[go: up one dir, main page]

MX2012000455A - Composiciones de matriz extra-celular y medio acondicionado a partir de celulas cultivadas bajo condiciones hipoxicas. - Google Patents

Composiciones de matriz extra-celular y medio acondicionado a partir de celulas cultivadas bajo condiciones hipoxicas.

Info

Publication number
MX2012000455A
MX2012000455A MX2012000455A MX2012000455A MX2012000455A MX 2012000455 A MX2012000455 A MX 2012000455A MX 2012000455 A MX2012000455 A MX 2012000455A MX 2012000455 A MX2012000455 A MX 2012000455A MX 2012000455 A MX2012000455 A MX 2012000455A
Authority
MX
Mexico
Prior art keywords
hypoxic conditions
under hypoxic
extracellular matrix
conditioned medium
cells cultured
Prior art date
Application number
MX2012000455A
Other languages
English (en)
Inventor
Gail K Naughton
Frank Ziegler
Mark Baumgartner
Kyle Nickey
Original Assignee
Histogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US12/501,312 external-priority patent/US20100166824A1/en
Priority claimed from US12/509,171 external-priority patent/US8530415B2/en
Priority claimed from US12/547,422 external-priority patent/US8524494B2/en
Priority claimed from US12/632,721 external-priority patent/US8535913B2/en
Application filed by Histogen Inc filed Critical Histogen Inc
Publication of MX2012000455A publication Critical patent/MX2012000455A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
    • C12M3/02—Tissue, human, animal or plant cell, or virus culture apparatus with means providing suspensions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0656—Adult fibroblasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A61K38/1866—Vascular endothelial growth factor [VEGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/02—Atmosphere, e.g. low oxygen conditions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1323—Adult fibroblasts

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Sustainable Development (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Divulgado es un método para producir composiciones incluyendo proteína embriónicas. El método incluye cultivar células bajo condiciones hipóxicas sobre un soporte biocompatible in vitro. El método de cultivo produce fracciones tanto soluble y no soluble, las cuales pueden usarse por separado o en combinación para obtener composiciones fisiológicamente aceptables útiles en una variedad de aplicaciones.
MX2012000455A 2009-07-10 2010-07-09 Composiciones de matriz extra-celular y medio acondicionado a partir de celulas cultivadas bajo condiciones hipoxicas. MX2012000455A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12/501,312 US20100166824A1 (en) 2008-01-30 2009-07-10 Extracellular matrix compositions
US12/509,171 US8530415B2 (en) 2008-01-30 2009-07-24 Repair and/or regeneration of cells with a composition produced by culturing fibroblast cells under hypoxic conditions
US12/547,422 US8524494B2 (en) 2008-01-30 2009-08-25 Low oxygen tension and BFGF generates a multipotent stem cell from a fibroblast in vitro
US12/632,721 US8535913B2 (en) 2008-01-30 2009-12-07 Soluble composition for promoting hair growth produced by hypoxic culture of fibroblasts cells
PCT/US2010/041583 WO2011006107A1 (en) 2009-07-10 2010-07-09 Conditioned medium and extracellular matrix compositions from cells cultured under hypoxic conditions

Publications (1)

Publication Number Publication Date
MX2012000455A true MX2012000455A (es) 2012-04-11

Family

ID=43429571

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012000455A MX2012000455A (es) 2009-07-10 2010-07-09 Composiciones de matriz extra-celular y medio acondicionado a partir de celulas cultivadas bajo condiciones hipoxicas.

Country Status (16)

Country Link
EP (1) EP2451964B1 (es)
KR (1) KR101834019B1 (es)
CN (1) CN102482698B (es)
AU (1) AU2010271212B2 (es)
BR (1) BR112012000517B1 (es)
CA (2) CA2767600C (es)
DK (1) DK2451964T3 (es)
ES (1) ES2667265T3 (es)
HR (1) HRP20180594T1 (es)
HU (1) HUE038882T2 (es)
MX (1) MX2012000455A (es)
NO (1) NO2451964T3 (es)
PL (1) PL2451964T3 (es)
PT (1) PT2451964T (es)
RU (1) RU2631488C2 (es)
WO (1) WO2011006107A1 (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103387959A (zh) * 2012-10-19 2013-11-13 夏佑红 一种乳牙干细胞及其制备方法和应用
AU2014209218B2 (en) 2013-01-25 2018-06-07 Xcell Biosciences, Inc. Methods, compositions, kits, and systems for selective enrichment of target cells
US10533191B2 (en) 2014-01-15 2020-01-14 Serucell Corporation Therapeutic serum obtained from co-cultured cells
JP6989591B2 (ja) * 2016-04-26 2022-01-05 アイレットワン・アーベー 多能性細胞の誘導及び自己再生並びにその使用
FR3055806B1 (fr) * 2016-09-15 2024-04-12 Symbioken Procede de preparation d’une composition pour la reparation tissulaire
KR101885373B1 (ko) 2016-10-20 2018-08-03 한남대학교 산학협력단 간헐적 저산소에 노출된 쥐 간의 유전자 분석방법
CN106511384A (zh) * 2016-11-08 2017-03-22 广州医科大学附属第三医院 一种用于促进糖尿病创面愈合的冻干粉及其制备方法
JP6557717B2 (ja) 2016-12-23 2019-08-07 インスコビー・インコーポレイテッドＩｎｓｃｏｂｅｅ，Ｉｎｃ． 生体植立用インプラント及びその製造方法
KR102009081B1 (ko) * 2016-12-23 2019-08-09 주식회사 인스코비 발모 촉진을 위한 생체 식립용 임플란트
CA3082896A1 (en) 2017-11-16 2019-05-23 Aivita Biomedical, Inc. Use of cell membrane-bound signaling factors
WO2019140267A1 (en) * 2018-01-12 2019-07-18 Histogen, Inc. Nutraceutical products from cell conditioned medium from cells cultured under hypoxic conditions
WO2019152522A1 (en) 2018-01-30 2019-08-08 Histogen, Inc. Extracellular vesicles derived from cells cultured under hypoxic conditions and uses thereof
KR102454189B1 (ko) * 2018-05-04 2022-10-14 연세대학교 산학협력단 저산소 조건을 이용한 모유두 세포 및 세포 스페로이드의 제조방법
WO2020028526A1 (en) * 2018-08-02 2020-02-06 Histogen, Inc. Conditioned medium and extracellular matrix compositions and uses thereof
KR20200040536A (ko) * 2018-10-10 2020-04-20 사회복지법인 삼성생명공익재단 저산소 조건에서 섬유아세포를 배양하여 제조한 조정배지를 포함하는 암세포 사멸 유도용 조성물 및 이의 제조 방법
KR102135178B1 (ko) 2019-01-15 2020-07-17 한남대학교 산학협력단 고중력에 노출된 쥐의 유전자 분석방법
US11352258B2 (en) 2019-03-04 2022-06-07 Honda Motor Co., Ltd. Multifunctional conductive wire and method of making
CN113748200A (zh) * 2019-04-03 2021-12-03 赛康特集团有限责任公司 用于纺织品和纤维的人细胞沉积的细胞外基质涂层
US10881693B2 (en) 2019-04-09 2021-01-05 Combangio, Inc. Processes for making and using a mesenchymal stem cell derived secretome
GB2606788A (en) * 2019-04-30 2022-11-23 Xcell Biosciences Inc Systems and methods for modulating a cell phenotype
AU2020354743B2 (en) * 2019-09-26 2024-05-02 Hiroshima University Method for manufacturing repairing agent for biological tissue damage, and repairing agent for biological tissue damage
KR102166453B1 (ko) 2020-02-03 2020-10-15 중앙대학교 산학협력단 Hapln1을 포함하는 폐질환 예방 또는 치료용 조성물
US12077780B2 (en) * 2020-02-14 2024-09-03 Allergan Sales, Llc Conditioned medium from cells cultured under hypoxic conditions and uses thereof
CN115968400A (zh) 2020-04-07 2023-04-14 康巴乔有限公司 冻干间充质干细胞来源的分泌蛋白质组及其用途
WO2022056198A1 (en) * 2020-09-14 2022-03-17 Ginkgo Bioworks, Inc. Use of bone morphogenetic proteins and their receptors for aesthetics and cosmetics
KR102406953B1 (ko) * 2021-05-17 2022-06-10 주식회사 에피바이오텍 신규한 모유두 세포 분리 방법
CN115518198B (zh) * 2022-10-11 2024-01-16 青岛大学 一种负载双向梯度ecm涂层的血管修复支架及其制备方法
KR102823859B1 (ko) 2022-10-24 2025-06-23 인하대학교 산학협력단 세포 배양 배지 내 산소 농도 조절 방법 및 이를 위한 장치
WO2024210477A1 (ko) * 2023-04-03 2024-10-10 에이치엘비셀 주식회사 세포외기질 및 기질결합 소포체를 포함하는 세포외기질 제조용 조성물 및 이의 제조방법

