MX2011013982A - Metodo para la preparacion de este ( r ) - 1 - aril - 2 - tetrazolil - etilico de acido carbomico. - Google Patents
Metodo para la preparacion de este ( r ) - 1 - aril - 2 - tetrazolil - etilico de acido carbomico.Info
- Publication number
- MX2011013982A MX2011013982A MX2011013982A MX2011013982A MX2011013982A MX 2011013982 A MX2011013982 A MX 2011013982A MX 2011013982 A MX2011013982 A MX 2011013982A MX 2011013982 A MX2011013982 A MX 2011013982A MX 2011013982 A MX2011013982 A MX 2011013982A
- Authority
- MX
- Mexico
- Prior art keywords
- tetrazolyl
- aryl
- preparation
- carbamic acid
- thyl ester
- Prior art date
Links
- KXDHJXZQYSOELW-UHFFFAOYSA-N carbonic acid monoamide Natural products NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 title abstract 2
- KJAMZCVTJDTESW-UHFFFAOYSA-N tiracizine Chemical compound C1CC2=CC=CC=C2N(C(=O)CN(C)C)C2=CC(NC(=O)OCC)=CC=C21 KJAMZCVTJDTESW-UHFFFAOYSA-N 0.000 title abstract 2
- 150000002148 esters Chemical class 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
- C07D257/06—Five-membered rings with nitrogen atoms directly attached to the ring carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
- C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Se divulga un método para la preparación de éster (R)-1-aril-2-tetrazolil-etílico de ácido carbámico, que comprende la reducción asimétrica de arilcetona y la carbamatación de alcohol.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20090055576 | 2009-06-22 | ||
| PCT/KR2009/005906 WO2010150946A1 (en) | 2009-06-22 | 2009-10-14 | Method for preparation of carbamic acid (r)-1-aryl-2-tetrazolyl-ethyl ester |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2011013982A true MX2011013982A (es) | 2013-01-29 |
Family
ID=43354688
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2011013982A MX2011013982A (es) | 2009-06-22 | 2009-10-14 | Metodo para la preparacion de este ( r ) - 1 - aril - 2 - tetrazolil - etilico de acido carbomico. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8501436B2 (es) |
| EP (1) | EP2445890B1 (es) |
| JP (1) | JP5683580B2 (es) |
| KR (1) | KR101708433B1 (es) |
| CN (1) | CN102803233B (es) |
| AU (1) | AU2009348523B2 (es) |
| BR (1) | BRPI0924997B1 (es) |
| CA (1) | CA2765566C (es) |
| CL (1) | CL2011003244A1 (es) |
| ES (1) | ES2541590T3 (es) |
| IL (1) | IL216786A (es) |
| MX (1) | MX2011013982A (es) |
| MY (1) | MY155662A (es) |
| PL (1) | PL2445890T3 (es) |
| RU (1) | RU2508290C2 (es) |
| WO (1) | WO2010150946A1 (es) |
| ZA (1) | ZA201109362B (es) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8404461B2 (en) * | 2009-10-15 | 2013-03-26 | SK Biopharmaceutical Co. Ltd. | Method for preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl ester |
| KR102421006B1 (ko) | 2016-05-19 | 2022-07-14 | 에스케이바이오팜 주식회사 | 두통의 예방학적 치료를 위한 카바메이트 화합물의 용도 |
| KR102489052B1 (ko) * | 2016-05-19 | 2023-01-16 | 에스케이바이오팜 주식회사 | 섬유근육통 또는 섬유근육통의 연관된 기능적 증후군을 예방 또는 치료하기 위한 카바메이트 화합물의 용도 |
