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FR2886855B1 - Utilisation de la fumagilline et de ses derives pour augmenter la biodisponibilite des lactones macrocyliques - Google Patents

Utilisation de la fumagilline et de ses derives pour augmenter la biodisponibilite des lactones macrocyliques

Info

Publication number
FR2886855B1
FR2886855B1 FR0505829A FR0505829A FR2886855B1 FR 2886855 B1 FR2886855 B1 FR 2886855B1 FR 0505829 A FR0505829 A FR 0505829A FR 0505829 A FR0505829 A FR 0505829A FR 2886855 B1 FR2886855 B1 FR 2886855B1
Authority
FR
France
Prior art keywords
biodavailability
fumagillin
derivatives
increase
macrocylic lactones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0505829A
Other languages
English (en)
Other versions
FR2886855A1 (fr
Inventor
Michel Alvinerie
Jacques Dupuy
Anne Lespine
Jean Francois Sutra
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut National de la Recherche Agronomique INRA
Original Assignee
Institut National de la Recherche Agronomique INRA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0505829A priority Critical patent/FR2886855B1/fr
Application filed by Institut National de la Recherche Agronomique INRA filed Critical Institut National de la Recherche Agronomique INRA
Priority to AU2006256616A priority patent/AU2006256616A1/en
Priority to EP06764749A priority patent/EP1888116A2/fr
Priority to CA002611201A priority patent/CA2611201A1/fr
Priority to BRPI0611642-6A priority patent/BRPI0611642A2/pt
Priority to US11/917,031 priority patent/US20080200402A1/en
Priority to MX2007015504A priority patent/MX2007015504A/es
Priority to PCT/FR2006/001297 priority patent/WO2006131649A2/fr
Priority to ZA200710600A priority patent/ZA200710600B/xx
Publication of FR2886855A1 publication Critical patent/FR2886855A1/fr
Application granted granted Critical
Publication of FR2886855B1 publication Critical patent/FR2886855B1/fr
Priority to US12/975,410 priority patent/US20110144045A1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR0505829A 2005-06-08 2005-06-08 Utilisation de la fumagilline et de ses derives pour augmenter la biodisponibilite des lactones macrocyliques Expired - Fee Related FR2886855B1 (fr)

Priority Applications (10)

Application Number Priority Date Filing Date Title
FR0505829A FR2886855B1 (fr) 2005-06-08 2005-06-08 Utilisation de la fumagilline et de ses derives pour augmenter la biodisponibilite des lactones macrocyliques
ZA200710600A ZA200710600B (en) 2005-06-08 2006-06-08 Use of fumagillin and the derivatives thereof to increase the bioavailability of the macrocyclic lactones
CA002611201A CA2611201A1 (fr) 2005-06-08 2006-06-08 Utilisation de la fumagilline et de ses derives pour augmenter la biodisponibilite des lactones macrocycliques
BRPI0611642-6A BRPI0611642A2 (pt) 2005-06-08 2006-06-08 utilização da fumagilina e de seus derivados para aumentar a biodisponibilidade das lactonas macrocìclicas
US11/917,031 US20080200402A1 (en) 2005-06-08 2006-06-08 Use Of Fumagillin And The Derivatives Thereof To Increase The Bioavilability Of The Macrocyclic Lactones
MX2007015504A MX2007015504A (es) 2005-06-08 2006-06-08 Uso de fumagilina y sus derivados para aumentar la biodisponibilidad de lactonas macrociclicas.
AU2006256616A AU2006256616A1 (en) 2005-06-08 2006-06-08 Use of fumagillin and the derivatives thereof to increase the bioavailability of the macrocyclic lactones
EP06764749A EP1888116A2 (fr) 2005-06-08 2006-06-08 Utilisation de la fumagilline et de ses derives pour augmenter la biodisponibilite des lactones macrocycliques
PCT/FR2006/001297 WO2006131649A2 (fr) 2005-06-08 2006-06-08 Utilisation de la fumagilline et de ses derives pour augmenter la biodisponibilite des lactones macrocycliques
US12/975,410 US20110144045A1 (en) 2005-06-08 2010-12-22 Use of fumagillin and the derivatives thereof to increase the bioavailability of the macrocyclic lactones