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1295796C (en) * 1984-03-27 1992-02-18 Conrad Whyne Biodegradable matrix and methods for producing same
US7410773B2 (en) * 1995-02-02 2008-08-12 Ghazi Jaswinder Dhoot Method of preparing an undifferentiated cell
US5830708A (en) 1995-06-06 1998-11-03 Advanced Tissue Sciences, Inc. Methods for production of a naturally secreted extracellular matrix
US6610540B1 (en) * 1998-11-18 2003-08-26 California Institute Of Technology Low oxygen culturing of central nervous system progenitor cells
US6372494B1 (en) * 1999-05-14 2002-04-16 Advanced Tissue Sciences, Inc. Methods of making conditioned cell culture medium compositions
US6280284B1 (en) 2000-03-17 2001-08-28 Carl Winefordner Toy submarine with counter rotating propellers
US20020155440A1 (en) * 2000-12-19 2002-10-24 Ljubimova Julia Y. Using overexpression of laminin alpha 4 subunit as a diagnostic and prognostic indicator of malignant tumors
EP1377661A4 (en) 2001-01-30 2009-10-21 Orthogene Inc COMPOSITIONS AND METHODS FOR TREATING OR REPAIRING DEFECTS OR LESIONS IN JOINT CARTILAGE USING SYNOVIAL LIQUID DERIVED TISSUE OR CELLS
ITPD20010032A1 (it) * 2001-02-09 2002-08-09 Fidia Advanced Biopolymers Srl Innesti ingegnerizzati per la riparazione di difetti osteocondrali
US20050032208A1 (en) * 2003-06-18 2005-02-10 Oh Steve Kah Weng Materials and methods to produce stem cells
ES2297516T3 (es) 2003-12-02 2008-05-01 Universiteit Gent Uso de alginato polisulfatado en matrices celulares.
WO2005104766A2 (en) * 2004-04-28 2005-11-10 Myocardial Therapeutics, Inc. Injection of bone marrow-derived conditioned medium for angiogenesis
US7828711B2 (en) * 2004-08-16 2010-11-09 Cardiac Pacemakers, Inc. Method and apparatus for modulating cellular growth and regeneration using ventricular assist device
AU2005279771A1 (en) * 2004-08-30 2006-03-09 Theregen, Inc Cultured three dimensional tissues and uses thereof
US20060115460A1 (en) * 2004-08-30 2006-06-01 Naughton Gail K Compositions and methods comprising WNT proteins to promote repair of damaged tissue
AU2009209022B2 (en) * 2008-01-30 2014-06-12 Histogen, Inc. Extracellular matrix compositions

