BRPI0815180A2 - hindantoinas substituídas - Google Patents
hindantoinas substituídasInfo
- Publication number
- BRPI0815180A2 BRPI0815180A2 BRPI0815180A BRPI0815180A BRPI0815180A2 BR PI0815180 A2 BRPI0815180 A2 BR PI0815180A2 BR PI0815180 A BRPI0815180 A BR PI0815180A BR PI0815180 A BRPI0815180 A BR PI0815180A BR PI0815180 A2 BRPI0815180 A2 BR PI0815180A2
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- hindantoins
- substituted
- mek2
- mek
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 3
- 102100031480 Dual specificity mitogen-activated protein kinase kinase 1 Human genes 0.000 abstract 1
- 101710146526 Dual specificity mitogen-activated protein kinase kinase 1 Proteins 0.000 abstract 1
- 102100023266 Dual specificity mitogen-activated protein kinase kinase 2 Human genes 0.000 abstract 1
- 101710146529 Dual specificity mitogen-activated protein kinase kinase 2 Proteins 0.000 abstract 1
- 102000043136 MAP kinase family Human genes 0.000 abstract 1
- 108091054455 MAP kinase family Proteins 0.000 abstract 1
- 229940124647 MEK inhibitor Drugs 0.000 abstract 1
- 102000001253 Protein Kinase Human genes 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 108060006633 protein kinase Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000019491 signal transduction Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95614507P | 2007-08-16 | 2007-08-16 | |
| PCT/EP2008/060326 WO2009021887A1 (en) | 2007-08-16 | 2008-08-06 | Substituted hydantoins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0815180A2 true BRPI0815180A2 (pt) | 2019-09-24 |
Family
ID=39830023
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0815180A BRPI0815180A2 (pt) | 2007-08-16 | 2008-08-06 | hindantoinas substituídas |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7557221B2 (pt) |
| EP (1) | EP2188276B1 (pt) |
| JP (1) | JP2010536723A (pt) |
| KR (1) | KR101147583B1 (pt) |
| CN (1) | CN101778839A (pt) |
| AT (1) | ATE551336T1 (pt) |
| AU (1) | AU2008288556A1 (pt) |
| BR (1) | BRPI0815180A2 (pt) |
| CA (1) | CA2695956A1 (pt) |
| ES (1) | ES2383927T3 (pt) |
| MX (1) | MX2010001581A (pt) |
| WO (1) | WO2009021887A1 (pt) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102020651B (zh) | 2010-11-02 | 2012-07-18 | 北京赛林泰医药技术有限公司 | 6-芳基氨基吡啶酮甲酰胺mek抑制剂 |
| BR112014002353B1 (pt) * | 2011-08-01 | 2022-09-27 | Genentech, Inc | Usos de antagonistas de ligação do eixo pd-1 e inibidores de mek, composições farmacêuticas, e kit |
| CA2890238A1 (en) | 2012-11-02 | 2014-05-08 | Merck Patent Gmbh | Method of reducing adverse effects in a cancer patient undergoing treatment with a mek inhibitor |
| AR097279A1 (es) | 2013-08-09 | 2016-03-02 | Actelion Pharmaceuticals Ltd | Derivados de benzimidazolil-metil urea como agonistas del receptor de alx |
| WO2015051458A1 (en) * | 2013-10-08 | 2015-04-16 | Lu qing-bin | Non-platimun-based anti-cancer compounds for use in targeted chemotherapy |
| CN106573060A (zh) | 2014-07-15 | 2017-04-19 | 豪夫迈·罗氏有限公司 | 使用pd‑1轴结合拮抗剂和mek抑制剂治疗癌症的组合物 |
| US12371667B2 (en) | 2021-05-13 | 2025-07-29 | Washington University | Enhanced methods for inducing and maintaining naive human pluripotent stem cells |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20010014362A (ko) | 1997-07-01 | 2001-02-26 | 로즈 암스트롱, 크리스틴 에이. 트러트웨인 | 4-브로모 또는 4-요오도 페닐아미노 벤즈히드록삼산유도체 및 ｍｅｋ 억제제로서의 그의 용도 |
| KR19990012061A (ko) | 1997-07-26 | 1999-02-25 | 성재갑 | 파네실 전이효소 저해제로 유용한 하이덴토인 유도체 |
| AU2001252270B2 (en) | 2000-05-03 | 2005-12-15 | F. Hoffmann-La Roche Ag | Hydantoin-containing glucokinase activators |
| US7235537B2 (en) | 2002-03-13 | 2007-06-26 | Array Biopharma, Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
| ES2331246T3 (es) * | 2003-07-24 | 2009-12-28 | Warner-Lambert Company Llc | Derivados de benzamidazol como inhibidores del mek. |
| JP2007523929A (ja) * | 2004-02-26 | 2007-08-23 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | ベンズイミダゾリル誘導体 |
| ES2313389T3 (es) | 2004-08-17 | 2009-03-01 | F. Hoffmann-La Roche Ag | Hidantoinas sustituidas. |
| TW200621766A (en) * | 2004-09-17 | 2006-07-01 | Hoffmann La Roche | Substituted hydantoins |
| WO2006124780A2 (en) | 2005-05-12 | 2006-11-23 | Kalypsys, Inc. | Ih-benzo [d] imidazole compounds as inhibitors of b-raf kinase |
| US7612212B2 (en) * | 2006-02-22 | 2009-11-03 | Hoffmann-La Roche Inc. | Substituted hydantoins |
-
2008
- 2008-08-06 CN CN200880102760A patent/CN101778839A/zh active Pending
- 2008-08-06 BR BRPI0815180A patent/BRPI0815180A2/pt not_active IP Right Cessation
- 2008-08-06 JP JP2010520534A patent/JP2010536723A/ja active Pending
- 2008-08-06 AT AT08786933T patent/ATE551336T1/de active
- 2008-08-06 ES ES08786933T patent/ES2383927T3/es active Active
- 2008-08-06 WO PCT/EP2008/060326 patent/WO2009021887A1/en not_active Ceased
- 2008-08-06 MX MX2010001581A patent/MX2010001581A/es active IP Right Grant
- 2008-08-06 US US12/186,648 patent/US7557221B2/en not_active Expired - Fee Related
- 2008-08-06 AU AU2008288556A patent/AU2008288556A1/en not_active Abandoned
- 2008-08-06 CA CA2695956A patent/CA2695956A1/en not_active Abandoned
- 2008-08-06 EP EP08786933A patent/EP2188276B1/en not_active Not-in-force
- 2008-08-06 KR KR1020107003298A patent/KR101147583B1/ko not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7557221B2 (en) | 2009-07-07 |
| KR20100031777A (ko) | 2010-03-24 |
| US20090048452A1 (en) | 2009-02-19 |
| ATE551336T1 (de) | 2012-04-15 |
| EP2188276A1 (en) | 2010-05-26 |
| ES2383927T3 (es) | 2012-06-27 |
| WO2009021887A1 (en) | 2009-02-19 |
| CN101778839A (zh) | 2010-07-14 |
| AU2008288556A1 (en) | 2009-02-19 |
| MX2010001581A (es) | 2010-03-15 |
| JP2010536723A (ja) | 2010-12-02 |
| CA2695956A1 (en) | 2009-02-19 |
| EP2188276B1 (en) | 2012-03-28 |
| KR101147583B1 (ko) | 2012-05-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |