MX2014013318A - Compuestos agonistas dobles de gip-glp-1 y procedimientos. - Google Patents
Compuestos agonistas dobles de gip-glp-1 y procedimientos.Info
- Publication number
- MX2014013318A MX2014013318A MX2014013318A MX2014013318A MX2014013318A MX 2014013318 A MX2014013318 A MX 2014013318A MX 2014013318 A MX2014013318 A MX 2014013318A MX 2014013318 A MX2014013318 A MX 2014013318A MX 2014013318 A MX2014013318 A MX 2014013318A
- Authority
- MX
- Mexico
- Prior art keywords
- gip
- glp
- agonist compounds
- methods
- dual agonist
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 229940125542 dual agonist Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 102100025101 GATA-type zinc finger protein 1 Human genes 0.000 abstract 1
- 101710198884 GATA-type zinc finger protein 1 Proteins 0.000 abstract 1
- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
La presente invención se refiere a análogos truncados de GIP que comprenden una o más sustituciones en comparación con el GIP silvestre y que pueden tener la propiedad de una actividad de GLP-1 alterada, preferentemente incrementada, por ejemplo, como se evalúa en ensayos de eficacia in vitro. La invención proporciona compuestos agonistas dobles GIP-GLP-1 y métodos asociados.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261642439P | 2012-05-03 | 2012-05-03 | |
| US201361765561P | 2013-02-15 | 2013-02-15 | |
| PCT/EP2013/059319 WO2013164483A1 (en) | 2012-05-03 | 2013-05-03 | Gip-glp-1 dual agonist compounds and methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2014013318A true MX2014013318A (es) | 2015-09-28 |
| MX356641B MX356641B (es) | 2018-06-07 |
Family
ID=48325702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014013318A MX356641B (es) | 2012-05-03 | 2013-05-03 | Compuestos agonistas dobles de gip-glp-1 y procedimientos. |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US10100097B2 (es) |
| EP (1) | EP2844669B1 (es) |
| JP (1) | JP6228187B2 (es) |
| KR (1) | KR102184241B1 (es) |
| CN (1) | CN104470948B (es) |
| AR (1) | AR090937A1 (es) |
| AU (1) | AU2013255751B2 (es) |
| BR (1) | BR112014027348B1 (es) |
| CA (1) | CA2872314C (es) |
| EA (1) | EA028665B1 (es) |
| HK (1) | HK1208232A1 (es) |
| IL (1) | IL235463A0 (es) |
| IN (1) | IN2014MN02304A (es) |
| MX (1) | MX356641B (es) |
| NZ (1) | NZ702333A (es) |
| PH (1) | PH12014502452A1 (es) |
| SG (1) | SG11201407137PA (es) |
| TR (1) | TR201815338T4 (es) |
| TW (1) | TWI689515B (es) |
| WO (1) | WO2013164483A1 (es) |
Families Citing this family (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2454282T3 (en) | 2009-07-13 | 2015-05-04 | Zealand Pharma As | acetylated glucagonanaloger |
| JP6228187B2 (ja) | 2012-05-03 | 2017-11-08 | ジーランド ファーマ アクティーゼルスカブ | Ｇｉｐ−ｇｌｐ−１デュアルアゴニスト化合物及び方法 |
| CA2878991C (en) | 2012-07-23 | 2021-12-07 | Zealand Pharma A/S | Glucagon analogues |
| TWI608013B (zh) | 2012-09-17 | 2017-12-11 | 西蘭製藥公司 | 升糖素類似物 |
| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
| US20150344540A1 (en) * | 2012-12-19 | 2015-12-03 | Novo Nordisk A/S | Novel glp-1 receptor agonists with cholesterol efflux activity |
| MX2015008114A (es) * | 2012-12-21 | 2015-11-06 | Sanofi Sa | Derivados de exendina-4. |
| GEP201706762B (en) | 2013-05-28 | 2017-10-25 | Takeda Pharmaceuticals Co | Peptide compound |
| US9988429B2 (en) | 2013-10-17 | 2018-06-05 | Zealand Pharma A/S | Glucagon analogues |
| PT3057984T (pt) | 2013-10-17 | 2018-10-24 | Boehringer Ingelheim Int | Análogos de glucagon acilados |
| MX2016005556A (es) | 2013-11-06 | 2016-07-15 | Zealand Pharma As | Compuestos agonistas duales de gip-glp-1 y procedimientos. |
| JP2017503474A (ja) | 2013-11-06 | 2017-02-02 | ジーランド ファーマ アクティーゼルスカブ | グルカゴン−ｇｌｐ−１−ｇｉｐトリプルアゴニスト化合物 |
| CN105934257B (zh) | 2013-12-06 | 2020-10-09 | 韩捷 | 用于含氮和羟基的药物的生物可逆引入基团 |
| US10253078B2 (en) * | 2014-10-29 | 2019-04-09 | Zealand Pharma A/S | GIP agonist compounds and methods |
| JOP20200119A1 (ar) * | 2015-01-09 | 2017-06-16 | Lilly Co Eli | مركبات مساعد مشترك من gip وglp-1 |
| DK3283507T3 (da) | 2015-04-16 | 2020-01-02 | Zealand Pharma As | Acyleret glucagonanalog |
| CN108135962A (zh) | 2015-10-07 | 2018-06-08 | 塞浦路迈德有限责任公司 | 用于口服递送肽类药物的药物制剂 |
| TWI622596B (zh) | 2015-10-26 | 2018-05-01 | 美國禮來大藥廠 | 升糖素受體促效劑 |
| US10501516B2 (en) | 2016-05-24 | 2019-12-10 | Takeda Pharmaceutical Company Limited | Peptide compound |
| WO2018065634A1 (en) | 2016-10-07 | 2018-04-12 | Cyprumed Gmbh | Pharmaceutical compositions for the nasal delivery of peptide or protein drugs |
| GB201620611D0 (en) | 2016-12-05 | 2017-01-18 | Univ Of Lancaster | Treatment of neurological diseases |
| WO2018104263A1 (en) | 2016-12-06 | 2018-06-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of enhancing the potency of incretin-based drugs in subjects in need thereof |
| JOP20180028A1 (ar) | 2017-03-31 | 2019-01-30 | Takeda Pharmaceuticals Co | مركب ببتيد |
| WO2019140030A1 (en) | 2018-01-12 | 2019-07-18 | Eli Lilly And Company | Combination therapy |
| US10577905B2 (en) | 2018-02-12 | 2020-03-03 | Eagle Technology, Llc | Hydrocarbon resource recovery system and RF antenna assembly with latching inner conductor and related methods |
| WO2019193204A1 (en) | 2018-04-06 | 2019-10-10 | Cyprumed Gmbh | Pharmaceutical compositions for the transmucosal delivery of therapeutic peptides and proteins |
| MA52483A (fr) * | 2018-05-04 | 2021-03-10 | Novo Nordisk As | Dérivés de gip et leurs utilisations |
| TWI705820B (zh) | 2018-06-22 | 2020-10-01 | 美商美國禮來大藥廠 | Gip/glp1促效劑組合物 |
| TWI842722B (zh) | 2018-07-23 | 2024-05-21 | 美商美國禮來大藥廠 | 使用gip/glp1共促效劑之療法 |
| BR112020026671A2 (pt) * | 2018-07-23 | 2021-04-06 | Eli Lilly And Company | Compostos coagonistas de gip/glp1 |
| CA3107108A1 (en) | 2018-07-23 | 2020-01-30 | Eli Lilly And Company | Method of using a gip/glp1 co-agonist for diabetes |
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| KR20210149747A (ko) * | 2019-04-11 | 2021-12-09 | 장쑤 한서 파마슈티칼 그룹 캄파니 리미티드 | 다중-수용체 작용제 및 그의 의학 용도 |
| AR119471A1 (es) | 2019-08-01 | 2021-12-22 | Lilly Co Eli | Compuestos agonistas de gipr |
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| KR20220131292A (ko) * | 2020-01-23 | 2022-09-27 | 일라이 릴리 앤드 캄파니 | Gip/glp1 공동-효능제 화합물 |
| AU2021241257A1 (en) * | 2020-03-25 | 2022-10-13 | Takeda Pharmaceutical Company Limited | QD dosing of GIP receptor agonist peptide compounds and uses thereof |
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| MX2023000403A (es) | 2020-07-22 | 2023-02-02 | Novo Nordisk As | Coagonistas de los receptores del peptido 1 similar al glucagon (glp-1) y del peptido insulinotropico dependiente de glucosa (gip). |
| WO2022018186A1 (en) | 2020-07-22 | 2022-01-27 | Novo Nordisk A/S | Co-agonists at glp-1 and gip receptors suitable for oral delivery |
| MX2023001532A (es) | 2020-08-07 | 2023-03-08 | Boehringer Ingelheim Int | Agonistas del receptor npy2 solubles. |
| JP2023541827A (ja) | 2020-09-07 | 2023-10-04 | サイプルメド ゲーエムベーハー | Ｇｌｐ－１受容体アゴニストの改善された医薬製剤 |
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| AU2022269659B2 (en) | 2021-05-07 | 2025-04-10 | Eli Lilly And Company | Erodible tablet |
| CN118307645A (zh) * | 2021-05-28 | 2024-07-09 | 广东众生睿创生物科技有限公司 | 多肽的制备及其应用 |
