MX2010009765A - Moleculas pequeñas que contienen boro como agentes anti-inflamatorios. - Google Patents
Moleculas pequeñas que contienen boro como agentes anti-inflamatorios.Info
- Publication number
- MX2010009765A MX2010009765A MX2010009765A MX2010009765A MX2010009765A MX 2010009765 A MX2010009765 A MX 2010009765A MX 2010009765 A MX2010009765 A MX 2010009765A MX 2010009765 A MX2010009765 A MX 2010009765A MX 2010009765 A MX2010009765 A MX 2010009765A
- Authority
- MX
- Mexico
- Prior art keywords
- boron
- small molecules
- inflammatory agents
- containing small
- inflammatory
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/04—Esters of boric acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Dermatology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
Abstract
La presente invención se refiere a compuestos y métodos para tratar condiciones anti-inflamatorias.
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3437108P | 2008-03-06 | 2008-03-06 | |
| US5263708P | 2008-05-12 | 2008-05-12 | |
| US9440608P | 2008-09-04 | 2008-09-04 | |
| US10599008P | 2008-10-16 | 2008-10-16 | |
| US11090308P | 2008-11-03 | 2008-11-03 | |
| US14370009P | 2009-01-09 | 2009-01-09 | |
| US14873109P | 2009-01-30 | 2009-01-30 | |
| PCT/US2009/036250 WO2009111676A2 (en) | 2008-03-06 | 2009-03-05 | Boron-containing small molecules as anti-inflammatory agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010009765A true MX2010009765A (es) | 2013-07-12 |
Family
ID=41342554
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010009765A MX2010009765A (es) | 2008-03-06 | 2009-03-05 | Moleculas pequeñas que contienen boro como agentes anti-inflamatorios. |
Country Status (12)
| Country | Link |
|---|---|
| US (5) | US8039450B2 (es) |
| EP (2) | EP2564857B1 (es) |
| KR (2) | KR101672511B1 (es) |
| CN (1) | CN102014927A (es) |
| AU (1) | AU2009221793B2 (es) |
| BR (1) | BRPI0908565A2 (es) |
| CA (1) | CA2718170A1 (es) |
| ES (1) | ES2630036T3 (es) |
| IL (1) | IL207955A (es) |
| MX (1) | MX2010009765A (es) |
| NZ (1) | NZ587955A (es) |
| RU (2) | RU2015109165A (es) |
Families Citing this family (102)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8512718B2 (en) | 2000-07-03 | 2013-08-20 | Foamix Ltd. | Pharmaceutical composition for topical application |
| IL152486A0 (en) | 2002-10-25 | 2003-05-29 | Meir Eini | Alcohol-free cosmetic and pharmaceutical foam carrier |
| US20080138296A1 (en) | 2002-10-25 | 2008-06-12 | Foamix Ltd. | Foam prepared from nanoemulsions and uses |
| EP1556009B2 (en) | 2002-10-25 | 2021-07-21 | Foamix Pharmaceuticals Ltd. | Cosmetic and pharmaceutical foam |
| US9265725B2 (en) | 2002-10-25 | 2016-02-23 | Foamix Pharmaceuticals Ltd. | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof |
| US7700076B2 (en) | 2002-10-25 | 2010-04-20 | Foamix, Ltd. | Penetrating pharmaceutical foam |
| US8486376B2 (en) | 2002-10-25 | 2013-07-16 | Foamix Ltd. | Moisturizing foam containing lanolin |
| US7704518B2 (en) | 2003-08-04 | 2010-04-27 | Foamix, Ltd. | Foamable vehicle and pharmaceutical compositions thereof |
| US9668972B2 (en) | 2002-10-25 | 2017-06-06 | Foamix Pharmaceuticals Ltd. | Nonsteroidal immunomodulating kit and composition and uses thereof |
| US9211259B2 (en) | 2002-11-29 | 2015-12-15 | Foamix Pharmaceuticals Ltd. | Antibiotic kit and composition and uses thereof |
| US10117812B2 (en) | 2002-10-25 | 2018-11-06 | Foamix Pharmaceuticals Ltd. | Foamable composition combining a polar solvent and a hydrophobic carrier |
| US7820145B2 (en) | 2003-08-04 | 2010-10-26 | Foamix Ltd. | Oleaginous pharmaceutical and cosmetic foam |
| US8900554B2 (en) | 2002-10-25 | 2014-12-02 | Foamix Pharmaceuticals Ltd. | Foamable composition and uses thereof |
