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MX2015013194A - Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 humanizado. - Google Patents

Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 humanizado.

Info

Publication number
MX2015013194A
MX2015013194A MX2015013194A MX2015013194A MX2015013194A MX 2015013194 A MX2015013194 A MX 2015013194A MX 2015013194 A MX2015013194 A MX 2015013194A MX 2015013194 A MX2015013194 A MX 2015013194A MX 2015013194 A MX2015013194 A MX 2015013194A
Authority
MX
Mexico
Prior art keywords
cancer
treatment
humanized anti
car
disclosure
Prior art date
Application number
MX2015013194A
Other languages
English (en)
Other versions
MX373779B (es
Inventor
Carl H June
John Scholler
Jennifer Brogdon
Marcela Maus
Andreas Loew
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2015013194A publication Critical patent/MX2015013194A/es
Publication of MX373779B publication Critical patent/MX373779B/es

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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
    • A61K40/4211—CD19 or B4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/622—Single chain antibody (scFv)
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    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

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  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Abstract

La presente invención se refiere a composiciones y métodos para el tratamiento de enfermedades asociadas con la expresión de CD19. La presente invención también se refiere a un receptor de antígeno quimérico (RAQ) específico de CD19, a vectores que codifican el mismo, y a células T recombinantes que comprenden el RAQ CD19. La presente invención también incluye métodos para la administración de una célula T genéticamente modificada, que expresa un RAQ que comprende un dominio de unión a CD19.
MX2015013194A 2013-03-16 2014-03-15 Receptor quimérico de antígeno anti-cd19 humanizado. MX373779B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361802629P 2013-03-16 2013-03-16
US201361838537P 2013-06-24 2013-06-24
PCT/US2014/029943 WO2014153270A1 (en) 2013-03-16 2014-03-15 Treatment of cancer using humanized anti-cd19 chimeric antigen receptor

Publications (2)

Publication Number Publication Date
MX2015013194A true MX2015013194A (es) 2016-04-20
MX373779B MX373779B (es) 2020-06-25

Family

ID=50680172

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2015013194A MX373779B (es) 2013-03-16 2014-03-15 Receptor quimérico de antígeno anti-cd19 humanizado.
MX2020007021A MX2020007021A (es) 2013-03-16 2015-09-15 Receptor quimerico de antigeno anti-cd19 humanizado.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2020007021A MX2020007021A (es) 2013-03-16 2015-09-15 Receptor quimerico de antigeno anti-cd19 humanizado.

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US (3) US10221245B2 (es)
EP (3) EP2970482B1 (es)
JP (4) JP6466401B2 (es)
KR (1) KR102293062B1 (es)
CN (2) CN105392888B (es)
AU (3) AU2014236098B8 (es)
BR (1) BR112015021819A2 (es)
CA (1) CA2907100C (es)
DK (2) DK2970482T3 (es)
ES (2) ES2923397T3 (es)
HR (1) HRP20220767T1 (es)
HU (2) HUE058832T2 (es)
IL (1) IL241261B (es)
LT (2) LT2970482T (es)
MX (2) MX373779B (es)
MY (1) MY187624A (es)
PL (2) PL3539986T3 (es)
PT (2) PT2970482T (es)
RU (1) RU2711975C2 (es)
SG (2) SG11201506603PA (es)
SI (1) SI3539986T1 (es)
TW (1) TWI654206B (es)
UY (1) UY35468A (es)
WO (1) WO2014153270A1 (es)

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RU2015144332A (ru) 2017-04-27
JP2024056877A (ja) 2024-04-23
WO2014153270A1 (en) 2014-09-25
CA2907100A1 (en) 2014-09-25
US20190135940A1 (en) 2019-05-09
EP2970482B1 (en) 2019-03-06
AU2019216689B2 (en) 2021-12-23
BR112015021819A2 (pt) 2017-08-29
JP2021090434A (ja) 2021-06-17
ES2923397T3 (es) 2022-09-27
IL241261B (en) 2020-02-27
EP3539986B1 (en) 2022-04-13
HUE058832T2 (hu) 2022-09-28

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