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BRPI0922180A2 - insoindolinona e análogos correlatos como moduladores de sirtuína - Google Patents

insoindolinona e análogos correlatos como moduladores de sirtuína

Info

Publication number
BRPI0922180A2
BRPI0922180A2 BRPI0922180A BRPI0922180A BRPI0922180A2 BR PI0922180 A2 BRPI0922180 A2 BR PI0922180A2 BR PI0922180 A BRPI0922180 A BR PI0922180A BR PI0922180 A BRPI0922180 A BR PI0922180A BR PI0922180 A2 BRPI0922180 A2 BR PI0922180A2
Authority
BR
Brazil
Prior art keywords
insoindolinone
sirtuin
modulators
related analogues
analogues
Prior art date
Application number
BRPI0922180A
Other languages
English (en)
Inventor
Charles Blum
Chi B Vu
Lauren Mcpherson
Pui Yee Ng
Original Assignee
Sirtris Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sirtris Pharmaceuticals Inc filed Critical Sirtris Pharmaceuticals Inc
Publication of BRPI0922180A2 publication Critical patent/BRPI0922180A2/pt

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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
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  • Diabetes (AREA)
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BRPI0922180A 2008-12-08 2009-12-08 insoindolinona e análogos correlatos como moduladores de sirtuína BRPI0922180A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20126308P 2008-12-08 2008-12-08
PCT/US2009/067206 WO2010077686A1 (en) 2008-12-08 2009-12-08 Isoindolinone and related analogs as sirtuin modulators

Publications (1)

Publication Number Publication Date
BRPI0922180A2 true BRPI0922180A2 (pt) 2015-12-29

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BRPI0922180A BRPI0922180A2 (pt) 2008-12-08 2009-12-08 insoindolinona e análogos correlatos como moduladores de sirtuína

Country Status (10)

Country Link
US (1) US20110319411A1 (pt)
EP (1) EP2373645A4 (pt)
KR (1) KR20110098789A (pt)
CN (1) CN102307871A (pt)
AU (1) AU2009333543A1 (pt)
BR (1) BRPI0922180A2 (pt)
CA (1) CA2746221A1 (pt)
MX (1) MX2011006084A (pt)
SG (1) SG172001A1 (pt)
WO (1) WO2010077686A1 (pt)

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KR20110036602A (ko) 2008-07-03 2011-04-07 서트리스 파마슈티컬즈, 인코포레이티드 시르투인 조절제로서의 벤즈이미다졸 및 관련 유사체
BRPI0919389A2 (pt) 2008-09-29 2016-01-19 Sirtris Pharmaceutical Inc análogos de cromenona como moduladores de sirtuína
NZ598942A (en) 2009-07-27 2014-02-28 Gilead Sciences Inc Fused heterocyclic compounds as ion channel modulators
CN102725291B (zh) 2009-10-29 2016-12-21 西特里斯药业公司 作为沉默调节蛋白调节剂的双环吡啶和相关的类似物
NZ604478A (en) 2010-07-02 2014-12-24 Gilead Sciences Inc Fused heterocyclic compounds as ion channel modulators
PL2707361T3 (pl) 2011-05-10 2018-01-31 Gilead Sciences Inc Skondensowane związki heterocykliczne stosowane jako modulatory kanału sodowego
US9938269B2 (en) 2011-06-30 2018-04-10 Abbvie Inc. Inhibitor compounds of phosphodiesterase type 10A
TWI549944B (zh) 2011-07-01 2016-09-21 吉李德科學股份有限公司 作為離子通道調節劑之稠合雜環化合物
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