) * 2004-05-25 2016-03-08 Oregon Health And Science University Siv and hiv vaccination using rhcmv-and hcmv-based vaccine vectors
US20060024332A1 (en) 2004-08-02 2006-02-02 Waters Wade R Recombinant ESAT-6:CFP-10 fusion protein useful for specific diagnosis of tuberculosis
WO2006026404A2 (en) * 2004-08-26 2006-03-09 Sequella, Inc. Assay for detecting tuberculosis in nonhuman primates
EA012436B1 (ru) * 2005-01-05 2009-10-30 Айсис Инновейшн Лимитед Композиции для иммунизации против микобактерий
JP5221337B2 (ja) 2005-03-31 2013-06-26 ライデン ユニバーシティ メディカル センター ミコバクテリア感染及び結核疾病の診断、予防及び治療のための方法及び手段
MX2007016165A (es) 2005-06-23 2008-03-14 Statens Seruminstitut Vacunas para tuberculosis que comprenden antigenos expresados durante la fase de infeccion latente.
CA2644338A1 (en) 2006-03-02 2007-09-07 The Uab Research Foundation Mycobacterial disease detection, treatment, and drug discovery
US20100129403A1 (en) 2006-06-20 2010-05-27 Transgene S.A. Recombinant viral vaccine
MX351247B (es) 2007-04-04 2017-10-05 Infectious Disease Res Institute Star Composiciones inmunogenicas que comprenden polipeptidos de mycobacterium tuberculosis y fusiones de los mismos.
HRP20120722T1 (hr) 2007-06-29 2012-10-31 Statens Serum Institut Uporaba monomikolil glicerola (mmg) kao adjuvansa
EP2176398B1 (en) 2007-07-03 2016-12-28 Transgene SA Immortalized avian cell lines
US8357531B2 (en) 2007-07-03 2013-01-22 Transgene S.A. Immortalized avian cell lines
CN101376891B (zh) * 2007-08-27 2012-05-23 上海生物制品研究所有限责任公司 新型结核病疫苗的制备及其应用
US7935354B2 (en) 2007-11-13 2011-05-03 Aeras Global Tb Vaccine Foundation Generation of new BCG vaccine strains protecting against the establishment of latent Mycobacterium tuberculosis infection and reactivation from the latent or persistent state
US8658350B2 (en) 2008-09-22 2014-02-25 Oregon Health & Science University Methods for detecting Mycobacterium tuberculosis disease
WO2010034974A2 (en) * 2008-09-24 2010-04-01 Adjuvantix Limited Tb vaccine
CN101538578B (zh) * 2009-03-02 2011-01-26 华中农业大学 三基因融合的重组牛结核特异性抗原蛋白及制备方法
CA2759583C (en) * 2009-04-24 2020-06-16 Statens Serum Institut A tuberculosis tb vaccine to prevent reactivation
EP2429580A1 (en) 2009-05-12 2012-03-21 Transgene SA Method for orthopoxvirus production and purification
TR201802619T4 (tr) 2009-05-20 2018-03-21 Aeras Kararlı, sprey ile kurutulmuş, immunojen, viral bileşimler.
GB201007790D0 (en) * 2010-05-10 2010-06-23 Isis Innovation Compositions
GB201008512D0 (en) * 2010-05-21 2010-07-07 Health Prot Agency Mycobacterial antigen composition
CN101900727A (zh) * 2010-06-01 2010-12-01 华中农业大学 一种应用Rv3872新型融合蛋白制备的牛结核抗体鉴别检测试纸条
WO2012031752A2 (en) 2010-09-07 2012-03-15 Institut Pasteur Korea Tuberculosis mutants
US20130345079A1 (en) * 2010-10-27 2013-12-26 Infectious Disease Research Institute Mycobacterium tuberculosis antigens and combinations thereof having high seroreactivity
WO2012129227A1 (en) * 2011-03-22 2012-09-27 Baylor Research Institute Dendritic cells (dcs) targeting for tuberculosis (tb) vaccine
CN102692509B (zh) * 2012-05-11 2014-11-26 中国农业科学院北京畜牧兽医研究所 重组蛋白混合物介导的牛结核病诊断方法及其试剂
WO2014009433A1 (en) * 2012-07-10 2014-01-16 Transgene Sa Mycobacterium resuscitation promoting factor for use as adjuvant
MX366206B (es) * 2012-07-10 2019-07-02 Transgene Sa Vacuna de antígeno micobacteriano.
CN102719438B (zh) * 2012-07-12 2013-10-30 章晓联 一种能特异结合结核菌抗原的核酸适配子及其应用
IN2015DN03962A (es) * 2012-10-23 2015-10-02 Statens Seruminstitut
CN103333251B (zh) * 2013-04-11 2014-08-20 广西壮族自治区动物疫病预防控制中心 基于重组融合抗原蛋白的γ-干扰素夹心ELISA检测方法
CN103204945A (zh) * 2013-05-03 2013-07-17 扬州大学 一种用于牛结核病诊断的真核表达cfp10-esat-6融合蛋白
ES2925950T3 (es) 2013-06-25 2022-10-20 Int Aids Vaccine Initiative Inc Composiciones para la tuberculosis y procedimientos de uso de las mismas
CN103386128B (zh) 2013-07-02 2017-02-08 中国食品药品检定研究院 一种含联合佐剂的结核亚单位疫苗