| US7575739B2 (en) | 2003-04-28 | 2009-08-18 | Foamix Ltd. | Foamable iodine composition |
| US8486374B2 (en) | 2003-08-04 | 2013-07-16 | Foamix Ltd. | Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses |
| US8795693B2 (en) | 2003-08-04 | 2014-08-05 | Foamix Ltd. | Compositions with modulating agents |
| PL1853251T3 (pl) | 2005-02-16 | 2013-09-30 | Anacor Pharmaceuticals Inc | Halogenopodstawione boronoftalidy do leczenia infekcji |
| CN106008583A (zh) | 2005-12-30 | 2016-10-12 | 安纳考尔医药公司 | 含硼的小分子 |
| EP2719388B1 (en) | 2006-02-16 | 2019-04-10 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as anti-inflammatory agents |
| US20080260655A1 (en) | 2006-11-14 | 2008-10-23 | Dov Tamarkin | Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses |
| US10265265B2 (en) | 2007-03-15 | 2019-04-23 | Drug Delivery Solutions Limited | Topical composition |
| US8636982B2 (en) | 2007-08-07 | 2014-01-28 | Foamix Ltd. | Wax foamable vehicle and pharmaceutical compositions thereof |
| US9439857B2 (en) | 2007-11-30 | 2016-09-13 | Foamix Pharmaceuticals Ltd. | Foam containing benzoyl peroxide |
| WO2010041141A2 (en) | 2008-10-07 | 2010-04-15 | Foamix Ltd. | Oil-based foamable carriers and formulations |
| WO2009072007A2 (en) | 2007-12-07 | 2009-06-11 | Foamix Ltd. | Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof |
| CA2712120A1 (en) | 2008-01-14 | 2009-07-23 | Foamix Ltd. | Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses |
| RU2015109165A (ru) * | 2008-03-06 | 2015-11-10 | Анакор Фармасьютикалз, Инк. | Борсодержащие малые молекулы в качестве противовоспалительных агентов |
| WO2010028005A1 (en) * | 2008-09-04 | 2010-03-11 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
| EP2348863A4 (en) * | 2008-09-04 | 2012-03-07 | Anacor Pharmaceuticals Inc | BORN SMALL MOLECULES |
| CN102223876A (zh) * | 2008-09-26 | 2011-10-19 | 纳米生物公司 | 纳米乳剂治疗性组合物及其使用方法 |
| WO2010045503A1 (en) * | 2008-10-15 | 2010-04-22 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as anti-protozoal agents |
| US20120087872A1 (en) | 2009-04-28 | 2012-04-12 | Foamix Ltd. | Foamable Vehicles and Pharmaceutical Compositions Comprising Aprotic Polar Solvents and Uses Thereof |
| WO2011013009A2 (en) | 2009-07-29 | 2011-02-03 | Foamix Ltd. | Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses |
| WO2011013008A2 (en) | 2009-07-29 | 2011-02-03 | Foamix Ltd. | Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses |
| AP4039A (en) | 2009-08-14 | 2017-02-28 | Daitao Chen | Boron-containing small molecules as antiprotozoal agents |
| US10029013B2 (en) | 2009-10-02 | 2018-07-24 | Foamix Pharmaceuticals Ltd. | Surfactant-free, water-free formable composition and breakable foams and their uses |
| US9849142B2 (en) | 2009-10-02 | 2017-12-26 | Foamix Pharmaceuticals Ltd. | Methods for accelerated return of skin integrity and for the treatment of impetigo |
| US9346834B2 (en) | 2009-10-20 | 2016-05-24 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as antiprotozoal agents |
| US20110212918A1 (en) * | 2009-11-11 | 2011-09-01 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
| WO2011094450A1 (en) | 2010-01-27 | 2011-08-04 | Anacor Pharmaceuticals, Inc | Boron-containing small molecules |
| AP2012006482A0 (en) | 2010-03-19 | 2012-10-31 | Anacor Pharmacueticals Inc | Boron-containing small molecules as anti-protozoalagent |
| CA2776482C (en) * | 2010-05-04 | 2022-06-07 | Foamix Ltd. | Compositions, gels and foams with rheology modulators and uses thereof |
| LT3251678T (lt) | 2010-09-07 | 2021-12-10 | Anacor Pharmaceuticals, Inc. | Benzoksaborolo dariniai, skirti bakterinių infekcijų gydymui |
| US9220715B2 (en) | 2010-11-08 | 2015-12-29 | Omeros Corporation | Treatment of addiction and impulse-control disorders using PDE7 inhibitors |
