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AR106520A1 - Forma sólida amorfa de un inhibidor de proteína bet - Google Patents

Forma sólida amorfa de un inhibidor de proteína bet

Info

Publication number
AR106520A1
AR106520A1 ARP160103304A ARP160103304A AR106520A1 AR 106520 A1 AR106520 A1 AR 106520A1 AR P160103304 A ARP160103304 A AR P160103304A AR P160103304 A ARP160103304 A AR P160103304A AR 106520 A1 AR106520 A1 AR 106520A1
Authority
AR
Argentina
Prior art keywords
compound
amorfa
solid form
pyridin
protein inhibitor
Prior art date
Application number
ARP160103304A
Other languages
English (en)
Inventor
Zhou Jiacheng
Liu Pingli
Jia Zhongjiang
Frietze William
Chen Shili
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of AR106520A1 publication Critical patent/AR106520A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente solicitud se relaciona con una forma sólida amorfa de (4S)-7-(3,5-dimetilisoxazol-4-il)-4-piridin-2-il-4,5-dihidroimidazo[1,5,4-de][1,4]benzoxazin-2(1H)-ona, y con procesos para su preparación, que es un inhibidor de proteínas BET tales como BRD2, BRD3, BRD4 y BRD-t y es útil en el tratamiento de varias enfermedades tal como cáncer. E intermediarios. Reivindicación 38: Un compuesto, en donde el compuesto es 5-nitro-3-(piridin-2-il)-3,4-dihidro-2H-benzo[b][1,4]oxazin-3-ol (Compuesto 1x) o una sal de este. Reivindicación 39: Un compuesto, en donde el compuesto es 7-yodo-4-piridin-2-il-4,5-dihidroimidazo[1,5,4-de][1,4]benzoxazin-2(1H)-ona (Compuesto 4x) o una sal de este.
ARP160103304A 2015-10-29 2016-10-28 Forma sólida amorfa de un inhibidor de proteína bet AR106520A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562248040P 2015-10-29 2015-10-29

Publications (1)

Publication Number Publication Date
AR106520A1 true AR106520A1 (es) 2018-01-24

Family

ID=57286856

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP160103304A AR106520A1 (es) 2015-10-29 2016-10-28 Forma sólida amorfa de un inhibidor de proteína bet

Country Status (4)

Country Link
US (5) US20170121347A1 (es)
AR (1) AR106520A1 (es)
TW (1) TW201722966A (es)
WO (1) WO2017075377A1 (es)

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EA034972B1 (ru) 2014-04-23 2020-04-13 Инсайт Корпорейшн 1h-пирроло[2,3-c]пиридин-7(6h)-оны в качестве ингибиторов белков bet
EP3194406B8 (en) 2014-09-15 2021-03-31 Incyte Corporation Tricyclic heterocycles for use as bet protein inhibitors
AR106520A1 (es) 2015-10-29 2018-01-24 Incyte Corp Forma sólida amorfa de un inhibidor de proteína bet
PT3472157T (pt) 2016-06-20 2023-05-30 Incyte Corp Formas sólidas cristalinas de um inibidor bet
TWI882964B (zh) * 2018-09-13 2025-05-11 大陸商恒翼生物醫藥（上海）股份有限公司 Bet 溴結構域(bromodomain)抑制劑之固體形式之製備方法
US11833155B2 (en) 2020-06-03 2023-12-05 Incyte Corporation Combination therapy for treatment of myeloproliferative neoplasms
CN113975278B (zh) * 2021-10-29 2023-04-07 中国科学院昆明动物研究所 溴隐亭在制备治疗非洲猪瘟的产品中的应用

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