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MX2010009644A - Derivados piridin-2-ilo como agentes inmunomoduladores. - Google Patents

Derivados piridin-2-ilo como agentes inmunomoduladores.

Info

Publication number
MX2010009644A
MX2010009644A MX2010009644A MX2010009644A MX2010009644A MX 2010009644 A MX2010009644 A MX 2010009644A MX 2010009644 A MX2010009644 A MX 2010009644A MX 2010009644 A MX2010009644 A MX 2010009644A MX 2010009644 A MX2010009644 A MX 2010009644A
Authority
MX
Mexico
Prior art keywords
derivatives
pyridin
immunomodulating agents
immunomodulating
agents
Prior art date
Application number
MX2010009644A
Other languages
English (en)
Inventor
Beat Steiner
Boris Mathys
Claus Mueller
Oliver Nayler
Martin Bolli
Cyrille Lescop
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40584746&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2010009644(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of MX2010009644A publication Critical patent/MX2010009644A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

La invención se refiere a derivados piridina de Fórmula (I) (ver fórmula (I) donde A, R1, R2, R3, R4, R5, R6 y R7 son tal como se han descrito en la descripción, su preparación y su uso como compuestos farmacéuticamente activos. Los compuestos actúan particularmente como agentes inmunomoduladores.
MX2010009644A 2008-03-07 2009-02-25 Derivados piridin-2-ilo como agentes inmunomoduladores. MX2010009644A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2008050848 2008-03-07
PCT/IB2009/050749 WO2009109872A1 (en) 2008-03-07 2009-02-25 Pyridin-2-yl derivatives as immunomodulating agents

Publications (1)

Publication Number Publication Date
MX2010009644A true MX2010009644A (es) 2010-09-22

Family

ID=40584746

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010009644A MX2010009644A (es) 2008-03-07 2009-02-25 Derivados piridin-2-ilo como agentes inmunomoduladores.

Country Status (26)

Country Link
US (1) US8575200B2 (es)
EP (1) EP2252609B1 (es)
JP (1) JP5435745B2 (es)
KR (1) KR101615779B1 (es)
CN (1) CN102015695B (es)
AR (1) AR070858A1 (es)
AU (1) AU2009220861B2 (es)
BR (1) BRPI0909055A2 (es)
CA (1) CA2715437C (es)
CL (1) CL2009000532A1 (es)
CY (1) CY1114096T1 (es)
DK (1) DK2252609T3 (es)
ES (1) ES2414533T3 (es)
HR (1) HRP20130641T1 (es)
IL (1) IL207972A (es)
MA (1) MA32173B1 (es)
MX (1) MX2010009644A (es)
MY (1) MY183039A (es)
NZ (1) NZ588438A (es)
PL (1) PL2252609T3 (es)
PT (1) PT2252609E (es)
RU (1) RU2494099C2 (es)
SI (1) SI2252609T1 (es)
TW (1) TWI444377B (es)
WO (1) WO2009109872A1 (es)
ZA (1) ZA201007136B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007292993B2 (en) * 2006-09-07 2013-01-24 Idorsia Pharmaceuticals Ltd Pyridin-4-yl derivatives as immunomodulating agents
BRPI0716633A2 (pt) * 2006-09-08 2013-09-24 Actelion Pharmaceuticals Ltd compostos derivados de piridin-3-ila, composiÇço farmacÊutica e uso de um composto como agente imunomodulador
KR20090051774A (ko) * 2006-09-21 2009-05-22 액테리온 파마슈티칼 리미티드 페닐 유도체 및 면역조절제로서 이들의 용도
CN101627034B (zh) * 2007-03-16 2013-05-15 埃科特莱茵药品有限公司 氨基-吡啶衍生物作为s1p1/edg1受体激动剂
PL2195311T3 (pl) * 2007-08-17 2011-08-31 Actelion Pharmaceuticals Ltd Pochodne pirydynowe jako modulatory receptora S1P1/EDG1
CA2700917A1 (en) * 2007-11-01 2009-05-07 Actelion Pharmaceuticals Ltd Novel pyrimidine derivatives
ES2441845T3 (es) 2009-07-16 2014-02-06 Actelion Pharmaceuticals Ltd. Derivados de piridin-4-ilo como agonistas de S1P1/EDG1
JP5778755B2 (ja) * 2010-04-15 2015-09-16 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ ヒドロキノンの製造方法
TWI546300B (zh) 2011-01-19 2016-08-21 艾克泰聯製藥有限公司 ２－甲氧基－吡啶－４－基衍生物
CN105189487B (zh) 2013-03-15 2017-12-26 爱杜西亚药品有限公司 吡啶‑4‑基衍生物
BR112017024785B1 (pt) 2015-05-20 2022-05-17 Idorsia Pharmaceuticals Ltd Forma cristalina do composto (s)-3-{4-[5-(2-ciclopentil-6-metoxi-piridin-4-il)-[1,2,4] oxadiazol-3- il]-2-etil-6-metilfenoxi}-propano-1,2-diol, composição farmacêutica, e, uso

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AU653957B2 (en) 1990-09-20 1994-10-20 Merrell Dow Pharmaceuticals Inc. 1-aryl-3-pyridinyl-2-propene-1-ones
DE4429465A1 (de) 1994-08-19 1996-02-22 Bayer Ag Verfahren zur Herstellung von 2-Halogenpyridinaldehyden und neue 2-Halogenpyridinaldehyde
JP2003034684A (ja) * 2001-06-29 2003-02-07 Biofor Inc 新規な種類の抗真菌剤
JP2005533058A (ja) * 2002-06-17 2005-11-04 メルク　エンド　カムパニー　インコーポレーテッド Ｅｄｇ受容体アゴニストとしての１−（（５−アリール−１，２，４−オキサジアゾール−３−イル）ベンジル）アゼチジン−３−カルボキシラートおよび１−（（５−アリール−１，２，４−オキサジアゾール−３−イル）ベンジル）ピロリジン−３−カルボキシラート
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AU2003279915A1 (en) * 2002-10-15 2004-05-04 Merck And Co., Inc. Process for making azetidine-3-carboxylic acid
EP1670463A2 (en) 2003-10-01 2006-06-21 Merck & Co., Inc. 3,5-aryl, heteroaryl or cycloalkyl substituted-1,2,4-oxadiazoles as s1p receptor agonists
CA2547198A1 (en) * 2003-12-17 2005-06-30 Merck & Co., Inc. (3,4-disubstituted)propanoic carboxylates as s1p (edg) receptor agonists
JP5315611B2 (ja) * 2004-06-23 2013-10-16 小野薬品工業株式会社 Ｓ１ｐ受容体結合能を有する化合物およびその用途
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MX2007011670A (es) 2005-03-23 2007-11-15 Actelion Pharmaceuticals Ltd Derivados de benzo(c) tiofeno hidrogenados como inmunomoduladores.
SI1863474T1 (sl) 2005-03-23 2009-04-30 Actelion Pharmaceuticals Ltd Novi derivati tiofena kot agonisti receptorja sfingozin-1-fosfat-1
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RU2007147940A (ru) * 2005-06-08 2009-07-20 Новартис АГ (CH) Полициклические оксадиазолы или изоксазолы и их применение в качестве лигандов s1p рецептора
AU2006256968A1 (en) * 2005-06-08 2006-12-14 Novartis Ag Polycyclic oxadiazoles or I soxazoles and their use as SIP receptor ligands
US20070043104A1 (en) 2005-06-10 2007-02-22 Luthman Ingrid K UII-modulating compounds and their use
KR20080024533A (ko) 2005-06-24 2008-03-18 액테리온 파마슈티칼 리미티드 신규한 티오펜 유도체
AR057894A1 (es) 2005-11-23 2007-12-26 Actelion Pharmaceuticals Ltd Derivados de tiofeno
TWI404706B (zh) 2006-01-11 2013-08-11 Actelion Pharmaceuticals Ltd 新穎噻吩衍生物
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BRPI0716633A2 (pt) * 2006-09-08 2013-09-24 Actelion Pharmaceuticals Ltd compostos derivados de piridin-3-ila, composiÇço farmacÊutica e uso de um composto como agente imunomodulador
KR20090051774A (ko) * 2006-09-21 2009-05-22 액테리온 파마슈티칼 리미티드 페닐 유도체 및 면역조절제로서 이들의 용도
KR20090057070A (ko) * 2006-09-29 2009-06-03 노파르티스 아게 소염성 및 면역억제성을 갖는 옥사디아졸 유도체
JP2008120794A (ja) 2006-10-16 2008-05-29 Daiichi Sankyo Co Ltd ヘテロ環化合物を含有する医薬組成物
BRPI0720043A2 (pt) * 2006-12-15 2014-01-07 Abbott Lab Composto oxadiazol
CN101627034B (zh) * 2007-03-16 2013-05-15 埃科特莱茵药品有限公司 氨基-吡啶衍生物作为s1p1/edg1受体激动剂
PL2195311T3 (pl) 2007-08-17 2011-08-31 Actelion Pharmaceuticals Ltd Pochodne pirydynowe jako modulatory receptora S1P1/EDG1
CA2700917A1 (en) * 2007-11-01 2009-05-07 Actelion Pharmaceuticals Ltd Novel pyrimidine derivatives
US8148410B2 (en) 2007-12-10 2012-04-03 Actelion Pharmaceuticals Ltd. Thiophene derivatives as agonists of S1P1/EDG1
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US20110046170A1 (en) 2008-03-06 2011-02-24 Martin Bolli Novel pyrimidine-pyridine derivatives
CA2715317A1 (en) 2008-03-07 2009-09-11 Actelion Pharmaceuticals Ltd Novel aminomethyl benzene derivatives
ES2441845T3 (es) 2009-07-16 2014-02-06 Actelion Pharmaceuticals Ltd. Derivados de piridin-4-ilo como agonistas de S1P1/EDG1

Also Published As

Publication number Publication date
NZ588438A (en) 2012-05-25
US8575200B2 (en) 2013-11-05
CY1114096T1 (el) 2016-07-27
PT2252609E (pt) 2013-06-24
CA2715437A1 (en) 2009-09-11
CN102015695A (zh) 2011-04-13
HRP20130641T1 (en) 2013-08-31
IL207972A0 (en) 2010-12-30
CA2715437C (en) 2016-05-24
AR070858A1 (es) 2010-05-12
RU2010140854A (ru) 2012-04-20
BRPI0909055A2 (pt) 2019-02-26
AU2009220861B2 (en) 2014-05-29
CN102015695B (zh) 2014-08-27
EP2252609A1 (en) 2010-11-24
IL207972A (en) 2016-03-31
KR20100137493A (ko) 2010-12-30
US20100331372A1 (en) 2010-12-30
MA32173B1 (fr) 2011-03-01
PL2252609T3 (pl) 2013-09-30
JP2011513381A (ja) 2011-04-28
KR101615779B1 (ko) 2016-04-26
DK2252609T3 (da) 2013-06-24
JP5435745B2 (ja) 2014-03-05
WO2009109872A1 (en) 2009-09-11
EP2252609B1 (en) 2013-04-17
CL2009000532A1 (es) 2010-04-09
SI2252609T1 (sl) 2013-07-31
RU2494099C2 (ru) 2013-09-27
TWI444377B (zh) 2014-07-11
ZA201007136B (en) 2014-03-26
ES2414533T3 (es) 2013-07-19
AU2009220861A1 (en) 2009-09-11
HK1150601A1 (en) 2012-01-06
MY183039A (en) 2021-02-08
TW200940532A (en) 2009-10-01

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