| NZ610925A (en) | 2010-11-08 | 2015-10-30 | Omeros Corp | Treatment of addiction and impulse-control disorders using pde7 inhibitors |
| EP2651407B1 (en) | 2010-12-15 | 2016-12-21 | Olatec Industries LLC | 3-methanesulfonylpropionitrile for treating inflammation and pain |
| US8802885B2 (en) | 2012-02-27 | 2014-08-12 | Olatec Industries Llc | Process for preparing 3-methylsulfonylpropionitrile |
| JP6178412B2 (ja) | 2012-06-05 | 2017-08-09 | オラテック セラピューティクス リミティド ライアビリティ カンパニー | 炎症及び疼痛を治療するための医薬組成物 |
| CA2875198C (en) | 2012-06-11 | 2020-06-02 | Olatec Industries Llc | Compounds for treating inflammation and pain |
| CN104471058A (zh) * | 2012-06-13 | 2015-03-25 | 弗雷德哈钦森癌症研究中心 | 包含硫族化物的组合物及相关方法 |
| US9114122B2 (en) | 2012-06-14 | 2015-08-25 | Olatec Industries Llc | Compounds for treating inflammation and pain |
| US11039617B2 (en) | 2013-01-30 | 2021-06-22 | Agrofresh Inc. | Large scale methods of uniformly coating packaging surfaces with a volatile antimicrobial to preserve food freshness |
| US8669207B1 (en) | 2013-01-30 | 2014-03-11 | Dow Agrosciences, Llc. | Compounds and compositions |
| US9585396B2 (en) | 2013-01-30 | 2017-03-07 | Agrofresh Inc. | Volatile applications against pathogens |
| AU2014212576B2 (en) | 2013-01-30 | 2015-08-13 | Agrofresh Inc. | Use of benzoxaboroles as volatile antimicrobial agents on meats, plants, or plant parts |
| US10070649B2 (en) | 2013-01-30 | 2018-09-11 | Agrofresh Inc. | Volatile applications against pathogens |
| US9598443B2 (en) | 2013-02-01 | 2017-03-21 | Anacor Pharmaceuticals, Inc. | Boron containing small molecules as antiprotozoal agents |
| AU2014202928B1 (en) | 2013-06-05 | 2014-09-11 | Agrofresh Inc. | Compounds and compositions |
| TW201625649A (zh) * | 2014-07-01 | 2016-07-16 | 第一三共股份有限公司 | 作爲抗菌劑的三環化合物 |
| PT3261437T (pt) | 2015-02-12 | 2019-11-29 | Agrofresh Inc | Compostos e composições fungicidas |
| WO2017031041A1 (en) * | 2015-08-17 | 2017-02-23 | Channel Therapeutics, Inc. | Functionalized aminobenzoboroxoles |
| WO2017093857A1 (en) * | 2015-11-30 | 2017-06-08 | Anacor Pharmaceuticals, Inc. | Topical pharmaceutical formulations for treating inflammatory-related conditions |
| NZ745681A (en) | 2016-03-07 | 2022-05-27 | Agrofresh Inc | Synergistic methods of using benzoxaborole compounds and preservative gases as an antimicrobial for crops |
| WO2017193914A1 (zh) * | 2016-05-09 | 2017-11-16 | 苏州科睿思制药有限公司 | 克立硼罗游离形式的晶型及其制备方法和用途 |
| MX2020012139A (es) | 2016-09-08 | 2021-01-29 | Vyne Pharmaceuticals Inc | Composiciones y metodos para tratar rosacea y acne. |
| GB201701583D0 (en) * | 2017-01-31 | 2017-03-15 | Drug Delivery Solutions Ltd | Topical composition |
| WO2018156554A1 (en) * | 2017-02-21 | 2018-08-30 | Dow Agrosciences Llc | 1-HYDROXY-1,3-DIHYDROBENZO[c][1,2]OXABOROLES AND THEIR USE AS HERBICIDES |
| CN108864160A (zh) * | 2017-05-16 | 2018-11-23 | 苏州旺山旺水生物医药有限公司 | 含硼小分子的制备方法 |
| DK3630752T3 (da) | 2017-06-01 | 2021-08-09 | Bristol Myers Squibb Co | Substituerede nitrogenholdige forbindelser |
| US20210163404A1 (en) * | 2017-06-14 | 2021-06-03 | UNIVERSITé LAVAL | Novel urea compounds and bioisosteres thereof and their use for treating inflammation and inflammation-related pathologies |
| CN109517003A (zh) * | 2017-09-18 | 2019-03-26 | 成都安满生物医药科技有限公司 | 一种克瑞沙硼的制备方法 |
| MX2020005464A (es) | 2017-11-30 | 2020-12-03 | Boragen Inc | Compuestos de benzoxaborol y formulaciones de los mismos. |
| US10329311B1 (en) | 2017-12-21 | 2019-06-25 | Olon S.P.A. | Process for the preparation of crisaborole |
| KR101974145B1 (ko) * | 2017-12-22 | 2019-04-30 | 한국생명공학연구원 | 보풀 추출물을 유효성분으로 함유하는 아토피 피부염의 예방, 개선 또는 치료용 조성물 |
| CN108148085B (zh) * | 2018-01-04 | 2019-11-01 | 合肥医工医药股份有限公司 | 具有抑制磷酸二酯酶4的化合物、制法及其药物用途 |
