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MX2014013329A - Variantes de enzimas mejoradas. - Google Patents

Variantes de enzimas mejoradas.

Info

Publication number
MX2014013329A
MX2014013329A MX2014013329A MX2014013329A MX2014013329A MX 2014013329 A MX2014013329 A MX 2014013329A MX 2014013329 A MX2014013329 A MX 2014013329A MX 2014013329 A MX2014013329 A MX 2014013329A MX 2014013329 A MX2014013329 A MX 2014013329A
Authority
MX
Mexico
Prior art keywords
enzyme variants
improved enzyme
chymosin
bovine
ratio
Prior art date
Application number
MX2014013329A
Other languages
English (en)
Other versions
MX355170B (es
Inventor
Marcel De Jong René
Petrus Jacobus Theodorus Dekker
Cornelis Marinus Muijlwijk
Michael Dennis Tabeling
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Publication of MX2014013329A publication Critical patent/MX2014013329A/es
Publication of MX355170B publication Critical patent/MX355170B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
    • A23C19/00—Cheese; Cheese preparations; Making thereof
    • A23C19/02—Making cheese curd
    • A23C19/032—Making cheese curd characterised by the use of specific microorganisms, or enzymes of microbial origin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
    • A23C19/00—Cheese; Cheese preparations; Making thereof
    • A23C19/02—Making cheese curd
    • A23C19/032—Making cheese curd characterised by the use of specific microorganisms, or enzymes of microbial origin
    • A23C19/0326—Rennet produced by fermentation, e.g. microbial rennet; Rennet produced by genetic engineering
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
    • A23C19/00—Cheese; Cheese preparations; Making thereof
    • A23C19/06—Treating cheese curd after whey separation; Products obtained thereby
    • A23C19/068—Particular types of cheese
    • A23C19/0684—Soft uncured Italian cheeses, e.g. Mozarella, Ricotta, Pasta filata cheese; Other similar stretched cheeses
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
    • A23C19/00—Cheese; Cheese preparations; Making thereof
    • A23C19/06—Treating cheese curd after whey separation; Products obtained thereby
    • A23C19/068—Particular types of cheese
    • A23C19/072—Cheddar type or similar hard cheeses without eyes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6478—Aspartic endopeptidases (3.4.23)
    • C12N9/6483—Chymosin (3.4.23.4), i.e. rennin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/23—Aspartic endopeptidases (3.4.23)
    • C12Y304/23004—Chymosin (3.4.23.4), i.e. rennin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
    • A23C2220/00—Biochemical treatment
    • A23C2220/20—Treatment with microorganisms
    • A23C2220/202—Genetic engineering of microorganisms used in dairy technology
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
    • A23C2250/00—Particular aspects related to cheese
    • A23C2250/15—Shredded non-dried cheese

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Dairy Products (AREA)

Abstract

La invención se refiere a un polipéptido que tiene actividad quimosina que: a. es capaz de hidrolizar alfa s1-caseína bovina en la posición F23F24 para formar as1-I CN (f24-199) más rápidamente que la quimosina de camello; y b. tiene una relación C/P mayor que la relación C/P de quimosina bovina.
MX2014013329A 2012-05-03 2013-05-03 Variantes de enzimas mejoradas. MX355170B (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201261642095P 2012-05-03 2012-05-03
EP12166673 2012-05-03
US201261745063P 2012-12-21 2012-12-21
EP12199178 2012-12-21
EP12199277 2012-12-21
PCT/EP2013/059317 WO2013164481A1 (en) 2012-05-03 2013-05-03 Improved enzyme variants

Publications (2)

Publication Number Publication Date
MX2014013329A true MX2014013329A (es) 2015-02-10
MX355170B MX355170B (es) 2018-04-05

Family

ID=49514227

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2014013329A MX355170B (es) 2012-05-03 2013-05-03 Variantes de enzimas mejoradas.
MX2014013333A MX357563B (es) 2012-05-03 2013-05-03 Variantes de enzima quimosina mejoradas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2014013333A MX357563B (es) 2012-05-03 2013-05-03 Variantes de enzima quimosina mejoradas.