| KR102421013B1 (ko) * | 2016-05-19 | 2022-07-14 | 에스케이바이오팜 주식회사 | 삼차신경통을 예방 또는 치료하기 위한 카바메이트 화합물의 용도 |
| US10905675B2 (en) | 2016-12-14 | 2021-02-02 | Sk Biopharmaceuticals Co., Ltd. | Use of carbamate compound for prevention, alleviation or treatment of pruritus |
| RU2761041C2 (ru) | 2016-12-14 | 2021-12-02 | ЭсКей БАЙОФАРМАСЬЮТИКАЛЗ КО., ЛТД. | Парентеральный жидкий препарат, включающий карбаматное соединение |
| MY199104A (en) | 2016-12-14 | 2023-10-13 | Sk Biopharmaceuticals Co Ltd | Use of carbamate compounds for prevention, alleviation or treatment of bipolar disorder |
| JP7090616B2 (ja) | 2016-12-14 | 2022-06-24 | エスケー バイオファーマスティカルズ カンパニー リミテッド | カルバメート化合物を含む口腔内崩壊錠 |
| ES3039979T3 (en) | 2016-12-14 | 2025-10-28 | Sk Biopharmaceuticals Co Ltd | Use of carbamate compound for preventing, alleviating, or treating tremors or tremor syndrome |
| WO2018111006A1 (ko) | 2016-12-14 | 2018-06-21 | 에스케이바이오팜 주식회사 | 탈수초성 질환의 예방, 경감 또는 치료를 위한 카바메이트 화합물의 용도 |
| KR102739607B1 (ko) | 2017-11-14 | 2024-12-06 | 에스케이바이오팜 주식회사 | 카바메이트 화합물을 포함하는 조현병의 예방, 경감 또는 치료용 배합물 |
| EP3711757B1 (en) | 2017-11-14 | 2025-05-07 | SK Biopharmaceuticals Co., Ltd. | Use of a carbamate compound to prevent, alleviate or treat visceralgia or pain arising from visceral disease |
| IL274431B2 (en) | 2017-11-14 | 2024-06-01 | Sk Biopharmaceuticals Co Ltd | Use of carbamate compound for reducing or treating developmental disorders including fragile x syndrome, angelman syndrome or rett syndrome |
| BR112020009265A2 (pt) * | 2017-11-14 | 2020-10-20 | Sk Biopharmaceuticals Co., Ltd. | medicamento e composição farmacêutica para a prevenção, alívio ou tratamento de crise de ausência ou epilepsia que apresenta crise de ausência, uso de um composto de carbamato ou um sal, solvato ou hidrato do mesmo, e, método para prevenir, aliviar ou tratar crise de ausência ou epilepsia que apresenta crise de ausência. |
| KR102900174B1 (ko) | 2017-11-14 | 2025-12-16 | 에스케이바이오팜 주식회사 | 근긴장증의 예방, 경감 또는 치료를 위한 카바메이트 화합물의 용도 |
| ES2973111T3 (es) | 2017-11-14 | 2024-06-18 | Sk Biopharmaceuticals Co Ltd | Uso de un compuesto de carbamato para prevenir o tratar enfermedades asociadas con el aumento de la corriente tardía de sodio |
| WO2020060252A1 (ko) | 2018-09-21 | 2020-03-26 | 에스케이바이오팜 주식회사 | 중첩발작의 예방, 경감 또는 치료에 대한 카바메이트 화합물의 용도 |
| BR112021005193A2 (pt) * | 2018-09-21 | 2021-06-08 | Sk Biopharmaceuticals Co., Ltd. | medicamento e combinação para a prevenção, alívio ou tratamento de transtorno de estresse agudo ou transtorno de estresse pós-traumático, e, medicamento para a prevenção, alívio ou tratamento de sintoma de transtorno de estresse pós-traumático |
| KR20210062029A (ko) | 2018-10-19 | 2021-05-28 | 에스케이바이오팜 주식회사 | 카바메이트 화합물의 당뇨병성 말초 신경병증 또는 화학요법 유발 말초 신경병증의 예방, 완화 또는 치료를 위한 용도 |
| CN118221604A (zh) * | 2019-10-24 | 2024-06-21 | 爱思开生物制药株式会社 | 具有改进的选择性的制备芳基2-四唑-2-基酮的方法 |
| US10611737B1 (en) * | 2019-10-24 | 2020-04-07 | Sk Biopharmaceuticals Co., Ltd. | Method for preparing aryl 2-tetrazol-2-yl ketone with improved selectivity |
| MX2022006104A (es) | 2019-11-22 | 2022-06-14 | Sk Biopharmaceuticals Co Ltd | Composicion farmaceutica oral que comprende compuesto de carbamato y metodo de preparacion para la misma. |
| CN110982757B (zh) * | 2019-12-30 | 2021-04-06 | 浙江工业大学 | 阴沟肠杆菌zjph1903及应用 |
| US20230338295A1 (en) | 2020-08-06 | 2023-10-26 | Sk Biopharmaceuticals Co., Ltd. | Solid oral composition comprising carbamate compound, and preparation method therefor |
| CN111778198B (zh) * | 2020-08-18 | 2021-12-10 | 杭州医学院 | 一种藤黄细球菌hmc01及其在不对称还原制备手性醇中的应用 |
| AR125970A1 (es) | 2021-05-28 | 2023-08-30 | Sk Biopharmaceuticals Co Ltd | Formulaciones de suspensión acuosa para administración oral que comprenden un compuesto de carbamato |
| US20250002466A1 (en) * | 2022-02-12 | 2025-01-02 | Metrochem Api Pvt Ltd | Process for the preparation of cenobamate annd intermediates thereof |
| ES2931000B2 (es) * | 2022-07-14 | 2023-07-07 | Univ Madrid Complutense | Proceso para la preparación de cenobamato |
| CN117736157B (zh) * | 2022-09-13 | 2025-08-19 | 江苏恩华药业股份有限公司 | 一种四唑取代的苯乙酮化合物的制备方法 |
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-
2009
- 2009-10-14 WO PCT/KR2009/005906 patent/WO2010150946A1/en not_active Ceased
- 2009-10-14 US US12/578,709 patent/US8501436B2/en active Active
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- 2009-10-14 RU RU2012102051/04A patent/RU2508290C2/ru active
- 2009-10-14 ES ES09846577.6T patent/ES2541590T3/es active Active
- 2009-10-14 AU AU2009348523A patent/AU2009348523B2/en active Active
- 2009-10-14 CA CA2765566A patent/CA2765566C/en active Active
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- 2009-10-14 EP EP20090846577 patent/EP2445890B1/en active Active
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|---|---|
| EP2445890A4 (en) | 2012-11-21 |
| IL216786A0 (en) | 2012-02-29 |
| BRPI0924997A2 (pt) | 2015-08-11 |
| EP2445890B1 (en) | 2015-05-06 |
| ZA201109362B (en) | 2012-08-29 |
| IL216786A (en) | 2014-09-30 |
| KR101708433B1 (ko) | 2017-02-22 |
| BRPI0924997B1 (pt) | 2024-01-16 |
| ES2541590T3 (es) | 2015-07-22 |
| US8501436B2 (en) | 2013-08-06 |
| PL2445890T3 (pl) | 2016-02-29 |
| MY155662A (en) | 2015-11-13 |
| CA2765566A1 (en) | 2010-12-29 |
| CN102803233A (zh) | 2012-11-28 |
| CN102803233B (zh) | 2017-03-01 |
| EP2445890A1 (en) | 2012-05-02 |
| WO2010150946A1 (en) | 2010-12-29 |
| CL2011003244A1 (es) | 2012-08-10 |
| JP2012530513A (ja) | 2012-12-06 |
| AU2009348523B2 (en) | 2015-02-26 |
| JP5683580B2 (ja) | 2015-03-11 |
| US20100323410A1 (en) | 2010-12-23 |
| KR20100137389A (ko) | 2010-12-30 |
| CA2765566C (en) | 2016-04-12 |
| AU2009348523A1 (en) | 2012-01-12 |
| RU2508290C2 (ru) | 2014-02-27 |
| RU2012102051A (ru) | 2013-07-27 |
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