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WO2009069764A1 - オピオイド鎮痛剤 - Google Patents

オピオイド鎮痛剤 Download PDF

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Publication number
WO2009069764A1
WO2009069764A1 PCT/JP2008/071689 JP2008071689W WO2009069764A1 WO 2009069764 A1 WO2009069764 A1 WO 2009069764A1 JP 2008071689 W JP2008071689 W JP 2008071689W WO 2009069764 A1 WO2009069764 A1 WO 2009069764A1
Authority
WO
WIPO (PCT)
Prior art keywords
compound
analgesic
analgesic agent
opioid analgesic
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/071689
Other languages
English (en)
French (fr)
Inventor
Hiromitsu Takayama
Mariko Kitajima
Syunji Horie
Kenjiro Matsumoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chiba University NUC
JOSAI UNIV CORP
Original Assignee
Chiba University NUC
JOSAI UNIV CORP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiba University NUC, JOSAI UNIV CORP filed Critical Chiba University NUC
Priority to JP2009543879A priority Critical patent/JP5308352B2/ja
Publication of WO2009069764A1 publication Critical patent/WO2009069764A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

【課題】鎮痛作用を有する化合物、該化合物を含有する医薬組成物および鎮痛剤、該化合物を使用する鎮痛処置方法、該化合物の鎮痛処置における使用を提供すること。 【解決手段】下式（I）： ［式中、R1 は水素原子またはハロゲン原子；R2、R3、R4 およびR5 は、独立して、水素原子、ヒドロキシ基、置換基を有していてもよいアルコキシ基等；R6 は、置換基を有していてもよいアルコキシカルボニル基またはカルボキシ基である］で表される化合物またはその塩。
PCT/JP2008/071689 2007-11-30 2008-11-28 オピオイド鎮痛剤 Ceased WO2009069764A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009543879A JP5308352B2 (ja) 2007-11-30 2008-11-28 オピオイド鎮痛剤

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-310939 2007-11-30
JP2007310939 2007-11-30

Publications (1)

Publication Number Publication Date
WO2009069764A1 true WO2009069764A1 (ja) 2009-06-04

Family

ID=40678653

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/071689 Ceased WO2009069764A1 (ja) 2007-11-30 2008-11-28 オピオイド鎮痛剤

Country Status (2)

Country Link
JP (1) JP5308352B2 (ja)
WO (1) WO2009069764A1 (ja)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013543378A (ja) * 2010-10-01 2013-12-05 エヌエスジーン・アクティーゼルスカブ アロディニア、痛覚過敏、自発痛及び幻肢痛の処置
CN103588669A (zh) * 2013-10-28 2014-02-19 史克勇 一种具有缓解癌性疼痛活性的化合物
CN104016879A (zh) * 2014-05-30 2014-09-03 西安交通大学 具有抗肿瘤活性的联苯酰胺化合物及其制备方法和应用
WO2015064573A1 (ja) * 2013-10-29 2015-05-07 国立大学法人 千葉大学 オピオイド鎮痛剤
JP7791620B1 (ja) * 2025-08-05 2025-12-24 国立大学法人千葉大学 化合物、鎮痛剤及び医薬組成物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09291091A (ja) * 1996-04-25 1997-11-11 Soyaku Gijutsu Kenkyusho:Kk インドールアルカロイド誘導体、その製造方法及び抗ウイルス剤
US8247428B2 (en) * 2007-11-08 2012-08-21 National University Corporation Chiba University Indole alkaloid derivatives having opioid receptor agonistic effect, and therapeutic compositions and methods relating to same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HERLEM,D. ET AL.: "Photochemical oxidation of tertiary amines and alkaloids.XI. Sensitized photooxidation of corynantheidine. Transformation of corynantheine-type derivatives into sarpagine-type derivatives", TETRAHEDRON, vol. 38, no. 2, 1982, pages 271 - 278 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013543378A (ja) * 2010-10-01 2013-12-05 エヌエスジーン・アクティーゼルスカブ アロディニア、痛覚過敏、自発痛及び幻肢痛の処置
CN103588669A (zh) * 2013-10-28 2014-02-19 史克勇 一种具有缓解癌性疼痛活性的化合物
WO2015064573A1 (ja) * 2013-10-29 2015-05-07 国立大学法人 千葉大学 オピオイド鎮痛剤
JPWO2015064573A1 (ja) * 2013-10-29 2017-03-09 国立大学法人 千葉大学 オピオイド鎮痛剤
CN104016879A (zh) * 2014-05-30 2014-09-03 西安交通大学 具有抗肿瘤活性的联苯酰胺化合物及其制备方法和应用
CN104016879B (zh) * 2014-05-30 2016-02-24 西安交通大学 具有抗肿瘤活性的联苯酰胺化合物及其制备方法和应用
JP7791620B1 (ja) * 2025-08-05 2025-12-24 国立大学法人千葉大学 化合物、鎮痛剤及び医薬組成物

Also Published As

Publication number Publication date
JPWO2009069764A1 (ja) 2011-04-21
JP5308352B2 (ja) 2013-10-09

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