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MX2009008921A - Derivados de tiazole en la forma de moduladores de receptores acoplados por proteina g. - Google Patents

Derivados de tiazole en la forma de moduladores de receptores acoplados por proteina g.

Info

Publication number
MX2009008921A
MX2009008921A MX2009008921A MX2009008921A MX2009008921A MX 2009008921 A MX2009008921 A MX 2009008921A MX 2009008921 A MX2009008921 A MX 2009008921A MX 2009008921 A MX2009008921 A MX 2009008921A MX 2009008921 A MX2009008921 A MX 2009008921A
Authority
MX
Mexico
Prior art keywords
protein
modulators
coupled receptors
thiazole derivatives
gpr120
Prior art date
Application number
MX2009008921A
Other languages
English (en)
Inventor
Robert Epple
Mihai Azimioara
Ross Russo
Christopher Cow
Victor Nikulin
Gerald Lelais
Original Assignee
Irm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Irm Llc filed Critical Irm Llc
Publication of MX2009008921A publication Critical patent/MX2009008921A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/04—Antipruritics
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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Abstract

La presente invención proporciona compuestos de la Fórmula (1A) o (1B) y composiciones farmacéuticas de los mismos, las cuales son útiles para modular el receptor 120 acoplado por proteína G (GPR120), y métodos para utilizar los compuestos para tratar, aminorar o prevenir una condición asociada con GPR120 anormal o desregulado.
MX2009008921A 2007-02-22 2008-01-07 Derivados de tiazole en la forma de moduladores de receptores acoplados por proteina g. MX2009008921A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89118407P 2007-02-22 2007-02-22
PCT/US2008/050434 WO2008103500A1 (en) 2007-02-22 2008-01-07 Thiazole derivatives as modulators of g protein-coupled receptors

Publications (1)

Publication Number Publication Date
MX2009008921A true MX2009008921A (es) 2009-08-28

Family

ID=39327203

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009008921A MX2009008921A (es) 2007-02-22 2008-01-07 Derivados de tiazole en la forma de moduladores de receptores acoplados por proteina g.

Country Status (11)

Country Link
US (1) US20100022592A1 (es)
EP (1) EP2121675A1 (es)
JP (1) JP2010519258A (es)
KR (1) KR20090113382A (es)
CN (1) CN101663298A (es)
AU (1) AU2008218950A1 (es)
BR (1) BRPI0807637A2 (es)
CA (1) CA2677705A1 (es)
EA (1) EA200901098A1 (es)
MX (1) MX2009008921A (es)
WO (1) WO2008103500A1 (es)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8299117B2 (en) 2010-06-16 2012-10-30 Metabolex Inc. GPR120 receptor agonists and uses thereof
US8309600B2 (en) 2008-12-18 2012-11-13 Metabolex Inc. GPR120 receptor agonists and uses thereof

Families Citing this family (23)

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AU2008311375A1 (en) * 2007-10-10 2009-04-16 Merck Sharp & Dohme Corp. Diphenyl substituted cycloalkanes
US8362050B2 (en) * 2008-06-24 2013-01-29 Irm Llc Compounds and methods for modulating G protein-coupled receptors
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
US8933024B2 (en) 2010-06-18 2015-01-13 Sanofi Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
CA2878625A1 (en) 2012-07-11 2014-01-16 Elcelyx Therapeutics, Inc. Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk
KR101942752B1 (ko) 2012-11-05 2019-01-28 주식회사 엘지화학 Ｇｐｒ120 효능제로서의 티오아릴 유도체
HUE049425T2 (hu) * 2013-06-27 2020-09-28 Lg Chemical Ltd GPR120 agonista biaril-származékok
WO2015125085A1 (en) 2014-02-19 2015-08-27 Piramal Enterprises Limited Compounds for use as gpr120 agonists
EP3172185B1 (en) 2014-07-25 2020-03-04 Piramal Enterprises Limited Substituted phenyl alkanoic acid compounds as gpr120 agonists and uses thereof
WO2016017826A1 (ja) * 2014-07-30 2016-02-04 帝人ファーマ株式会社 キサンチンオキシダーゼ阻害薬
EP3191463B1 (en) 2014-09-11 2019-10-30 Piramal Enterprises Limited Fused heterocyclic compounds as gpr120 agonists
WO2016105118A2 (ko) * 2014-12-24 2016-06-30 주식회사 엘지생명과학 Gpr120 효능제로서의 바이아릴 유도체
CA2974060C (en) 2015-02-05 2022-08-30 Piramal Enterprises Limited Compounds containing carbon-carbon linker as gpr120 agonists
EP3053920B1 (en) * 2015-02-05 2020-04-08 AB Science Compounds with anti-tumoral activity
KR102537985B1 (ko) * 2016-09-12 2023-05-30 인테그랄 헬스 인코퍼레이티드 Gpr120 조정제로서 유용한 단환형 화합물
GB201704714D0 (en) * 2017-03-24 2017-05-10 Caldan Therapeutics Ltd Pharmaceutical compounds
US11291655B2 (en) * 2017-07-11 2022-04-05 Cyteir Therapeutics, Inc. RAD51 inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ270418A (en) * 1994-02-07 1997-09-22 Eisai Co Ltd Polycyclic triazole & imidazole derivatives, antifungal compositions
US7163952B2 (en) * 2001-12-03 2007-01-16 Japan Tobacco Inc. Azole compound and medicinal use thereof
US7585880B2 (en) * 2003-12-26 2009-09-08 Takeda Pharmaceutical Company Limited Phenylpropanoic acid derivatives
WO2007043400A1 (ja) * 2005-10-07 2007-04-19 Kissei Pharmaceutical Co., Ltd. 含窒素芳香族複素環化合物およびそれを含有する医薬組成物

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8309600B2 (en) 2008-12-18 2012-11-13 Metabolex Inc. GPR120 receptor agonists and uses thereof
US8598374B2 (en) 2008-12-18 2013-12-03 Metabolex, Inc. GPR120 receptor agonists and uses thereof
US8299117B2 (en) 2010-06-16 2012-10-30 Metabolex Inc. GPR120 receptor agonists and uses thereof
US8476308B2 (en) 2010-06-16 2013-07-02 Metabolex, Inc. GPR120 receptor agonists and uses thereof

Also Published As

Publication number Publication date
EA200901098A1 (ru) 2010-04-30
WO2008103500A1 (en) 2008-08-28
CN101663298A (zh) 2010-03-03
AU2008218950A1 (en) 2008-08-28
US20100022592A1 (en) 2010-01-28
BRPI0807637A2 (pt) 2014-06-03
EP2121675A1 (en) 2009-11-25
CA2677705A1 (en) 2008-08-28
JP2010519258A (ja) 2010-06-03
KR20090113382A (ko) 2009-10-30

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