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MX2010003333A - Sal de amina organica de 6-fluoro-3-hidroxi-2-pirazincarbonitrilo y metodo para su produccion. - Google Patents

Sal de amina organica de 6-fluoro-3-hidroxi-2-pirazincarbonitrilo y metodo para su produccion.

Info

Publication number
MX2010003333A
MX2010003333A MX2010003333A MX2010003333A MX2010003333A MX 2010003333 A MX2010003333 A MX 2010003333A MX 2010003333 A MX2010003333 A MX 2010003333A MX 2010003333 A MX2010003333 A MX 2010003333A MX 2010003333 A MX2010003333 A MX 2010003333A
Authority
MX
Mexico
Prior art keywords
fluoro
hydroxy
pyrazinecarbonitrile
organic amine
amine salt
Prior art date
Application number
MX2010003333A
Other languages
English (en)
Inventor
Kenji Yonezawa
Tamotsu Takamatsu
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Publication of MX2010003333A publication Critical patent/MX2010003333A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se revela una sal de amina org?nica de 6-fluoro-3- hidroxi-2-pirazincarbonitrilo, que es excelente en cristalinidad y es ?til como un producto intermedio para la fabricaci?n de 6-fluoro-3-hidroxi-2- pirazincarboxamida.
MX2010003333A 2007-09-27 2008-09-25 Sal de amina organica de 6-fluoro-3-hidroxi-2-pirazincarbonitrilo y metodo para su produccion. MX2010003333A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007251191 2007-09-27
PCT/JP2008/067251 WO2009041473A1 (ja) 2007-09-27 2008-09-25 ６－フルオロ－３－ヒドロキシ－２－ピラジンカルボニトリルの有機アミン塩およびその製造法

Publications (1)

Publication Number Publication Date
MX2010003333A true MX2010003333A (es) 2010-04-09

Family

ID=40511356

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010003333A MX2010003333A (es) 2007-09-27 2008-09-25 Sal de amina organica de 6-fluoro-3-hidroxi-2-pirazincarbonitrilo y metodo para su produccion.

Country Status (21)

Country Link
US (1) US8168789B2 (es)
EP (1) EP2192117B1 (es)
JP (1) JP5550347B2 (es)
KR (2) KR101686813B1 (es)
CN (2) CN101809003A (es)
AU (1) AU2008304956B2 (es)
BR (1) BRPI0817305B1 (es)
CA (1) CA2700490C (es)
CY (1) CY1115218T1 (es)
DK (1) DK2192117T3 (es)
ES (1) ES2470740T3 (es)
HR (1) HRP20140837T1 (es)
IL (1) IL204516A (es)
MX (1) MX2010003333A (es)
NZ (1) NZ584157A (es)
PL (1) PL2192117T3 (es)
PT (1) PT2192117E (es)
RU (1) RU2470924C2 (es)
SI (1) SI2192117T1 (es)
WO (1) WO2009041473A1 (es)
ZA (1) ZA201002001B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG188662A1 (en) 2010-09-30 2013-05-31 Toyama Chemical Co Ltd Meglumine salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide
CN103209966B (zh) * 2010-09-30 2015-06-10 富山化学工业株式会社 6-氟-3-羟基-2-吡嗪甲酰胺的钠盐
EP2639235B1 (en) * 2010-11-12 2015-04-08 FUJIFILM Corporation Pyrazino[2,3-d]isooxazole derivative
CN104496917B (zh) * 2014-12-15 2017-06-20 南京华威医药科技开发有限公司 一种法匹拉韦的合成方法
JP6705817B2 (ja) * 2015-06-09 2020-06-03 富士フイルム富山化学株式会社 ６−ブロモ−３−ヒドロキシ−２−ピラジンカルボキサミドの結晶およびその製造方法
CN107641106A (zh) * 2016-07-22 2018-01-30 大连鸿凯化工科技发展有限公司 法匹拉韦中间体以及法匹拉韦的合成方法
CN113248450B (zh) * 2020-02-07 2024-04-12 北京四环制药有限公司 一种法匹拉韦的制备方法
WO2021260516A1 (en) * 2020-06-22 2021-12-30 Pi Industries Ltd. An organic amine salt of favipiravir and a process for the purification of favipiravir
WO2022009036A1 (en) * 2020-07-06 2022-01-13 Optimus Drugs (P) Ltd Synthesis of favipiravir
CN114057656B (zh) * 2020-08-05 2025-11-18 广东东阳光药业股份有限公司 一种法匹拉韦共晶及其制备方法
CN112645889A (zh) * 2020-12-24 2021-04-13 杭州煌森生物科技有限公司 一种法匹拉韦的精制方法
CN114478404A (zh) * 2022-03-17 2022-05-13 浙江海正药业股份有限公司 一种法维拉韦中间体羟基物的纯化方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB879259A (en) 1956-11-20 1961-10-11 Riker Laboratories Inc Acid addition salts of 2-dimethylaminoethanol and central nervous system stimulant compositions containing them
CZ282939B6 (cs) * 1992-03-04 1997-11-12 Lonza A.G. Mikrobiologický způsob hydroxylace dusíkatých heterocyklických karboxylových kyselin
ES2237550T3 (es) 2000-02-16 2005-08-01 Toyama Chemical Co., Ltd. Nuevos derivados de pirazina o sus sales, composiciones farmaceuticas que contienen estos derivados o sus sales e intermediarios utilizados en su preparacion.
RU2297414C2 (ru) * 2001-02-14 2007-04-20 Тояма Кемикал Ко., Лтд. Производные пиразина или их соли, фармацевтическая композиция, содержащая данные соединения, и промежуточные соединения для их получения
JP4398631B2 (ja) * 2002-07-12 2010-01-13 富山化学工業株式会社 新規なピラジン誘導体またはその塩並びにそれらを含有する抗ウイルス剤
GB0407908D0 (en) 2004-04-07 2004-05-12 Univ York Ionic liquids

Also Published As

Publication number Publication date
CY1115218T1 (el) 2017-01-04
EP2192117A4 (en) 2011-04-20
KR101686813B1 (ko) 2016-12-16
RU2470924C2 (ru) 2012-12-27
CN104672153A (zh) 2015-06-03
NZ584157A (en) 2012-04-27
HRP20140837T1 (hr) 2014-10-10
DK2192117T3 (da) 2014-06-30
EP2192117B1 (en) 2014-06-04
PT2192117E (pt) 2014-07-09
PL2192117T3 (pl) 2014-10-31
ZA201002001B (en) 2011-05-25
BRPI0817305A2 (pt) 2015-03-17
CA2700490C (en) 2015-10-27
SI2192117T1 (sl) 2014-10-30
AU2008304956B2 (en) 2013-05-16
WO2009041473A1 (ja) 2009-04-02
KR20150100958A (ko) 2015-09-02
IL204516A (en) 2014-02-27
IL204516A0 (en) 2010-11-30
BRPI0817305B1 (pt) 2021-10-19
US8168789B2 (en) 2012-05-01
EP2192117A1 (en) 2010-06-02
CN104672153B (zh) 2019-04-23
US20100286394A1 (en) 2010-11-11
RU2010116390A (ru) 2011-11-10
KR101574567B1 (ko) 2015-12-07
JP5550347B2 (ja) 2014-07-16
CA2700490A1 (en) 2009-04-02
JPWO2009041473A1 (ja) 2011-01-27
KR20100061701A (ko) 2010-06-08
ES2470740T3 (es) 2014-06-24
CN101809003A (zh) 2010-08-18
AU2008304956A1 (en) 2009-04-02

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