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| JP2024532503A (ja) * | 2021-09-02 | 2024-09-05 | サンシャイン・レイク・ファーマ・カンパニー・リミテッド | Ｇｌｐ－１／ｇｉｐデュアルターゲット型ポリペプチド及び融合タンパク質並びにこれらの適用 |
| EP4259647A4 (en) | 2021-09-15 | 2025-03-26 | Viking Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR THE TREATMENT OF METABOLIC AND LIVER DISEASES |
| WO2023083301A1 (zh) * | 2021-11-12 | 2023-05-19 | 福建盛迪医药有限公司 | Glp-1受体和gip受体双重激动剂的药物组合物及其用途 |
| TW202330584A (zh) | 2022-01-20 | 2023-08-01 | 丹麥商諾佛 儂迪克股份有限公司 | 前藥及其用途 |
| CN116947978A (zh) * | 2022-04-19 | 2023-10-27 | 北京惠之衡生物科技有限公司 | 一种glp-1和gip受体共激动多肽衍生物及其盐和制剂 |
| PE20251259A1 (es) | 2022-07-13 | 2025-05-06 | Hangzhou Zhongmeihuadong Pharmaceutical Co Ltd | Agonista dual de glp-1/gip, metodo de preparacion y uso del mismo |
| JP2025523903A (ja) * | 2022-07-15 | 2025-07-25 | ペプトゥータンゴ・セラピューティクス・インコーポレイテッド | マルチアゴニストペプチドを含む組成物並びに製造及び使用方法 |
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| WO2024050289A1 (en) | 2022-08-29 | 2024-03-07 | Eli Lilly And Company | Compositions for oral delivery |
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| CN121001710A (zh) | 2022-12-30 | 2025-11-21 | 阿尔吉法玛公司 | 提高口服多肽治疗剂的全身生物利用度的组合物和方法 |
| CN120981479A (zh) | 2023-01-31 | 2025-11-18 | 伊莱利利公司 | Gip/glp1/gcg三受体激动剂及其用途 |
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2013
- 2013-05-03 JP JP2015509461A patent/JP6228187B2/ja active Active
- 2013-05-03 US US14/398,260 patent/US10100097B2/en active Active
- 2013-05-03 EP EP13720931.8A patent/EP2844669B1/en active Active
- 2013-05-03 BR BR112014027348-0A patent/BR112014027348B1/pt active IP Right Grant
- 2013-05-03 AR ARP130101524A patent/AR090937A1/es unknown
- 2013-05-03 HK HK15108788.2A patent/HK1208232A1/xx unknown
- 2013-05-03 EA EA201491918A patent/EA028665B1/ru not_active IP Right Cessation
- 2013-05-03 TR TR2018/15338T patent/TR201815338T4/tr unknown
- 2013-05-03 MX MX2014013318A patent/MX356641B/es active IP Right Grant
- 2013-05-03 TW TW102115949A patent/TWI689515B/zh active
- 2013-05-03 CN CN201380032714.4A patent/CN104470948B/zh active Active
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- 2013-05-03 SG SG11201407137PA patent/SG11201407137PA/en unknown
- 2013-05-03 WO PCT/EP2013/059319 patent/WO2013164483A1/en not_active Ceased
- 2013-05-03 KR KR1020147033952A patent/KR102184241B1/ko active Active
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- 2013-05-03 IN IN2304MUN2014 patent/IN2014MN02304A/en unknown
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| TW201348252A (zh) | 2013-12-01 |
| AU2013255751A1 (en) | 2014-12-18 |
| EA028665B1 (ru) | 2017-12-29 |
| JP6228187B2 (ja) | 2017-11-08 |
| IN2014MN02304A (es) | 2015-08-07 |
| EP2844669B1 (en) | 2018-08-01 |
| IL235463A0 (en) | 2014-12-31 |
| MX356641B (es) | 2018-06-07 |
| KR20150003910A (ko) | 2015-01-09 |
| PH12014502452A1 (en) | 2015-02-02 |
| EA201491918A1 (ru) | 2015-07-30 |
| AR090937A1 (es) | 2014-12-17 |
| TWI689515B (zh) | 2020-04-01 |
| CA2872314A1 (en) | 2013-11-07 |
| EP2844669A1 (en) | 2015-03-11 |
| US20190135886A1 (en) | 2019-05-09 |
| SG11201407137PA (en) | 2014-11-27 |
| CA2872314C (en) | 2021-08-31 |
| AU2013255751B2 (en) | 2017-10-05 |
| JP2015517459A (ja) | 2015-06-22 |
| BR112014027348B1 (pt) | 2022-12-20 |
| CN104470948A (zh) | 2015-03-25 |
| HK1208232A1 (en) | 2016-02-26 |
| US20150299281A1 (en) | 2015-10-22 |
| BR112014027348A2 (pt) | 2017-06-27 |
| TR201815338T4 (tr) | 2018-11-21 |
| NZ702333A (en) | 2017-06-30 |
| KR102184241B1 (ko) | 2020-12-01 |
| WO2013164483A1 (en) | 2013-11-07 |
| CN104470948B (zh) | 2018-06-15 |
| US10100097B2 (en) | 2018-10-16 |
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