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MX2012005222A - Composiciones y metodos para inhibir la adhesion celular o dirigir agentes de diagnostico o terapeuticos a sitios de enlace rgd. - Google Patents

Composiciones y metodos para inhibir la adhesion celular o dirigir agentes de diagnostico o terapeuticos a sitios de enlace rgd.

Info

Publication number
MX2012005222A
MX2012005222A MX2012005222A MX2012005222A MX2012005222A MX 2012005222 A MX2012005222 A MX 2012005222A MX 2012005222 A MX2012005222 A MX 2012005222A MX 2012005222 A MX2012005222 A MX 2012005222A MX 2012005222 A MX2012005222 A MX 2012005222A
Authority
MX
Mexico
Prior art keywords
sub
binding sites
methods
therapeutic agents
rgd binding
Prior art date
Application number
MX2012005222A
Other languages
English (en)
Other versions
MX346362B (es
Inventor
John Park
Michael John Mackel
Original Assignee
Allegro Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allegro Pharmaceuticals Inc filed Critical Allegro Pharmaceuticals Inc
Publication of MX2012005222A publication Critical patent/MX2012005222A/es
Publication of MX346362B publication Critical patent/MX346362B/es

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
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    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
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    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
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    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
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  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Surgery (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)

Abstract

Compuestos que comprenden ácido R-G-cistéico (es decir, R-G-NH-CH (CH2-SO3H) COOH o Arg-GIy-NH-CH (CH2-SO3H) COOH) y sus derivados, incluyendo sus sales farmacéuticas aceptables, hidratos, estereoisómeros, multímeros, formas cíclicas, formas lineares, conjugados-fármaco, pro-fármacos y sus derivados. También se describen métodos para producir y usar tales compuestos incluyendo los métodos para inhibir la adhesión celular a los sitios de enlace RGD o suministrar otros agentes de diagnóstico o terapéuticos a los sitios de enlace RGD en sujetos humanos o animales.
MX2012005222A 2009-11-10 2010-11-10 Composiciones y metodos para inhibir la adhesion celular o dirigir agentes de diagnostico o terapeuticos a sitios de enlace rgd. MX346362B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25974809P 2009-11-10 2009-11-10
PCT/US2010/056277 WO2011060104A2 (en) 2009-11-10 2010-11-10 Compositions and methods for inhibiting cellular adhesion or directing diagnostic or therapeutic agents to rgd binding sites

Publications (2)

Publication Number Publication Date
MX2012005222A true MX2012005222A (es) 2012-08-15
MX346362B MX346362B (es) 2017-03-15

Family

ID=43992385

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012005222A MX346362B (es) 2009-11-10 2010-11-10 Composiciones y metodos para inhibir la adhesion celular o dirigir agentes de diagnostico o terapeuticos a sitios de enlace rgd.

Country Status (17)

Country Link
US (5) US9018352B2 (es)
EP (2) EP3586879A1 (es)
JP (3) JP5912082B2 (es)
KR (2) KR102237243B1 (es)
CN (3) CN110559422A (es)
AU (2) AU2010319559A1 (es)
BR (1) BR112012011731A2 (es)
CA (1) CA2780243C (es)
ES (1) ES2730927T3 (es)
HK (1) HK1218075A1 (es)
IL (2) IL219701A (es)
MX (1) MX346362B (es)
NZ (2) NZ599899A (es)
PL (1) PL2504035T3 (es)
RU (1) RU2642625C2 (es)
WO (1) WO2011060104A2 (es)
ZA (1) ZA201204209B (es)

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KR102509892B1 (ko) * 2016-08-18 2023-03-13 트로이 브레머 리포솜 작제물을 사용한 황반 및 망막의 세포에의 우레아의 전달
JP7330510B2 (ja) * 2017-01-19 2023-08-22 アレグロ ファーマシューティカルズ エルエルシー 非滲出型または萎縮型の黄斑変性にて以前に失われた視力を回復させるための医薬組成物
US12454549B2 (en) 2017-06-19 2025-10-28 Jenius Pharma, Llc Treatments for diseases and disorders that involve oxidative stress
KR20200022435A (ko) 2017-06-19 2020-03-03 알레그로 파마슈티칼스, 엘엘씨 펩타이드 조성물 및 관련된 방법
CN113825542A (zh) * 2019-03-21 2021-12-21 库特克希米公司 精氨酸牙龈蛋白酶抑制剂
CN114040783A (zh) * 2019-04-22 2022-02-11 阿雷格罗眼科有限责任公司 可用于治疗干眼症的组合物和方法
CN110669142B (zh) * 2019-09-30 2021-10-12 湖南农业大学 融合rgd的猪圆环病毒2型病毒样颗粒、突变型感染性克隆及其制备方法和应用
US20210275624A1 (en) * 2020-03-06 2021-09-09 Allegro Pharmaceuticals, LLC Treatments for improving or lessening impairment of mitochondrial function
TWI776410B (zh) * 2021-03-02 2022-09-01 台灣基督長老教會馬偕醫療財團法人馬偕紀念醫院 短合成胜肽及其用於治療乾眼症之用途
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CN113577246B (zh) * 2021-08-02 2023-11-03 赛克赛斯生物科技股份有限公司 一种预防瘢痕粘连的组合物、术后防粘连材料及应用
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