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UA83875C2 - Производные хинолина для применения в качестве микобактериальных ингибиторов - Google Patents

Производные хинолина для применения в качестве микобактериальных ингибиторов

Info

Publication number
UA83875C2
UA83875C2 UAA200605776A UAA200605776A UA83875C2 UA 83875 C2 UA83875 C2 UA 83875C2 UA A200605776 A UAA200605776 A UA A200605776A UA A200605776 A UAA200605776 A UA A200605776A UA 83875 C2 UA83875 C2 UA 83875C2
Authority
UA
Ukraine
Prior art keywords
quinoline derivatives
mycobacterial
mycobacterial inhibitors
inhibitors
useful
Prior art date
Application number
UAA200605776A
Other languages
English (en)
Ukrainian (uk)
Inventor
Жером Эмиль Жорж Жильмон
Элизабет Тереза Жанна Паскье
Давид Франсис Ален Ланкуа
Original Assignee
Янссен Фармацевтика Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармацевтика Н.В. filed Critical Янссен Фармацевтика Н.В.
Publication of UA83875C2 publication Critical patent/UA83875C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

Данное изобретение касается новых замещенных производных хинолина формулы (І), пригодных для лечения микобактериальных заболеваний, таких как ТБ.
UAA200605776A 2004-01-29 2005-01-28 Производные хинолина для применения в качестве микобактериальных ингибиторов UA83875C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04075286 2004-01-29
PCT/EP2005/050375 WO2005075428A1 (en) 2004-01-29 2005-01-28 Quinoline derivatives for use as mycobacterial inhibitors

Publications (1)

Publication Number Publication Date
UA83875C2 true UA83875C2 (ru) 2008-08-26

Family

ID=34833674

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200605776A UA83875C2 (ru) 2004-01-29 2005-01-28 Производные хинолина для применения в качестве микобактериальных ингибиторов

Country Status (20)

Country Link
US (1) US7790894B2 (ru)
EP (1) EP1713776B1 (ru)
JP (1) JP4919810B2 (ru)
KR (1) KR101160183B1 (ru)
CN (1) CN1910154B (ru)
AP (1) AP2321A (ru)
AT (1) ATE395336T1 (ru)
AU (1) AU2005210036B2 (ru)
BR (1) BRPI0507312A (ru)
CA (1) CA2554049C (ru)
DE (1) DE602005006744D1 (ru)
EA (1) EA011572B9 (ru)
ES (1) ES2306098T3 (ru)
IL (1) IL177101A (ru)
MX (1) MXPA06008596A (ru)
NO (1) NO337253B1 (ru)
NZ (1) NZ547614A (ru)
UA (1) UA83875C2 (ru)
WO (1) WO2005075428A1 (ru)
ZA (1) ZA200606291B (ru)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2855B1 (en) * 2005-08-03 2015-03-15 شركة جانسين فارماسوتيكا ان. في Quinoline derivatives acting as antibacterial agents
JO2970B1 (en) 2006-12-06 2016-03-15 جانسين فارماسوتيكا ان. في Quinoline antibacterial derivatives
JO2683B1 (en) * 2006-12-06 2013-03-03 جانسين فارماسوتيكا ان. في Quinoline antibacterial derivatives
JO2684B1 (en) * 2006-12-06 2013-03-03 جانسين فارماسوتيكا ان في Quinoline antibacterial derivatives
JO3271B1 (ar) 2006-12-06 2018-09-16 Janssen Pharmaceutica Nv مشتقات الكوينولين المضادة للجراثيم
JO2685B1 (en) * 2006-12-06 2013-03-03 جانسين فارماسوتيكا ان في Quinoline antibacterial derivatives
EP2387564A1 (en) 2009-01-15 2011-11-23 Rutgers, The State University of New Jersey Benzo ýc¨phenanthridines as antimicrobial agents
CA2760526A1 (en) 2009-04-30 2010-11-04 Rutgers, The State University Of New Jersey Antimicrobial agents
CA2810162A1 (en) 2010-06-09 2011-12-15 Rutgers, The State University Of New Jersey Antimicrobial agents
US9102617B2 (en) 2010-06-25 2015-08-11 Rutgers, The State University Of New Jersey Antimicrobial agents
RU2486175C2 (ru) * 2011-09-12 2013-06-27 Закрытое Акционерное Общество "Фарм-Синтез" Производные хинолина, в частности 5,6,7-замещенные 1-(2-хлорхинолин-3-ил)-4-диметиламино-2-(нафталин-1-ил)-1-фенилбутан-2-олы, способ получения и применение соединений
US9822108B2 (en) 2012-01-13 2017-11-21 Rutgers, The State University Of New Jersey Antimicrobial agents
WO2013142712A1 (en) 2012-03-21 2013-09-26 Rutgers, The State University Of New Jersey Antimicrobial agents
ES2576491T3 (es) 2012-04-27 2016-07-07 Janssen Pharmaceutica, N.V. Derivados de quinolina antibacterianos
US9617244B2 (en) 2012-04-27 2017-04-11 Janssen Pharmaceutica Nv Antibacterial quinoline derivatives
AU2013331496B2 (en) 2012-10-16 2017-07-27 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of ROR-gamma-t
CA2888485C (en) 2012-10-16 2021-01-26 Janssen Pharmaceutica Nv Phenyl linked quinolinyl modulators of ror.gamma.t
BR112015008515A2 (pt) 2012-10-16 2017-07-04 Janssen Pharmaceutica Nv moduladores de ror t de quinolinila ligada à heteroarila
US9403816B2 (en) 2013-10-15 2016-08-02 Janssen Pharmaceutica Nv Phenyl linked quinolinyl modulators of RORγt
US9221804B2 (en) 2013-10-15 2015-12-29 Janssen Pharmaceutica Nv Secondary alcohol quinolinyl modulators of RORγt
EP3057422B1 (en) * 2013-10-15 2019-05-15 Janssen Pharmaceutica NV Quinolinyl modulators of ror(gamma)t
US10555941B2 (en) 2013-10-15 2020-02-11 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of RORγt
US9284308B2 (en) 2013-10-15 2016-03-15 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of RORγt
US9328095B2 (en) 2013-10-15 2016-05-03 Janssen Pharmaceutica Nv Heteroaryl linked quinolinyl modulators of RORgammat
JP6423423B2 (ja) 2013-10-15 2018-11-14 ヤンセン ファーマシューティカ エヌ．ベー． Ｒｏｒγｔのアルキル結合キノリニルモジュレーター
US9458150B2 (en) 2013-11-08 2016-10-04 Rutgers, The State University Of New Jersey Antimicrobial agents
JP2019507801A (ja) 2016-02-25 2019-03-22 タクシス ファーマシューティカルズ， インコーポレイテッド 合成プロセス及び中間体
US10774093B2 (en) 2017-03-30 2020-09-15 Taxis Pharmaceuticals, Inc. Synthetic processes and synthetic intermediates

