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MX2014015158A - Derivados de piridinona y piridazinona. - Google Patents

Derivados de piridinona y piridazinona.

Info

Publication number
MX2014015158A
MX2014015158A MX2014015158A MX2014015158A MX2014015158A MX 2014015158 A MX2014015158 A MX 2014015158A MX 2014015158 A MX2014015158 A MX 2014015158A MX 2014015158 A MX2014015158 A MX 2014015158A MX 2014015158 A MX2014015158 A MX 2014015158A
Authority
MX
Mexico
Prior art keywords
formula
pyridinone
compounds
pyridazinone derivatives
diseases
Prior art date
Application number
MX2014015158A
Other languages
English (en)
Inventor
John K Pratt
Le Wang
Michael D Wendt
Chang H Park
Keith F Mcdaniel
Dachun Liu
George S Sheppard
Chaohong Sun
Robert D Hubbard
Todd N Soltwedel
James H Holmes
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of MX2014015158A publication Critical patent/MX2014015158A/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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Abstract

La presente invención proporciona compuestos de la fórmula (I) (ver Fórmula) en donde J es un grupo de la fórmula IIa o IIb; A1, A2, A3, A4, J, y X3 tienen cualquiera de los valores definidos por ello en la especificación, y sales farmacéuticamente aceptable de los mismos, que son útiles como agentes en el tratamiento de enfermedades y afecciones, incluyendo enfermedades inflamatorias, diabetes, obesidad, cáncer, y SIDA. También se proporcionan composiciones farmacéuticas que comprenden uno o más compuestos de la fórmula I.
MX2014015158A 2012-06-12 2013-06-11 Derivados de piridinona y piridazinona. MX2014015158A (es)

Applications Claiming Priority (3)

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PCT/CN2012/076748 WO2013185284A1 (en) 2012-06-12 2012-06-12 Pyridinone and pyridazinone derivatives
US13/796,437 US9561231B2 (en) 2012-06-12 2013-03-12 Pyridinone and pyridazinone derivatives
PCT/US2013/045151 WO2013188381A1 (en) 2012-06-12 2013-06-11 Pyridinone and pyridazinone derivatives

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