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WO2008100977A3 - Carbamates therapeutic release agents as amidase inhibitors - Google Patents

Carbamates therapeutic release agents as amidase inhibitors Download PDF

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Publication number
WO2008100977A3
WO2008100977A3 PCT/US2008/053785 US2008053785W WO2008100977A3 WO 2008100977 A3 WO2008100977 A3 WO 2008100977A3 US 2008053785 W US2008053785 W US 2008053785W WO 2008100977 A3 WO2008100977 A3 WO 2008100977A3
Authority
WO
WIPO (PCT)
Prior art keywords
carbamates
release agents
therapeutic release
inhibitors
faah
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/053785
Other languages
French (fr)
Other versions
WO2008100977A2 (en
Inventor
Olivier Dasse
Jeff A Parrott
David Putman
Julia Adam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon NV
Original Assignee
Organon NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon NV filed Critical Organon NV
Publication of WO2008100977A2 publication Critical patent/WO2008100977A2/en
Publication of WO2008100977A3 publication Critical patent/WO2008100977A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/56—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Pharmacological inhibition of fatty acid amide hydrolase (FAAH) activity leads to increased levels of fatty acid amides. Esters of alkylcarbamic acids are disclosed that are inhibitors of FAAH activity. Compounds disclosed herein inhibit FAAH activity. Described herein are processes for the preparation of esters of alkylcarbamic acid compounds, compositions that include them, and methods of use thereof.
PCT/US2008/053785 2007-02-14 2008-02-13 Carbamates therapeutic release agents as amidase inhibitors Ceased WO2008100977A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US88990907P 2007-02-14 2007-02-14
US60/889,909 2007-02-14
US94808207P 2007-07-05 2007-07-05
US60/948,082 2007-07-05

Publications (2)

Publication Number Publication Date
WO2008100977A2 WO2008100977A2 (en) 2008-08-21
WO2008100977A3 true WO2008100977A3 (en) 2008-12-18

Family

ID=39595757

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/053785 Ceased WO2008100977A2 (en) 2007-02-14 2008-02-13 Carbamates therapeutic release agents as amidase inhibitors

Country Status (1)

Country Link
WO (1) WO2008100977A2 (en)

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CN103027909B (en) * 2011-11-28 2015-01-14 贵阳中医学院 Application of coumarins compounds and method for extracting coumarins compounds from winter daphne
US11332459B2 (en) 2017-10-19 2022-05-17 Teijin Pharma Limited Benzimidazole derivatives and their uses

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004033422A2 (en) * 2002-10-07 2004-04-22 The Regents Of The University Of California Modulation of anxiety through blockade of anandamide hydrolysis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004033422A2 (en) * 2002-10-07 2004-04-22 The Regents Of The University Of California Modulation of anxiety through blockade of anandamide hydrolysis

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FEGLEY ET AL: "Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3'-carbamoyl-biphenyl-3-yl ester (URB597): Effects on anandamide and oleoylethanolamide deactivation", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, EXPERIMENTAL THERAPEUTICS, BALTIMORE, MD, vol. 313, no. 1, 1 January 2005 (2005-01-01), pages 352 - 358, XP002459348, ISSN: 0022-3565 *
GREENWALD R B: "Drug delivery systems: Anticancer prodrugs and their polymeric conjugates", EXPERT OPINION ON THERAPEUTIC PATENTS, ASHLEY PUBLICATIONS, GB, vol. 7, no. 6, 6 June 1997 (1997-06-06), pages 601 - 609, XP002296827, ISSN: 1354-3776 *
HERTZOG D L: "Recent advances in the cannabinoids", EXPERT OPINION ON THERAPEUTIC PATENTS, ASHLEY PUBLICATIONS, GB, vol. 14, no. 10, 1 January 2004 (2004-01-01), pages 1435 - 1452, XP002362228, ISSN: 1354-3776 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103027909B (en) * 2011-11-28 2015-01-14 贵阳中医学院 Application of coumarins compounds and method for extracting coumarins compounds from winter daphne
US11332459B2 (en) 2017-10-19 2022-05-17 Teijin Pharma Limited Benzimidazole derivatives and their uses

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