MX2009008779A - Composicion farmacéutica que comprende derivado de pirazina y método para usar el derivado de pirazina en combinación. - Google Patents
Composicion farmacéutica que comprende derivado de pirazina y método para usar el derivado de pirazina en combinación.Info
- Publication number
- MX2009008779A MX2009008779A MX2009008779A MX2009008779A MX2009008779A MX 2009008779 A MX2009008779 A MX 2009008779A MX 2009008779 A MX2009008779 A MX 2009008779A MX 2009008779 A MX2009008779 A MX 2009008779A MX 2009008779 A MX2009008779 A MX 2009008779A
- Authority
- MX
- Mexico
- Prior art keywords
- pyrazine derivative
- pharmaceutical composition
- combination
- treatment
- influenza
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Emergency Medicine (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se divulga una composición farmacéutica que comprende un derivado de pirazina representado por la formula general: [En donde R1 y R2 representan un átomo de hidrogeno o un átomo de halógeno y R3 representa un átomo de hidrogeno o un grupo protector de amino] o una sal del mismo y por lo menos un inhibidor de neuraminidasa. La composición farmacéutica es útil para el tra5tamiento incluyendo el tratamiento o prevención de la influenza. También se divulga un método para usar estos compuestos en combinación. El método es útil para el tratamiento que incluye el tratamiento prevención de la influenza.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007035975 | 2007-02-16 | ||
| PCT/JP2008/052425 WO2008099874A1 (ja) | 2007-02-16 | 2008-02-14 | ピラジン誘導体を含有する医薬組成物およびピラジン誘導体を組み合わせて使用する方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2009008779A true MX2009008779A (es) | 2009-11-05 |
Family
ID=39690101
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2009008779A MX2009008779A (es) | 2007-02-16 | 2008-02-14 | Composicion farmacéutica que comprende derivado de pirazina y método para usar el derivado de pirazina en combinación. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US8759354B2 (es) |
| EP (1) | EP2123276B1 (es) |
| JP (1) | JP5255456B2 (es) |
| KR (1) | KR101479083B1 (es) |
| CN (1) | CN101610772B (es) |
| AU (1) | AU2008215397B2 (es) |
| BR (1) | BRPI0807597B8 (es) |
| CA (1) | CA2677905C (es) |
| CY (1) | CY1113435T1 (es) |
| DK (1) | DK2123276T3 (es) |
| ES (1) | ES2396595T3 (es) |
| HR (1) | HRP20130111T1 (es) |
| IL (1) | IL200285A (es) |
| MX (1) | MX2009008779A (es) |
| NZ (1) | NZ578989A (es) |
| PL (1) | PL2123276T3 (es) |
| PT (1) | PT2123276E (es) |
| RU (1) | RU2463051C2 (es) |
| SI (1) | SI2123276T1 (es) |
| WO (1) | WO2008099874A1 (es) |
| ZA (1) | ZA200905536B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010117114A1 (en) * | 2009-04-09 | 2010-10-14 | Lg Electronics Inc. | Display apparatus |
| AU2011250970B2 (en) * | 2010-05-10 | 2016-12-15 | Sinica, Academia | Zanamivir phosphonate congeners with anti-influenza activity and determining oseltamivir susceptibility of influenza viruses |
| ES2561878T3 (es) | 2010-09-30 | 2016-03-01 | Toyama Chemical Co., Ltd. | Sal de meglumina de 6-fluoro-3-hidroxi-2-pirazinacarboxamida |
| EP2623498B1 (en) | 2010-09-30 | 2015-11-18 | Toyama Chemical Co., Ltd. | Sodium salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide |
| AT510585B1 (de) | 2010-11-18 | 2012-05-15 | Apeptico Forschung & Entwicklung Gmbh | Zusammensetzung umfassend ein peptid und ein hemmstoff der viralen neuraminidase |
| EP2996685B1 (en) * | 2013-05-14 | 2019-03-27 | Biocryst Pharmaceuticals, Inc. | Anti-influenza compositions and methods |
| CN104402833B (zh) * | 2014-11-20 | 2016-08-24 | 广东东阳光药业有限公司 | 含有环丁烷取代基的吡嗪类化合物及其组合物及用途 |
| CN104447585B (zh) * | 2014-11-20 | 2016-08-24 | 广东东阳光药业有限公司 | 吡嗪类化合物及其组合物及用途 |
| CN104447584B (zh) * | 2014-11-20 | 2016-08-24 | 广东东阳光药业有限公司 | 含有环丁烷取代基的吡嗪类化合物及其组合物及用途 |
| CN104447583B (zh) * | 2014-11-20 | 2016-08-24 | 广东东阳光药业有限公司 | 含有环丁烷取代基的吡嗪类化合物及其组合物及用途 |
| CN104496918B (zh) * | 2014-12-10 | 2016-08-24 | 广东东阳光药业有限公司 | 吡嗪衍生物及其用途 |
| CN104817511B (zh) * | 2015-04-27 | 2017-04-19 | 济南大学 | 一种丁烯二酸酐制备法匹拉韦关键中间体的方法 |