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998018326A1 (en) * 1996-10-28 1998-05-07 Department Of The Army, U.S. Government Compounds, compositions and methods for treating antibiotic-resistant infections
US6103905A (en) 1997-06-19 2000-08-15 Sepracor, Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
US6172084B1 (en) * 1997-06-19 2001-01-09 Sepracor, Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
AU2717899A (en) * 1998-01-26 1999-08-09 Smithkline Beecham Plc Quinoline derivatives as antibacterials
BRPI0312927B8 (pt) * 2002-07-25 2021-05-25 Janssen Pharmaceutica Nv "compostos, derivados de quinolina, composição, seu uso como inibidores micobacteriais, bem como processo para preparação dos referidos derivados".
EP1711492B1 (en) * 2004-01-23 2008-04-16 Janssen Pharmaceutica N.V. Substituted quinolines and their use as mycobacterial inhibitors

Also Published As

Publication number Publication date
NO337253B1 (no) 2016-02-22
HK1099297A1 (en) 2007-08-10
DE602005006744D1 (de) 2008-06-26
ZA200606291B (en) 2008-02-27
US20070299106A1 (en) 2007-12-27
AU2005210036B2 (en) 2010-12-23
ES2306098T3 (es) 2008-11-01
NO20063821L (no) 2006-08-28
US7790894B2 (en) 2010-09-07
KR20070004597A (ko) 2007-01-09
AU2005210036A1 (en) 2005-08-18
BRPI0507312A (pt) 2007-06-26
IL177101A0 (en) 2006-12-10
EP1713776A1 (en) 2006-10-25
JP2007519687A (ja) 2007-07-19
WO2005075428A1 (en) 2005-08-18
ATE395336T1 (de) 2008-05-15
NZ547614A (en) 2009-04-30
MXPA06008596A (es) 2006-08-28
EA011572B1 (ru) 2009-04-28
CA2554049A1 (en) 2005-08-18
CN1910154A (zh) 2007-02-07
IL177101A (en) 2012-01-31
EA011572B9 (ru) 2018-01-31
EP1713776B1 (en) 2008-05-14
JP4919810B2 (ja) 2012-04-18
EA200601391A1 (ru) 2006-12-29
CN1910154B (zh) 2011-08-17
AP2006003705A0 (en) 2006-08-31
KR101160183B1 (ko) 2012-06-26
AP2321A (en) 2011-11-16
CA2554049C (en) 2012-12-18

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