Also Published As

Publication number Publication date
AU2010271212A1 (en) 2012-03-01
WO2011006107A1 (en) 2011-01-13
BR112012000517B1 (pt) 2022-04-12
BR112012000517A2 (pt) 2021-01-05
RU2012104650A (ru) 2013-08-20
PL2451964T3 (pl) 2018-08-31
EP2451964A1 (en) 2012-05-16
CA3152419A1 (en) 2011-01-13
PT2451964T (pt) 2018-05-07
ES2667265T3 (es) 2018-05-10
EP2451964A4 (en) 2013-04-17
EP2451964B1 (en) 2018-01-24
DK2451964T3 (en) 2018-04-30
HRP20180594T1 (hr) 2018-08-10
CA2767600A1 (en) 2011-01-13
HUE038882T2 (hu) 2018-12-28
KR20120089235A (ko) 2012-08-09
CN102482698A (zh) 2012-05-30
NO2451964T3 (es) 2018-06-23
KR101834019B1 (ko) 2018-03-02
RU2631488C2 (ru) 2017-09-22
CA2767600C (en) 2022-05-31
AU2010271212B2 (en) 2015-07-16
CN102482698B (zh) 2018-09-25

Similar Documents

Publication Publication Date Title
MX2012000455A (es) Composiciones de matriz extra-celular y medio acondicionado a partir de celulas cultivadas bajo condiciones hipoxicas.
SG10201906494PA (en) Extracellular matrix compositions
WO2008060541A3 (en) In vitro expansion of postpartum-derived cells using microcarriers
IL273159B1 (en) A culture medium preparation, and a method for culturing cells or tissues by using the preparation
WO2012118799A3 (en) Cell culture system
TW200613556A (en) Isolation, cultivation and uses of stem/progenitor cells
WO2009137624A3 (en) Hemangio colony forming cells and non-engrafting hemangio cells
WO2012056110A3 (en) Cell culture material based on microbial cellulose
WO2007080590A3 (en) Human embryonic stem cell-derived connective tissue progenitors for tissue engineering
EP2548950A3 (en) Reprogramming T cells and hematopoietic cells
PL2274419T3 (pl) Sposoby wytwarzania mikromieszków włosowych i brodawek de novo i stosowanie ich w badaniach in vitro i przeszczepach in vivo
EP4517321A3 (en) Method of nociceptor differentiantion of human embryonic stem cells and uses thereof
MY156588A (en) Systems using cell culture for production of isoprene
MX2012005782A (es) Procedimientos, composiciones y kits de liofilizacion.
GB2449042A (en) Erythroid cells producing adult-type b-hemoglobin generated from human embryonic stem cells
MX2009008559A (es) Hepatocitos y condorcitos de celulas madre de la placenta adherentes, y poblaciones de celulas enriquecidas con celulas madre de la placenta cd34+, cd45-.
MX2009009371A (es) Produccion mejorada de derivados de acidos grasos.
MX2019015321A (es) Composiciones tridimensionales de tejido y métodos de uso.
MX2015005797A (es) Produccion de vacuna recombinante en e.coli mediante conjugacion enzimatica.
WO2009002456A3 (en) Methods and compositions relating to progenitor cells
WO2011091350A3 (en) Methods & compositions for improving protein production
BRPI0506839A (pt) composições e métodos para induzir a cardiomiogênese
EP1702064A4 (en) BIOMETRIC COMPOSITION REINFORCED BY A POLYELECTROLYTIC COMPLEX OF HYALURONIC ACID AND CHITOSAN
SG148171A1 (en) Methods of proliferating stem cells
CL2010000774A1 (es) Medio para el cultivo de celulas de mamiferos que comprende ademas de los nutrientes habituales de los medios de cultivo basales para cultivo de celulas de mamiferos, sobrenadante de la fraccion ii+iii del plasma humano segun el metodo de cohn; procedimiento de preparacion; y su uso.