| CN108047261B (zh) * | 2018-01-10 | 2020-12-18 | 苏州旺山旺水生物医药有限公司 | 一种克立硼罗的制备方法 |
| EP3542788A1 (en) | 2018-03-19 | 2019-09-25 | MC2 Therapeutics Limited | Topical composition comprising calcipotriol and betamethasone dipropionate |
| CN108546245A (zh) * | 2018-05-22 | 2018-09-18 | 绍兴文理学院 | 一种抗增殖活性中间体ml-098的制备方法 |
| GB201809378D0 (en) * | 2018-06-07 | 2018-07-25 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| CN108997394A (zh) * | 2018-06-12 | 2018-12-14 | 广州百霆医药科技有限公司 | 苯并氧杂硼杂环戊烷类化合物及其制备方法 |
| CN108997399A (zh) * | 2018-07-24 | 2018-12-14 | 武汉轻工大学 | 克立硼罗中间体的制备方法 |
| ES3039445T3 (en) * | 2018-07-31 | 2025-10-21 | Mc2 Therapeutics Ltd | Topical composition |
| MX2021001904A (es) * | 2018-08-18 | 2021-05-27 | Boragen Inc | Formas solidas de benzoxaborol sustituido y composiciones de las mismas. |
| CU20210023A7 (es) * | 2018-10-05 | 2021-10-12 | Pfizer | Inhibidores fenil sustituidos de la piridinil 1,2-oxaborolan-2-ol fosfodiesterasa 4 |
| DK3952995T3 (da) * | 2019-04-12 | 2023-10-30 | Riboscience Llc | Bicykliske heteroarylderivater som ectonukleotidpyrophosphatase-phosphodiesterase-1-hæmmere |
| EP3969458A4 (en) | 2019-05-13 | 2023-05-17 | Borah, Inc. | CHEMICAL COMPOUNDS |
| WO2021003501A1 (en) * | 2019-07-03 | 2021-01-07 | Boragen, Inc. | Chemical compounds |
| AR120504A1 (es) | 2019-11-22 | 2022-02-16 | Agrofresh Inc | Composición y método para tratar a plantas y partes de plantas con activos volátiles para el control de organismos de descomposición |
| KR102334997B1 (ko) * | 2019-11-27 | 2021-12-03 | 한국화학연구원 | 보풀 속 식물 추출물을 유효성분으로 포함하는 구강질환 또는 골질환의 예방 또는 치료용 조성물 |
| IL295239A (en) | 2020-02-05 | 2022-10-01 | Agrofresh Inc | Antimicrobial compounds and preparations |
| MX2022013657A (es) | 2020-05-05 | 2023-02-01 | Nuvalent Inc | Quimioterápicos de éter macrocíclico heteroaromático. |
| WO2021226269A1 (en) | 2020-05-05 | 2021-11-11 | Nuvalent, Inc. | Heteroaromatic macrocyclic ether chemotherapeutic agents |
| CN111595974A (zh) * | 2020-05-30 | 2020-08-28 | 山东希尔康泰药业有限公司 | 罗氟司特原料药的分析方法 |
| CN113801089B (zh) * | 2020-06-15 | 2024-03-15 | 鲁南制药集团股份有限公司 | 一种克立硼罗中间体的制备方法 |
| CA3202251A1 (en) * | 2020-12-25 | 2022-06-30 | Zhongli WANG | Borate derivative and uses thereof |
| CN114685537A (zh) * | 2020-12-28 | 2022-07-01 | 南京理工大学 | 丁苯酞衍生物g-3702在制备脑缺血再灌注损伤预防和治疗药物中的应用 |
| RU2756250C1 (ru) * | 2021-02-04 | 2021-09-28 | Федеральное бюджетное учреждение науки «Екатеринбургский медицинский-научный центр профилактики и охраны здоровья рабочих промпредприятий» Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ЕМНЦ ПОЗРПП Роспотребнадзора) | Способ повышения устойчивости организма к цитотоксическому действию кристаллического диоксида кремния |
| CN113387971B (zh) * | 2021-04-19 | 2023-10-27 | 安徽普利药业有限公司 | 克立硼罗的合成方法 |
| EP4408844A1 (en) | 2021-10-01 | 2024-08-07 | Nuvalent, Inc. | Solid forms, pharmaceutical compositions and preparation of heteroaromatic macrocyclic ether compounds |
| TW202404610A (zh) | 2022-06-24 | 2024-02-01 | 大陸商瑞石生物醫藥有限公司 | 一種硼酸酯衍生物的結晶、其製備方法及用途 |
| CN120230131A (zh) * | 2023-12-31 | 2025-07-01 | 上海鼎雅药物化学科技有限公司 | 4-[(1,3-二氢-1-羟基-2,1-苯并氧杂硼杂环戊烷-5-基)氧基]苯甲腈的制备方法 |
| CN119285528B (zh) * | 2024-12-11 | 2025-05-09 | 济南大学 | 一种1,2-环戊二甲酰亚胺的合成方法 |
Family Cites Families (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2260336A (en) | 1939-10-16 | 1941-10-28 | Dow Chemical Co | Method of preparation of organic borates |
| US3686398A (en) | 1970-07-20 | 1972-08-22 | Chevron Res | 10,9-boroxarophenanthrene as fungicides |
| GB1396904A (en) | 1972-08-11 | 1975-06-11 | Ici Ltd | Method for the control of micro-organisms |
| US4602011A (en) | 1975-10-24 | 1986-07-22 | Chapman Chemical Company | Antimicrobial compositions and methods of using same |
| US4766113A (en) | 1975-10-24 | 1988-08-23 | Chapman Chemical Company | Antimicrobial compositions and methods of using same |
| US5169637A (en) | 1983-03-24 | 1992-12-08 | The Liposome Company, Inc. | Stable plurilamellar vesicles |
| CA1237671A (en) | 1983-08-01 | 1988-06-07 | Michael W. Fountain | Enhancement of pharmaceutical activity |
| US4716035A (en) | 1985-05-24 | 1987-12-29 | The Procter & Gamble Company | Oral compositions and methods for treating gingivitis |
| US5409704A (en) | 1985-06-26 | 1995-04-25 | The Liposome Company, Inc. | Liposomes comprising aminoglycoside phosphates and methods of production and use |
| US4975282A (en) | 1985-06-26 | 1990-12-04 | The Liposome Company, Inc. | Multilamellar liposomes having improved trapping efficiencies |
| US5023087A (en) | 1986-02-10 | 1991-06-11 | Liposome Technology, Inc. | Efficient method for preparation of prolonged release liposome-based drug delivery system |
| US5962498A (en) | 1986-06-11 | 1999-10-05 | Procyon Pharmaceuticals, Inc. | Protein kinase C modulators. C. indolactam structural-types with anti-inflammatory activity |
| IE60901B1 (en) | 1986-08-21 | 1994-08-24 | Vestar Inc | Improved treatment of systemic fungal infections with phospholipid particles encapsulating polyene antifungal antibiotics |
| US5049388A (en) | 1986-11-06 | 1991-09-17 | Research Development Foundation | Small particle aerosol liposome and liposome-drug combinations for medical use |
| US4894220A (en) | 1987-01-30 | 1990-01-16 | Colgate-Palmolive Company | Antibacterial antiplaque oral composition |
| US5032582A (en) | 1987-02-27 | 1991-07-16 | Liposome Technology, Inc. | Method for treating fungal infections with amphotericin B/cholesterol sulfate composition |
| US4994213A (en) | 1988-05-17 | 1991-02-19 | Liposome Technology, Inc. | Method of preparing lipid structures |
| US4919934A (en) | 1989-03-02 | 1990-04-24 | Richardson-Vicks Inc. | Cosmetic sticks |
| US5194266A (en) | 1989-08-08 | 1993-03-16 | Liposome Technology, Inc. | Amphotericin B/cholesterol sulfate composition and method |
| US5356633A (en) | 1989-10-20 | 1994-10-18 | Liposome Technology, Inc. | Method of treatment of inflamed tissues |
| DK0580817T3 (da) | 1991-04-19 | 1996-08-05 | Nexstar Pharmaceuticals Inc | Farmaceutisk præparat og fremgangsmåde til fremstilling deraf |
| SG47101A1 (en) | 1992-07-31 | 1998-03-20 | Us Bioscience | Crystalline amifostine compositions and methods for the preparation and use of same |
| US5552155A (en) | 1992-12-04 | 1996-09-03 | The Liposome Company, Inc. | Fusogenic lipsomes and methods for making and using same |
| US5348948A (en) | 1993-05-07 | 1994-09-20 | American Cyanamid Company | 2,2-diaryl-1-(oxa and thia)-2a-azonia-2-borataacenaphthene fungicidal |
| US5348947A (en) | 1993-05-07 | 1994-09-20 | American Cyanamid Company | Diarylboron ester and thioester fungicidal agents |
| US5594151A (en) | 1994-01-28 | 1997-01-14 | Prolinx, Inc. | Phenylboronic acid complexing reagents derived from aminosalicylic acid |
| GB9411587D0 (en) | 1994-06-09 | 1994-08-03 | Zeneca Ltd | Compound, composition and use |
| US6083903A (en) | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
| GB9500856D0 (en) | 1995-01-17 | 1995-03-08 | Zeneca Ltd | Composition and use |
| WO1996040061A1 (en) | 1995-06-07 | 1996-12-19 | Nexstar Pharmaceuticals, Inc. | Method for encapsulating pharmaceutical materials |
| WO1998024753A1 (en) | 1996-12-02 | 1998-06-11 | Chisso Corporation | Optically active nitro alcohol derivatives, optically active amino alcohol derivates, and process for preparing the same |
| GB9604926D0 (en) | 1996-03-08 | 1996-05-08 | Sandoz Ltd | Organic compounds |