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0505829A FR2886855B1 (fr) 2005-06-08 2005-06-08 Utilisation de la fumagilline et de ses derives pour augmenter la biodisponibilite des lactones macrocyliques

Publications (2)

Publication Number Publication Date
FR2886855A1 FR2886855A1 (fr) 2006-12-15
FR2886855B1 true FR2886855B1 (fr) 2009-07-17

Family

ID=35064492

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0505829A Expired - Fee Related FR2886855B1 (fr) 2005-06-08 2005-06-08 Utilisation de la fumagilline et de ses derives pour augmenter la biodisponibilite des lactones macrocyliques

Country Status (9)

Country Link
US (2) US20080200402A1 (fr)
EP (1) EP1888116A2 (fr)
AU (1) AU2006256616A1 (fr)
BR (1) BRPI0611642A2 (fr)
CA (1) CA2611201A1 (fr)
FR (1) FR2886855B1 (fr)
MX (1) MX2007015504A (fr)
WO (1) WO2006131649A2 (fr)
ZA (1) ZA200710600B (fr)

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WO2013055385A2 (fr) 2011-10-03 2013-04-18 Zafgen Corporation Méthodes de traitement de troubles liés à l'âge
US8642650B2 (en) 2008-12-04 2014-02-04 Zafgen, Inc. Methods of treating an overweight or obese subject
WO2010065877A2 (fr) 2008-12-04 2010-06-10 Zafgen Corporation Procédés de traitement d'un sujet en surpoids ou obèse
EP2486004B1 (fr) 2009-10-09 2017-05-03 Zafgen, Inc. Composés sulfonés et leur utilisation pour le traitement de l'obésité
WO2011085201A1 (fr) 2010-01-08 2011-07-14 Zafgen Corporation Composés de type fumagillol, et procédés correspondants de fabrication et d'utilisation
WO2011085198A1 (fr) 2010-01-08 2011-07-14 Zafgen Corporation Inhibiteur de metap-2 pour utilisation dans le traitement d'une hypertrophie bénigne de la prostate (bph)
WO2011127304A2 (fr) 2010-04-07 2011-10-13 Zafgen Corporation Méthodes de traitement d'un sujet en surpoids
BR112013001613A2 (pt) 2010-07-22 2016-05-24 Zafgen Inc compostos tricíclicos e métodos para fazer e usar os mesmos.
PH12013500934A1 (en) 2010-11-09 2022-10-24 Zafgen Inc Crystalline solids of a metap-2 inhibitor and methods of making and using same
WO2012075020A1 (fr) 2010-11-29 2012-06-07 Zafgen Corporation Traitement de l'obésité à l'aide d'une administration non quotidienne de 6 - 0 - (4 - diméthylaminoéthoxy) cinnamoyl fumagillol
WO2012103333A1 (fr) 2011-01-26 2012-08-02 Zafgen Corporation Composés de tétrazole et procédés de préparation et d'utilisation de ceux-ci
MX342257B (es) 2011-03-08 2016-09-21 Zafgen Inc Derivados y análogos de oxaspiro [2.5] octano.
US9351988B2 (en) 2011-05-02 2016-05-31 Universite De Geneve Macrocyclic lactones and use thereof
MX343688B (es) 2011-05-06 2016-11-16 Zafgen Inc Compuestos tricíclicos de sulfonamida y pirazolo y métodos para su fabricación y uso.
EA025526B1 (ru) 2011-05-06 2017-01-30 Зафджен Инк. Частично насыщенные трициклические соединения и способы их получения и применения
CN103748094B (zh) 2011-05-06 2016-06-29 扎夫根股份有限公司 三环磺酰胺化合物及其制备和使用方法
JP6035347B2 (ja) 2012-01-18 2016-11-30 ザフゲン，インコーポレイテッド 三環式スルホンアミド化合物ならびにその作製および使用方法
JP2015509102A (ja) 2012-01-18 2015-03-26 ザフゲン，インコーポレイテッド 三環式スルホン化合物並びにその作製および使用方法
AU2013259760A1 (en) 2012-05-07 2014-11-20 Zafgen, Inc. Polymorphic salt of the oxalate salt of 6-O-(4-dimethylaminoethoxy) cinnamoyl fumagillol and methods of making and using same
CA2872876A1 (fr) 2012-05-08 2013-11-14 Zafgen, Inc. Traitement de l'obesite hypothalamique au moyen d'inhibiteurs de metap2
WO2013169860A1 (fr) 2012-05-09 2013-11-14 Zafgen, Inc. Composés de type fumagillol, leurs procédés de fabrication et d'utilisation
JP6169716B2 (ja) 2012-11-05 2017-07-26 ザフゲン，インコーポレイテッド 肝疾患を治療する方法
CN104870433A (zh) 2012-11-05 2015-08-26 扎夫根股份有限公司 三环化合物及其制备方法和用途
AU2013337288A1 (en) 2012-11-05 2015-05-21 Zafgen, Inc. Tricyclic compounds for use in the treatment and/or control of obesity
JP2016513722A (ja) 2013-03-14 2016-05-16 ザフゲン，インコーポレイテッド 腎臓病及び他の疾患の治療方法
PT2970101T (pt) 2013-03-14 2018-10-04 Alkermes Pharma Ireland Ltd Pró-fármacos de fumaratos e seu uso no tratamento de várias doenças
US8669281B1 (en) 2013-03-14 2014-03-11 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
AU2015218587B2 (en) 2014-02-24 2017-04-27 Alkermes Pharma Ireland Limited Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases
TW201636342A (zh) 2014-12-19 2016-10-16 武田藥品工業有限公司 煙黴醇衍生物
AR105671A1 (es) 2015-08-11 2017-10-25 Zafgen Inc Compuestos heterocíclicos de fumagillol y sus métodos de elaboración y uso
CN106432255A (zh) 2015-08-11 2017-02-22 扎夫根公司 烟曲霉素醇螺环化合物和制备和使用其的方法

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US5135919A (en) * 1988-01-19 1992-08-04 Children's Medical Center Corporation Method and a pharmaceutical composition for the inhibition of angiogenesis
US5328930A (en) * 1993-03-01 1994-07-12 Emory University Treatment of microsporidial and acanthamoeba keratoconjunctivitis with topical fumagillin
DE69417169T2 (de) * 1993-09-24 1999-07-22 Takeda Chemical Industries, Ltd., Osaka Antineoplastische pharmazeutische Zusammensetzung enthaltend ein Fumagillolderivat und einen Platinkomplex
DK0817626T3 (da) * 1995-03-27 1999-07-12 Assist Publ Hopitaux De Paris Anvendelse af fumagillol og derivater deraf til fremstilling af lægemidler mod tarminfektioner
CA2210600A1 (fr) * 1996-07-17 1998-01-17 Takashi Houkan Inhibiteur des metastases tumorales ou de la recurrence
EP1258248A3 (fr) * 2001-05-18 2003-06-04 TAP Pharmaceutical Products, Inc. Traitement de tumeurs avec un dérivé de fumagillol et un autre agent antinéoplastique
HUP0203718A2 (hu) * 2002-10-31 2004-08-30 Annamária Szőke Orális adagolású, állatgyógyászati hatóanyagot tartalmazó készítmény, és/vagy táplálékkiegészítő készítmény, eljárás annak előállítására és annak alkalmazása

Also Published As

Publication number Publication date
MX2007015504A (es) 2008-03-18
ZA200710600B (en) 2009-05-27
FR2886855A1 (fr) 2006-12-15
WO2006131649A3 (fr) 2007-06-21
US20080200402A1 (en) 2008-08-21
WO2006131649A2 (fr) 2006-12-14
US20110144045A1 (en) 2011-06-16
AU2006256616A1 (en) 2006-12-14
EP1888116A2 (fr) 2008-02-20
CA2611201A1 (fr) 2006-12-14
BRPI0611642A2 (pt) 2010-09-28

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Legal Events

Date Code Title Description
ST Notification of lapse

Effective date: 20120229