[go: up one dir, main page]

MX2012014348A - Formas cristalinas de inhibidores de cinasa. - Google Patents

Formas cristalinas de inhibidores de cinasa.

Info

Publication number
MX2012014348A
MX2012014348A MX2012014348A MX2012014348A MX2012014348A MX 2012014348 A MX2012014348 A MX 2012014348A MX 2012014348 A MX2012014348 A MX 2012014348A MX 2012014348 A MX2012014348 A MX 2012014348A MX 2012014348 A MX2012014348 A MX 2012014348A
Authority
MX
Mexico
Prior art keywords
crystalline forms
kinase inhibitors
thieno
pyrazol
pyridin
Prior art date
Application number
MX2012014348A
Other languages
English (en)
Inventor
Jonathan Miller
Geoff G Z Zhang
Doug H Hoffman
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of MX2012014348A publication Critical patent/MX2012014348A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Las sales de citrato de N-(4-{4-amino-7-[1-(2-hidroxietil)-1H-pira zol-4-iI]tieno[3, 2-c]piridin-3-iI}fenil)N'-(3-fluorofenil)urea y las formas cristalinas de la misma, son ingredientes farmacéuticos adecuados para composiciones farmacéuticas útiles en el tratamiento de una enfermedad, por ejemplo, cáncer.
MX2012014348A 2010-06-09 2011-06-08 Formas cristalinas de inhibidores de cinasa. MX2012014348A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35303810P 2010-06-09 2010-06-09
PCT/US2011/039591 WO2011156464A1 (en) 2010-06-09 2011-06-08 Crystalline forms of kinase inhibitors

Publications (1)

Publication Number Publication Date
MX2012014348A true MX2012014348A (es) 2013-04-24

Family

ID=44454811

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012014348A MX2012014348A (es) 2010-06-09 2011-06-08 Formas cristalinas de inhibidores de cinasa.

Country Status (17)

Country Link
US (2) US8633217B2 (es)
EP (1) EP2580220B1 (es)
JP (1) JP5727598B2 (es)
KR (1) KR20130112856A (es)
CN (1) CN103038239A (es)
AR (1) AR083152A1 (es)
AU (1) AU2011264902B2 (es)
BR (1) BR112012031485A2 (es)
CA (1) CA2802029A1 (es)
ES (1) ES2536503T3 (es)
MX (1) MX2012014348A (es)
NZ (1) NZ604649A (es)
RU (1) RU2012157469A (es)
SG (2) SG186250A1 (es)
TW (1) TWI482770B (es)
WO (1) WO2011156464A1 (es)
ZA (1) ZA201209648B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015200635A1 (en) * 2014-06-25 2015-12-30 Abbvie Inc. N-(4-{4-AMINO-7-[1-(2-HYDROXYETHYL)-1H-PYRAZOL-4-yl]THIENO[3,2-c]PYRIDIN-3-YL}PHENYL)-N'-(3-FLUOROPHENYL)UREA DOCUSATE

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7202363B2 (en) * 2003-07-24 2007-04-10 Abbott Laboratories Thienopyridine and furopyridine kinase inhibitors
US20050026944A1 (en) * 2003-07-24 2005-02-03 Patrick Betschmann Thienopyridine and furopyridine kinase inhibitors
GB0402518D0 (en) * 2004-02-05 2004-03-10 Astrazeneca Ab Therapeutic agents
EP1968979A2 (en) * 2005-12-08 2008-09-17 Abbott Laboratories 9-membered heterobicyclic compounds as inhibitors of protein kinases
AR070539A1 (es) * 2008-03-05 2010-04-14 Methylgene Inc Inhibidores de la actividad de proteina tirosina quinasa
UY32291A (es) * 2008-12-05 2010-07-30 Abbott Lab Inhibidores de quinasa con perfiles de seguridad cyp mejorados

Also Published As

Publication number Publication date
BR112012031485A2 (pt) 2016-11-01
AU2011264902B2 (en) 2015-01-29
WO2011156464A1 (en) 2011-12-15
US8633217B2 (en) 2014-01-21
CA2802029A1 (en) 2011-12-15
TW201202235A (en) 2012-01-16
TWI482770B (zh) 2015-05-01
CN103038239A (zh) 2013-04-10
NZ604649A (en) 2014-11-28
JP2013528221A (ja) 2013-07-08
HK1179255A1 (en) 2013-09-27
KR20130112856A (ko) 2013-10-14
US20140296284A1 (en) 2014-10-02
AU2011264902A1 (en) 2013-01-10
US8940759B2 (en) 2015-01-27
SG2014014278A (en) 2014-06-27
EP2580220B1 (en) 2015-02-11
EP2580220A1 (en) 2013-04-17
ZA201209648B (en) 2013-08-28
SG186250A1 (en) 2013-01-30
ES2536503T3 (es) 2015-05-26
US20120202844A1 (en) 2012-08-09
WO2011156464A8 (en) 2012-10-11
JP5727598B2 (ja) 2015-06-03
AR083152A1 (es) 2013-02-06
RU2012157469A (ru) 2014-07-20

Similar Documents

Publication Publication Date Title
PH12012502432A1 (en) Solid dispersions containing kinase inhibitors
MX2012014386A (es) Formas cristalinas de inhibidores de cinasa.
MX2010006799A (es) Benzofuropirimidinonas como inhibidores de la proteina cinasa.
SA515360229B1 (ar) مثبطات‎ ‎عامل التمايز والنمو 8‏
MY147994A (en) Azabiphenylaminobenzoic acid derivatives as dhodh inhibitors
NZ593295A (en) Preparation method of dihydroindene amide compounds, their pharmaceutical compositions containing compounds thereof and use as protein kinase inhibitor
EA201100030A1 (ru) Пиразольные соединения 436
MX2015017435A (es) Inhibidores cristalinos de bromodominio.
MX2013004491A (es) Boronatos como inhibidores de arginasa.
PH12013501594A1 (en) Substituted indazole derivatives active as kinase inhibitors
RU2012156958A (ru) ПРОИЗВОДНЫЕ ТИЕНО[3,2-c]ПИРИДИНА В КАЧЕСТВЕ ИНГИБИТОРОВ КИНАЗ ДЛЯ ПРИМЕНЕНИЯ В ЛЕЧЕНИИ РАКА
MX2013008296A (es) Diarilacetileno hidracido que contiene inhibidores de tirosina quinasa.
MX2009009592A (es) Aminopiridinas utiles como inhibidores de proteinas cinasas.
PH12014501277A1 (en) Kinase inhibitors
PL2324008T3 (pl) 3,4-diarylopirazole jako inhibitory kinazy białkowej
PH12014501278A1 (en) Kinase inhibitors
WO2012064396A3 (en) Novel ezrin inhibitors and methods of making and using
MX2012014348A (es) Formas cristalinas de inhibidores de cinasa.
MX2012014385A (es) Formas cristalinas de inhibidores de cinasa.
PH12014501333A1 (en) Compositions containing kinase inhibitors
EA201000889A1 (ru) Тризамещенные пиперидины в качестве ингибиторов ренина
MX2012008611A (es) Sales farmaceuticas aceptables de derivados heterociclicos pirrolo-nitrogenosos, su metodo de preparacion y uso medico.
WO2011133475A3 (en) Compositions and method for the treatment of multiple myeloma
HK1161879A (en) Pharmaceutically acceptable salts of pyrrolo-nitrogenous heterocyclic derivatives, preparation method and medical use thereof
UA99734C2 (ru) Производные азабифениламинобензойной кислоты как ингибиторы dhodh

Legal Events

Date Code Title Description
FG Grant or registration