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MX2010002506A - Compuestos de nicotinamida sustituidos y uso de estos en medicamentos. - Google Patents

Compuestos de nicotinamida sustituidos y uso de estos en medicamentos.

Info

Publication number
MX2010002506A
MX2010002506A MX2010002506A MX2010002506A MX2010002506A MX 2010002506 A MX2010002506 A MX 2010002506A MX 2010002506 A MX2010002506 A MX 2010002506A MX 2010002506 A MX2010002506 A MX 2010002506A MX 2010002506 A MX2010002506 A MX 2010002506A
Authority
MX
Mexico
Prior art keywords
pharmaceutical products
compounds
nicotinamide compounds
substituted nicotinamide
substituted
Prior art date
Application number
MX2010002506A
Other languages
English (en)
Inventor
Beatrix Merla
Wolfgang Schroeder
Sven Kuehnert
Klaus Schiene
Dagmar Kaulartz
Robert Frank
Gregor Bahrenberg
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of MX2010002506A publication Critical patent/MX2010002506A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se relaciona con compuestos de nicotinamida sustituidos, métodos para la producción de estos, productos farmacéuticos que contienen los compuestos referidos y con el uso de los compuestos referidos para la producción de productos farmacéuticos.
MX2010002506A 2007-09-17 2008-09-15 Compuestos de nicotinamida sustituidos y uso de estos en medicamentos. MX2010002506A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007044277A DE102007044277A1 (de) 2007-09-17 2007-09-17 Substituierte Nicotinamid-Verbindungen und deren Verwendung in Arzneimitteln
PCT/EP2008/007633 WO2009036938A1 (de) 2007-09-17 2008-09-15 Substituierte nicotinamid-verbindungen und deren verwendung in arzneimitteln

Publications (1)

Publication Number Publication Date
MX2010002506A true MX2010002506A (es) 2010-03-26

Family

ID=40347805

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010002506A MX2010002506A (es) 2007-09-17 2008-09-15 Compuestos de nicotinamida sustituidos y uso de estos en medicamentos.

Country Status (23)

Country Link
US (1) US8084470B2 (es)
EP (1) EP2188258B1 (es)
JP (1) JP5539205B2 (es)
KR (1) KR20100068453A (es)
CN (1) CN101801932A (es)
AR (1) AR068467A1 (es)
BR (1) BRPI0817044A2 (es)
CA (1) CA2699689C (es)
CO (1) CO6260092A2 (es)
CY (1) CY1113551T1 (es)
DE (1) DE102007044277A1 (es)
DK (1) DK2188258T3 (es)
ES (1) ES2400407T3 (es)
HR (1) HRP20130166T1 (es)
IL (1) IL204496A (es)
MX (1) MX2010002506A (es)
NZ (1) NZ583684A (es)
PE (1) PE20090652A1 (es)
PL (1) PL2188258T3 (es)
PT (1) PT2188258E (es)
RU (1) RU2489425C2 (es)
SI (1) SI2188258T1 (es)
WO (1) WO2009036938A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI475020B (zh) * 2009-03-12 2015-03-01 The substituted nicotine amide as a KCNQ2 / 3 modifier
DK2609083T3 (da) * 2010-08-27 2015-03-30 Gruenenthal Gmbh Substituerede 2-oxy-quinolin-3-carboxamider som KCNQ2/3 modulatorer
EP3318556A1 (en) * 2010-10-20 2018-05-09 Grünenthal GmbH Substituted 6-amino-nicotinamides as kcnq2/3 modulators
FR2968661B1 (fr) * 2010-12-14 2016-01-01 Oreal Procede de depigmentation des matieres keratiniques a l'aide de composes thiopyridinones
WO2014056620A1 (en) * 2012-10-11 2014-04-17 Grünenthal GmbH Treatment and/or prophylaxis of tspo mediated diseases and/or disorders
US9284286B2 (en) 2012-11-28 2016-03-15 Grünenthal GmbH Specific carboxamides as KCNQ2/3 modulators
US9248122B2 (en) 2012-11-28 2016-02-02 Grünenthal GmbH Heteroquinoline-3-carboxamides as KCNQ2/3 modulators
US11046683B2 (en) 2016-12-15 2021-06-29 Ono Pharmaceutical Co., Ltd. Activator of TREK (TWIK RElated K+ channels) channels

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6022884A (en) * 1997-11-07 2000-02-08 Amgen Inc. Substituted pyridine compounds and methods of use
GB9919588D0 (en) * 1999-08-18 1999-10-20 Hoechst Schering Agrevo Gmbh Fungicidal compounds
CA2438868A1 (en) 2001-02-20 2002-09-19 Valentin K. Gribkoff Modulators of kcnq potassium channels and use thereof in treating migraine and mechanistically related diseases
GB0319793D0 (en) * 2003-08-22 2003-09-24 Lilly Co Eli Pyridinylmorpholine derivatives

Also Published As

Publication number Publication date
EP2188258B1 (de) 2012-11-28
RU2489425C2 (ru) 2013-08-10
AU2008300945A1 (en) 2009-03-26
US20090076086A1 (en) 2009-03-19
PT2188258E (pt) 2013-01-23
RU2010115184A (ru) 2011-10-27
PL2188258T3 (pl) 2013-04-30
JP2010539124A (ja) 2010-12-16
ES2400407T3 (es) 2013-04-09
IL204496A (en) 2013-02-28
WO2009036938A1 (de) 2009-03-26
HRP20130166T1 (hr) 2013-03-31
JP5539205B2 (ja) 2014-07-02
SI2188258T1 (sl) 2013-01-31
NZ583684A (en) 2011-04-29
CO6260092A2 (es) 2011-03-22
US8084470B2 (en) 2011-12-27
CN101801932A (zh) 2010-08-11
CA2699689C (en) 2015-03-24
DE102007044277A1 (de) 2009-03-19
AR068467A1 (es) 2009-11-18
PE20090652A1 (es) 2009-05-28
CA2699689A1 (en) 2009-03-26
KR20100068453A (ko) 2010-06-23
DK2188258T3 (da) 2013-01-14
HK1144422A1 (en) 2011-02-18
CY1113551T1 (el) 2016-06-22
EP2188258A1 (de) 2010-05-26
BRPI0817044A2 (pt) 2015-03-24

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