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MX2010001581A - Hidantoinas substituidas. - Google Patents

Hidantoinas substituidas.

Info

Publication number
MX2010001581A
MX2010001581A MX2010001581A MX2010001581A MX2010001581A MX 2010001581 A MX2010001581 A MX 2010001581A MX 2010001581 A MX2010001581 A MX 2010001581A MX 2010001581 A MX2010001581 A MX 2010001581A MX 2010001581 A MX2010001581 A MX 2010001581A
Authority
MX
Mexico
Prior art keywords
compounds
mek
substituted hydantoins
enzymes
cancer
Prior art date
Application number
MX2010001581A
Other languages
English (en)
Inventor
Norman Kong
Nicholas John Silvester Huby
Shaoqing Chen
John Anthony Moliterni
Omar Jose Morales
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2010001581A publication Critical patent/MX2010001581A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Esta invención se refiere a los compuestos e la fórmula (1) o a las sales de los mismos farmacéuticamente aceptables, en donde R1, R2, R3, R4, R5 y R6 son descritos en esta solicitud. Estos compuestos inhiben las enzimas MEK 1 y MEK 2, que son proteínas cinasas que son componentes de la ruta de transducción de la señal de la MAP cinasa. Como tales, los compuestos tienen una actividad celular anti-hiperproliferativa y por consiguiente son útiles en el tratamiento de los trastornos proliferativos celulares, tales como el cáncer.
MX2010001581A 2007-08-16 2008-08-06 Hidantoinas substituidas. MX2010001581A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95614507P 2007-08-16 2007-08-16
PCT/EP2008/060326 WO2009021887A1 (en) 2007-08-16 2008-08-06 Substituted hydantoins

Publications (1)

Publication Number Publication Date
MX2010001581A true MX2010001581A (es) 2010-03-15

Family

ID=39830023

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010001581A MX2010001581A (es) 2007-08-16 2008-08-06 Hidantoinas substituidas.

Country Status (12)

Country Link
US (1) US7557221B2 (es)
EP (1) EP2188276B1 (es)
JP (1) JP2010536723A (es)
KR (1) KR101147583B1 (es)
CN (1) CN101778839A (es)
AT (1) ATE551336T1 (es)
AU (1) AU2008288556A1 (es)
BR (1) BRPI0815180A2 (es)
CA (1) CA2695956A1 (es)
ES (1) ES2383927T3 (es)
MX (1) MX2010001581A (es)
WO (1) WO2009021887A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102020651B (zh) 2010-11-02 2012-07-18 北京赛林泰医药技术有限公司 6-芳基氨基吡啶酮甲酰胺mek抑制剂
BR112014002353B1 (pt) * 2011-08-01 2022-09-27 Genentech, Inc Usos de antagonistas de ligação do eixo pd-1 e inibidores de mek, composições farmacêuticas, e kit
CA2890238A1 (en) 2012-11-02 2014-05-08 Merck Patent Gmbh Method of reducing adverse effects in a cancer patient undergoing treatment with a mek inhibitor
AR097279A1 (es) 2013-08-09 2016-03-02 Actelion Pharmaceuticals Ltd Derivados de benzimidazolil-metil urea como agonistas del receptor de alx
WO2015051458A1 (en) * 2013-10-08 2015-04-16 Lu qing-bin Non-platimun-based anti-cancer compounds for use in targeted chemotherapy
CN106573060A (zh) 2014-07-15 2017-04-19 豪夫迈·罗氏有限公司 使用pd‑1轴结合拮抗剂和mek抑制剂治疗癌症的组合物
US12371667B2 (en) 2021-05-13 2025-07-29 Washington University Enhanced methods for inducing and maintaining naive human pluripotent stem cells

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010014362A (ko) 1997-07-01 2001-02-26 로즈 암스트롱, 크리스틴 에이. 트러트웨인 4-브로모 또는 4-요오도 페닐아미노 벤즈히드록삼산유도체 및 ｍｅｋ 억제제로서의 그의 용도
KR19990012061A (ko) 1997-07-26 1999-02-25 성재갑 파네실 전이효소 저해제로 유용한 하이덴토인 유도체
AU2001252270B2 (en) 2000-05-03 2005-12-15 F. Hoffmann-La Roche Ag Hydantoin-containing glucokinase activators
US7235537B2 (en) 2002-03-13 2007-06-26 Array Biopharma, Inc. N3 alkylated benzimidazole derivatives as MEK inhibitors
ES2331246T3 (es) * 2003-07-24 2009-12-28 Warner-Lambert Company Llc Derivados de benzamidazol como inhibidores del mek.
JP2007523929A (ja) * 2004-02-26 2007-08-23 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング ベンズイミダゾリル誘導体
ES2313389T3 (es) 2004-08-17 2009-03-01 F. Hoffmann-La Roche Ag Hidantoinas sustituidas.
TW200621766A (en) * 2004-09-17 2006-07-01 Hoffmann La Roche Substituted hydantoins
WO2006124780A2 (en) 2005-05-12 2006-11-23 Kalypsys, Inc. Ih-benzo [d] imidazole compounds as inhibitors of b-raf kinase
US7612212B2 (en) * 2006-02-22 2009-11-03 Hoffmann-La Roche Inc. Substituted hydantoins

Also Published As

Publication number Publication date
US7557221B2 (en) 2009-07-07
KR20100031777A (ko) 2010-03-24
US20090048452A1 (en) 2009-02-19
ATE551336T1 (de) 2012-04-15
EP2188276A1 (en) 2010-05-26
ES2383927T3 (es) 2012-06-27
WO2009021887A1 (en) 2009-02-19
CN101778839A (zh) 2010-07-14
AU2008288556A1 (en) 2009-02-19
JP2010536723A (ja) 2010-12-02
CA2695956A1 (en) 2009-02-19
EP2188276B1 (en) 2012-03-28
KR101147583B1 (ko) 2012-05-21
BRPI0815180A2 (pt) 2019-09-24

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