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MX2011004889A - Analogos de triazina, pirimidina y pirimidina y su uso como agentes terapeuticos y sondas de diagnostico. - Google Patents

Analogos de triazina, pirimidina y pirimidina y su uso como agentes terapeuticos y sondas de diagnostico.

Info

Publication number
MX2011004889A
MX2011004889A MX2011004889A MX2011004889A MX2011004889A MX 2011004889 A MX2011004889 A MX 2011004889A MX 2011004889 A MX2011004889 A MX 2011004889A MX 2011004889 A MX2011004889 A MX 2011004889A MX 2011004889 A MX2011004889 A MX 2011004889A
Authority
MX
Mexico
Prior art keywords
formula
triazine
pyrimidine
therapeutic agents
compounds
Prior art date
Application number
MX2011004889A
Other languages
English (en)
Inventor
Vladimir Cmiljanovic
Natasa Cmiljanovic
Bernd Giese
Matthias Wymann
Original Assignee
Univ Basel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Basel filed Critical Univ Basel
Publication of MX2011004889A publication Critical patent/MX2011004889A/es

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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Abstract

La presente invención se refiere a nuevos agentes terapéuticos y sondas de diagnóstico. La invención también se refiere a fosfoinositido 3-cinasa (PI3K) y compuestos a base de triazina, pirimidina. y piridina inhibidores del objetivo mamífero de rapamicina (mTOR) de la fórmula (I), sus estereoisómeros, isómeros geométricos, tautómeros, solvatos, metabolitos, derivados de N-óxido, sales farmacéuticamente aceptables, y profármacos de los mismos; composiciones de los nuevos compuestos, ya sea solos o en combinación con al menos un agente terapéutico adicional, con un portador farmacéuticamente aceptable; y usos de los nuevos compuestos, ya sea solos o en combinación con al menos un agente terapéutico adicional, para tratar trastornos mediados por cinasas lípidas. Se describen métodos para usar compuestos de la fórmula (I) para diagnóstico, prevención o tratamiento in vitro, in situ, e in vivo, de tales trastornos en células de mamíferos, o condiciones patológicas asociadas.
MX2011004889A 2008-11-10 2009-11-10 Analogos de triazina, pirimidina y pirimidina y su uso como agentes terapeuticos y sondas de diagnostico. MX2011004889A (es)

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GB0821219A GB2465405A (en) 2008-11-10 2008-11-10 Triazine, pyrimidine and pyridine analogues and their use in therapy
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