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MX2015005734A - Metodos de tratamiento de enfermedades hepaticas. - Google Patents

Metodos de tratamiento de enfermedades hepaticas.

Info

Publication number
MX2015005734A
MX2015005734A MX2015005734A MX2015005734A MX2015005734A MX 2015005734 A MX2015005734 A MX 2015005734A MX 2015005734 A MX2015005734 A MX 2015005734A MX 2015005734 A MX2015005734 A MX 2015005734A MX 2015005734 A MX2015005734 A MX 2015005734A
Authority
MX
Mexico
Prior art keywords
treatment
methods
hepatic diseases
compounds
fibrosis
Prior art date
Application number
MX2015005734A
Other languages
English (en)
Inventor
James E Vath
Thomas E Hughes
Original Assignee
Zafgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zafgen Inc filed Critical Zafgen Inc
Publication of MX2015005734A publication Critical patent/MX2015005734A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)

Abstract

La invención proporciona compuestos tricíclicos y su uso en el tratamiento de trastornos hepáticos, como la esteatohepatitis no alcohólica y trastornos relacionados (por ejemplo, fibrosis); se contempla que los compuestos tienen actividad contra la metionil aminopeptidasa 2.
MX2015005734A 2012-11-05 2013-11-05 Metodos de tratamiento de enfermedades hepaticas. MX2015005734A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261722529P 2012-11-05 2012-11-05
US201361779396P 2013-03-13 2013-03-13
PCT/US2013/068483 WO2014071368A1 (en) 2012-11-05 2013-11-05 Methods of treating liver diseases

Publications (1)

Publication Number Publication Date
MX2015005734A true MX2015005734A (es) 2016-02-10

Family

ID=49585655

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015005734A MX2015005734A (es) 2012-11-05 2013-11-05 Metodos de tratamiento de enfermedades hepaticas.

Country Status (14)

Country Link
US (2) US9561209B2 (es)
EP (1) EP2916833A1 (es)
JP (1) JP6169716B2 (es)
KR (1) KR20150079951A (es)
CN (1) CN104918615B (es)
AU (1) AU2013337287B2 (es)
BR (1) BR112015010196A2 (es)
CA (1) CA2890343A1 (es)
EA (1) EA028367B1 (es)
IL (1) IL238592B (es)
MX (1) MX2015005734A (es)
NZ (1) NZ707773A (es)
SG (1) SG11201503521QA (es)
WO (1) WO2014071368A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH12013502261A1 (en) 2011-05-06 2022-10-26 Zafgen Inc Partially saturated tricyclic compounds and methods of making and using same
CN104870433A (zh) 2012-11-05 2015-08-26 扎夫根股份有限公司 三环化合物及其制备方法和用途
US9868717B2 (en) 2012-11-05 2018-01-16 Zafgen, Inc. Tricyclic sulphonamide compounds and methods of making and using same
JP6169716B2 (ja) 2012-11-05 2017-07-26 ザフゲン，インコーポレイテッド 肝疾患を治療する方法
TW201605433A (zh) * 2013-09-12 2016-02-16 以斯提夫博士實驗室股份有限公司 ＮＳＡＩＤ與西克馬（ｓｉｇｍａ）受體配位體之組合

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Also Published As

Publication number Publication date
SG11201503521QA (en) 2015-06-29
NZ707773A (en) 2019-05-31
WO2014071368A1 (en) 2014-05-08
JP6169716B2 (ja) 2017-07-26
EA201590884A1 (ru) 2015-10-30
EP2916833A1 (en) 2015-09-16
US20170326099A1 (en) 2017-11-16
CN104918615A (zh) 2015-09-16
CA2890343A1 (en) 2014-05-08
US9561209B2 (en) 2017-02-07
US10064839B2 (en) 2018-09-04
AU2013337287B2 (en) 2017-03-23
IL238592A0 (en) 2015-06-30
KR20150079951A (ko) 2015-07-08
CN104918615B (zh) 2018-10-12
US20160058731A1 (en) 2016-03-03
EA028367B1 (ru) 2017-11-30
IL238592B (en) 2018-04-30
JP2015536982A (ja) 2015-12-24
AU2013337287A1 (en) 2015-05-21
BR112015010196A2 (pt) 2017-07-11

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