| CA3008607A1 (en) * | 2015-12-15 | 2017-06-22 | Shionogi & Co., Ltd. | A medicament for treating influenza characterized by combining a cap-dependent endonuclease inhibitor and an anti-influenza drug |
| WO2020138067A1 (ja) * | 2018-12-25 | 2020-07-02 | 富士フイルム富山化学株式会社 | ピラジン誘導体と細胞内におけるピラジン誘導体リボース三リン酸体の量を増加させる化合物とを組み合わせてなるｒｎａウイルス感染症治療剤 |
| WO2021221043A1 (ja) * | 2020-04-30 | 2021-11-04 | 富士フイルム富山化学株式会社 | ピラジン誘導体と他のコロナウイルス感染症治療薬とを組み合わせてなるコロナウイルス感染症治療剤 |
| US20230201238A1 (en) | 2020-05-27 | 2023-06-29 | Fujifilm Toyama Chemical Co., Ltd. | Therapeutic agent for an rna virus infection comprising a combination of a pyrazine derivative and a thiopurine derivative |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01197437A (ja) * | 1988-01-29 | 1989-08-09 | Dso Pharmachim | 抗ウイルス薬 |
| EP1112743B1 (en) * | 1998-08-20 | 2007-10-24 | Toyama Chemical Co., Ltd. | Nitrogenous heterocyclic carboxamide derivatives or salt thereof as antiviral agents |
| CA2456292A1 (en) | 2001-08-14 | 2003-02-27 | Toyama Chemical Co., Ltd. | Novel virus growth inhibitor and/or virucidal method, and novel pyrazine nucleotide or pirazine nucleoside analog |
| JP2005354833A (ja) * | 2004-06-11 | 2005-12-22 | Fujinon Corp | アクチュエータ |
| JP4689989B2 (ja) * | 2004-08-27 | 2011-06-01 | オリンパス株式会社 | 振動波リニアモータ及びそれを用いたレンズ装置 |
| DE102008031715A1 (de) | 2008-07-04 | 2010-01-07 | Henkel Ag & Co. Kgaa | Haarkonditionierende Mittel mit Imidazolinen |
-
2008
- 2008-02-14 HR HRP20130111AT patent/HRP20130111T1/hr unknown
- 2008-02-14 CA CA2677905A patent/CA2677905C/en active Active
- 2008-02-14 PL PL08711267T patent/PL2123276T3/pl unknown
- 2008-02-14 MX MX2009008779A patent/MX2009008779A/es active IP Right Grant
- 2008-02-14 EP EP08711267A patent/EP2123276B1/en active Active
- 2008-02-14 SI SI200830895T patent/SI2123276T1/sl unknown
- 2008-02-14 NZ NZ578989A patent/NZ578989A/en unknown
- 2008-02-14 US US12/527,260 patent/US8759354B2/en active Active
- 2008-02-14 RU RU2009134516/15A patent/RU2463051C2/ru active
- 2008-02-14 ZA ZA200905536A patent/ZA200905536B/xx unknown
- 2008-02-14 KR KR20097017506A patent/KR101479083B1/ko active Active
- 2008-02-14 DK DK08711267.8T patent/DK2123276T3/da active
- 2008-02-14 CN CN200880005061XA patent/CN101610772B/zh active Active
- 2008-02-14 BR BRPI0807597A patent/BRPI0807597B8/pt active IP Right Grant
- 2008-02-14 PT PT87112678T patent/PT2123276E/pt unknown
- 2008-02-14 ES ES08711267T patent/ES2396595T3/es active Active
- 2008-02-14 JP JP2008558114A patent/JP5255456B2/ja active Active
- 2008-02-14 AU AU2008215397A patent/AU2008215397B2/en active Active
- 2008-02-14 WO PCT/JP2008/052425 patent/WO2008099874A1/ja not_active Ceased
-
2009
- 2009-08-06 IL IL200285A patent/IL200285A/en not_active IP Right Cessation
-
2012
- 2012-12-03 CY CY20121101175T patent/CY1113435T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2008215397A1 (en) | 2008-08-21 |
| CY1113435T1 (el) | 2016-06-22 |
| EP2123276A4 (en) | 2011-05-18 |
| BRPI0807597A2 (pt) | 2014-05-06 |
| IL200285A0 (en) | 2010-04-29 |
| RU2009134516A (ru) | 2011-03-27 |
| KR101479083B1 (ko) | 2015-01-07 |
| US20100087447A1 (en) | 2010-04-08 |
| PL2123276T3 (pl) | 2013-04-30 |
| NZ578989A (en) | 2011-07-29 |
| BRPI0807597B1 (pt) | 2021-03-02 |
| JP5255456B2 (ja) | 2013-08-07 |
| PT2123276E (pt) | 2013-01-16 |
| BRPI0807597B8 (pt) | 2021-05-25 |
| WO2008099874A1 (ja) | 2008-08-21 |
| ES2396595T3 (es) | 2013-02-22 |
| SI2123276T1 (sl) | 2013-03-29 |
| JPWO2008099874A1 (ja) | 2010-05-27 |
| US8759354B2 (en) | 2014-06-24 |
| CA2677905C (en) | 2015-03-24 |
| ZA200905536B (en) | 2010-10-27 |
| EP2123276A1 (en) | 2009-11-25 |
| DK2123276T3 (da) | 2013-01-02 |
| HRP20130111T1 (hr) | 2013-02-28 |
| RU2463051C2 (ru) | 2012-10-10 |
| IL200285A (en) | 2014-06-30 |
| EP2123276B1 (en) | 2012-11-28 |
| AU2008215397B2 (en) | 2012-09-06 |
| CN101610772B (zh) | 2013-01-16 |
| KR20090121289A (ko) | 2009-11-25 |
| CN101610772A (zh) | 2009-12-23 |
| CA2677905A1 (en) | 2008-08-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |