MX2010005483A - Inhibidores de transcriptasa inversa no nucleosidos. - Google Patents
Inhibidores de transcriptasa inversa no nucleosidos.Info
- Publication number
- MX2010005483A MX2010005483A MX2010005483A MX2010005483A MX2010005483A MX 2010005483 A MX2010005483 A MX 2010005483A MX 2010005483 A MX2010005483 A MX 2010005483A MX 2010005483 A MX2010005483 A MX 2010005483A MX 2010005483 A MX2010005483 A MX 2010005483A
- Authority
- MX
- Mexico
- Prior art keywords
- reverse transcriptase
- transcriptase inhibitors
- compounds
- nucleoside reverse
- prodrugs
- Prior art date
Links
- 229940042402 non-nucleoside reverse transcriptase inhibitor Drugs 0.000 title 1
- 239000002726 nonnucleoside reverse transcriptase inhibitor Substances 0.000 title 1
- 108010078851 HIV Reverse Transcriptase Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000651 prodrug Substances 0.000 abstract 2
- 229940002612 prodrug Drugs 0.000 abstract 2
- 238000011321 prophylaxis Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 238000011282 treatment Methods 0.000 abstract 2
- 208000030507 AIDS Diseases 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 150000002390 heteroarenes Chemical class 0.000 abstract 1
- 239000002955 immunomodulating agent Substances 0.000 abstract 1
- 229940121354 immunomodulator Drugs 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 229940042443 other antivirals in atc Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000003419 rna directed dna polymerase inhibitor Substances 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
Abstract
Compuestos heteroaromáticos de fórmula (1), son inhibidores de transcriptasa inversa VIH, en donde el anillo A es: (ver fórmulas ii-a, ii-b, ii-c, ii-d, ii-e) (ii-a), (ii-b), (ii-c), (ii-c), (ii-d), o (ii-e), y en donde n, L, M, U, X, Y, Z, RE, RF, R1, R2A, R2B, R2C, R3, R8, R9 y R10 se definen en la presente; los compuestos de fórmula I (ver fórmula I) sus sales farmacéuticamente aceptables y profármacos son útiles en la inhibición de transcriptasa inversa VIH, la profilaxis y tratamiento de infección mediante VIH y en la profilaxis, retardo en el inicio o progreso, y tratamiento de SIDA; los compuestos y sus sales y profármacos se pueden emplear como ingredientes en composiciones farmacéuticas, opcionalmente en combinación con otros antivirales, inmunomoduladores, antibióticos o vacunas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US376907P | 2007-11-20 | 2007-11-20 | |
| PCT/US2008/012774 WO2009067166A2 (en) | 2007-11-20 | 2008-11-14 | Non-nucleoside reverse transcriptase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010005483A true MX2010005483A (es) | 2010-06-11 |
Family
ID=40336474
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010005483A MX2010005483A (es) | 2007-11-20 | 2008-11-14 | Inhibidores de transcriptasa inversa no nucleosidos. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8404856B2 (es) |
| EP (1) | EP2222661B1 (es) |
| JP (1) | JP5539216B2 (es) |
| KR (1) | KR20100088142A (es) |
| CN (1) | CN101952274A (es) |
| AU (1) | AU2008326784B2 (es) |
| BR (1) | BRPI0820162A2 (es) |
| CA (1) | CA2705834A1 (es) |
| IL (1) | IL205386A0 (es) |
| MX (1) | MX2010005483A (es) |
| RU (1) | RU2010125220A (es) |
| WO (1) | WO2009067166A2 (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010026075A1 (en) * | 2008-09-04 | 2010-03-11 | F. Hoffmann-La Roche Ag | Pyridine derivatives as inhibitors of hiv-i reverse transcriptase |
| US20120232062A1 (en) * | 2009-10-20 | 2012-09-13 | Eiger Biopharmaceuticals, Inc. | Azaindazoles to treat flaviviridae virus infection |
| ME02181B (me) * | 2010-03-30 | 2015-10-20 | Merck Canada Inc | Ne-nukleozidni inhibitori reverzne transkriptaze |
| US20130040914A1 (en) * | 2010-04-08 | 2013-02-14 | Samson M. Jolly | Prodrugs of an hiv reverse transcriptase inhibitor |
| EP2900240B1 (en) * | 2012-09-26 | 2020-01-08 | Merck Sharp & Dohme Corp. | Crystalline form of a reverse transcriptase inhibitor |
| JO3470B1 (ar) * | 2012-10-08 | 2020-07-05 | Merck Sharp & Dohme | مشتقات 5- فينوكسي-3h-بيريميدين-4-أون واستخدامها كمثبطات ناسخ عكسي ل hiv |
| CA2892919A1 (en) * | 2012-12-05 | 2014-06-12 | Merck Sharp & Dohme Corp. | Process for making reverse transcriptase inhibitors |
| MX367369B (es) * | 2013-12-04 | 2019-08-16 | Merck Sharp & Dohme | Proceso para preparar inhibidores de la transcriptasa inversa. |
| LT3125894T (lt) * | 2014-04-01 | 2020-12-10 | Merck Sharp & Dohme Corp. | Živ atvirkštinės transkriptazės inhibitorių provaistai |
| CN112961149A (zh) | 2014-08-11 | 2021-06-15 | 安吉恩生物医药公司 | 细胞色素p450抑制剂及其用途 |
| EP3240778A4 (en) | 2014-12-31 | 2018-07-11 | Angion Biomedica Corp. | Methods and agents for treating disease |
| US10953029B2 (en) * | 2015-09-23 | 2021-03-23 | Merck Sharp & Dohme Corp. | 4′-Substituted nucleoside reverse transcriptase inhibitors and preparations thereof |
| CN114702495A (zh) | 2015-11-20 | 2022-07-05 | 福马治疗有限公司 | 作为泛素-特异性蛋白酶1抑制剂的嘌呤酮 |
| KR102590848B1 (ko) | 2016-12-28 | 2023-10-19 | 다트 뉴로사이언스, 엘엘씨 | Pde2 억제제로서 치환된 피라졸로피리미디논 화합물 |
| ES2902365T3 (es) | 2017-11-27 | 2022-03-28 | Dart Neuroscience Llc | Compuestos de furanopirimidina sustituidos como inhibidores de PDE1 |
| MA54549A (fr) | 2018-12-18 | 2022-03-30 | Merck Sharp & Dohme | Dérivés de pyrimidone en tant qu'agents cytotoxiques sélectifs contre des cellules infectées par le vih |
| AU2020279954B2 (en) * | 2019-05-22 | 2025-11-13 | Merck Sharp & Dohme Llc | Pyridinone derivatives as selective cytotoxic agents against HIV infected cells |
| CN110066273A (zh) * | 2019-06-05 | 2019-07-30 | 山东大学 | 一种含三氮唑环的单芳基嘧啶类hiv-1逆转录酶抑制剂及其制备方法与应用 |
| CN112876409A (zh) * | 2021-01-20 | 2021-06-01 | 都创(上海)医药科技股份有限公司 | 一种2-(5-溴-6-甲氧基吡啶-2-基)乙腈及其衍生物的合成方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL99731A0 (en) * | 1990-10-18 | 1992-08-18 | Merck & Co Inc | Hydroxylated pyridine derivatives,their preparation and pharmaceutical compositions containing them |
| DE69430747T2 (de) * | 1993-07-28 | 2003-03-06 | Aventis Pharma Ltd., West Malling | Verbindungen als pde iv und tnf inhibitoren |
| CN1303378A (zh) | 1998-04-27 | 2001-07-11 | 国家科研中心 | 3－(氨基－或氨基烷基)吡啶酮衍生物和它们在hiv相关疾病治疗中的用途 |
| GB9910577D0 (en) | 1999-05-08 | 1999-07-07 | Zeneca Ltd | Chemical compounds |
| SE9904045D0 (sv) | 1999-11-09 | 1999-11-09 | Astra Ab | Compounds |
| WO2001056990A2 (en) * | 2000-02-03 | 2001-08-09 | Eli Lilly And Company | Pyridine derivates as potentiators of glutamate receptors |
| ES2242771T5 (es) | 2000-09-15 | 2011-10-14 | Vertex Pharmaceuticals Incorporated | Compuestos de pirazol útiles como inhibidores de proteína quinasas. |
| EP1318995B1 (en) * | 2000-09-19 | 2006-03-08 | Centre National De La Recherche Scientifique (Cnrs) | Pyridinone and pyridinethione derivatives having hiv inhibiting properties |
| GB0129260D0 (en) | 2001-12-06 | 2002-01-23 | Eisai London Res Lab Ltd | Pharmaceutical compositions and their uses |
| JP4164031B2 (ja) * | 2002-02-14 | 2008-10-08 | ファルマシア コーポレーション | Ｐ３８ｍａｐキナーゼのモジュレータとしての置換されたピリジノン |
| NZ541902A (en) * | 2003-02-07 | 2008-12-24 | Janssen Pharmaceutica Nv | Pyrimidine derivatives for the prevention of HIV infection |
| KR20050119652A (ko) | 2003-03-24 | 2005-12-21 | 에프. 호프만-라 로슈 아게 | 역전사 효소 저해제로서의 벤질-피리다진온 |
| US20050014774A1 (en) * | 2003-04-28 | 2005-01-20 | Richard Storer | Oxo-pyrimidine compounds |
| AU2005235692B2 (en) | 2004-04-23 | 2011-11-10 | F. Hoffmann-La Roche Ag | Non-nucleoside reverse transcriptase inhibitors |
| US7166738B2 (en) * | 2004-04-23 | 2007-01-23 | Roche Palo Alto Llc | Non-nucleoside reverse transcriptase inhibitors |
| TWI360539B (en) * | 2004-10-28 | 2012-03-21 | Shionogi & Co | 3-carbamoyl-2-pyridone derivatives |
| CA2592092A1 (en) | 2004-12-22 | 2006-06-29 | Pfizer Limited | Nonnucleoside inhibitors of hiv-1 reverse transcriptase |
| AR057455A1 (es) | 2005-07-22 | 2007-12-05 | Merck & Co Inc | Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica |
| CA2625047A1 (en) * | 2005-10-19 | 2007-04-26 | F. Hoffmann-La Roche Ag | Phenyl-acetamide nnrt inhibitors |
| ATE425138T1 (de) | 2005-10-19 | 2009-03-15 | Hoffmann La Roche | N-phenyl-phenylacetamid-nichtnukleosidinhibitor n reverser transkriptase |
| EP2038272B8 (en) * | 2006-06-30 | 2013-10-23 | Sunesis Pharmaceuticals, Inc. | Pyridinonyl pdk1 inhibitors |
| US8314119B2 (en) * | 2006-11-06 | 2012-11-20 | Abbvie Inc. | Azaadamantane derivatives and methods of use |
| TW200831085A (en) * | 2006-12-13 | 2008-08-01 | Merck & Co Inc | Non-nucleoside reverse transcriptase inhibitors |
| WO2008098143A2 (en) * | 2007-02-08 | 2008-08-14 | Trius Therapeutics | Antimicrobial compounds and methods of use |
-
2008
- 2008-11-14 MX MX2010005483A patent/MX2010005483A/es not_active Application Discontinuation
- 2008-11-14 BR BRPI0820162A patent/BRPI0820162A2/pt not_active IP Right Cessation
- 2008-11-14 AU AU2008326784A patent/AU2008326784B2/en not_active Ceased
- 2008-11-14 CA CA2705834A patent/CA2705834A1/en active Pending
- 2008-11-14 RU RU2010125220/04A patent/RU2010125220A/ru unknown
- 2008-11-14 WO PCT/US2008/012774 patent/WO2009067166A2/en not_active Ceased
- 2008-11-14 EP EP08851089.6A patent/EP2222661B1/en not_active Not-in-force
- 2008-11-14 JP JP2010534947A patent/JP5539216B2/ja not_active Expired - Fee Related
- 2008-11-14 CN CN2008801168055A patent/CN101952274A/zh active Pending
- 2008-11-14 US US12/742,159 patent/US8404856B2/en active Active
- 2008-11-14 KR KR1020107011127A patent/KR20100088142A/ko not_active Withdrawn
-
2010
- 2010-04-27 IL IL205386A patent/IL205386A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2222661B1 (en) | 2016-04-20 |
| KR20100088142A (ko) | 2010-08-06 |
| JP2011503230A (ja) | 2011-01-27 |
| CA2705834A1 (en) | 2009-05-28 |
| BRPI0820162A2 (pt) | 2019-09-24 |
| AU2008326784A1 (en) | 2009-05-28 |
| RU2010125220A (ru) | 2011-12-27 |
| IL205386A0 (en) | 2010-12-30 |
| JP5539216B2 (ja) | 2014-07-02 |
| AU2008326784B2 (en) | 2014-04-24 |
| WO2009067166A2 (en) | 2009-05-28 |
| CN101952274A (zh) | 2011-01-19 |
| US20100256181A1 (en) | 2010-10-07 |
| WO2009067166A3 (en) | 2009-07-16 |
| US8404856B2 (en) | 2013-03-26 |
| EP2222661A2 (en) | 2010-09-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |