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MX2013015274A - Anatagonista trpm8 y su uso en tratamientos. - Google Patents

Anatagonista trpm8 y su uso en tratamientos.

Info

Publication number
MX2013015274A
MX2013015274A MX2013015274A MX2013015274A MX2013015274A MX 2013015274 A MX2013015274 A MX 2013015274A MX 2013015274 A MX2013015274 A MX 2013015274A MX 2013015274 A MX2013015274 A MX 2013015274A MX 2013015274 A MX2013015274 A MX 2013015274A
Authority
MX
Mexico
Prior art keywords
compounds
trpm8
treatments
formula
disorders
Prior art date
Application number
MX2013015274A
Other languages
English (en)
Inventor
James Brown
Scott Harried
Holger Monenschein
Wenge Zhong
Kaustav Biswas
J Chen Jian
Keshav Gore Vijay
B Horne Daniel
R Kaller Matthew
Liu Qingyian
Vu Van Ma
T Nguyen Thomas
Chenguang Yuan Chester
J Jr St Jean David
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MX2013015274A publication Critical patent/MX2013015274A/es

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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Abstract

Los compuestos de la Fórmula I son útiles como antagonistas de TRPM8. Tales compuestos son útiles al tratar un número de trastornos y afecciones mediados por TRPM8 y pueden usarse para preparar medicamentos y composiciones farmacéuticas útiles para tratar tales trastornos y afecciones. Los ejemplos de tales trastornos incluyen, pero no se limitan a, migrañas y dolor neuropático. Los compuestos de la Fórmula I tienen la siguiente estructura: (Ver Formula) donde las definiciones de las variables se proporcionan en la presente.
MX2013015274A 2011-06-24 2012-06-21 Anatagonista trpm8 y su uso en tratamientos. MX2013015274A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161500843P 2011-06-24 2011-06-24
PCT/US2012/043566 WO2012177893A2 (en) 2011-06-24 2012-06-21 Trpm8 antagonists and their use in treatments

Publications (1)

Publication Number Publication Date
MX2013015274A true MX2013015274A (es) 2014-03-31

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MX2013015274A MX2013015274A (es) 2011-06-24 2012-06-21 Anatagonista trpm8 y su uso en tratamientos.

Country Status (23)

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US (3) US8710043B2 (es)
EP (1) EP2723717A2 (es)
JP (1) JP2014527511A (es)
KR (1) KR20140045507A (es)
CN (1) CN103906733A (es)
AP (1) AP2013007331A0 (es)
AR (1) AR086750A1 (es)
AU (1) AU2012272895B2 (es)
BR (1) BR112013033316A2 (es)
CA (1) CA2839699A1 (es)
CL (1) CL2013003715A1 (es)
CO (1) CO6852073A2 (es)
CR (1) CR20140037A (es)
EA (1) EA201490152A1 (es)
MA (1) MA35271B1 (es)
MX (1) MX2013015274A (es)
MY (1) MY157429A (es)
PE (1) PE20140868A1 (es)
PH (1) PH12013502611A1 (es)
TN (1) TN2013000529A1 (es)
TW (2) TWI448454B (es)
UY (1) UY34160A (es)
WO (1) WO2012177893A2 (es)

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US20130157996A1 (en) 2013-06-20
US20140171406A1 (en) 2014-06-19
MA35271B1 (fr) 2014-07-03
US9096527B2 (en) 2015-08-04
TN2013000529A1 (en) 2015-03-30
MY157429A (en) 2016-06-15
US20140171639A1 (en) 2014-06-19
WO2012177893A3 (en) 2013-06-13
CL2013003715A1 (es) 2014-06-27
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UY34160A (es) 2012-08-31
JP2014527511A (ja) 2014-10-16
CA2839699A1 (en) 2012-12-27
US8710043B2 (en) 2014-04-29
BR112013033316A2 (pt) 2017-01-31
CN103906733A (zh) 2014-07-02
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KR20140045507A (ko) 2014-04-16
TW201311643A (zh) 2013-03-16
CR20140037A (es) 2014-03-13
AP2013007331A0 (en) 2013-12-31
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