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MX2013006598A - Inhibidores de la amida hidrolasa de acidos grasos (faah). - Google Patents

Inhibidores de la amida hidrolasa de acidos grasos (faah).

Info

Publication number
MX2013006598A
MX2013006598A MX2013006598A MX2013006598A MX2013006598A MX 2013006598 A MX2013006598 A MX 2013006598A MX 2013006598 A MX2013006598 A MX 2013006598A MX 2013006598 A MX2013006598 A MX 2013006598A MX 2013006598 A MX2013006598 A MX 2013006598A
Authority
MX
Mexico
Prior art keywords
compounds
disclosure
faah inhibitors
faah
inhibitors
Prior art date
Application number
MX2013006598A
Other languages
English (en)
Other versions
MX341110B (es
Inventor
Kevin Sprott
Timothy C Barden
Xiang Y Yu
Ara Mermerian
Angelika Fretzen
Colleen Hudson
James Jia
Bo Peng
Jane Yang
Original Assignee
Ironwood Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45509695&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2013006598(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ironwood Pharmaceuticals Inc filed Critical Ironwood Pharmaceuticals Inc
Publication of MX2013006598A publication Critical patent/MX2013006598A/es
Publication of MX341110B publication Critical patent/MX341110B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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Abstract

La presente descripción se relaciona con compuestos útiles como inhibidores de la enzima amida hidrolasa de ácidos grasos (FAAH). La descripción proporciona, además, composiciones farmacéuticamente aceptables que comprenden los compuestos de la descripción y métodos para usar las composiciones en el tratamiento de diversos trastornos. Los compuestos de la invención se describen en la Tabla 1.
MX2013006598A 2010-12-22 2011-12-22 Inhibidores de la amida hidrolasa de acidos grasos (faah). MX341110B (es)

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PCT/US2011/066972 WO2012088469A1 (en) 2010-12-22 2011-12-22 Faah inhibitors

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TW201307284A (zh) 2013-02-16
AR084433A1 (es) 2013-05-15
AU2011348113A1 (en) 2013-06-27
CA2822842C (en) 2019-06-04
EP2655356B1 (en) 2016-08-03
CA2822842A1 (en) 2012-06-28
MX341110B (es) 2016-08-09
ES2601499T3 (es) 2017-02-15
NZ611798A (en) 2015-07-31
CN103502237A (zh) 2014-01-08
CN103502237B (zh) 2016-01-20
CO6781493A2 (es) 2013-10-31
UY33832A (es) 2012-07-31
WO2012088469A1 (en) 2012-06-28
US20150175599A1 (en) 2015-06-25
JP5982397B2 (ja) 2016-08-31
RU2013133884A (ru) 2015-01-27
JP2014500332A (ja) 2014-01-09
US9657012B2 (en) 2017-05-23
BR112013016154A2 (pt) 2018-07-10
CL2013001772A1 (es) 2013-12-27
KR20140002709A (ko) 2014-01-08
EP2655356A1 (en) 2013-10-30

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