Also Published As

Publication number Publication date
SG11201605595YA (en) 2016-08-30
IL246659A0 (en) 2016-08-31
CN106103471B (zh) 2020-01-07
WO2015104380A1 (en) 2015-07-16
BR112016015936A2 (pt) 2017-09-19
EP3092000A1 (en) 2016-11-16
RU2016131853A (ru) 2018-02-12
JP6605480B2 (ja) 2019-11-13
US10765731B2 (en) 2020-09-08
CN106103471A (zh) 2016-11-09
RU2016131853A3 (es) 2018-06-26
KR20160130216A (ko) 2016-11-10
RU2695462C2 (ru) 2019-07-23
US20160331823A1 (en) 2016-11-17
JP2017505605A (ja) 2017-02-23
CA2936131A1 (en) 2015-07-16

Similar Documents

Publication Publication Date Title
MX2016009072A (es) Fusion de antigenos micobacterianos heterooligomericos.
CN106715699A8 (zh) 用于减弱抗病毒转移载体免疫应答的方法和组合物
MX2018001213A (es) Nuevos metodos para inducir una respuesta inmunitaria.
EA201990566A1 (ru) Композиции, содержащие бактериальные штаммы
MX2022003116A (es) Factor ix modificado, y composiciones, metodos y usos para la transferencia de genes a celulas, organos y tejidos.
WO2016019134A8 (en) Flagellin-based agents and uses including effective vaccination
WO2019226939A8 (en) Immune checkpoint inhibitor co-expression vectors
IN2015DN03962A (es)
PH12018501336A1 (en) Dendritic cell composition
WO2016014434A3 (en) Anti-cd74 antibodies, compositions comprising anti-cd74 antibodies and methods of using anti-cd74 antibodies
EA201391183A1 (ru) Способы усиления иммуногенспецифических иммунных ответов при помощи векторных вакцин
PH12014502855A1 (en) Attenuated streptococcus suis vaccines and methods of making and use thereof
BR112016027196A2 (pt) cepa bacteriana gram-negativa recombinante, vetor, método para liberar uma proteína heteróloga em uma célula eucariótica, método para purificar uma proteína heteróloga e uso de uma cepa bacteriana gram-negativa recombinante
MX350306B (es) Vacuna y metodos para reducir una infeccion por campylobacter.
MX2017016401A (es) Composiciones inmunogenas.
PH12016501689A1 (en) Tatk-cdkl5 fusion proteins, compositions, formulations, and use thereof
PH12015500771A1 (en) Novel fc gamma receptor iib variants
NZ751014A (en) New ehv insertion site orf70
PH12019500578A1 (en) New promoters
MX2018015224A (es) Composicion que comprende la proteina de fusion de rv2299c y esat-6 para promover la maduracion de las celulas dendriticas.
NZ618125A (en) Genetic vaccines against hendra virus and nipah virus
MX2018001841A (es) Composiciones de mycoplasma bovis.
BR112017004576A2 (pt) vacina multivalente ou composição imunogênica, cepa quimérica de brucella, plasmídeo pns4leub, método para proteger ou tratar um indivíduo em risco de ou que sofre a partir de pelo menos uma doença causada por uma ou mais bactéria, e método de suscitar uma resposta imune tanto para mycobacterium e brucella em um indivíduo
PH12018500372A1 (en) Fcv recombinant vaccines and uses thereof
MY190213A (en) Modified factor ix, and compositions, methods and uses for gene transfer to cells, organs and tissues