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TW200612918A - Lonidamine analogs - Google Patents

Lonidamine analogs

Info

Publication number
TW200612918A
TW200612918A TW094126067A TW94126067A TW200612918A TW 200612918 A TW200612918 A TW 200612918A TW 094126067 A TW094126067 A TW 094126067A TW 94126067 A TW94126067 A TW 94126067A TW 200612918 A TW200612918 A TW 200612918A
Authority
TW
Taiwan
Prior art keywords
lonidamine analogs
lonidamine
analogs
bph
cancer
Prior art date
Application number
TW094126067A
Other languages
Chinese (zh)
Inventor
Mark Matteucci
Photon Rao
Jian-Xin Duan
Original Assignee
Threshold Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Threshold Pharmaceuticals Inc filed Critical Threshold Pharmaceuticals Inc
Publication of TW200612918A publication Critical patent/TW200612918A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/72—Benzo[c]thiophenes; Hydrogenated benzo[c]thiophenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Lonidamine analogs are useful in the treatment of cancer and BPH.
TW094126067A 2004-07-29 2005-07-29 Lonidamine analogs TW200612918A (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US59272304P 2004-07-29 2004-07-29
US59283304P 2004-07-29 2004-07-29
US59966604P 2004-08-05 2004-08-05
US64618805P 2005-01-21 2005-01-21
US65170505P 2005-02-09 2005-02-09
US66106705P 2005-03-11 2005-03-11
US68308705P 2005-05-19 2005-05-19

Publications (1)

Publication Number Publication Date
TW200612918A true TW200612918A (en) 2006-05-01

Family

ID=35787877

Family Applications (1)

Application Number Title Priority Date Filing Date
TW094126067A TW200612918A (en) 2004-07-29 2005-07-29 Lonidamine analogs

Country Status (2)

Country Link
TW (1) TW200612918A (en)
WO (1) WO2006015263A2 (en)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
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US7514463B2 (en) * 2004-08-20 2009-04-07 University Of Kansas Lonidamine analogues and their use in male contraception and cancer treatment
WO2006103511A1 (en) 2005-03-31 2006-10-05 Pfizer Products Inc. Cyclopentapyridine and tetrahydroquinoline derivatives
JP5180824B2 (en) 2005-06-29 2013-04-10 スレッシュホールド ファーマシューティカルズ， インコーポレイテッド Phosphoramidate alkylating agent prodrug
KR20080085232A (en) 2006-02-17 2008-09-23 화이자 리미티드 3-deazapurine derivatives as TLR7 modulators
US7501438B2 (en) 2006-07-07 2009-03-10 Forest Laboratories Holdings Limited Pyridoimidazole derivatives
EP2049520A4 (en) 2006-08-07 2011-01-05 Ironwood Pharmaceuticals Inc Indole compounds
KR20140127367A (en) 2006-09-19 2014-11-03 다이이찌 산쿄 가부시키가이샤 Pyrazolopyrimidine derivative
US7858645B2 (en) * 2006-11-01 2010-12-28 Hoffmann-La Roche Inc. Indazole derivatives
DE102007026341A1 (en) 2007-06-06 2008-12-11 Merck Patent Gmbh Benzoxazolonderivate
DE102007032507A1 (en) 2007-07-12 2009-04-02 Merck Patent Gmbh pyridazinone derivatives
DE102007061963A1 (en) 2007-12-21 2009-06-25 Merck Patent Gmbh pyridazinone derivatives
CA2714573A1 (en) * 2008-02-29 2009-09-03 Pfizer Inc. Indazole derivatives
DE102008019907A1 (en) 2008-04-21 2009-10-22 Merck Patent Gmbh pyridazinone derivatives
DE102008028905A1 (en) 2008-06-18 2009-12-24 Merck Patent Gmbh 3- (3-pyrimidin-2-yl-benzyl) - [1,2,4] triazolo [4,3-b] pyridazine derivatives
DE102008037790A1 (en) * 2008-08-14 2010-02-18 Merck Patent Gmbh Bicyclic triazole derivatives
DK2361250T3 (en) 2008-12-22 2013-11-04 Merck Patent Gmbh NEW POLYMORPHE FORMS OF 6- (1-METHYL-1H-PYRAZOL-4-YL) -2- {3- [5- (2-MORPHOLIN-4-YL-ETHOXY) -PYRIMIDIN-2-YL] -BENZYL} - 2H-PYRIDAZINE-3-ON DIHYDROGEN PHOSPHATE AND PROCEDURES FOR PREPARING THEREOF
WO2010098344A1 (en) 2009-02-25 2010-09-02 第一三共株式会社 Tricyclic pyrazolopyrimidine derivative
KR20130099006A (en) 2010-08-23 2013-09-05 다이이찌 산쿄 가부시키가이샤 Free crystal of tricyclic pyrazolopyrimidine derivative
JP5701884B2 (en) 2010-08-23 2015-04-15 第一三共株式会社 Crystals of tricyclic pyrazolopyrimidine derivatives
AR084433A1 (en) 2010-12-22 2013-05-15 Ironwood Pharmaceuticals Inc FAAH INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
JP6371284B2 (en) 2012-08-22 2018-08-08 コーネル ユニヴァーシティー How to inhibit fascin
US9527835B2 (en) 2014-02-13 2016-12-27 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
MY183499A (en) 2014-02-13 2021-02-22 Incyte Corp Cyclopropylamines as lsd1 inhibitors
ES2672797T3 (en) 2014-02-13 2018-06-18 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
CR20160395A (en) 2014-02-13 2016-12-20 Incyte Corp CYCLOPROPILAMINS AS INHIBITORS OF LSD1
CN111349087B (en) 2014-02-20 2023-07-14 康奈尔大学 Compounds and methods for inhibiting fascin
US9695168B2 (en) 2014-07-10 2017-07-04 Incyte Corporation Substituted imidazo[1,5-α]pyridines and imidazo[1,5-α]pyrazines as LSD1 inhibitors
US9758523B2 (en) 2014-07-10 2017-09-12 Incyte Corporation Triazolopyridines and triazolopyrazines as LSD1 inhibitors
US9695180B2 (en) 2014-07-10 2017-07-04 Incyte Corporation Substituted imidazo[1,2-a]pyrazines as LSD1 inhibitors
US9695167B2 (en) 2014-07-10 2017-07-04 Incyte Corporation Substituted triazolo[1,5-a]pyridines and triazolo[1,5-a]pyrazines as LSD1 inhibitors
MA51438A (en) 2015-04-03 2021-04-14 Incyte Corp HETEROCYCLIC COMPOUNDS USED AS LSD1 INHIBITORS
SG10202001219UA (en) 2015-08-12 2020-03-30 Incyte Corp Salts of an lsd1 inhibitor
CN108602775B (en) * 2016-01-14 2022-04-29 贝思以色列女会吏医学中心公司 Mast cell regulators and uses thereof
WO2017121693A1 (en) 2016-01-15 2017-07-20 Bayer Pharma Aktiengesellschaft Substituted thiazole and thiadiazole amides, and use thereof
CR20180553A (en) 2016-04-22 2019-02-01 Incyte Corp FORMULATIONS OF AN LSD1 INHIBITOR
EP3564214B1 (en) 2018-05-04 2024-07-03 Universita' Degli Studi G. D'annunzio Chieti - Pescara Indazole derivatives as modulators of the cannabinoid system
WO2020047198A1 (en) 2018-08-31 2020-03-05 Incyte Corporation Salts of an lsd1 inhibitor and processes for preparing the same
BR112021005920A2 (en) 2018-09-28 2021-06-29 Acucela Inc. vap-1 inhibitors
US11787791B2 (en) 2018-09-28 2023-10-17 Acucela Inc. Inhibitors of VAP-1
KR102241064B1 (en) * 2019-07-30 2021-04-16 부산대학교 산학협력단 Novel indole derivatives and composition for preventing or treating inflammatory diseases comprising the same
WO2022061008A2 (en) * 2020-09-17 2022-03-24 Escient Pharmaceuticals, Inc. Modulators of mas-related g-protein receptor x4 and related products and methods
WO2024109642A1 (en) * 2023-07-28 2024-05-30 常州大学 USE OF BENZOAZACYCLIC COMPOUND AS ALLOSTERIC MODULATOR OF β2-ADRENOCEPTOR

Also Published As

Publication number Publication date
WO2006015263A2 (en) 2006-02-09
WO2006015263A3 (en) 2006-07-27

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