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MX2009011867A - Nuevos inhibidores macrociclicos de la replicacion del virus de hepatitis c. - Google Patents

Nuevos inhibidores macrociclicos de la replicacion del virus de hepatitis c.

Info

Publication number
MX2009011867A
MX2009011867A MX2009011867A MX2009011867A MX2009011867A MX 2009011867 A MX2009011867 A MX 2009011867A MX 2009011867 A MX2009011867 A MX 2009011867A MX 2009011867 A MX2009011867 A MX 2009011867A MX 2009011867 A MX2009011867 A MX 2009011867A
Authority
MX
Mexico
Prior art keywords
hepatitis
methods
virus replication
novel macrocyclic
macrocyclic inhibitors
Prior art date
Application number
MX2009011867A
Other languages
English (en)
Inventor
Leonid Beigelman
April Kennedy
Steven W Andrews
Pierre Martin
Andreas Schumacher
Robert Kaus
Timothy Kercher
Michael Lyon
Bin Wang
Yutong Jiang
Scott Seiwert
Lawrence M Blatt
Lin Pan
Jyanwei Liu
Kevin CONDROSKI
Original Assignee
Array Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc
Publication of MX2009011867A publication Critical patent/MX2009011867A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Compuestos de fórmula general I, y composiciones, incluyendo composiciones farmacéuticas, que comprenden dicho compuesto. Además, en las modalidades se proporcionan métodos de tratamiento, incluyendo métodos para tratar una infección de virus de hepatitis C y métodos para tratar la fibrosis hepática, donde los métodos generalmente comprenden administrarle a un individuo que lo necesita una cantidad eficaz del compuesto o la composición mencionada.
MX2009011867A 2007-05-03 2008-05-02 Nuevos inhibidores macrociclicos de la replicacion del virus de hepatitis c. MX2009011867A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US91589607P 2007-05-03 2007-05-03
US95763007P 2007-08-23 2007-08-23
US1564407P 2007-12-20 2007-12-20
PCT/US2008/062552 WO2008137779A2 (en) 2007-05-03 2008-05-02 Novel macrocyclic inhibitors of hepatitis c virus replication

Publications (1)

Publication Number Publication Date
MX2009011867A true MX2009011867A (es) 2010-03-22

Family

ID=39638815

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009011867A MX2009011867A (es) 2007-05-03 2008-05-02 Nuevos inhibidores macrociclicos de la replicacion del virus de hepatitis c.

Country Status (22)

Country Link
US (1) US20090155209A1 (es)
EP (2) EP2177523A1 (es)
JP (1) JP2010528987A (es)
KR (1) KR20100024920A (es)
CN (1) CN101784549A (es)
AP (1) AP2009005053A0 (es)
AR (1) AR066448A1 (es)
AU (1) AU2008247509A1 (es)
BR (1) BRPI0811020A2 (es)
CA (1) CA2686138A1 (es)
CL (1) CL2008001274A1 (es)
CO (1) CO6251243A2 (es)
EA (1) EA200971026A1 (es)
EC (1) ECSP099780A (es)
IL (1) IL201757A0 (es)
MA (1) MA31496B1 (es)
MX (1) MX2009011867A (es)
NZ (1) NZ581606A (es)
SG (1) SG174809A1 (es)
TN (1) TN2009000457A1 (es)
TW (1) TW200906830A (es)
WO (1) WO2008137779A2 (es)

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CN101784549A (zh) 2010-07-21
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