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AU2003279915A1 - Process for making azetidine-3-carboxylic acid - Google Patents

Process for making azetidine-3-carboxylic acid

Info

Publication number
AU2003279915A1
AU2003279915A1 AU2003279915A AU2003279915A AU2003279915A1 AU 2003279915 A1 AU2003279915 A1 AU 2003279915A1 AU 2003279915 A AU2003279915 A AU 2003279915A AU 2003279915 A AU2003279915 A AU 2003279915A AU 2003279915 A1 AU2003279915 A1 AU 2003279915A1
Authority
AU
Australia
Prior art keywords
azetidine
making
carboxylic acid
carboxylic
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003279915A
Inventor
Fengrui Lang
Ross Miller
Zhiguo Jake Song
Daniel Zewge
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU2003279915A1 publication Critical patent/AU2003279915A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D205/00Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2003279915A 2002-10-15 2003-10-10 Process for making azetidine-3-carboxylic acid Abandoned AU2003279915A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41856502P 2002-10-15 2002-10-15
US60/418,565 2002-10-15
PCT/US2003/032074 WO2004035538A1 (en) 2002-10-15 2003-10-10 Process for making azetidine-3-carboxylic acid

Publications (1)

Publication Number Publication Date
AU2003279915A1 true AU2003279915A1 (en) 2004-05-04

Family

ID=32107946

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003279915A Abandoned AU2003279915A1 (en) 2002-10-15 2003-10-10 Process for making azetidine-3-carboxylic acid

Country Status (2)

Country Link
AU (1) AU2003279915A1 (en)
WO (1) WO2004035538A1 (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006010379A1 (en) 2004-07-29 2006-02-02 Actelion Pharmaceuticals Ltd. Novel thiophene derivatives as immunosuppressive agents
PT1650186E (en) * 2004-10-22 2008-09-16 Bioprojet Soc Civ Novel dicarboxylic acid derivatives
CA2583681A1 (en) * 2004-10-22 2006-05-04 Merck & Co., Inc. 2-(aryl)azacyclylmethyl carboxylates, sulfonates, phosphonates, phosphinates and heterocycles as s1p receptor agonists
SI1863474T1 (en) 2005-03-23 2009-04-30 Actelion Pharmaceuticals Ltd Novel thiophene derivatives as sphingosine-1-phosphate-1 receptor agonists
MX2007011670A (en) 2005-03-23 2007-11-15 Actelion Pharmaceuticals Ltd Hydrogenated benzo (c) thiophene derivatives as immunomodulators.
AU2006256968A1 (en) * 2005-06-08 2006-12-14 Novartis Ag Polycyclic oxadiazoles or I soxazoles and their use as SIP receptor ligands
TWI404706B (en) * 2006-01-11 2013-08-11 Actelion Pharmaceuticals Ltd Novel thiophene derivatives
CA2635124C (en) 2006-01-24 2014-04-29 Actelion Pharmaceuticals Ltd Novel pyridine derivatives
EP2021338A1 (en) 2006-05-09 2009-02-11 Pfizer Products Inc. Cycloalkylamino acid derivatives and pharmaceutical compositions thereof
AR061841A1 (en) 2006-09-07 2008-09-24 Actelion Pharmaceuticals Ltd DERIVATIVES OF THIOFEN-OXADIAZOLS, AGONISTS OF THE S1P1 / EDG1 RECEPTOR, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USES AS IMMUNOMODULATING AGENTS.
AU2007292993B2 (en) 2006-09-07 2013-01-24 Idorsia Pharmaceuticals Ltd Pyridin-4-yl derivatives as immunomodulating agents
BRPI0716633A2 (en) 2006-09-08 2013-09-24 Actelion Pharmaceuticals Ltd pyridin-3-yl derivatives, pharmaceutical composition and use of a compound as an immunomodulatory agent
KR20090051774A (en) * 2006-09-21 2009-05-22 액테리온 파마슈티칼 리미티드 Phenyl derivatives and their use as immunomodulators
BRPI0720043A2 (en) 2006-12-15 2014-01-07 Abbott Lab OXADIAZOL COMPOUND
CN101627034B (en) 2007-03-16 2013-05-15 埃科特莱茵药品有限公司 Amino-pyridine derivatives as S1P1/EDG1 receptor agonists
EP2014653A1 (en) * 2007-06-15 2009-01-14 Bioprojet Novel dicarboxylic acid derivatives as S1P1 receptor agonists
PL2195311T3 (en) 2007-08-17 2011-08-31 Actelion Pharmaceuticals Ltd Pyridine derivatives as s1p1/edg1 receptor modulators
CA2700917A1 (en) 2007-11-01 2009-05-07 Actelion Pharmaceuticals Ltd Novel pyrimidine derivatives
US8148410B2 (en) 2007-12-10 2012-04-03 Actelion Pharmaceuticals Ltd. Thiophene derivatives as agonists of S1P1/EDG1
CA2715317A1 (en) * 2008-03-07 2009-09-11 Actelion Pharmaceuticals Ltd Novel aminomethyl benzene derivatives
PL2252609T3 (en) * 2008-03-07 2013-09-30 Idorsia Pharmaceuticals Ltd Pyridin-2-yl derivatives as immunomodulating agents
ES2441845T3 (en) 2009-07-16 2014-02-06 Actelion Pharmaceuticals Ltd. Pyridin-4-yl derivatives as S1P1 / EDG1 agonists
US8399451B2 (en) 2009-08-07 2013-03-19 Bristol-Myers Squibb Company Heterocyclic compounds
US8791100B2 (en) 2010-02-02 2014-07-29 Novartis Ag Aryl benzylamine compounds
TWI546300B (en) 2011-01-19 2016-08-21 艾克泰聯製藥有限公司 2-methoxy-pyridin-4-yl derivative
CN105189487B (en) 2013-03-15 2017-12-26 爱杜西亚药品有限公司 Pyridin-4-yl derivatives
CN103450171B (en) * 2013-09-22 2015-07-08 苏州康乃德生物医药有限公司 Novel immune adjustment compound, application thereof and medicine combination comprising same
CN105315266B (en) * 2014-08-01 2019-10-01 苏州康乃德生物医药有限公司 The crystal form of 1- { the fluoro- 4- of 2- [5- (4- isobutyl phenenyl) -1,2,4- oxadiazoles -3- base]-benzyl } -3- azetidinecarboxylic acid
BR112017024785B1 (en) 2015-05-20 2022-05-17 Idorsia Pharmaceuticals Ltd CRYSTALLINE FORM OF COMPOUND (S)-3-{4-[5-(2-CYCLOPENTYL-6-METOXY-PYRIDIN-4-YL)-[1,2,4]OXADIAZOLE-3-YL]-2-ETHYL- 6-METHYLPHENOXY}-PROPANE-1,2-DIOL, PHARMACEUTICAL COMPOSITION, AND USE
CN107857760A (en) * 2017-11-21 2018-03-30 南京天翔医药科技有限公司 The phosphate receptor modulators of sphingol 1 and its application
CN109956912B (en) * 2017-12-26 2021-10-22 中国医学科学院药物研究所 Carboxylic acid compound containing diphenyloxadiazole, its preparation method and medical use
ES2978392T3 (en) 2018-05-04 2024-09-11 Suzhou Connect Biopharmaceuticals Ltd Addition salt of S1P1 receptor agonist and crystalline form thereof, and pharmaceutical composition
JP7692032B2 (en) * 2020-06-30 2025-06-12 上海 インスティテュート オブ マテリア メディカ、チャイニーズ アカデミー オブ サイエンシーズ Oxadiazole compounds, their preparation, pharmaceutical compositions and uses
WO2025151705A1 (en) * 2024-01-10 2025-07-17 Vrise Therapeutics, Inc. Novel inhibitors of dna damage repair pathway

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005533058A (en) * 2002-06-17 2005-11-04 メルク エンド カムパニー インコーポレーテッド 1-((5-Aryl-1,2,4-oxadiazol-3-yl) benzyl) azetidine-3-carboxylate and 1-((5-aryl-1,2,4) as EDG receptor agonists -Oxadiazol-3-yl) benzyl) pyrrolidine-3-carboxylate

Also Published As

Publication number Publication date
WO2004035538A1 (en) 2004-04-29

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase