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MX2009008559A - Hepatocitos y condorcitos de celulas madre de la placenta adherentes, y poblaciones de celulas enriquecidas con celulas madre de la placenta cd34+, cd45-. - Google Patents

Hepatocitos y condorcitos de celulas madre de la placenta adherentes, y poblaciones de celulas enriquecidas con celulas madre de la placenta cd34+, cd45-.

Info

Publication number
MX2009008559A
MX2009008559A MX2009008559A MX2009008559A MX2009008559A MX 2009008559 A MX2009008559 A MX 2009008559A MX 2009008559 A MX2009008559 A MX 2009008559A MX 2009008559 A MX2009008559 A MX 2009008559A MX 2009008559 A MX2009008559 A MX 2009008559A
Authority
MX
Mexico
Prior art keywords
placental stem
hepatocytes
stem cells
chondrocytes
cell
Prior art date
Application number
MX2009008559A
Other languages
English (en)
Inventor
Robert J Hariri
Qian Ye
Jia-Lun Wang
James W Edinger
Sascha Dawn Abramson
Kristen S Labazzo
Marian Pereira
Original Assignee
Anthrogenesis Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anthrogenesis Corp filed Critical Anthrogenesis Corp
Publication of MX2009008559A publication Critical patent/MX2009008559A/es

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Abstract

En la presente se proveen métodos y composiciones para la producción de hepatocitos de células madre de la placenta. Además en la presente se provee el uso de los hepatocitos en el tratamiento de, e intervención en, por ejemplo, trauma, inflamación y trastornos degenerativos del hígado. También en la presente se proveen composiciones y métodos que se refieren a combinación se estratos nanofibrosos y células madre de la placenta adherentes y métodos para usar los mismos en reparación de cartílagos. Finalmente, en la presente se proveen composiciones y métodos que se refieren a células madre CD34+ CD45- no adherentes.
MX2009008559A 2007-02-12 2008-02-12 Hepatocitos y condorcitos de celulas madre de la placenta adherentes, y poblaciones de celulas enriquecidas con celulas madre de la placenta cd34+, cd45-. MX2009008559A (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US90107607P 2007-02-12 2007-02-12
US90106607P 2007-02-12 2007-02-12
US90566407P 2007-03-07 2007-03-07
US90606407P 2007-03-08 2007-03-08
US96657707P 2007-08-28 2007-08-28
PCT/US2008/001830 WO2008100497A1 (en) 2007-02-12 2008-02-12 Hepatocytes and chondrocytes from adherent placental stem cells; and cd34+, cd45- placental stem cell-enriched cell populations

Publications (1)

Publication Number Publication Date
MX2009008559A true MX2009008559A (es) 2009-08-21

Family

ID=39363987

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Application Number Title Priority Date Filing Date
MX2009008559A MX2009008559A (es) 2007-02-12 2008-02-12 Hepatocitos y condorcitos de celulas madre de la placenta adherentes, y poblaciones de celulas enriquecidas con celulas madre de la placenta cd34+, cd45-.

Country Status (11)

Country Link
US (2) US10494607B2 (es)
EP (1) EP2129775A1 (es)
JP (1) JP2010518812A (es)
KR (1) KR20090109127A (es)
CN (1) CN101688177A (es)
AU (1) AU2008216748A1 (es)
CA (1) CA2677679A1 (es)
IL (1) IL200336A0 (es)
MX (1) MX2009008559A (es)
WO (1) WO2008100497A1 (es)
ZA (2) ZA200905374B (es)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7311905B2 (en) * 2002-02-13 2007-12-25 Anthrogenesis Corporation Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells
EP2206772A3 (en) 2000-12-06 2010-08-04 Robert J. Hariri Method of collecting placental stem cells
WO2002063962A1 (en) 2001-02-14 2002-08-22 Hariri Robert J Renovation and repopulation of decellularized tissues and cadaveric organs by stem cells
US7700090B2 (en) * 2002-02-13 2010-04-20 Anthrogenesis Corporation Co-culture of placental stem cells and stem cells from a second source
US7498171B2 (en) * 2002-04-12 2009-03-03 Anthrogenesis Corporation Modulation of stem and progenitor cell differentiation, assays, and uses thereof
CN1717177A (zh) * 2002-11-26 2006-01-04 人类起源公司 细胞治疗剂、细胞治疗单元及其用于治疗的方法
CN1961283A (zh) * 2004-03-26 2007-05-09 细胞基因公司 建立干细胞库的系统和方法
CA2624916A1 (en) * 2005-10-13 2007-04-26 Anthrogenesis Corporation Production of oligodendrocytes from placenta-derived stem cells
AU2006304277B2 (en) * 2005-10-13 2012-07-05 Celularity Inc. Immunomodulation using placental stem cells
KR101900809B1 (ko) 2005-12-29 2018-09-20 안트로제네시스 코포레이션 태반 줄기 세포 집단
KR20080097190A (ko) 2005-12-29 2008-11-04 안트로제네시스 코포레이션 태반 줄기세포의 수집과 보존을 위한 개선된 조성물과 이조성물의 이용 방법
US7993918B2 (en) 2006-08-04 2011-08-09 Anthrogenesis Corporation Tumor suppression using placental stem cells
EP3483263A1 (en) 2006-10-23 2019-05-15 Celularity, Inc. Methods and compositions for treatment of bone defects with placental cell populations
EP2687220A3 (en) 2007-02-12 2014-05-14 Anthrogenesis Corporation Treatment of inflammatory diseases using placental stem cells
CA2677679A1 (en) 2007-02-12 2008-08-21 Anthrogenesis Corporation Hepatocytes and chondrocytes from adherent placental stem cells; and cd34+, cd45- placental stem cell-enriched cell populations
WO2008157594A2 (en) 2007-06-18 2008-12-24 New Jersey Institute Of Technology Electrospun ceramic-polymer composite as a scaffold for tissue repair
US9200253B1 (en) 2007-08-06 2015-12-01 Anthrogenesis Corporation Method of producing erythrocytes
KR101644659B1 (ko) * 2007-09-26 2016-08-01 안트로제네시스 코포레이션 인간 태반 관류액으로부터의 혈관형성 세포
KR20230065354A (ko) 2007-09-28 2023-05-11 셀룰래리티 인코포레이티드 인간 태반 관류액 및 인간 태반-유래 중간체 천연 킬러 세포를 사용한 종양 억제 방법
US8431162B2 (en) * 2007-10-30 2013-04-30 University Of Louisville Research Foundation, Inc. Subpopulations of bone marrow-derived adherent stem cells and methods of use therefor
US20090325296A1 (en) * 2008-03-25 2009-12-31 New Jersey Institute Of Technology Electrospun electroactive polymers for regenerative medicine applications
EP3539380A3 (en) 2008-08-20 2019-12-18 Celularity, Inc. Improved cell composition and methods of making the same
JP5950577B2 (ja) 2008-08-20 2016-07-13 アンスロジェネシス コーポレーション 単離胎盤細胞を使用した脳卒中の治療
ES2426241T3 (es) * 2008-08-22 2013-10-22 Anthrogenesis Corporation Métodos y composiciones para el tratamiento de defectos óseos con poblaciones de células placentarias
US8008075B2 (en) 2008-11-04 2011-08-30 Viacyte, Inc. Stem cell aggregate suspension compositions and methods of differentiation thereof
US8895300B2 (en) 2008-11-04 2014-11-25 Viacyte, Inc. Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof
CA2907326A1 (en) * 2008-11-04 2010-05-14 Chad Green Stem cell aggregate suspension compositions and methods for differentiation thereof
CN103540566A (zh) * 2008-11-14 2014-01-29 路易斯维尔大学研究基金会有限公司 用于长期造血种群恢复的方法和组合物
WO2010059828A1 (en) 2008-11-19 2010-05-27 Anthrogenesis Corporation Amnion derived adherent cells
US9771557B2 (en) 2009-03-12 2017-09-26 New Jersey Institute Of Technology Piezoelectric scaffold for nerve growth and repair
US9334476B2 (en) * 2009-03-12 2016-05-10 New Jersey Institute Of Technology Method for nerve growth and repair using a piezoelectric scaffold
US9192655B2 (en) 2009-03-12 2015-11-24 New Jersey Institute Of Technology System and method for a hydrogel and hydrogel composite for cartilage repair applications
US9476026B2 (en) 2009-03-12 2016-10-25 New Jersey Institute Of Technology Method of tissue repair using a piezoelectric scaffold
WO2010151782A1 (en) * 2009-06-25 2010-12-29 Geron Corporation Differentiated pluripotent stem cell progeny depleted of extraneous phenotypes
MX353489B (es) 2009-07-02 2018-01-16 Anthrogenesis Corp Metodo para producir eritrocitos sin celulas alimentadoras.
AU2011209819A1 (en) 2010-01-26 2012-08-16 Anthrogenesis Corporation Treatment of bone-related cancers using placental stem cells
US9180166B2 (en) 2010-03-12 2015-11-10 New Jersey Institute Of Technology Cartilage repair systems and applications utilizing a glycosaminoglycan mimic
TW202011974A (zh) * 2010-04-07 2020-04-01 美商安瑟吉納西斯公司 利用胎盤幹細胞之血管新生
JP2013523823A (ja) 2010-04-08 2013-06-17 アントフロゲネシス コーポレーション 胎盤幹細胞を用いるサルコイドーシスの治療
US8883210B1 (en) 2010-05-14 2014-11-11 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US20120020931A1 (en) * 2010-06-02 2012-01-26 Rutgers, The State University Of New Jersey Therapeutic encapsulated embryonic stem cells and mesenchymal stromal cells
AU2011279201B2 (en) 2010-07-13 2016-01-21 Celularity Inc. Methods of generating natural killer cells
WO2012054501A1 (en) 2010-10-18 2012-04-26 Sunshine Biotech Inc. Human multipotent embryonic stem cell-like progenitor cells
CN102028970A (zh) * 2010-12-27 2011-04-27 协和干细胞基因工程有限公司 一种用于治疗肝硬化的干细胞制剂
AR084752A1 (es) * 2010-12-30 2013-06-05 Anthrogenesis Corp Metodos para crioconservar y encapsular celulas
AR093183A1 (es) 2010-12-31 2015-05-27 Anthrogenesis Corp Aumento de la potencia de celulas madre de placenta usando moleculas de arn moduladoras
EP2696806B1 (en) 2011-04-13 2017-12-27 New Jersey Institute of Technology System and method for electrospun biodegradable scaffold for bone repair
KR101637895B1 (ko) * 2011-05-13 2016-07-11 고려대학교 산학협력단 B 세포 분리를 위한 특이적 결합분자-나노섬유 복합체 및 그를 이용한 분리 방법
AU2012262273B2 (en) 2011-06-01 2017-09-14 Celularity Inc. Treatment of pain using placental stem cells
WO2013055476A1 (en) 2011-09-09 2013-04-18 Anthrogenesis Corporation Treatment of amyotrophic lateral sclerosis using placental stem cells
TWI571513B (zh) * 2011-09-28 2017-02-21 幹細胞生物科技股份有限公司 體幹細胞及其製備方法
GB201119335D0 (en) * 2011-11-09 2011-12-21 Univ Leuven Kath Hepatitis virus infectable stem cells
WO2013082417A1 (en) * 2011-11-30 2013-06-06 Anthrogenesis Corporation Treatment using placental stem cells
GB201202138D0 (en) * 2012-02-07 2012-03-21 Electrospinning Company The Ltd Multi-well plate
TWI615614B (zh) * 2012-03-18 2018-02-21 國立大學法人九州大學 疾病樣本分析裝置、分析系統及分析方法
CN104797264A (zh) * 2012-10-09 2015-07-22 桑比欧公司 用于治疗视网膜变性的方法和组合物
US9155763B2 (en) 2012-12-06 2015-10-13 StemBios Technologies, Inc. Lgr5+ somatic stem cells
US9763983B2 (en) 2013-02-05 2017-09-19 Anthrogenesis Corporation Natural killer cells from placenta
EP2970914B1 (en) * 2013-03-13 2019-07-03 The University of Queensland A method of isolating cells for therapy and prophylaxis
MX2016006270A (es) * 2013-11-15 2016-09-07 Anthrogenesis Corp Composiciones que comprenden células perfundidas de placenta humana, subpoblaciones de las mismas y sus usos.
GB201406716D0 (en) * 2014-04-15 2014-05-28 Insphero Ag Method of preparing cells for 3D tissue culture
JP6619353B2 (ja) 2014-10-31 2019-12-11 国立大学法人東京農工大学 細胞単離方法及び細胞捕捉フィルタ
CN113521107A (zh) * 2014-11-19 2021-10-22 干细胞生物科技公司 用于治疗骨骼缺损的体干细胞
CN114923837B (zh) 2015-02-09 2025-09-19 弹弓生物科学公司 具有可调光学性质的水凝胶颗粒以及使用其的方法
CA2986702C (en) 2015-05-21 2023-04-04 David Wang Modified demineralized cortical bone fibers
JP2018520211A (ja) * 2015-05-28 2018-07-26 セルラリティ インコーポレイテッド 再生機関を回復させる、プロテオームの欠陥を補正する、寿命を延長するための、胎盤由来幹細胞およびその使用
WO2017039251A1 (ko) * 2015-08-28 2017-03-09 주식회사 차바이오텍 향상된 산후 부착형 세포 및 그의 용도
US11312940B2 (en) 2015-08-31 2022-04-26 University Of Louisville Research Foundation, Inc. Progenitor cells and methods for preparing and using the same
WO2017152073A1 (en) 2016-03-04 2017-09-08 University Of Louisville Research Foundation, Inc. Methods and compositions for ex vivo expansion of very small embryonic-like stem cells (vsels)
US20190224244A1 (en) * 2016-07-11 2019-07-25 Bonus Therapeutics Ltd. Cell compositions for tissue regeneration
WO2018093069A1 (ko) * 2016-11-15 2018-05-24 광주과학기술원 세포 3d 배양 방법
CN108721707B (zh) * 2017-04-25 2021-04-09 北京纳米能源与系统研究所 可降解导线及其制备方法
KR101952762B1 (ko) * 2017-05-08 2019-02-27 강원대학교산학협력단 알긴산과 콜라겐의 조합으로 생성된 줄기세포를 캡슐화하는 미세캡슐 조성물 및 그 제조방법
EP3877508A1 (en) * 2018-11-08 2021-09-15 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Anchorage-independent cells and use thereof
US20220305176A1 (en) * 2019-08-30 2022-09-29 Northwestern University Biodegradable soft elastomers for regenerative engineering
KR102141641B1 (ko) * 2020-01-31 2020-08-06 주식회사 래디안 인간지방 유래 중간엽 줄기세포로부터 모유두세포로의 분화방법
KR102307115B1 (ko) * 2021-05-12 2021-10-01 주식회사 스마트셀랩 시프로플록사신에 의한 줄기세포의 연골전구세포로의 유도 및 연골세포로의 분화
AU2023265684A1 (en) 2022-05-05 2024-11-21 Slingshot Biosciences, Inc. Engineered particles as red blood cell mimics and compositions containing same for hematology
WO2024254494A2 (en) * 2023-06-09 2024-12-12 Kanzo Biomedicines, Inc. Liver support systems and methods of use
US12461007B2 (en) 2023-08-29 2025-11-04 Slingshot Biosciences, Inc. CD34 stem cell mimics

Family Cites Families (167)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3862002A (en) * 1962-05-08 1975-01-21 Sanfar Lab Inc Production of physiologically active placental substances
US4829000A (en) * 1985-08-30 1989-05-09 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Reconstituted basement membrane complex with biological activity
US4798824A (en) * 1985-10-03 1989-01-17 Wisconsin Alumni Research Foundation Perfusate for the preservation of organs
US5192553A (en) 1987-11-12 1993-03-09 Biocyte Corporation Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood and methods of therapeutic use
US5004681B1 (en) * 1987-11-12 2000-04-11 Biocyte Corp Preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood
GB8803697D0 (en) 1988-02-17 1988-03-16 Deltanine Research Ltd Clinical developments using amniotic membrane cells
US5635386A (en) * 1989-06-15 1997-06-03 The Regents Of The University Of Michigan Methods for regulating the specific lineages of cells produced in a human hematopoietic cell culture
US5763266A (en) * 1989-06-15 1998-06-09 The Regents Of The University Of Michigan Methods, compositions and devices for maintaining and growing human stem and/or hematopoietics cells
US5399493A (en) 1989-06-15 1995-03-21 The Regents Of The University Of Michigan Methods and compositions for the optimization of human hematopoietic progenitor cell cultures
US5437994A (en) 1989-06-15 1995-08-01 Regents Of The University Of Michigan Method for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells
US5605822A (en) * 1989-06-15 1997-02-25 The Regents Of The University Of Michigan Methods, compositions and devices for growing human hematopoietic cells
US5464764A (en) * 1989-08-22 1995-11-07 University Of Utah Research Foundation Positive-negative selection methods and vectors
US5272071A (en) 1989-12-22 1993-12-21 Applied Research Systems Ars Holding N.V. Method for the modification of the expression characteristics of an endogenous gene of a given cell line
US5061620A (en) * 1990-03-30 1991-10-29 Systemix, Inc. Human hematopoietic stem cell
US5635387A (en) * 1990-04-23 1997-06-03 Cellpro, Inc. Methods and device for culturing human hematopoietic cells and their precursors
US5837539A (en) 1990-11-16 1998-11-17 Osiris Therapeutics, Inc. Monoclonal antibodies for human mesenchymal stem cells
US5226914A (en) * 1990-11-16 1993-07-13 Caplan Arnold I Method for treating connective tissue disorders
US5733542A (en) * 1990-11-16 1998-03-31 Haynesworth; Stephen E. Enhancing bone marrow engraftment using MSCS
US5486359A (en) * 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5197985A (en) * 1990-11-16 1993-03-30 Caplan Arnold I Method for enhancing the implantation and differentiation of marrow-derived mesenchymal cells
US5811094A (en) 1990-11-16 1998-09-22 Osiris Therapeutics, Inc. Connective tissue regeneration using human mesenchymal stem cell preparations
US5190556A (en) * 1991-03-19 1993-03-02 O.B. Tech, Inc. Cord cutter sampler
US5744361A (en) * 1991-04-09 1998-04-28 Indiana University Expansion of human hematopoietic progenitor cells in a liquid medium
US5750376A (en) * 1991-07-08 1998-05-12 Neurospheres Holdings Ltd. In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny
WO1993003139A1 (fr) 1991-08-08 1993-02-18 Kao Corporation Support pour la culture de cellules, production de ce support et production d'un amas de cellules au moyen de ce support
EP0529751A1 (en) 1991-08-09 1993-03-03 W.R. Grace & Co.-Conn. Cell culture substrate, test material for cell culture and preparations thereof
EP0590156A4 (en) 1992-03-31 1994-07-13 Toray Industries Novel, physiologically active protein and hemopoietic stem cell growth promoter
US5552267A (en) 1992-04-03 1996-09-03 The Trustees Of Columbia University In The City Of New York Solution for prolonged organ preservation
US5460964A (en) 1992-04-03 1995-10-24 Regents Of The University Of Minnesota Method for culturing hematopoietic cells
AU4543193A (en) 1992-06-22 1994-01-24 Henry E. Young Scar inhibitory factor and use thereof
US5672346A (en) 1992-07-27 1997-09-30 Indiana University Foundation Human stem cell compositions and methods
US5849553A (en) 1992-07-27 1998-12-15 California Institute Of Technology Mammalian multipotent neural stem cells
WO1994011493A1 (en) 1992-11-16 1994-05-26 Applied Immune Sciences, Inc. Pluripotential quiescent stem cell population
US5654186A (en) 1993-02-26 1997-08-05 The Picower Institute For Medical Research Blood-borne mesenchymal cells
US5709854A (en) * 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
US5698579A (en) 1993-07-02 1997-12-16 Celgene Corporation Cyclic amides
US5372581A (en) 1993-07-21 1994-12-13 Minneapolis Children's Services Corporation Method and apparatus for placental blood collection
IL107483A0 (en) 1993-11-03 1994-02-27 Yeda Res & Dev Bone marrow transplantation
US5591625A (en) * 1993-11-24 1997-01-07 Case Western Reserve University Transduced mesenchymal stem cells
DE69532976T2 (de) * 1994-03-14 2005-05-04 Cryolife, Inc. Herstellungsverfahren von gewebe zur implantation
DE4422667A1 (de) * 1994-06-30 1996-01-04 Boehringer Ingelheim Int Verfahren zur Herstellung und Züchtung hämatopoetischer Vorläuferzellen
US6103522A (en) * 1994-07-20 2000-08-15 Fred Hutchinson Cancer Research Center Human marrow stromal cell lines which sustain hematopoiesis
US5516532A (en) * 1994-08-05 1996-05-14 Children's Medical Center Corporation Injectable non-immunogenic cartilage and bone preparation
US5827742A (en) 1994-09-01 1998-10-27 Beth Israel Deaconess Medical Center, Inc. Method of selecting pluripotent hematopioetic progenitor cells
US5665557A (en) 1994-11-14 1997-09-09 Systemix, Inc. Method of purifying a population of cells enriched for hematopoietic stem cells populations of cells obtained thereby and methods of use thereof
WO1996015230A2 (en) * 1994-11-16 1996-05-23 Amgen Inc. Use of stem cell factor and soluble interleukin-6 receptor for the ex vivo expansion of hematopoietic multipotential cells
US5874301A (en) * 1994-11-21 1999-02-23 National Jewish Center For Immunology And Respiratory Medicine Embryonic cell populations and methods to isolate such populations
US5914268A (en) * 1994-11-21 1999-06-22 National Jewish Center For Immunology & Respiratory Medicine Embryonic cell populations and methods to isolate such populations
US5789147A (en) 1994-12-05 1998-08-04 New York Blood Center, Inc. Method for concentrating white cells from whole blood by adding a red cell sedimentation reagent to whole anticoagulated blood
US5695998A (en) * 1995-02-10 1997-12-09 Purdue Research Foundation Submucosa as a growth substrate for islet cells
US5716616A (en) * 1995-03-28 1998-02-10 Thomas Jefferson University Isolated stromal cells for treating diseases, disorders or conditions characterized by bone defects
US5733541A (en) * 1995-04-21 1998-03-31 The Regent Of The University Of Michigan Hematopoietic cells: compositions and methods
US5830708A (en) 1995-06-06 1998-11-03 Advanced Tissue Sciences, Inc. Methods for production of a naturally secreted extracellular matrix
US5654381A (en) 1995-06-16 1997-08-05 Massachusetts Institute Of Technology Functionalized polyester graft copolymers
US5877299A (en) * 1995-06-16 1999-03-02 Stemcell Technologies Inc. Methods for preparing enriched human hematopoietic cell preparations
US5935576A (en) 1995-09-13 1999-08-10 Fordham University Compositions and methods for the treatment and prevention of neoplastic diseases using heat shock proteins complexed with exogenous antigens
US5858782A (en) * 1995-11-13 1999-01-12 Regents Of The University Of Michigan Functional human hematopoietic cells
US5716794A (en) * 1996-03-29 1998-02-10 Xybernaut Corporation Celiac antigen
US5919176A (en) 1996-05-14 1999-07-06 Children's Hospital Medical Center Of Northern California Apparatus and method for collecting blood from an umbilical cord
US5798368A (en) 1996-08-22 1998-08-25 Celgene Corporation Tetrasubstituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines and method of reducing TNFα levels
US5635517B1 (en) * 1996-07-24 1999-06-29 Celgene Corp Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines
HU228769B1 (en) * 1996-07-24 2013-05-28 Celgene Corp Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha
US6281230B1 (en) 1996-07-24 2001-08-28 Celgene Corporation Isoindolines, method of use, and pharmaceutical compositions
US5827740A (en) 1996-07-30 1998-10-27 Osiris Therapeutics, Inc. Adipogenic differentiation of human mesenchymal stem cells
EP1361210B1 (en) 1996-08-12 2008-12-24 Celgene Corporation Novel immunotherapeutic agents and their use in the reduction of cytokine levels
US5851984A (en) 1996-08-16 1998-12-22 Genentech, Inc. Method of enhancing proliferation or differentiation of hematopoietic stem cells using Wnt polypeptides
US5916202A (en) * 1996-08-30 1999-06-29 Haswell; John N. Umbilical cord blood collection
US6152142A (en) 1997-02-28 2000-11-28 Tseng; Scheffer C. G. Grafts made from amniotic membrane; methods of separating, preserving, and using such grafts in surgeries
US5879318A (en) * 1997-08-18 1999-03-09 Npbi International B.V. Method of and closed system for collecting and processing umbilical cord blood
US5955476A (en) 1997-11-18 1999-09-21 Celgene Corporation Substituted 2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing inflammatory cytokine levels
US5874448A (en) * 1997-11-18 1999-02-23 Celgene Corporation Substituted 2-(2,6 dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing TNFα levels
US6059968A (en) * 1998-01-20 2000-05-09 Baxter International Inc. Systems for processing and storing placenta/umbilical cord blood
SK13642000A3 (sk) * 1998-03-16 2001-04-09 Celgene Corporation 2-(2,6-dioxopiperidin-3-yl)izoindolínové deriváty, farmaceutický prostriedok s ich obsahom a ich použitie
US6030836A (en) * 1998-06-08 2000-02-29 Osiris Therapeutics, Inc. Vitro maintenance of hematopoietic stem cells
AU4336499A (en) 1998-06-08 1999-12-30 Osiris Therapeutics, Inc. Regulation of hematopoietic stem cell differentiation by the use of human mesenchymal stem cells
US6361998B1 (en) 1998-06-25 2002-03-26 Hemosol Inc. Efficient culture of stem cells for the production of hemoglobin
WO2000017325A1 (en) 1998-09-23 2000-03-30 Mount Sinai Hospital Trophoblast cell preparations
CA2354591A1 (en) 1998-12-17 2000-06-22 F. Hoffmann-La Roche Ag 4-aryloxindoles as inhibitors of jnk protein kinases
US6288089B1 (en) 1998-12-21 2001-09-11 Michael Zawada Use of kinase inhibitors for treating neurodegenerative diseases
WO2000055134A1 (en) * 1999-03-18 2000-09-21 Celgene Corporation Substituted 1-oxo- and 1,3-dioxoisoindolines and their use in pharmaceutical compositions for reducing inflammatory cytokine levels
US6233476B1 (en) 1999-05-18 2001-05-15 Mediguide Ltd. Medical positioning system
WO2000073421A2 (en) 1999-06-02 2000-12-07 Lifebank Services, L.L.C. Methods of isolation, cryopreservation, and therapeutic use of human amniotic epithelial cells
AU7611500A (en) 1999-09-24 2001-04-24 Abt Holding Company Pluripotent embryonic-like stem cells, compositions, methods and uses thereof
EP1110957A1 (en) 1999-12-24 2001-06-27 Applied Research Systems ARS Holding N.V. Benzazole derivatives and their use as JNK modulators
JP2003519796A (ja) 2000-01-12 2003-06-24 ヴェンタナ メディカル システムズ インコーポレイテッド 画像分析によるタンパク質の定量法
JP2004500824A (ja) * 2000-03-09 2004-01-15 クリオ−セル インターナショナル インコーポレーティッド 脳および脊髄の修復のための神経組織源としてのヒト臍帯血
WO2001075094A1 (en) 2000-04-04 2001-10-11 Thomas Jefferson University Application of myeloid-origin cells to the nervous system
US7282366B2 (en) * 2000-04-27 2007-10-16 Geron Corporation Hepatocytes for therapy and drug screening made from embryonic stem cells
US6458810B1 (en) 2000-11-14 2002-10-01 George Muller Pharmaceutically active isoindoline derivatives
AU3929402A (en) 2000-11-22 2002-06-11 Geron Corp Tolerizing allografts of pluripotent stem cells
US20030032179A1 (en) * 2000-12-06 2003-02-13 Hariri Robert J. Post-partum mammalian placenta, its use and placental stem cells therefrom
US20080152629A1 (en) * 2000-12-06 2008-06-26 James Edinger Placental stem cell populations
US7311905B2 (en) 2002-02-13 2007-12-25 Anthrogenesis Corporation Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells
EP2206772A3 (en) * 2000-12-06 2010-08-04 Robert J. Hariri Method of collecting placental stem cells
US7091353B2 (en) * 2000-12-27 2006-08-15 Celgene Corporation Isoindole-imide compounds, compositions, and uses thereof
US20030045552A1 (en) * 2000-12-27 2003-03-06 Robarge Michael J. Isoindole-imide compounds, compositions, and uses thereof
WO2002063962A1 (en) * 2001-02-14 2002-08-22 Hariri Robert J Renovation and repopulation of decellularized tissues and cadaveric organs by stem cells
US20020132343A1 (en) 2001-03-19 2002-09-19 Clark Lum System and method for delivering umbilical cord-derived tissue-matched stem cells for transplantation
DE10139783C1 (de) 2001-08-14 2003-04-17 Transtissue Technologies Gmbh Zellzusammensetzungen zur Behandlung von Osteoarthrose, sowie Verfahren zu deren Herstellung
WO2003018780A1 (en) * 2001-08-27 2003-03-06 Advanced Cell Technology, Inc. De-differentiation and re-differentiation of somatic cells and production of cells for cell therapies
EP1288293A1 (en) 2001-08-30 2003-03-05 Norio Sakuragawa Human neural stem cells originated from human amniotic mesenchymal cell layer
CN1195055C (zh) 2001-09-06 2005-03-30 周胜利 从胎盘组织中提取造血干细胞用于建立造血干细胞库的新方法
US8021876B2 (en) 2001-11-15 2011-09-20 Children's Medical Center Corporation Methods of isolation, expansion and differentiation of fetal stem cells from chorionic villus, amniotic fluid, and placenta and therapeutic uses thereof
US7799324B2 (en) 2001-12-07 2010-09-21 Geron Corporation Using undifferentiated embryonic stem cells to control the immune system
US7700090B2 (en) 2002-02-13 2010-04-20 Anthrogenesis Corporation Co-culture of placental stem cells and stem cells from a second source
NZ534643A (en) * 2002-02-13 2010-06-25 Anthrogenesis Corp Embryonic-like stem cells derived from post-partum mammalian placenta and uses and methods of treatment using said cells
US20030187515A1 (en) * 2002-03-26 2003-10-02 Hariri Robert J. Collagen biofabric and methods of preparing and using the collagen biofabric
JP2003274973A (ja) * 2002-03-27 2003-09-30 Nara Institute Of Science & Technology キサントシンメチル化酵素およびその用途
US7498171B2 (en) * 2002-04-12 2009-03-03 Anthrogenesis Corporation Modulation of stem and progenitor cell differentiation, assays, and uses thereof
ZA200408369B (en) 2002-04-12 2006-11-29 Celgene Corp Methods for identification of modulators of angiogenesis, compounds discovered thereby, and methods of treatment using the compounds
MXPA04009997A (es) * 2002-04-12 2004-12-13 Celgene Corp Modulacion de la diferenciacion de celulas madre y progenitoras, ensayos y usos de las mismas.
US20040161419A1 (en) 2002-04-19 2004-08-19 Strom Stephen C. Placental stem cells and uses thereof
CA2488013A1 (en) * 2002-05-30 2003-12-11 Celgene Corporation Methods of using jnk or mkk inhibitors to modulate cell differentiation and to treat myeloproliferative disorders and myelodysplastic syndromes
US7422736B2 (en) 2002-07-26 2008-09-09 Food Industry Research And Development Institute Somatic pluripotent cells
CN1717177A (zh) * 2002-11-26 2006-01-04 人类起源公司 细胞治疗剂、细胞治疗单元及其用于治疗的方法
AU2004212009B2 (en) * 2003-02-13 2010-07-29 Celularity Inc. Use of umbilical cord blood to treat individuals having a disease, disorder or condition
CN1548529A (zh) 2003-05-09 2004-11-24 中国人民解放军军事医学科学院基础医 一种人胎盘间充质干细胞的分离方法
ES2568463T3 (es) 2003-06-27 2016-04-29 DePuy Synthes Products, Inc. Regeneración y reparación de tejido neural usando células del postparto derivadas del cordon umbilical
JP5089170B2 (ja) 2003-12-02 2012-12-05 セルジーン コーポレイション 異常ヘモグロビン症及び貧血症の治療及び管理のための方法及び組成物
US20050266391A1 (en) 2004-01-15 2005-12-01 Bennett Brydon L Methods for preserving tissue
WO2005093044A1 (en) 2004-03-22 2005-10-06 Osiris Therapeutics, Inc. Mesenchymal stem cells and uses therefor
CN1961283A (zh) 2004-03-26 2007-05-09 细胞基因公司 建立干细胞库的系统和方法
US7244759B2 (en) 2004-07-28 2007-07-17 Celgene Corporation Isoindoline compounds and methods of making and using the same
US7909806B2 (en) * 2004-09-23 2011-03-22 Anthrogenesis Corporation Cord blood and placenta collection kit
US7147626B2 (en) * 2004-09-23 2006-12-12 Celgene Corporation Cord blood and placenta collection kit
US20060128012A1 (en) * 2004-12-03 2006-06-15 Treena Arinzeh Substrate recognition by differentiable human mesenchymal stem cells
EP1838842A2 (en) 2004-12-23 2007-10-03 Ethicon, Incorporated Treatment of osteochondral diseases using postpartum-derived cells and products thereof
WO2006088867A2 (en) * 2005-02-15 2006-08-24 Medistem Laboratories, Incorporated Method for expansion of stem cells
US8435787B2 (en) 2005-05-10 2013-05-07 Rutgers, The State University Of New Jersey Alginate polyelectrolyte encapsulation of embryonic stem cells
BRPI0611739A2 (pt) * 2005-06-10 2011-12-20 Celgene Corp colágeno de atelopeptìdeo, composição, método e kit para aumentar, avolumar ou substituir tecido de um mamìfero, e, processos para preparar e para reticular colágeno de atelopeptìdeo, e para reduzir a quantidade de partìculas virais em uma composição de colágeno