Country Status (12)

Country Link
US (3) US9822352B2 (es)
EP (3) EP3450552A3 (es)
AU (2) AU2013255747A1 (es)
BR (2) BR112014027283A2 (es)
CA (2) CA2872309C (es)
DK (2) DK2844751T3 (es)
EA (2) EA035275B1 (es)
HK (2) HK1207881A1 (es)
LT (2) LT2844751T (es)
MX (2) MX355170B (es)
NZ (1) NZ701125A (es)
WO (2) WO2013164479A2 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112014029012B1 (pt) * 2012-05-25 2022-05-03 Chr. Hansen A/S Métodos para a produção de uma variante de polipeptídeo de quimosina isolada, e para fabricar um alimento ou produto alimentício à base de leite
BR112016017502B1 (pt) * 2014-02-26 2023-10-24 Chr. Hansen A/S Variantes de polipeptídeo de quimosina isoladas método para a produção das mesmas e método para a fabricação de um produto de alimentação humana ou animal
CA2976358A1 (en) 2015-02-10 2016-08-18 Chr. Hansen A/S Blends of chymosins with improved milk-clotting properties
RU2740317C2 (ru) 2015-06-22 2021-01-13 Кхр. Хансен А/С Варианты химозина с улучшенными свойствами
WO2017037092A1 (en) * 2015-08-31 2017-03-09 Chr. Hansen A/S Variants of chymosin with improved properties
DK3143879T3 (da) 2015-09-18 2025-04-22 Dsm Ip Assets Bv Yoghurt med reduceret modning
GB201517601D0 (en) * 2015-10-06 2015-11-18 Dale Farm Ltd Improvements relating to cheese making
CN109688825A (zh) 2016-05-19 2019-04-26 科·汉森有限公司 具有改善的凝乳特性的凝乳酶的变体
MX389656B (es) * 2016-05-19 2025-03-20 Chr Hansen As Variantes de quimosina con propiedades mejoradas de coagulación de leche.
CN106754840B (zh) * 2016-12-22 2019-06-21 江南大学 一种酶活及热稳定性改善的凝乳酶突变体
CA3087722A1 (en) * 2018-01-11 2019-07-18 Chr. Hansen A/S Interactions between cultures, coagulants and technology to increase cheese yields
CN109182311B (zh) * 2018-10-11 2021-07-27 山东隆科特酶制剂有限公司 一种用于沂蒙黑山羊乳奶酪的凝乳酶
WO2023001832A1 (en) 2021-07-20 2023-01-26 Chr. Hansen A/S Composition for clotting milk, methods and uses thereof
EP4504929A2 (en) 2022-04-06 2025-02-12 Chr. Hansen A/S Aspartic protease, methods and uses thereof
EP4680032A1 (en) 2023-03-15 2026-01-21 DSM IP Assets B.V. Novel process for producing a fermented milk product and new fermented milk product so produced
WO2025099224A1 (en) 2023-11-08 2025-05-15 Dsm Ip Assets B.V. Improved enzyme variants
WO2025099225A1 (en) 2023-11-08 2025-05-15 Dsm Ip Assets B.V. Improved enzyme variants

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002036752A2 (en) 2000-11-06 2002-05-10 Chr. Hansen A/S Method of producing non-bovine chymosin and use thereof
WO2008008766A2 (en) * 2006-07-10 2008-01-17 Ohio University Co-expression of proline hydroxylases to facilitate hyp-glycosylation of proteins expressed and secreted in plant cells
EP3763220A1 (en) 2007-02-13 2021-01-13 Chr. Hansen A/S Coagulation of milk

Also Published As

Publication number Publication date
LT2844750T (lt) 2018-09-10
DK2844751T3 (en) 2019-02-04
US20180030427A1 (en) 2018-02-01
WO2013164479A3 (en) 2013-12-19
US10167463B2 (en) 2019-01-01
HK1207881A1 (en) 2016-02-12
MX357563B (es) 2018-07-13
MX355170B (es) 2018-04-05
CA2872132A1 (en) 2013-11-07
US9822352B2 (en) 2017-11-21
EA201401211A1 (ru) 2015-05-29
WO2013164481A1 (en) 2013-11-07
EA038324B1 (ru) 2021-08-10
CA2872309A1 (en) 2013-11-07
CA2872309C (en) 2021-03-02
LT2844751T (lt) 2019-02-11
EP2844750A1 (en) 2015-03-11
EA201401209A1 (ru) 2015-05-29
BR112014027371A2 (pt) 2017-08-08
EP3450552A3 (en) 2019-05-08
US20150140169A1 (en) 2015-05-21
EP2844751A2 (en) 2015-03-11
AU2013255749A1 (en) 2014-11-06
HK1207880A1 (en) 2016-02-12
BR112014027283A2 (pt) 2017-08-08
EP2844751B1 (en) 2018-10-17
AU2013255747A1 (en) 2014-11-06
MX2014013333A (es) 2015-02-10
NZ701125A (en) 2016-11-25
EP3450552A2 (en) 2019-03-06
DK2844750T3 (en) 2018-10-01
EA035275B1 (ru) 2020-05-22
CA2872132C (en) 2020-06-16
US10253305B2 (en) 2019-04-09
WO2013164479A2 (en) 2013-11-07
US20150118356A1 (en) 2015-04-30
EP2844750B1 (en) 2018-06-20

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