MX2014003832A - Molecula de union al antigeno que induce la inmunorespuesta al antigeno objetivo. - Google Patents
Molecula de union al antigeno que induce la inmunorespuesta al antigeno objetivo.Info
- Publication number
- MX2014003832A MX2014003832A MX2014003832A MX2014003832A MX2014003832A MX 2014003832 A MX2014003832 A MX 2014003832A MX 2014003832 A MX2014003832 A MX 2014003832A MX 2014003832 A MX2014003832 A MX 2014003832A MX 2014003832 A MX2014003832 A MX 2014003832A
- Authority
- MX
- Mexico
- Prior art keywords
- antigen
- antigen binding
- binding molecule
- domain
- binding
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Los inventores descubrieron que una inmunorespuesta a un antígeno se indujo en un organismo vivo que tiene una molécula de unión al antígeno administrada al mismo, dicha molécula de unión al antígeno incluye un dominio de unión al antígeno donde la actividad de unión con relación al antígeno cambia dependiendo de las condiciones de concentración iónica, y un dominio de unión a FcRn que tiene la actividad de unión a FcRn al pH neutro. Los inventores también encontraron que, además de la inmunorespuesta al antígeno inducida, también se descubrió una acción tóxica o una acción inhibitoria del crecimiento en organismos extraños, células cancerosas, o similares que expresan el antígeno al cual dicha molécula de unión al antígeno se une en el organismo vivo que tiene la molécula de unión al antígeno administrada al mismo, dicha molécula de unión al antígeno incluye el dominio de unión al antígeno donde la actividad de unión con relación al antígeno cambia dependiendo de las condiciones de concentración iónica, y el dominio de unión a FcRn que tiene la actividad de unión a FcRn al pH neutro.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011216958 | 2011-09-30 | ||
| PCT/JP2012/075043 WO2013047729A1 (ja) | 2011-09-30 | 2012-09-28 | 標的抗原に対する免疫応答を誘導する抗原結合分子 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2014003832A true MX2014003832A (es) | 2014-08-27 |
| MX366968B MX366968B (es) | 2019-08-01 |
Family
ID=47995754
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014003832A MX366968B (es) | 2011-09-30 | 2012-09-28 | Molecula de union al antigeno que induce la inmunorespuesta al antigeno objetivo. |
| MX2019006188A MX2019006188A (es) | 2011-09-30 | 2014-03-28 | Molecula de union al antigeno que induce la inmunorespuesta al antigeno objetivo. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019006188A MX2019006188A (es) | 2011-09-30 | 2014-03-28 | Molecula de union al antigeno que induce la inmunorespuesta al antigeno objetivo. |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US10556949B2 (es) |
| EP (1) | EP2752200B1 (es) |
| JP (3) | JP6352634B2 (es) |
| KR (3) | KR102492584B1 (es) |
| CN (4) | CN110627902A (es) |
| AU (1) | AU2012317395B2 (es) |
| BR (1) | BR112014007484A2 (es) |
| CA (1) | CA2850322C (es) |
| HK (1) | HK1198813A1 (es) |
| MX (2) | MX366968B (es) |
| RU (1) | RU2722829C9 (es) |
| SG (2) | SG11201401100UA (es) |
| TW (2) | TWI681970B (es) |
| WO (1) | WO2013047729A1 (es) |
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| KR102385507B1 (ko) | 2010-11-30 | 2022-04-12 | 추가이 세이야쿠 가부시키가이샤 | 복수 분자의 항원에 반복해서 결합하는 항원 결합 분자 |
| CA2827923C (en) | 2011-02-25 | 2021-11-23 | Chugai Seiyaku Kabushiki Kaisha | Fc.gamma.riib-specific fc antibody |
| RU2641256C2 (ru) | 2011-06-30 | 2018-01-16 | Чугаи Сейяку Кабусики Кайся | Гетеродимеризованный полипептид |
| JP6322411B2 (ja) | 2011-09-30 | 2018-05-09 | 中外製薬株式会社 | 複数の生理活性を有する抗原の消失を促進する抗原結合分子 |
| TW201817745A (zh) | 2011-09-30 | 2018-05-16 | 日商中外製藥股份有限公司 | 具有促進抗原清除之ＦｃＲｎ結合域的治療性抗原結合分子 |
| TWI681970B (zh) | 2011-09-30 | 2020-01-11 | 日商中外製藥股份有限公司 | 包含依離子濃度之條件對抗原之結合活性會改變之抗原結合分域、及於pH中性之條件下對FcRn有結合活性之FcRn結合分域、且誘導對標的抗原的免疫反應之抗原結合分子 |
| RU2634417C2 (ru) | 2011-10-28 | 2017-10-26 | Регенерон Фармасьютикалс, Инк. | Гуманизированные il-6 и рецептор il-6 |
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