US20070038298A1 (en) * 2005-06-30 2007-02-15 Sulner Joseph W Repair of tympanic membrane using placenta derived collagen biofabric
US7928280B2 (en) * 2005-07-13 2011-04-19 Anthrogenesis Corporation Treatment of leg ulcers using placenta derived collagen biofabric
WO2007009061A2 (en) * 2005-07-13 2007-01-18 Anthrogenesis Corporation Ocular plug formed from placenta derived collagen biofabric
CA2624916A1 (en) * 2005-10-13 2007-04-26 Anthrogenesis Corporation Production of oligodendrocytes from placenta-derived stem cells
AU2006304277B2 (en) 2005-10-13 2012-07-05 Celularity Inc. Immunomodulation using placental stem cells
CN100344757C (zh) 2005-10-18 2007-10-24 天津昂赛细胞基因工程有限公司 人胎盘、脐带间充质干细胞库及其构建方法
KR20080097190A (ko) 2005-12-29 2008-11-04 안트로제네시스 코포레이션 태반 줄기세포의 수집과 보존을 위한 개선된 조성물과 이조성물의 이용 방법
KR101900809B1 (ko) 2005-12-29 2018-09-20 안트로제네시스 코포레이션 태반 줄기 세포 집단
AU2007238660C1 (en) 2006-04-14 2013-11-07 Astellas Institute For Regenerative Medicine Hemangio-colony forming cells
CN101501185A (zh) * 2006-06-09 2009-08-05 人类起源公司 胎盘巢(placental niche)及其培养干细胞的用途
WO2008003042A2 (en) * 2006-06-28 2008-01-03 The University Of Medicine And Dentistry Of New Jersey Amnion-derived stem cells and uses thereof
US7993918B2 (en) * 2006-08-04 2011-08-09 Anthrogenesis Corporation Tumor suppression using placental stem cells
US8105634B2 (en) * 2006-08-15 2012-01-31 Anthrogenesis Corporation Umbilical cord biomaterial for medical use
US8122763B2 (en) * 2006-09-01 2012-02-28 Avair, Llc Breathing gas supply visual broadcast apparatus
WO2008036374A2 (en) 2006-09-21 2008-03-27 Medistem Laboratories, Inc. Allogeneic stem cell transplants in non-conditioned recipients
WO2008042441A1 (en) * 2006-10-03 2008-04-10 Anthrogenesis Corporation Use of umbilical cord biomaterial for ocular surgery
WO2008060377A2 (en) 2006-10-04 2008-05-22 Anthrogenesis Corporation Placental or umbilical cord tissue compositions
CA3178363A1 (en) 2006-10-06 2008-05-15 Celularity Inc. Human placental collagen compositions, and methods of making and using the same
EP3483263A1 (en) 2006-10-23 2019-05-15 Celularity, Inc. Methods and compositions for treatment of bone defects with placental cell populations
EP2687220A3 (en) 2007-02-12 2014-05-14 Anthrogenesis Corporation Treatment of inflammatory diseases using placental stem cells
CA2677679A1 (en) 2007-02-12 2008-08-21 Anthrogenesis Corporation Hepatocytes and chondrocytes from adherent placental stem cells; and cd34+, cd45- placental stem cell-enriched cell populations
US20100172830A1 (en) 2007-03-29 2010-07-08 Cellx Inc. Extraembryonic Tissue cells and method of use thereof
KR101644659B1 (ko) * 2007-09-26 2016-08-01 안트로제네시스 코포레이션 인간 태반 관류액으로부터의 혈관형성 세포
KR20230065354A (ko) 2007-09-28 2023-05-11 셀룰래리티 인코포레이티드 인간 태반 관류액 및 인간 태반-유래 중간체 천연 킬러 세포를 사용한 종양 억제 방법
KR20170116221A (ko) * 2007-11-07 2017-10-18 안트로제네시스 코포레이션 조산 합병증의 치료에 있어서의 제대혈의 용도
EP3539380A3 (en) 2008-08-20 2019-12-18 Celularity, Inc. Improved cell composition and methods of making the same
JP5950577B2 (ja) 2008-08-20 2016-07-13 アンスロジェネシス コーポレーション 単離胎盤細胞を使用した脳卒中の治療
ES2426241T3 (es) 2008-08-22 2013-10-22 Anthrogenesis Corporation Métodos y composiciones para el tratamiento de defectos óseos con poblaciones de células placentarias
WO2010059828A1 (en) 2008-11-19 2010-05-27 Anthrogenesis Corporation Amnion derived adherent cells
MX2011005230A (es) 2008-11-21 2011-06-16 Anthrogenesis Corp Tratamiento de enfermedades, desordenes o condiciones del pulmon usando celulas de placenta.
US20100323446A1 (en) 2009-06-05 2010-12-23 Jill Renee Barnett Method of collecting placental cells
MX353489B (es) * 2009-07-02 2018-01-16 Anthrogenesis Corp Metodo para producir eritrocitos sin celulas alimentadoras.
AU2011209819A1 (en) 2010-01-26 2012-08-16 Anthrogenesis Corporation Treatment of bone-related cancers using placental stem cells
US20110280849A1 (en) 2010-03-26 2011-11-17 Anthrogenesis Corporation Tumor suppression using human placenta-derived intermediate natural killer cells and immunomodulatory compounds
TW202011974A (zh) 2010-04-07 2020-04-01 美商安瑟吉納西斯公司 利用胎盤幹細胞之血管新生
JP2013523823A (ja) 2010-04-08 2013-06-17 アントフロゲネシス コーポレーション 胎盤幹細胞を用いるサルコイドーシスの治療
AU2011279201B2 (en) 2010-07-13 2016-01-21 Celularity Inc. Methods of generating natural killer cells

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EP2129775A1 (en) 2009-12-09

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