| EP0934307B1 (en) | 1996-06-19 | 2011-04-27 | Aventis Pharma Limited | Substituted azabicylic compounds and their use as inhibitors of the production of tnf and cyclic amp phosphodiesterase |
| US5831046A (en) | 1996-08-05 | 1998-11-03 | Prolinx, Incorporated | Boronic acid-contaning nucleic acid monomers |
| WO1998012206A1 (en) | 1996-09-19 | 1998-03-26 | The Board Of Trustees Of Leland Stanford Jr. University | Dna adenine methyltransferases and uses thereof |
| US6221640B1 (en) | 1997-05-14 | 2001-04-24 | Cubist Pharmaceuticals, Inc. | Enterococcal aminoacyl-trna synthetase proteins, nucleic acids and strains comprising same |
| DE19829947A1 (de) | 1998-07-04 | 2000-01-05 | Bayer Ag | Elektrolumineszierende Anordnungen mit Bor-Chelaten |
| US6462036B1 (en) | 1998-11-06 | 2002-10-08 | Basf Aktiengesellschaft | Tricyclic pyrazole derivatives |
| SK5282001A3 (en) | 1998-11-06 | 2002-01-07 | Knoll Gmbh | Tricyclic pyrazole derivatives |
| WO2000044387A1 (fr) | 1999-01-29 | 2000-08-03 | Nitto Kasei Co., Ltd. | Composes organobores presentant une activite de coccidiostats |
| AU774404C (en) | 1999-05-25 | 2005-06-30 | Board Of Trustees Of The Leland Stanford Junior University | DNA methyltransferase inhibitors |
| US6306628B1 (en) | 1999-08-25 | 2001-10-23 | Ambergen, Incorporated | Methods for the detection, analysis and isolation of Nascent proteins |
| ATE349548T1 (de) | 1999-08-25 | 2007-01-15 | Ambergen Inc | Verfahren zur erkennung, analyse und isolierung von freiwerdenden proteinen |
| WO2001025226A1 (en) | 1999-10-05 | 2001-04-12 | Bethesda Pharmaceuticals, Inc. | Dithiolane derivatives |
| EP1250142A4 (en) | 2000-01-06 | 2007-07-11 | Marantech Holding Llc | ADDED COMPOSITIONS WITH ELECTRONIC ELECTRODES AND METHOD FOR THE PRODUCTION AND USE THEREOF |
| US6521619B2 (en) | 2000-06-29 | 2003-02-18 | Icos Corporation | Aryl phenylcyclopropyl sulfide derivatives and their use as cell adhesion inhibiting anti-inflammatory and immune suppressive agents |
| US7169603B2 (en) | 2000-07-14 | 2007-01-30 | Mgi Pharma Biologics, Inc. | α-MSH related compounds and methods of use |
| EP1339725B1 (en) | 2000-11-30 | 2006-11-22 | The Penn State Research Foundation | Dna methyl transferase inhibitors |
| US6537733B2 (en) * | 2001-02-23 | 2003-03-25 | Applied Materials, Inc. | Method of depositing low dielectric constant silicon carbide layers |
| DE10110051C2 (de) | 2001-03-02 | 2003-07-03 | Clariant Gmbh | Verfahren zur Herstellung von Boron- und Borinsäuren |
| CA2446904A1 (en) | 2001-05-24 | 2003-04-03 | Alexza Molecular Delivery Corporation | Delivery of drug esters through an inhalation route |
| US7766013B2 (en) | 2001-06-05 | 2010-08-03 | Alexza Pharmaceuticals, Inc. | Aerosol generating method and device |
| GB0117645D0 (en) | 2001-07-19 | 2001-09-12 | Isis Innovation | Therapeutic stratergies for prevention and treatment of alzheimers disease |
| DE10143979A1 (de) | 2001-09-07 | 2003-03-27 | Clariant Gmbh | Verfahren zur Herstellung von Bisallylboranen und nicht-aromatischen Boronsäuren |
| US7217701B2 (en) | 2001-10-11 | 2007-05-15 | Katsuhiko Mikoshiba | Intracellular calcium concentration increase inhibitors |
| CN1325504C (zh) | 2002-01-10 | 2007-07-11 | 宾夕法尼亚州研究基金会 | 制备二芳基硼酸烷基酯和络合的二芳基硼酸的方法 |
| AU2003265264A1 (en) | 2002-07-09 | 2004-01-23 | Point Therapeutics, Inc. | Methods and compositions relating to isoleucine boroproline compounds |
| US20050288299A1 (en) | 2002-10-09 | 2005-12-29 | Mavunkel Babu J | Azaindole derivatives as inhibitors of p38 kinase |
| JP2006508161A (ja) | 2002-12-02 | 2006-03-09 | ソルヴィーアス アクチェンゲゼルシャフト | 炭素−ヘテロ原子二重結合の接触水素化 |
| US20040224923A1 (en) | 2002-12-18 | 2004-11-11 | Ving Lee | Antibiotics containing borinic acid complexes and methods of use |
