MX2014001371A - Composicion farmaceutica para el tratamiento y/o prevencion de cancer. - Google Patents
Composicion farmaceutica para el tratamiento y/o prevencion de cancer.Info
- Publication number
- MX2014001371A MX2014001371A MX2014001371A MX2014001371A MX2014001371A MX 2014001371 A MX2014001371 A MX 2014001371A MX 2014001371 A MX2014001371 A MX 2014001371A MX 2014001371 A MX2014001371 A MX 2014001371A MX 2014001371 A MX2014001371 A MX 2014001371A
- Authority
- MX
- Mexico
- Prior art keywords
- cancer
- antibody
- prophylaxis
- treatment
- pharmaceutical composition
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 7
- 201000011510 cancer Diseases 0.000 title abstract 7
- 238000011321 prophylaxis Methods 0.000 title abstract 4
- 238000011282 treatment Methods 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 102100029949 Caprin-1 Human genes 0.000 abstract 2
- 101710072528 Caprin-1 Proteins 0.000 abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000001900 immune effect Effects 0.000 abstract 1
- 230000009257 reactivity Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Maintenance And Inspection Apparatuses For Elevators (AREA)
Abstract
El propósito de la presente invención es producir un anticuerpo que tenga una mayor actividad antitumoral que los anticuerpos convencionales que se dirigen a CAPRIN-1, que se expresa específicamente en la superficie de una célula cancerosa, y proporcionar el uso del anticuerpo como un agente para el tratamiento y/o prevención del cáncer. La presente invención proporciona el uso, como un agente para el tratamiento y/o prevención del cáncer, de un anticuerpo que identifica y se dirige a una proteína de antígeno de cáncer que se expresa específicamente en la superficie de una célula cancerosa. Más específicamente, la presente invención proporciona una composición farmacéutica para el tratamiento y/o prevención del cáncer, la composición farmacéutica se caracteriza por que contiene, como ingrediente activo: un anticuerpo que tiene reactividad inmunológica con proteína CAPRIN-1 y que comprende una región variable de la cadena pesada que incluye secuencias de aminoácidos representadas por las SEQ ID NO: 5, 6 y 7 y una región variable de la cadena ligera que incluye secuencias de aminoácidos representadas por las SEQ ID NO: 9, 10 y 11, o un fragmento de dicho anticuerpo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011171377 | 2011-08-04 | ||
| PCT/JP2012/069853 WO2013018891A1 (ja) | 2011-08-04 | 2012-08-03 | 癌の治療及び／又は予防用医薬組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2014001371A true MX2014001371A (es) | 2014-03-21 |
| MX348578B MX348578B (es) | 2017-06-20 |
Family
ID=47629405
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014001371A MX348578B (es) | 2011-08-04 | 2012-08-03 | Composicion farmaceutica para el tratamiento y/o prevencion de cancer. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9175074B2 (es) |
| EP (1) | EP2740794B1 (es) |
| JP (1) | JP6065590B2 (es) |
| KR (1) | KR101980557B1 (es) |
| CN (1) | CN103717739B (es) |
| AU (1) | AU2012290954B2 (es) |
| BR (1) | BR112014002613B1 (es) |
| CA (1) | CA2844040C (es) |
| DK (1) | DK2740794T3 (es) |
| ES (1) | ES2672695T3 (es) |
| HU (1) | HUE039219T2 (es) |
| MX (1) | MX348578B (es) |
| PL (1) | PL2740794T3 (es) |
| PT (1) | PT2740794T (es) |
| RU (1) | RU2610428C2 (es) |
| TR (1) | TR201808595T4 (es) |
| WO (1) | WO2013018891A1 (es) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2733492T3 (pl) | 2008-08-05 | 2016-08-31 | Toray Industries | Sposób wykrywania nowotworów |
| US9416192B2 (en) | 2008-08-05 | 2016-08-16 | Toray Industries, Inc. | Pharmaceutical composition for treatment and prevention of cancers |
| RU2603742C2 (ru) | 2010-02-04 | 2016-11-27 | Торэй Индастриз, Инк. | Фармацевтическая композиция для лечения и/или профилактики рака |
| KR102041832B1 (ko) * | 2011-08-04 | 2019-11-08 | 도레이 카부시키가이샤 | 췌장암의 치료 및/또는 예방용 의약 조성물 |
| JP6094220B2 (ja) | 2011-08-04 | 2017-03-15 | 東レ株式会社 | 膵臓癌の検出方法 |
| DK2818483T3 (en) | 2012-02-21 | 2017-10-23 | Toray Industries | Medical composition for the treatment and / or prevention of cancer |
| HUE036425T2 (hu) | 2012-03-30 | 2018-07-30 | Toray Industries | Gyógyászati készítmény epehólyagrák kezelésére és/vagy megelõzésére |
| ES2656620T3 (es) | 2012-03-30 | 2018-02-27 | Toray Industries, Inc. | Composición farmacéutica para el tratamiento y/o la prevención del cáncer de hígado |
| AU2013291051C1 (en) * | 2012-07-19 | 2019-07-04 | Toray Industries, Inc. | Cancer detection method |
| PL2876446T3 (pl) | 2012-07-19 | 2019-06-28 | Toray Industries, Inc. | Sposób wykrywania nowotworu |
| EP3031826B1 (en) | 2013-08-09 | 2018-10-10 | Toray Industries, Inc. | Pharmaceutical composition for treatment and/or prevention of cancer |
| RU2655461C2 (ru) * | 2013-12-26 | 2018-05-28 | Витро, С.А.Б. Де С.В. | Органический светоизлучающий диод с испускающим свет электродом |
| CN115317603A (zh) | 2016-07-07 | 2022-11-11 | 小利兰·斯坦福大学托管委员会 | 抗体佐剂缀合物 |
| US12274745B2 (en) * | 2016-10-28 | 2025-04-15 | Toray Industries, Inc. | Conjugate of CAPRIN-1 antibody linked to immune activator for cancer treatment |
| BR112020019935A2 (pt) | 2018-03-30 | 2021-01-26 | Toray Industries, Inc. | medicamento para o tratamento e/ou prevenção do câncer, agentes que aumentam a eficácia de um fármaco e método de tratamento e/ou prevenção do câncer |
| EP3937984A1 (en) | 2019-03-15 | 2022-01-19 | Bolt Biotherapeutics, Inc. | Immunoconjugates targeting her2 |
| JP7281951B2 (ja) * | 2019-04-22 | 2023-05-26 | シャープ株式会社 | 電子機器、制御装置、制御プログラムおよび制御方法 |
| CA3142887A1 (en) | 2019-06-13 | 2020-12-17 | Bolt Biotherapeutics, Inc. | Aminobenzazepine compounds, immunoconjugates, and uses thereof |
| AU2020359446A1 (en) | 2019-09-30 | 2022-04-21 | Bolt Biotherapeutics, Inc. | Amide-linked, aminobenzazepine immunoconjugates, and uses thereof |
| IL292396A (en) | 2019-10-25 | 2022-06-01 | Bolt Biotherapeutics Inc | Thianozapine immunoconjugates and uses thereof |
| JPWO2021182574A1 (es) | 2020-03-12 | 2021-09-16 | ||
| JP7715041B2 (ja) | 2020-03-12 | 2025-07-30 | 東レ株式会社 | 癌の治療及び／又は予防のための医薬品 |
| US20230139178A1 (en) * | 2020-03-12 | 2023-05-04 | Toray Industries, Inc. | Medicament for treatment and/or prevention of cancer |
| EP4119159A4 (en) | 2020-03-12 | 2024-03-27 | Toray Industries, Inc. | MEDICINE FOR THE TREATMENT AND/OR PREVENTION OF CANCER |
| US20230129035A1 (en) | 2020-03-12 | 2023-04-27 | Toray Industries, Inc. | Medicament for treatment and/or prevention of cancer |
| WO2021226440A1 (en) | 2020-05-08 | 2021-11-11 | Bolt Biotherapeutics, Inc. | Elastase-substrate, peptide linker immunoconjugates, and uses thereof |
| MX2023001679A (es) | 2020-08-13 | 2023-02-22 | Bolt Biotherapeutics Inc | Inmunoconjugados de pirazolazepina y usos de estos. |
| MX2023014500A (es) | 2021-06-23 | 2024-01-25 | Toray Industries | Medicamento para el tratamiento y/o prevencion de cancer. |
| KR20240024074A (ko) | 2021-06-23 | 2024-02-23 | 도레이 카부시키가이샤 | 암의 치료 및/또는 예방을 위한 의약품 |
| AU2022320304A1 (en) | 2021-07-27 | 2024-02-29 | Toray Industries, Inc. | Medicament for treatment and/or prevention of cancer |
| EP4378477A4 (en) | 2021-07-27 | 2025-08-13 | Toray Industries | MEDICINE FOR THE TREATMENT AND/OR PREVENTION OF CANCER |
| AU2022319362A1 (en) | 2021-07-27 | 2024-02-29 | Toray Industries, Inc. | Medicament for treatment and/or prevention of cancer |
| CA3230737A1 (en) | 2021-09-03 | 2023-03-09 | Toray Industries, Inc. | Pharmaceutical composition for cancer treatment and/or prevention |
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| AU2023298568A1 (en) | 2022-06-30 | 2025-01-09 | Toray Industries, Inc. | Pharmaceutical composition for cancer treatment and/or prevention |
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| CN119768182A (zh) | 2022-08-24 | 2025-04-04 | 东丽株式会社 | 用于癌的治疗和/或预防的药品 |
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- 2012-08-03 TR TR2018/08595T patent/TR201808595T4/tr unknown
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- 2012-08-03 JP JP2012543816A patent/JP6065590B2/ja active Active
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- 2012-08-03 KR KR1020147005859A patent/KR101980557B1/ko active Active
- 2012-08-03 PT PT128200912T patent/PT2740794T/pt unknown
- 2012-08-03 WO PCT/JP2012/069853 patent/WO2013018891A1/ja not_active Ceased
- 2012-08-03 HU HUE12820091A patent/HUE039219T2/hu unknown
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Also Published As
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|---|---|
| EP2740794B1 (en) | 2018-04-04 |
| AU2012290954B2 (en) | 2017-08-31 |
| PL2740794T3 (pl) | 2018-09-28 |
| AU2012290954A1 (en) | 2014-03-20 |
| CN103717739B (zh) | 2015-07-29 |
| RU2610428C2 (ru) | 2017-02-10 |
| BR112014002613B1 (pt) | 2022-08-23 |
| CA2844040A1 (en) | 2013-02-07 |
| US9175074B2 (en) | 2015-11-03 |
| HUE039219T2 (hu) | 2018-12-28 |
| ES2672695T3 (es) | 2018-06-15 |
| PT2740794T (pt) | 2018-06-14 |
| CA2844040C (en) | 2019-05-07 |
| JP6065590B2 (ja) | 2017-01-25 |
| CN103717739A (zh) | 2014-04-09 |
| RU2014108043A (ru) | 2015-09-10 |
| BR112014002613A2 (pt) | 2018-06-05 |
| JPWO2013018891A1 (ja) | 2015-03-05 |
| US20140154261A1 (en) | 2014-06-05 |
| MX348578B (es) | 2017-06-20 |
| EP2740794A1 (en) | 2014-06-11 |
| KR20140054180A (ko) | 2014-05-08 |
| DK2740794T3 (en) | 2018-06-14 |
| KR101980557B1 (ko) | 2019-05-21 |
| WO2013018891A1 (ja) | 2013-02-07 |
| TR201808595T4 (tr) | 2018-07-23 |
| EP2740794A4 (en) | 2015-04-22 |
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