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MX2010005432A - Metodo para producir geles de adapaleno. - Google Patents

Metodo para producir geles de adapaleno.

Info

Publication number
MX2010005432A
MX2010005432A MX2010005432A MX2010005432A MX2010005432A MX 2010005432 A MX2010005432 A MX 2010005432A MX 2010005432 A MX2010005432 A MX 2010005432A MX 2010005432 A MX2010005432 A MX 2010005432A MX 2010005432 A MX2010005432 A MX 2010005432A
Authority
MX
Mexico
Prior art keywords
adapalene
medium
adapal
gels
produce
Prior art date
Application number
MX2010005432A
Other languages
English (en)
Inventor
Maurice Ebel
Richard Dugat
Original Assignee
Galderma Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galderma Res & Dev filed Critical Galderma Res & Dev
Publication of MX2010005432A publication Critical patent/MX2010005432A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención se refiere a un método para producir un gel acuoso de adapaleno, el método comprenden preparar un medio de gelificación A mezclando el agua y propilenglicol y agregando un agente gelificante; preparar un medio de adapaleno B por la dispersión del adapaleno en agua, en la presencia de un agente tensioactivo; agregar el medio de adapaleno B al medio de gelificación A; y ajustar el pH a aproximadamente 4.7-5.3.
MX2010005432A 2007-11-27 2008-11-27 Metodo para producir geles de adapaleno. MX2010005432A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US99661807P 2007-11-27 2007-11-27
EP07121665A EP2065032A1 (en) 2007-11-27 2007-11-27 A method for producing adapalene gels
PCT/EP2008/066339 WO2009068610A1 (en) 2007-11-27 2008-11-27 A method for producing adapalene gels

Publications (1)

Publication Number Publication Date
MX2010005432A true MX2010005432A (es) 2010-06-02

Family

ID=39247232

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010005432A MX2010005432A (es) 2007-11-27 2008-11-27 Metodo para producir geles de adapaleno.

Country Status (13)

Country Link
US (1) US8404220B2 (es)
EP (3) EP2065032A1 (es)
JP (2) JP5526035B2 (es)
KR (1) KR101563379B1 (es)
CN (2) CN103830163B (es)
AR (1) AR071737A1 (es)
AU (1) AU2008328764B2 (es)
BR (1) BRPI0819026B8 (es)
CA (1) CA2706379A1 (es)
ES (2) ES2887225T3 (es)
MX (1) MX2010005432A (es)
RU (1) RU2476203C2 (es)
WO (1) WO2009068610A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1684782E (pt) 2003-10-03 2015-12-21 Thorn Bioscience Llc Processo para a sincronização da ovulação para reprodução regulada sem detecção do cio
FR2910321B1 (fr) 2006-12-21 2009-07-10 Galderma Res & Dev S N C Snc Gel creme comprenant au moins un retinoide et du peroxyde de benzole
FR2910320B1 (fr) 2006-12-21 2009-02-13 Galderma Res & Dev S N C Snc Emulsion comprenant au moins un retinoide et du peroxyde de benzole
PL2421545T3 (pl) 2009-04-23 2018-05-30 Jbs United Animal Health Ii Llc Sposób i kompozycja do synchronizacji czasu inseminacji
FR2969492B1 (fr) * 2010-12-23 2013-07-05 Galderma Res & Dev Mousses dermatologiques obtenues a partir d'un gel ou d'une suspension contenant de l'adapalene
CN102274159A (zh) * 2011-07-12 2011-12-14 广东东阳光药业有限公司 一种经皮渗透给药的维甲酸类药物组合物及其制备方法
FR2991177B1 (fr) 2012-06-01 2014-12-19 Galderma Res & Dev Compositions topiques, contenant un retinoide, de type emulsion huile dans eau sans emulsionnant
CN103099775B (zh) * 2012-10-08 2014-12-31 天津金耀集团有限公司 阿达帕林凝胶
JP2016508030A (ja) 2012-11-28 2016-03-17 ジェイビーエス ユナイテッド アニマル ヘルス セカンド エルエルシー 未経産ブタにおける授精の時期を同期化するための方法および組成物
TW201625218A (zh) * 2014-04-18 2016-07-16 Ｊｂｓ聯合動物保健有限責任公司 製造含ｇｎｒｈ凝膠之方法
CN105411999A (zh) * 2015-11-23 2016-03-23 安徽新和成皖南药业有限公司 一种阿达帕林凝胶的制备方法
US9987239B1 (en) 2017-03-14 2018-06-05 Rey Ventures, LLC Pharmaceutical retinoid preparation for topical use
CN108066332A (zh) * 2017-12-21 2018-05-25 兆科药业（广州）有限公司 一种凝胶制剂中阿达帕林的分散工艺
WO2019240290A1 (ja) * 2018-06-16 2019-12-19 ロート製薬株式会社 外用組成物
US12133907B2 (en) 2021-01-07 2024-11-05 Actera Ingredients, Inc. Lipophilic third generation retinoid
CN116139071A (zh) * 2022-12-29 2023-05-23 江苏知原药业股份有限公司 一种阿达帕林凝胶及其制备方法
EP4534072A1 (en) 2023-10-06 2025-04-09 Dr. August Wolff GmbH & Co. KG Arzneimittel Non-aqueous pharmaceutical gel formulation containing dissolved adapalene

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU85849A1 (fr) 1985-04-11 1986-11-05 Cird Derives benzonaphtaleniques,leur procede de preparation et leur application dans les domaines pharmaceutiques et cosmetiques
FR2636061B1 (fr) 1988-09-07 1990-11-09 Cird Procede de preparation de derives de l'adamantane-1
FR2833841B1 (fr) * 2001-12-21 2005-07-22 Galderma Res & Dev Gel comprenant au moins un retinoide et du peroxyde de benzoyle
US7820186B2 (en) * 2001-12-21 2010-10-26 Galderma Research & Development Gel composition for once-daily treatment of common acne comprising a combination of benzoyl peroxide and adapalene and/or adapalene salt
DE60327745D1 (de) * 2002-03-12 2009-07-09 Galderma Res & Dev Verwendung von adapalen zur behandlung dermatologischer erkrankungen
PL374779A1 (pl) * 2002-12-12 2005-10-31 Galderma Research & Development, S.N.C. Wodno-alkoholowy żel odbarwiający, zawierający pochodną fenolową i retinoid
FR2871377B1 (fr) * 2004-06-11 2007-08-24 Galderma Res & Dev Gel depigmentant hydroalcoolique comprenant du mequinol et de l'adapalene
KR20070091613A (ko) * 2004-11-08 2007-09-11 그렌마크 파머수티칼스 엘티디. 항여드름 화합물 및 항생제 화합물을 함유하는 국소적 제약조성물
JP5074401B2 (ja) * 2005-09-16 2012-11-14 ガルデルマ・リサーチ・アンド・デヴェロップメント 少なくとも１つのナフトエ酸誘導体および少なくとも１つのポリウレタンポリマータイプの化合物またはその誘導体を含む組成物、その調製方法、およびその使用
US20080175810A1 (en) * 2007-01-22 2008-07-24 Jerry Zhang Topical compositions for cosmetic and pharmaceutical use

Also Published As

Publication number Publication date
EP2065032A1 (en) 2009-06-03
AR071737A1 (es) 2010-07-14
ES2887225T3 (es) 2021-12-22
CN101878022B (zh) 2014-02-19
BRPI0819026B8 (pt) 2021-05-25
ES2464455T3 (es) 2014-06-02
JP2011504912A (ja) 2011-02-17
BRPI0819026A2 (pt) 2017-04-04
CN103830163B (zh) 2016-12-07
RU2476203C2 (ru) 2013-02-27
EP2460513B1 (en) 2021-07-21
RU2010126103A (ru) 2012-01-10
EP2224906B1 (en) 2014-02-19
KR101563379B1 (ko) 2015-10-26
WO2009068610A1 (en) 2009-06-04
KR20100098539A (ko) 2010-09-07
EP2460513A1 (en) 2012-06-06
CA2706379A1 (en) 2009-06-04
JP2014101373A (ja) 2014-06-05
CN103830163A (zh) 2014-06-04
CN101878022A (zh) 2010-11-03
US8404220B2 (en) 2013-03-26
BRPI0819026B1 (pt) 2020-05-05
US20100280121A1 (en) 2010-11-04
JP5526035B2 (ja) 2014-06-18
AU2008328764A1 (en) 2009-06-04
EP2224906A1 (en) 2010-09-08
AU2008328764B2 (en) 2013-11-21

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