| US7390806B2 (en) | 2002-12-18 | 2008-06-24 | Anacor Pharmaceuticals, Inc. | Antibiotics containing borinic acid complexes and methods of use |
| US20050125852A1 (en) | 2003-05-09 | 2005-06-09 | Sugen, Inc. | Novel kinases |
| CA2529792A1 (en) | 2003-06-16 | 2005-02-17 | Anacor Pharmaceuticals, Inc. | Hydrolytically-resistant boron-containing therapeutics and methods of use |
| US10022424B2 (en) | 2004-05-12 | 2018-07-17 | The Brigham And Women's Hospital, Inc. | Use of gelsolin to treat infections |
| AR049915A1 (es) | 2004-06-14 | 2006-09-13 | Anacor Pharmaceuticals Inc | Compuestos con contenido de boro y metodos de uso de los mismos |
| WO2006062731A1 (en) | 2004-11-19 | 2006-06-15 | University Of North Texas Health Science Center At Fort Worth | Phenanthroline and derivatives thereof used to lower intraocular pressure in an affected eye |
| GB0501944D0 (en) | 2005-01-31 | 2005-03-09 | Univ Cambridge Tech | Compounds for use in chemical detection and/or quantitation |
| PL1853251T3 (pl) * | 2005-02-16 | 2013-09-30 | Anacor Pharmaceuticals Inc | Halogenopodstawione boronoftalidy do leczenia infekcji |
| WO2006096131A1 (en) | 2005-03-08 | 2006-09-14 | Agency For Science, Technology And Research | Chiral bisoxazoline catalysts |
| PE20061303A1 (es) | 2005-03-30 | 2006-12-07 | Astion Dev As | Composicion farmaceutica que comprende oxaprozina |
| US20080234229A1 (en) * | 2005-08-18 | 2008-09-25 | Auspex Pharmaceuticals, Inc. | Novel Therapeutic Agents for the Treatment of Cancer, Metabolic Diseases and Skin Disorders |
| CN106008583A (zh) | 2005-12-30 | 2016-10-12 | 安纳考尔医药公司 | 含硼的小分子 |
| EP2719388B1 (en) * | 2006-02-16 | 2019-04-10 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as anti-inflammatory agents |
| AU2007257689A1 (en) | 2006-06-12 | 2007-12-21 | Anacor Pharmaceuticals, Inc. | Compounds for the treatment of periodontal disease |
| US20070286822A1 (en) | 2006-06-12 | 2007-12-13 | Anacor Pharmaceuticals Inc. | Compounds for the Treatment of Periodontal Disease |
| KR100848491B1 (ko) | 2007-01-16 | 2008-07-28 | 영진약품공업주식회사 | 베타아미노기를 갖는 2-싸이아졸리딘 유도체, 이의약학적으로 허용 가능한 염 및 이의 제조 방법 |
| JO3396B1 (ar) | 2007-06-20 | 2019-10-20 | Anacor Pharmaceuticals Inc | جزيئات صغيرة تحتوي على البورون |
| KR100895300B1 (ko) | 2007-07-20 | 2009-05-07 | 한국전자통신연구원 | 생체신호 측정의복과 생체신호 처리시스템 |
| EP2187893A4 (en) | 2008-03-06 | 2012-02-22 | Anacor Pharmaceuticals Inc | SMALL BORON-CONTAINING MOLECULES AS ANTI-INFLAMMATORY AGENTS |
| RU2015109165A (ru) * | 2008-03-06 | 2015-11-10 | Анакор Фармасьютикалз, Инк. | Борсодержащие малые молекулы в качестве противовоспалительных агентов |
| US20100256092A1 (en) | 2008-05-12 | 2010-10-07 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
| WO2010028005A1 (en) | 2008-09-04 | 2010-03-11 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
| WO2010045503A1 (en) | 2008-10-15 | 2010-04-22 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as anti-protozoal agents |
| WO2010045505A1 (en) | 2008-10-15 | 2010-04-22 | Anacor Pharmaceuticals, Inc | Boron-containing small molecules as anti-protozoal agents |
-
2009
- 2009-03-05 RU RU2015109165/04A patent/RU2015109165A/ru not_active Application Discontinuation
- 2009-03-05 AU AU2009221793A patent/AU2009221793B2/en not_active Ceased
- 2009-03-05 ES ES12178640.4T patent/ES2630036T3/es active Active
- 2009-03-05 US US12/399,015 patent/US8039450B2/en active Active
- 2009-03-05 BR BRPI0908565A patent/BRPI0908565A2/pt not_active IP Right Cessation
- 2009-03-05 NZ NZ58795509A patent/NZ587955A/xx not_active IP Right Cessation
- 2009-03-05 CN CN2009801162797A patent/CN102014927A/zh active Pending
- 2009-03-05 CA CA 2718170 patent/CA2718170A1/en not_active Abandoned
- 2009-03-05 EP EP12178640.4A patent/EP2564857B1/en not_active Not-in-force
- 2009-03-05 KR KR1020107022132A patent/KR101672511B1/ko not_active Expired - Fee Related
- 2009-03-05 MX MX2010009765A patent/MX2010009765A/es active IP Right Grant
- 2009-03-05 RU RU2010140803/04A patent/RU2547441C2/ru not_active IP Right Cessation
- 2009-03-05 EP EP17158536.7A patent/EP3246034A1/en not_active Withdrawn
- 2009-03-05 KR KR1020157014083A patent/KR20150065941A/ko not_active Ceased
-
2010
- 2010-09-02 IL IL207955A patent/IL207955A/en not_active IP Right Cessation
-
2011
- 2011-09-19 US US13/236,543 patent/US8461135B2/en active Active
-
2013
- 2013-06-11 US US13/915,494 patent/US9012431B2/en active Active
-
2015
- 2015-03-23 US US14/666,075 patent/US9416146B2/en active Active
-
2016
- 2016-07-08 US US15/205,995 patent/US20160318955A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2009221793B2 (en) | 2015-02-19 |
| KR20110000739A (ko) | 2011-01-05 |
| EP2564857A1 (en) | 2013-03-06 |
| IL207955A (en) | 2015-05-31 |
| CA2718170A1 (en) | 2009-09-11 |
| US9012431B2 (en) | 2015-04-21 |
| EP3246034A1 (en) | 2017-11-22 |
| US20120214765A1 (en) | 2012-08-23 |
| US20150291629A1 (en) | 2015-10-15 |
| US9416146B2 (en) | 2016-08-16 |
| KR20150065941A (ko) | 2015-06-15 |
| EP2564857B1 (en) | 2017-05-03 |
| CN102014927A (zh) | 2011-04-13 |
| BRPI0908565A2 (pt) | 2017-05-23 |
| US8461135B2 (en) | 2013-06-11 |
| NZ587955A (en) | 2012-10-26 |
| AU2009221793A1 (en) | 2009-09-11 |
| US20090291917A1 (en) | 2009-11-26 |
| ES2630036T3 (es) | 2017-08-17 |
| RU2547441C2 (ru) | 2015-04-10 |
| KR101672511B1 (ko) | 2016-11-03 |
| RU2015109165A (ru) | 2015-11-10 |
| RU2010140803A (ru) | 2012-04-20 |
| US8039450B2 (en) | 2011-10-18 |
| US20160318955A1 (en) | 2016-11-03 |
| US20140011768A1 (en) | 2014-01-09 |
| IL207955A0 (en) | 2010-12-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2010009765A (es) | Moleculas pequeñas que contienen boro como agentes anti-inflamatorios. | |
| WO2009111676A3 (en) | Boron-containing small molecules as anti-inflammatory agents | |
| MX360301B (es) | Moleculas pequeñas que contienen boro como agentes antiinflamatorios. | |
| GB0920703D0 (en) | Compositions containing satiogens and methods of use | |
| JO2788B1 (en) | Amido phenoxyendazole compounds beneficial as C-MET inhibitors | |
| PH12012502128B1 (en) | Chemical compounds | |
| IN2012DN03883A (es) | ||
| MX2011006290A (es) | Compuestos de aza-azuleno. | |
| JO2860B1 (en) | Phenylendazolyl compounds | |
| SG148142A1 (en) | Aryloazol-2-yl cyanoethylamino compunds, method of making and method of using thereof | |
| WO2012034116A3 (en) | Small molecules as epigenetic modulators of lysine-specific demethylase 1 and methods of treating disorders | |
| MX2009009761A (es) | Composiciones y estuches para tratamiento de la influenza. | |
| MX2010010209A (es) | 4-hidroxipirimidina-5-carboxamidas sustituidas. | |
| IL206970A0 (en) | Compositions and methods for the treatment of tumor of hematopoietic origin | |
| MX2012012966A (es) | Indoles. | |
| EA201170832A1 (ru) | Пуриновые соединения | |
| EA201170288A1 (ru) | Оксабициклогептаны и оксабициклогептены, их получение и применение | |
| MX2010005395A (es) | Metodo para tratar artritis. | |
| BR112012003111A8 (pt) | Métodos para tratar iontoforeticamente náusea e enxaqueca | |
| MX2011013878A (es) | 4-hidroxipirimidina-5-carboxamidas sustituidas. | |
| EP2597949A4 (en) | SUBMIKROMETERZUSAMMENSETZUNGEN | |
| MX2011013879A (es) | 4-hidroxipirimidina-5-carboxamidas sustituidas. | |
| UA34487U (en) | Aquananomagnesium | |
| UA101379C2 (en) | Amidophenoxyindazoles useful in the treatment of cancer | |
| TN2011000013A1 (en) | Amidophenoxyindazoles useful as inhibitors of c-met |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |