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MX2012008611A - Sales farmaceuticas aceptables de derivados heterociclicos pirrolo-nitrogenosos, su metodo de preparacion y uso medico. - Google Patents

Sales farmaceuticas aceptables de derivados heterociclicos pirrolo-nitrogenosos, su metodo de preparacion y uso medico.

Info

Publication number
MX2012008611A
MX2012008611A MX2012008611A MX2012008611A MX2012008611A MX 2012008611 A MX2012008611 A MX 2012008611A MX 2012008611 A MX2012008611 A MX 2012008611A MX 2012008611 A MX2012008611 A MX 2012008611A MX 2012008611 A MX2012008611 A MX 2012008611A
Authority
MX
Mexico
Prior art keywords
pyrrolo
preparation
pharmaceutically acceptable
acceptable salts
medical use
Prior art date
Application number
MX2012008611A
Other languages
English (en)
Inventor
Peng Cho Tang
Original Assignee
Jiangsu Hengrui Medicine Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Hengrui Medicine Co filed Critical Jiangsu Hengrui Medicine Co
Publication of MX2012008611A publication Critical patent/MX2012008611A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se describen sales farmacéuticas aceptables de derivados heterocíclicos pirrolo-nitrogenosos, método de preparación y uso médico de las mismas. Más específicamente, se describen sales farmacéuticamente aceptables de (R,Z)-2-(5-fluoro-2-oxo-1,2-dihidr o-indol-3-metilen)-5-(2-hidroxi-3-morfolinil-4-il-propil)-3-metil -5,6,7,8-tetrahidro-1H-pirrolo [3, 2-c] azepin-4-ona representadas por la fórmula (I), el método de preparación y su uso como agentes terapéuticos, en especial como inhibidores de proteína quinasa. (ver fórmula (I)).
MX2012008611A 2010-02-04 2011-01-07 Sales farmaceuticas aceptables de derivados heterociclicos pirrolo-nitrogenosos, su metodo de preparacion y uso medico. MX2012008611A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2010101090685A CN102146082A (zh) 2010-02-04 2010-02-04 吡咯并n杂环类衍生物的可药用的盐、其制备方法及其在医药上的应用
PCT/CN2011/070076 WO2011095068A1 (zh) 2010-02-04 2011-01-07 吡咯并n杂环类衍生物的可药用的盐、其制备方法及其在医药上的应用

Publications (1)

Publication Number Publication Date
MX2012008611A true MX2012008611A (es) 2012-08-15

Family

ID=44354948

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012008611A MX2012008611A (es) 2010-02-04 2011-01-07 Sales farmaceuticas aceptables de derivados heterociclicos pirrolo-nitrogenosos, su metodo de preparacion y uso medico.

Country Status (11)

Country Link
US (1) US20120295887A1 (es)
EP (1) EP2532666A1 (es)
JP (1) JP2013518828A (es)
KR (1) KR20120130089A (es)
CN (2) CN102146082A (es)
AU (1) AU2011213440A1 (es)
BR (1) BR112012018658A2 (es)
CA (1) CA2786927A1 (es)
MX (1) MX2012008611A (es)
RU (1) RU2012136378A (es)
WO (1) WO2011095068A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201402071D0 (en) * 2014-02-07 2014-03-26 Galapagos Nv Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders
CN112778187B (zh) * 2021-01-06 2022-10-28 烟台舜康生物科技有限公司 一种海那替尼中间体的合成方法及所得的海纳替尼中间体

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001064681A2 (en) * 2000-02-28 2001-09-07 Sugen, Inc. 3-(pyrolyllactone)-2-indolinone compounds as kinase inhibitors
DK1973910T3 (da) * 2006-01-27 2013-08-12 Shanghai Hengrui Pharm Co Ltd Pyrrolo[3,2-c]pyridin-4-on-2-indolinon-proteinkinaseinhibitorer
WO2008138184A1 (fr) * 2007-05-14 2008-11-20 Shanghai Hengrui Pharmaceutical Co.Ltd. Dérivés de pyrrolo-azacycles, leur procédé de fabrication et leur utilisation en tant qu'inhibiteurs de protéine kinases
WO2008138232A1 (en) * 2007-05-14 2008-11-20 Shanghai Hengrui Pharmaceutical Co., Ltd. Pyrrolo-nitrogenous heterocyclic derivatives, the preparation and the pharmaceutical use thereof

Also Published As

Publication number Publication date
CN102421781A (zh) 2012-04-18
EP2532666A1 (en) 2012-12-12
CN102146082A (zh) 2011-08-10
JP2013518828A (ja) 2013-05-23
BR112012018658A2 (pt) 2016-05-03
CA2786927A1 (en) 2011-08-11
KR20120130089A (ko) 2012-11-28
US20120295887A1 (en) 2012-11-22
AU2011213440A1 (en) 2012-08-09
WO2011095068A1 (zh) 2011-08-11
RU2012136378A (ru) 2014-03-10

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